Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress

Laboratory Investigation

Volumn 91, Issue 11, 2011, Pages 1572-1583

  Blackburn, Anneke C ^a   Coggan, Marjorie ^a   Shield, Alison J ^a,b   Cappello, Jean ^a   Theodoratos, Angelo ^a   Murray, Tracy P ^a   Rooke, Melissa ^a   Larter, Claire Z ^c   Koina, Mark E ^c   Dahlstrom, Jane E ^a,c   Matthaei, Klaus I ^a   Board, Philip G ^a  

^a Biology and Environment   (Australia)

^b UNIVERSITY OF CANBERRA   (Australia)

^c CANBERRA HOSPITAL   (Australia)

Author keywords

glomerular nephropathy; glutathione transferase kappa; GSTK1 1 deficiency; knockout mice; mitochondria

Indexed keywords

ALBUMIN; CREATININE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE KAPPA 1; LIPID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; CELL STRUCTURE; ELECTRON MICROSCOPY; ENZYME DEFICIENCY; GLOMERULONEPHRITIS; GLOMERULUS BASEMENT MEMBRANE; KIDNEY TUBULE; LIPID BLOOD LEVEL; MALE; MICROALBUMINURIA; MITOCHONDRION; MOUSE; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; URINARY TRACT DISEASE; WESTERN BLOTTING;

EID: 80155151944     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.107     Document Type: Article

References (38)

1. Morel F, Rauch C, Petit E, et al. Gene and protein characterization of the human glutathione S-transferase kappa and evidence for a peroxisomal localization. J Biol Chem 2004;279:16246-16253. (Pubitemid 38509318)
2. Jowsey IR, Thomson RE, Orton TC, et al. Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase. Biochem J 2003;373(Part 2):559-569. (Pubitemid 36897858)
3. Robinson A, Huttley GA, Booth HS, et al. Modelling and bioinformatics studies of the human kappa class glutathione transferase predict a novel third glutathione transferase family with homology to prokaryotic 2-hydroxychromene-2- carboxylate (HCCA) isomerases. Biochem J 2004;379(Part 3):541-552. (Pubitemid 38703638)
4. Ladner JE, Parsons JF, Rife CL, et al. Parallel evolutionary pathways for glutathione transferases: structure and mechanism of the mitochondrial class kappa enzyme rGSTK1-1. Biochemistry 2004;43: 352-361. (Pubitemid 38082557)
5. Thomson RE, Bigley AL, Foster JR, et al. Tissue-specific expression and subcellular distribution of murine glutathione S-transferase class kappa. J Histochem Cytochem 2004;52:653-662. (Pubitemid 38658197)
6. Kuhm AE, Knackmuss HJ, Stolz A. Purification and properties of 20- hydroxybenzalpyruvate aldolase from a bacterium that degrades naphthalenesulfonates. J Biol Chem 1993;268:9484-9489. (Pubitemid 23146001)
7. Thomas KR, Capecchi MR. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 1987;51:503-512.
8. Lim CE, Matthaei KI, Blackburn AC, et al. Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. Am J Pathol 2004;165: 679-693. (Pubitemid 38971397)
9. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130-7139.
10. Mannervik B, MW. Human glutathione transferases: classification, tissue distribution, structure and functional properties. In: PG M, FG N (eds). Advances in Drug Metabolism in Man. The European Commission: Brussels, 1995, pp 407-460.
11. Baker MA, Cerniglia GJ, Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem 1990;190:360-365. (Pubitemid 20371981)
12. Blackburn AC, Matthaei KI, Lim C, et al. Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Mol Pharmacol 2006;69:650-657. (Pubitemid 43121962)
13. Jo YI, Cheng H, Wang S, et al. Puromycin induces reversible proteinuric injury in transgenic mice expressing cyclooxygenase-2 in podocytes. Nephron Exp Nephrol 2007;107:e87-e94. (Pubitemid 350073618)
14. Sharma R, Ahmad H, Singhal SS, et al. Comparative studies on the effect of butylated hydroxyanisole on glutathione and glutathione Stransferases in the tissues of male and female CD-1 mice. Comp Biochem Physiol C 1993;105:31-37. (Pubitemid 23186382)
15. Engle MR, Singh SP, Czernik PJ, et al. Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse. Toxicol Appl Pharmacol 2004;194: 296-308. (Pubitemid 38180461)
16. Chen A, Sheu LF, Chou WY, et al. Involvement of immunopathogenic mechanisms in a spontaneously occurring glomerulopathy in mice. Nephron 1998;78:63-72. (Pubitemid 28014462)
17. Bargman JM. Management of minimal lesion glomerulonephritis: evidence-based recommendations. Kidney Int Suppl 1999;70:S3-16.
18. Cattran D. Management of membranous nephropathy: when and what for treatment. J Am Soc Nephrol 2005;16:1188-1194. (Pubitemid 41716503)
19. Asanuma K, Mundel P. The role of podocytes in glomerular pathobiology. Clin Exp Nephrol 2003;7:255-259. (Pubitemid 38031285)
20. Liu M, Zhou L, Xu A, et al. A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci U S A 2008;105:18302-18307.
21. Sharma K, Ramachandrarao S, Qiu G, et al. Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 2008;118: 1645-1656. (Pubitemid 351632369)
22. Savige J. Hereditary abnormalities of renal basement membranes. Pathology 1991;23:350-355.
23. Olson JL. The Nephrotic Syndrome and Minimal Change Disease; Vol. 1, 6th edn, Lippincott Williams and Wilkins: Philadelphia, 2007, pp 136-146.
24. Mathieson PW. The cellular basis of albuminuria. Clin Sci (Lond) 2004;107:533-538. (Pubitemid 39627200)
25. Koop K, Eikmans M, Baelde HJ, et al. Expression of podocyte-associated molecules in acquired human kidney diseases. J Am Soc Nephrol 2003;14:2063-2071. (Pubitemid 36909914)
26. Jarad G, Cunningham J, Shaw AS, et al. Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. J Clin Invest 2006;116: 2272-2279. (Pubitemid 44162337)
27. Harris JM, Meyer DJ, Coles B, et al. A novel glutathione transferase (13- 13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes. Biochem J 1991;278(Part 1):137-141.
28. Peng M, Falk MJ, Haase VH, et al. Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease. PLoS Genet 2008;4:e1000061.
29. Diomedi-Camassei F, Di Giandomenico S, Santorelli FM, et al. COQ2 nephropathy: a newly described inherited mitochondriopathy with primary renal involvement. J Am Soc Nephrol 2007;18:2773-2780. (Pubitemid 47531205)
30. Holthofer H, Kretzler M, Haltia A, et al. Altered gene expression and functions of mitochondria in human nephrotic syndrome. Faseb J 1999;13:523-532. (Pubitemid 29115570)
31. Solin ML, Pitkanen S, Taanman JW, et al. Mitochondrial dysfunction in congenital nephrotic syndrome. Lab Invest 2000;80:1227-1232. (Pubitemid 30637062)
32. Krick S, Shi S, Ju W, et al. Mpv17 l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease. Proc Natl Acad Sci USA 2008;105:14106-14111.
33. Weiher H, Noda T, Gray DA, et al. Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome. Cell 1990;62:425-434.
34. Binder CJ, Weiher H, Exner M, et al. Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy. Am J Pathol 1999;154:1067-1075. (Pubitemid 29169741)
35. O'Bryan T, Weiher H, Rennke HG, et al. Course of renal injury in the Mpv17-deficient transgenic mouse. J Am Soc Nephrol 2000; 11:1067-1074. (Pubitemid 30367936)
36. Meyer zum Gottesberge AM, Reuter A, Weiher H. Inner ear defect similar to Alport's syndrome in the glomerulosclerosis mouse model Mpv17. Eur Arch Otorhinolaryngol 1996;253:470-474. (Pubitemid 26387921)
37. Smithies O. Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function. Proc Natl Acad Sci USA 2003;100:4108-4113. (Pubitemid 36418165)
38. Petit E, Michelet X, Rauch C, et al. Glutathione transferases kappa 1 and kappa 2 localize in peroxisomes and mitochondria, respectively, and are involved in lipid metabolism and respiration in Caenorhabditis elegans. Febs J 2009;276:5030-5040.