HCG hastens both the development of mammary carcinoma and the metastatization of HCG/LH and ERBB-2 receptor-positive cells in mice

International Journal of Immunopathology and Pharmacology

Volumn 24, Issue 3, 2011, Pages 621-630

  Iezzi, Manuela ^a   Quaglino, E ^d   Cappello, P ^b   Toto, V ^a   Sabatini, F ^a   Curcio, C ^a   Garotta, G ^c   Musiani, P ^a   Cavallo, F ^d  

^a UNIVERSITY OF CHIETI   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

^c NatMab   (Italy)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

2 neu; ERBB; hCG; Her2; Mammary carcinoma; Metastases; Murine model

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LUTEINIZING HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; BREAST HYPERPLASIA; CANCER GROWTH; CANCER INCIDENCE; CELL PROLIFERATION; CONTROLLED STUDY; ERBB 2 ONCOGENE; FEMALE; GENE EXPRESSION; HORMONE RELEASE; IN VITRO STUDY; IN VIVO STUDY; METASTASIS; MOUSE; NONHUMAN; NULLIPARA; ONCOGENE; PREGNANCY; PRIORITY JOURNAL; TRANSGENIC MOUSE; BREAST CARCINOGENESIS; CANCER SURVIVAL; CELL VACUOLE; EPITHELIUM CELL; GENE OVEREXPRESSION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; LUNG ALVEOLUS CELL; OVARIECTOMY;

EID: 80055113576     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463201102400308     Document Type: Article

References (27)

1. Gharib SD, Wierman ME, Shupnik MA, Chin WW. Molecular biology of the pituitary gonadotropins. Endocr Rev 1990; 11:177-99. (Pubitemid 20101343)
2. Themmen APN, Huhtaniemi IT. Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr Rev 2000; 21:551-83.
3. Risch HA. Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst 1998; 90:1774-86. (Pubitemid 28559889)
4. Hudelist G, Wuelfing P, Czerwenka K, et al. Beta-hCG/LH receptor (b-HCG/LH-R) expression is increased in invasive versus preinvasive breast cancer: implications for breast carcinogenesis? J Cancer Res Clin Oncol 2009; 135:191-5.
5. Iles RK, Delves PJ, Butler SA. Does hCG or hCGβ play a role in cancer cell biology? Mol Cell Endocrinol 2010; 329:62-70.
6. Risma KA, Clay CM, Nett TM, Wagner T, Yun J, Nilson JH. Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors. Proc Natl Acad Sci USA 1995; 92:1322-6.
7. Keri RA, Lozada KL, Abdul-Karim FW, Nadeau JH, Nilson JH. Luteinizing hormone induction of ovarian tumors: oligogenic differences between mouse strains dictates tumor disposition. Proc Natl Acad Sci USA 2000; 97:383-7. (Pubitemid 30055840)
8. Rulli SB, Kuorelahti A, Karaer O, Pelliniemi LJ, Poutanen M, Huhtaniemi I. Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin. Endocrinology 2002; 143:4084-95. (Pubitemid 35244387)
9. Milliken EL, Ameduri RK, Landis MD, Behrooz A, Abdul-Karim FW, Keri RA. Ovarian hyperstimulation by LH leads to mammary gland hyperplasia and cancer predisposition in transgenic mice. Endocrinology 2002; 143:3671-80. (Pubitemid 34925744)
10. Russo IH, Koszalka M, Gimotty PA, Russo J. Protective effect of chorionic gonadotropin on DMBA-induced mammary carcinogenesis. Br J Cancer 1990; 62:243-7. (Pubitemid 20242443)
11. Srivastava P, Russo J, Russo IH. Inhibition of rat mammary tumorigenesis by human chorionic gonadotropin associated with increased expression of inhibin. Mol Carcinog 1999; 26:10-9. (Pubitemid 29420181)
12. Russo IH, Russo J. Primary prevention of breast cancer by hormone-induced differentiation. Recent Results Cancer Res 2007; 174:111-30.
13. Quaglino E, Iezzi M, Mastini C, et al. Electroporated DNA vaccine clears away multifocal mammary carcinomas in her-2/neu transgenic mice. Cancer Res 2004; 64:2858-64. (Pubitemid 38500626)
14. Rovero S, Amici A, Di Carlo E, et al. DNA vaccination against rat her-2/Neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in trnsgenic BALB/c mice. J Immunol 2000; 165:5133-42.
15. Nanni P, De Giovanni C, Lollini PL, Nicoletti G, Prodi G. TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma. Clin Exp Metastasis 1983; 1:373-80. (Pubitemid 14221672)
16. Jones FE, Stern DF. Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation. Oncogene 1999; 18:3481-90. (Pubitemid 29317343)
17. Chalepakis G, Arnemann J, Slater E, Brüller HJ, Gross B, Beato M. Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus. Cell 1988; 53:371-82.
18. Weinstein EJ, Kitsberg DI, Leder P. A mouse model for breast cancer induced by amplification and overexpression of the neu promoter and transgene. Mol Med 2000; 6:4-16.
19. Grubbs CJ, Juliana MM, Hill DL, Whitaker LM. Suppression by pregnancy of chemically induced preneoplastic cells of the rat mammary gland. Anticancer Res 1986; 6:1395-400.
20. Russo IH, Koszalka M, Russo J. Effect of human chorionic gonadotropin on mammary gland differentiation and carcinogenesis. Carcinogenesis 1990; 11:1849-55. (Pubitemid 20331455)
21. Ascoli M, Fanelli F, Segaloff DL. The lutropin/ choriogonadotropin receptor, a 2002 perspective. Endocr Rev 2002; 23:141-74. (Pubitemid 34299022)
22. Ryu KS, Ji I, Chang L, Ji TH. Molecular mechanism of LH/CG receptor activation. Mol Cell Endocrinol 1996; 125:93-100. (Pubitemid 27037788)
23. Atwood CS, Hovey RC, Glover JP, Chepko G, Ginsburg E, Robison WG, Vonderhaar BK. Progesterone induces side-branching of the ductal epithelium in the mammary glands of peripubertal mice. J Endocrinol 2000; 167:39-52.
24. Shyamala G, Yang X, Cardiff RD, Dale E. Impact of progesterone receptor on cell-fate decisions during mammary gland development. Proc Natl Acad Sci USA 2000; 97:3044-9. (Pubitemid 30183252)
25. Meduri G, Charnaux N, Loosfelt H, Jolivet A, Spyratos F, Brailly S, Milgrom E. Luteinizing hormone/human chorionic gonadotropin receptors in breast cancer. Cancer Res 1997; 57:857-64. (Pubitemid 27098009)
26. Lojun S, Bao S, Lei ZM, Rao CV. Presence of functional luteinizing hormone/chorionic gonadotropin (hCG) receptors in human breast cell lines: implications supporting the premise that hCG protects women against breast cancer. Biol Reprod 1997; 57:1202-10. (Pubitemid 27461214)
27. Tanaka Y, Kuwabara K, Okazaki T, Fujita T, Oizumi I, Kaiho S, Ogata E. Gonadotropins stimulate growth of MCF-7 human breast cancer cells by promoting intracellular conversion of adrenal androgens to estrogens. Oncology 2000; 59:19-23.