Synthesis and evaluation of pyridone-phenoxypropyl-R-2-methylpyrrolidine analogues as histamine H 3 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7076-7080

  Becknell, Nadine C ^a   Lyons, Jacquelyn A ^a   Aimone, Lisa D ^a   Gruner, John A ^a   Mathiasen, Joanne R ^a   Raddatz, Rita ^a   Hudkins, Robert L ^a  

^a CEPHALON INC   (United States)

Author keywords

CEP 26401; H 3 Antagonists; Histamine H 3; Pyridone; Sleep wake

Indexed keywords

HISTAMINE H3 RECEPTOR ANTAGONIST; PYRIDONE PHENOXYPROPYL R 2 METHYLPYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; DRUG SYNTHESIS; HUMAN; IN VIVO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; DISEASE MODELS, ANIMAL; HISTAMINE H3 ANTAGONISTS; HUMANS; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIDAZINES; PYRROLIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 80255127310     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.091     Document Type: Article

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