The m segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the Guinea pig model

Journal of Virology

Volumn 85, Issue 21, 2011, Pages 11235-11241

  Chou, Yi Ying ^a   Albrecht, Randy A ^a   Pica, Natalie ^a   Lowen, Anice C ^b   Richt, Jürgen A ^c   García Sastre, Adolfo ^a   Palese, Peter ^a   Hai, Rong ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2009 H1N1 INFLUENZA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC REASSORTMENT; GUINEA PIG; HEMAGGLUTINATION INHIBITION TEST; INFLUENZA VIRUS A H1N1; M SEGMENT; NONHUMAN; PRIORITY JOURNAL; SEROCONVERSION; VIRUS MORPHOLOGY; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TRANSMISSION;

ANIMALS; DISEASE MODELS, ANIMAL; GUINEA PIGS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; ORTHOMYXOVIRIDAE INFECTIONS; REASSORTANT VIRUSES; VIRAL MATRIX PROTEINS; VIRULENCE FACTORS;

CAVIA; ORTHOMYXOVIRIDAE; SUIDAE; SWINE INFLUENZA VIRUS;

EID: 80055120822     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05794-11     Document Type: Article

References (37)

1. Calder, L. J., S. Wasilewski, J. A. Berriman, and P. B. Rosenthal. 2010. Structural organization of a filamentous influenza A virus. Proc. Natl. Acad. Sci. U. S. A. 107:10685-10690.
2. CDC. 2009. Swine influenza A (H1N1) infection in two children-Southern California, March-April 2009. CDC, Atlanta, GA. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5815a5.htm.
3. Chen, L. M., et al. 2011. Receptor specificity of subtype H1 influenza A viruses isolated from swine and humans in the United States. Virology 412:401-410.
4. Dawood, F. S., et al. 2009. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. New Engl. J. Med. 360:2605-2615.
5. Fodor, E., et al. 1999. Rescue of influenza A virus from recombinant DNA. J. Virol. 73:9679-9682.
6. Gao, Q., E. W. Brydon, and P. Palese. 2008. A seven-segmented influenza A virus expressing the influenza C virus glycoprotein HEF. J. Virol. 82:6419-6426.
7. Garten, R. J., et al. 2009. Antigenic and genetic characteristics of swineorigin 2009 A(H1N1) influenza viruses circulating in humans. Science 325: 197-201.
8. Hai, R., et al. 2010. PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models. J. Virol. 84:4442-4450.
9. Hale, B. G., et al. 2010. Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein. J. Virol. 84:6909-6922.
10. Herfst, S., et al. 2010. Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission. J. Virol. 84:3752-3758.
11. Hinshaw, V. S., W. J. Bean, Jr., R. G. Webster, and B. C. Easterday. 1978. The prevalence of influenza viruses in swine and the antigenic and genetic relatedness of influenza viruses from man and swine. Virology 84:51-62.
12. Jagger, B. W., et al. 2010. The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase. mBio 1(1): e00067-10. doi:10.1128/mBio.00067-10.
13. Lam, T. T., et al. 27 July 2011. Reassortment events among swine influenza A viruses in China: implications for the origin of the 2009 influenza pandemic. J. Virol. doi:10.1128/JVI.05262-11.
14. Lowen, A. C., S. Mubareka, J. Steel, and P. Palese. 2007. Influenza virus transmission is dependent on relative humidity and temperature. PLoS Pathog. 3:1470-1476.
15. Lowen, A. C., S. Mubareka, T. M. Tumpey, A. Garcia-Sastre, and P. Palese. 2006. The guinea pig as a transmission model for human influenza viruses. Proc. Natl. Acad. Sci. U. S. A. 103:9988-9992.
16. Munster, V. J., et al. 2009. Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets. Science 325:481-483.
17. Myers, K. P., C. W. Olsen, and G. C. Gray. 2007. Cases of swine influenza in humans: a review of the literature. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 44:1084-1088.
18. Neumann, G., et al. 1999. Generation of influenza A viruses entirely from cloned cDNAs. Proc. Natl. Acad. Sci. U. S. A. 96:9345-9350.
19. Ozawa, M., et al. 2011. Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses. J. Virol. 85:4596-4601.
20. Palese, P., and M. L. Shaw. 2006. Orthomyxoviridae: the viruses and their replication, p. 1647-1690. In D. M. Knipe et al. (ed.), Fields virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA.
21. Quinlivan, M., et al. 2005. Attenuation of equine influenza viruses through truncations of the NS1 protein. J. Virol. 79:8431-8439.
22. Shinde, V., et al. 2009. Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009. N. Engl. J. Med. 360:2616-2625.
23. Shope, R. E. 1931. Swine influenza. III. Filtration experiments and etiology. J. Exp. Med. 54:373-385.
24. Smith, G. J., et al. 2009. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459:1122-1125.
25. Solorzano, A., et al. 2005. Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J. Virol. 79:7535-7543.
26. Song, M. S., et al. 2011. Virulence and genetic compatibility of polymerase reassortant viruses derived from the pandemic (H1N1) 2009 influenza virus and circulating influenza A viruses. J. Virol. 85:6275-6286.
27. Steel, J., A. C. Lowen, S. Mubareka, and P. Palese. 2009. Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N. PLoS Pathog. 5:e1000252.
28. Steel, J., et al. 2010. Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment. J. Virol. 84:21-26.
29. Terebuh, P., et al. 2010. Transmission of influenza A viruses between pigs and people, Iowa, 2002-2004. Influenza Other Respi. Viruses 4:387-396.
30. Thaa, B., A. Herrmann, and M. Veit. 2010. Intrinsic cytoskeleton-dependent clustering of influenza virus M2 protein with hemagglutinin assessed by FLIM-FRET. J. Virol. 84:12445-12449.
31. Tumpey, T. M., et al. 2007. A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. Science 315:655-659.
32. Van Hoeven, N., et al. 2009. Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding. J. Virol. 83:2851-2861.
33. Van Hoeven, N., et al. 2009. Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proc. Natl. Acad. Sci. U. S. A. 106:3366-3371.
34. Webby, R. J., et al. 2000. Evolution of swine H3N2 influenza viruses in the United States. J. Virol. 74:8243-8251.
35. WHO. 2009. Influenza A(H1N1)-update 61. WHO, Geneva, Switzerland. http://www.who.int/csr/don/2009_08_12/en/index.html.
36. Yang, H., P. Carney, and J. Stevens. 2010. Structure and receptor binding properties of a pandemic H1N1 virus hemagglutinin. PLoS Curr. 2:RRN1152.
37. Yen, H. L., et al. 2011. Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets. Proc. Natl. Acad. Sci. U. S. A. 108:14264-14269.