Circulating AST, H-FABP, and NGAL are early and accurate biomarkers of graft injury and dysfunction in a preclinical model of kidney transplantation

Annals of Surgery

Volumn 254, Issue 5, 2011, Pages 784-791

  Jochmans, Ina ^a   Lerut, Evelyne ^a   Van Pelt, Jos ^b   Monbaliu, Diethard ^a   Pirenne, Jacques ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CREATININE; HEART TYPE FATTY ACID BINDING PROTEIN; N ACETYL BETA GLUCOSAMINIDASE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; UNCLASSIFIED DRUG; 2 OXOGLUTARIC ACID; ASPARTIC ACID; FATTY ACID BINDING PROTEIN; GLUTAMIC ACID; HEART TYPE FATTY AFCID BINDING PROTEIN; MESSENGER RNA; OXALOACETIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOTRANSPLANTATION; CENTRAL VENOUS PRESSURE; COLD ISCHEMIA; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE CLEARANCE; DIURESIS; EXPERIMENTAL PIG; FEMALE; HISTOPATHOLOGY; INJURY SEVERITY; ISCHEMIA; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TRANSPLANTATION; LIMIT OF DETECTION; MEAN ARTERIAL PRESSURE; METABOLIC CLEARANCE RATE; NONHUMAN; OPERATION DURATION; PRIORITY JOURNAL; RENAL GRAFT DYSFUNCTION; TISSUE PRESERVATION; TREATMENT OUTCOME; UNINEPHRECTOMY; CATALYSIS; EXPERIMENTAL MODEL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KNOCKOUT MOUSE; LIVER FUNCTION; LIVER ISCHEMIA; NOTE; OXIDATIVE STRESS; UPREGULATION;

ACETYLGLUCOSAMINIDASE; ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CREATININE; FATTY ACID-BINDING PROTEINS; FEMALE; KIDNEY FUNCTION TESTS; KIDNEY TRANSPLANTATION; LIPOCALINS; MODELS, ANIMAL; PRIMARY GRAFT DYSFUNCTION; SWINE;

EID: 80155149532     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e3182368fa7     Document Type: Conference Paper

References (39)

1. Halloran PF, Melk A, Barth C. Rethinking chronic allograft nephropathy: the concept of accelerated senescence. J Am Soc Nephrol. 1999;10:167-181. (Pubitemid 29034957)
2. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol. 1994;12:991-1045. (Pubitemid 24140436)
3. Pascual M, Theruvath T, Kawai T, et al. Strategies to improve long-term outcomes after renal transplantation. N Engl J Med. 2002;346:580-590. (Pubitemid 34438820)
4. Olthoff KM, Kulik L, Samstein B, et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl. 2010;16:943-949.
5. Gonzalez FX, Rimola A, Grande L, et al. Predictive factors of early postoperative graft function in human liver transplantation. Hepatology. 1994;20: 565-573. (Pubitemid 24271262)
6. McCormack L, Petrowsky H, Jochum W, et al. Use of severely steatotic grafts in liver transplantation: a matched case-control study. Ann Surg. 2007;246: 940-946. (Pubitemid 350179176)
7. Fiocchi R, Vernocchi A, Mammana C, et al. Continuous retrograde warm blood reperfusion reduces cardiac troponin I release after heart transplantation: a prospective randomized study. Transpl Int. 2000;13(suppl 1):S240-S244.
8. Carrier M, Solymoss BC, Cartier R, et al. Cardiac troponin T and creatine kinase MB isoenzyme as biochemical markers of ischemia after heart preservation and transplantation. J Heart Lung Transplant. 1994;13:696-700. (Pubitemid 24249613)
9. Schneeberger S, Biebl M, Steurer W, et al. A prospective randomized mul-ticenter trial comparing histidine-tryptophane-ketoglutarate versus University of Wisconsin perfusion solution in clinical pancreas transplantation. Transpl Int. 2009;22:217-224.
10. Stratta RJ, Sollinger HW, Perlman SB, et al. Early detection of rejection in pancreas transplantation. Diabetes. 1989;38(suppl 1):63-67. (Pubitemid 19029240)
11. Daly PJ, Power RE, Healy DA, et al. Delayed graft function: a dilemma in renal transplantation. BJU Int. 2005;96:498-501. (Pubitemid 41224316)
12. Halloran PF, Hunsicker LG. Delayed graft function: state of the art, November 10-11, 2000. Summit meeting, Scottsdale, Arizona, USA. Am J Transplant. 2001;1:115-120. (Pubitemid 33674150)
13. Mehta RL, Chertow GM. Acute renal failure definitions and classification: time for change? J Am Soc Nephrol. 2003;14:2178-2187. (Pubitemid 36909928)
14. Bonventre JV, Vaidya VS, Schmouder R, et al. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol. 2010;28:436-440.
15. Coca SG, Yalavarthy R, Concato J, et al. Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review. Kidney Int. 2008;73:1008-1016. (Pubitemid 351543898)
16. Waikar SS, Sabbisetti VS, Bonventre JV. Normalization of urinary biomark-ers to creatinine during changes in glomerular filtration rate. Kidney Int. 2010;78:486-494.
17. Kwon O, Nelson WJ, Sibley R, et al. Backleak, tight junctions, and cell-cell adhesion in postischemic injury to the renal allograft. J Clin Invest. 1998;101:2054-2064. (Pubitemid 28244089)
18. Panteghini M. Aspartate aminotransferase isoenzymes. Clin Biochem. 1990;23:311-319. (Pubitemid 20281412)
19. Liangos O, Perianayagam MC, Vaidya VS, et al. Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol. 2007;18: 904-912. (Pubitemid 46434507)
20. Hofstra JM, Deegens JK, Steenbergen EJ, et al. Urinary excretion of fatty acid-binding proteins in idiopathic membranous nephropathy. Nephrol Dial Transplant. 2008;23:3160-3165.
21. Parikh CR, Jani A, Mishra J, et al. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant. 2006;6:1639-1645. (Pubitemid 43945804)
22. Jochmans I, Lerut E, Heedfeld V, et al. Reproducible Model for Kidney Auto-transplantation in Pigs. Transplant Proc. 2009;41:3417-3421.
23. Commision of the European Communities. Guidelines for the Accommodation and Care of Animals Used for Experimental and Other Scientific Purposes; 2007/526/EC. Available at: www.eur-lex.europa.eu.
24. Richardson JA, Philbin PE. The one-hour creatinine clearance rate in healthy men. JAMA. 1971;216:987-990.
25. Hall IE, Yarlagadda SG, Coca SG, et al. IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation. J Am Soc Nephrol. 2009;21:189-197.
26. Snoeijs MG, van Bijnen A, Swennen E, et al. Tubular epithelial injury and inflammation after ischemia and reperfusion in human kidney transplantation. Ann Surg. 2011;253(3):598-604.
27. Perico N, Cattaneo D, Sayegh MH, et al. Delayed graft function in kidney transplantation. Lancet. 2004;364:1814-1827. (Pubitemid 39488068)
28. Pelsers MM, Hermens WT, Glatz JF. Fatty acid-binding proteins as plasma markers of tissue injury. Clin Chim Acta. 2005;352:15-35. (Pubitemid 40093855)
29. Bolignano D, Donato V, Coppolino G, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis. 2008;52:595-605.
30. Moers C, Varnav OC, van Heurn E, et al. The value of machine perfusion per-fusate biomarkers for predicting kidney transplant outcome. Transplantation. 2010;90:966-973.
31. Gok MA, Shenton BK, Buckley PE, et al. How to improve the quality of kidneys from non-heart-beating donors: a randomised controlled trial of thrombolysis in non-heart-beating donors. Transplantation. 2003;76:1714-1719. (Pubitemid 38032419)
32. Mori K, Lee HT, Rapoport D, et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest. 2005;115:610-621. (Pubitemid 40322235)
33. Mishra J, Dent C, Tarabishi R, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005;365:1231-1238. (Pubitemid 40469655)
34. Mishra J, Ma Q, Kelly C, et al. Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol. 2006;21:856-863. (Pubitemid 43740956)
35. Mitsnefes MM, Kathman TS, Mishra J, et al. Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol. 2007;22:101-108. (Pubitemid 46138368)
36. Furuhashi M, Ura N, Hasegawa K, et al. Serum ratio of heart-type fatty acid-binding protein to myoglobin. A novel marker of cardiac damage and volume overload in hemodialysis patients. Nephron Clin Pract. 2003;93:C69-C74.
37. Malyszko J, Malyszko JS, Kozminski P, et al. Possible relationship between neutrophil gelatinase-associated lipocalin, hepcidin, and inflammation in haemodialysed patients. Nephron Clin Pract. 2010;115:c268-c275.
38. Kusaka M, Kuroyanagi Y, Mori T, et al. Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death. Cell Transplant. 2008;17:129-134. (Pubitemid 351551388)
39. Bobek I, Gong D, De Cal M, et al. Removal of neutrophil gelatinase-associated lipocalin by extracorporeal therapies. Hemodial Int. 2010;14:302-307.