Addition of novel degenerate electrical waveform stimulation with photodynamic therapy significantly enhances its cytotoxic effect in keloid fibroblasts: First report of a potential combination therapy

Journal of Dermatological Science

Volumn 64, Issue 3, 2011, Pages 174-184

  Sebastian, Anil ^a   Allan, Ernest ^b   Allan, Donald ^a,b   Colthurst, James ^c   Bayat, Ardeshir ^a,d  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

^c Fenzian Ltd   (United Kingdom)

^d WYTHENSHAWE HOSPITAL   (United Kingdom)

Author keywords

ALA; Apoptosis; Degenerate wave; Electrical stimulation; Keloid fibroblasts; MAL; Necrosis; Normal skin fibroblasts; Photodynamic therapy; Reactive oxygen species

Indexed keywords

AMINOLEVULINIC ACID; AMINOLEVULINIC ACID METHYL ESTER; CASPASE 3; CASPASE 7; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GELATINASE A; REACTIVE OXYGEN METABOLITE;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ELECTROSTIMULATION THERAPY; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HEME SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KELOID; MITOCHONDRIAL MEMBRANE POTENTIAL; NUCLEOTIDE SEQUENCE; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN FIBROBLAST; WESTERN BLOTTING;

ADULT; AGED; AMINOLEVULINIC ACID; APOPTOSIS; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CASPASE 3; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN TYPE I; COLLAGEN TYPE III; COMBINED MODALITY THERAPY; ELECTRIC STIMULATION THERAPY; ENZYME ACTIVATION; FEMALE; FIBROBLASTS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; KELOID; L-LACTATE DEHYDROGENASE; MALE; MATRIX METALLOPROTEINASE 2; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; NECROSIS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLYMERASE CHAIN REACTION; PROTOPORPHYRINS; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 80055087953     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.08.012     Document Type: Article

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