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Volumn 77, Issue 7, 2011, Pages 677-683

Glycine and its synaptic interactions: Functional and clinical implications

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; GEPHYRIN; GLUTAMIC ACID; GLYCINE; GLYCINE TRANSPORTER; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 80055079419     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31822a2791     Document Type: Review
Times cited : (18)

References (56)
  • 3
    • 59649097914 scopus 로고    scopus 로고
    • Glycine transporters and synaptic function
    • Zafra F, Gimenez C. Glycine transporters and synaptic function. IUBMB Life 2008;60:810-817.
    • (2008) IUBMB Life , vol.60 , pp. 810-817
    • Zafra, F.1    Gimenez, C.2
  • 4
    • 33745033309 scopus 로고    scopus 로고
    • Glycine receptors: Recent insights into their structural organization and functional diversity
    • DOI 10.1111/j.1471-4159.2006.03908.x
    • Betz H, Laube B. Glycine receptors: recent insights into their structural organization and functional diversity. J Neurochem 2006;97:1600-1610. (Pubitemid 43873655)
    • (2006) Journal of Neurochemistry , vol.97 , Issue.6 , pp. 1600-1610
    • Betz, H.1    Laube, B.2
  • 5
    • 58049120621 scopus 로고    scopus 로고
    • Native glycine receptor subtypes and their physiological roles
    • Lynch JW. Native glycine receptor subtypes and their physiological roles. Neuropharmacology 2009;56:303-309.
    • (2009) Neuropharmacology , vol.56 , pp. 303-309
    • Lynch, J.W.1
  • 6
    • 51249125051 scopus 로고    scopus 로고
    • Molecular architecture of glycinergic synapses
    • Dresbach T, Nawrotzki R, Kremer T, et al. Molecular architecture of glycinergic synapses. Histochem Cell Biol 2008;130:617-633.
    • (2008) Histochem Cell Biol , vol.130 , pp. 617-633
    • Dresbach, T.1    Nawrotzki, R.2    Kremer, T.3
  • 8
    • 48649091869 scopus 로고    scopus 로고
    • Glycine cleavage system: Reaction mechanism, physiological significance, and hyperglycinemia
    • Kikuchi G, Motokawa Y, Yoshida T, Hiraga K. Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia. Proc Jpn Acad Ser B Phys Biol Sci 2008;84:246-263.
    • (2008) Proc Jpn Acad ser B Phys Biol Sci , vol.84 , pp. 246-263
    • Kikuchi, G.1    Motokawa, Y.2    Yoshida, T.3    Hiraga, K.4
  • 9
    • 84873454709 scopus 로고    scopus 로고
    • The glycinergic system in human startle disease: A genetic screening approach
    • Davies JS, Chung SK, Thomas RH, et al. The glycinergic system in human startle disease: a genetic screening approach. Front Mol Neurosci 2010;3:8.
    • (2010) Front Mol Neurosci , vol.3 , pp. 8
    • Davies, J.S.1    Chung, S.K.2    Thomas, R.H.3
  • 10
    • 0030840107 scopus 로고    scopus 로고
    • Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases
    • DOI 10.1016/S0014-5793(97)01279-9, PII S0014579397012799
    • Sagne C, El Mestikawy S, Isambert MF, et al. Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases. FEBS Lett 1997;417:177-183. (Pubitemid 27491728)
    • (1997) FEBS Letters , vol.417 , Issue.2 , pp. 177-183
    • Sagne, C.1    El Mestikawy, S.2    Isambert, M.-F.3    Hamon, M.4    Henry, J.-P.5    Giros, B.6    Gasnier, B.7
  • 12
    • 33646429180 scopus 로고    scopus 로고
    • A shared vesicular carrier allows synaptic corelease of GABA and glycine
    • Wojcik SM, Katsurabayashi S, Guillemin I, et al. A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron 2006;50:575-587.
    • (2006) Neuron , vol.50 , pp. 575-587
    • Wojcik, S.M.1    Katsurabayashi, S.2    Guillemin, I.3
  • 13
    • 22244485980 scopus 로고    scopus 로고
    • Target-dependent use of coreleased inhibitory transmitters at central synapses
    • DOI 10.1523/JNEUROSCI.1500-05.2005
    • Dugue GP, Dumoulin A, Triller A, Dieudonne S. Targetdependent use of co-released inhibitory transmitters at central synapses. J Neurosci 2005;25:6490-6498. (Pubitemid 40995281)
    • (2005) Journal of Neuroscience , vol.25 , Issue.28 , pp. 6490-6498
    • Dugue, G.P.1    Dumoulin, A.2    Triller, A.3    Dieudonne, S.4
  • 14
    • 0025368953 scopus 로고
    • Light microscope study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat
    • DOI 10.1002/cne.902960312
    • Todd AJ, Sullivan AC. Light microscope study of the coexistence of GABA-like and glycine-like immunoreactivities in the spinal cord of the rat. J Comp Neurol 1990;296: 496-505. (Pubitemid 20188821)
    • (1990) Journal of Comparative Neurology , vol.296 , Issue.3 , pp. 496-505
    • Todd, A.J.1    Sullivan, A.C.2
  • 15
    • 10744221393 scopus 로고    scopus 로고
    • Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition
    • DOI 10.1016/S0896-6273(03)00672-X
    • Gomeza J, Hulsmann S, Ohno K, et al. Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition. Neuron 2003;40: 785-796. (Pubitemid 37431038)
    • (2003) Neuron , vol.40 , Issue.4 , pp. 785-796
    • Gomeza, J.1    Hulsmann, S.2    Ohno, K.3    Eulenburg, V.4    Szoke, K.5    Richter, D.6    Betz, H.7
  • 16
    • 0242544067 scopus 로고    scopus 로고
    • Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality
    • DOI 10.1016/S0896-6273(03)00673-1
    • Gomeza J, Ohno K, Hulsmann S, et al. Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality. Neuron 2003;40: 797-806. (Pubitemid 37431039)
    • (2003) Neuron , vol.40 , Issue.4 , pp. 797-806
    • Gomeza, J.1    Ohno, K.2    Hulsmann, S.3    Armsen, W.4    Eulenburg, V.5    Richter, D.W.6    Laube, B.7    Betz, H.8
  • 19
    • 33747808897 scopus 로고    scopus 로고
    • A receptor- and glycine receptor-mediated effects on spontaneous circuit activity in hippocampal cell culture
    • DOI 10.1016/j.neulet.2006.06.064, PII S0304394006006598
    • Wang W, Xu TL. Chloride homeostasis differentially affects GABA(A) receptor- and glycine receptor-mediated effects on spontaneous circuit activity in hippocampal cell culture. Neurosci Lett 2006;406:11-16. (Pubitemid 44278369)
    • (2006) Neuroscience Letters , vol.406 , Issue.1-2 , pp. 11-16
    • Wang, W.1    Xu, T.-L.2
  • 20
    • 0028030040 scopus 로고
    • GABA and glycine frequently colocalize in terminals on cat spinal motoneurons
    • Taal W, Holstege JC. GABA and glycine frequently colocalize in terminals on cat spinal motoneurons. Neuroreport 1994;5:2225-2228. (Pubitemid 24374841)
    • (1994) NeuroReport , vol.5 , Issue.17 , pp. 2225-2228
    • Taal, W.1    Holstege, J.C.2
  • 21
    • 0029927346 scopus 로고    scopus 로고
    • Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord
    • Todd AJ, Watt C, Spike RC, Sieghart W. Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord. J Neurosci 1996;16:974-982. (Pubitemid 26140853)
    • (1996) Journal of Neuroscience , vol.16 , Issue.3 , pp. 974-982
    • Todd, A.J.1    Watt, C.2    Spike, R.C.3    Sieghart, W.4
  • 22
    • 4344677489 scopus 로고    scopus 로고
    • Differential distribution of synaptic endings containing glutamate, glycine, and GABA in the rat dorsal cochlear nucleus
    • DOI 10.1002/cne.20248
    • Rubio ME, Juiz JM. Differential distribution of synaptic endings containing glutamate, glycine, and GABA in the rat dorsal cochlear nucleus. J Comp Neurol 2004;477: 253-272. (Pubitemid 39129611)
    • (2004) Journal of Comparative Neurology , vol.477 , Issue.3 , pp. 253-272
    • Rubio, M.E.1
  • 23
    • 0027771338 scopus 로고
    • Colocalization of GABA and glycine in the rabbit oculomotor nucleus
    • DOI 10.1016/0304-3940(93)90848-F
    • Wentzel PR, De Zeeuw CI, Holstege JC, Gerrits NM. Colocalization of GABA and glycine in the rabbit oculomotor nucleus. Neurosci Lett 1993;164:25-29. (Pubitemid 24040672)
    • (1993) Neuroscience Letters , vol.164 , Issue.1-2 , pp. 25-29
    • Wentzel, P.R.1    De Zeeuw, C.I.2    Holstege, J.C.3    Gerrits, N.M.4
  • 24
    • 0023932504 scopus 로고
    • Colocalization of glycine-like and GABA-like immunoreactivities in Golgi cell terminals in the rat cerebellum: A postembedding light and electron microscopic study
    • Ottersen OP, Storm-Mathisen J, Somogyi P. Colocalization of glycine-like and GABA-like immunoreactivities in Golgi cell terminals in the rat cerebellum: a postembedding light and electron microscopic study. Brain Res 1988; 450:342-353.
    • (1988) Brain Res , vol.450 , pp. 342-353
    • Ottersen, O.P.1    Storm-Mathisen, J.2    Somogyi, P.3
  • 25
    • 77649243932 scopus 로고    scopus 로고
    • Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: An immunohistochemical study
    • Waldvogel HJ, Baer K, Eady E, et al. Differential localization of gamma-aminobutyric acid type A and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: an immunohistochemical study. J Comp Neurol 2010;518:305-328.
    • (2010) J Comp Neurol , vol.518 , pp. 305-328
    • Waldvogel, H.J.1    Baer, K.2    Eady, E.3
  • 26
    • 0032540919 scopus 로고    scopus 로고
    • Corelease of two fast neurotransmitters at a central synapse
    • DOI 10.1126/science.281.5375.419
    • Jonas P, Bischofberger J, Sandkuhler J. Corelease of two fast neurotransmitters at a central synapse. Science 1998; 281:419-424. (Pubitemid 28340787)
    • (1998) Science , vol.281 , Issue.5375 , pp. 419-424
    • Jonas, P.1    Bischofberger, J.2    Sandkuhler, J.3
  • 27
    • 0037095949 scopus 로고    scopus 로고
    • GABA and glycine co-release optimizes functional inhibition in rat brainstem motoneurons in vitro
    • DOI 10.1113/jphysiol.2001.016063
    • Russier M, Kopysova IL, Ankri N, Ferrand N, Debanne D. GABA and glycine co-release optimizes functional inhibition in rat brainstem motoneurons in vitro. J Physiol 2002;541:123-137. (Pubitemid 35190189)
    • (2002) Journal of Physiology , vol.541 , Issue.1 , pp. 123-137
    • Russier, M.1    Kopysova, I.L.2    Ankri, N.3    Ferrand, N.4    Debanne, D.5
  • 28
    • 12544254568 scopus 로고    scopus 로고
    • Staggered development of GABAergic and glycinergic transmission in the MNTB
    • Awatramani GB, Turecek R, Trussell LO. Staggered development of GABAergic and glycinergic transmission in the MNTB. J Neurophysiol 2005;93:819-828.
    • (2005) J Neurophysiol , vol.93 , pp. 819-828
    • Awatramani, G.B.1    Turecek, R.2    Trussell, L.O.3
  • 30
    • 39449128016 scopus 로고    scopus 로고
    • Glycinergic Transmission Shaped by the Corelease of GABA in a Mammalian Auditory Synapse
    • DOI 10.1016/j.neuron.2007.12.010, PII S0896627307010100
    • Lu T, Rubio ME, Trussell LO. Glycinergic transmission shaped by the corelease of GABA in a mammalian auditory synapse. Neuron 2008;57:524-535. (Pubitemid 351273989)
    • (2008) Neuron , vol.57 , Issue.4 , pp. 524-535
    • Lu, T.1    Rubio, M.E.2    Trussell, L.O.3
  • 31
    • 39449137859 scopus 로고    scopus 로고
    • GABA Is an Endogenous Ligand for Synaptic Glycine Receptors
    • DOI 10.1016/j.neuron.2008.02.007, PII S0896627308001293
    • Singer JH. GABA is an endogenous ligand for synaptic glycine receptors. Neuron 2008;57:475-477. (Pubitemid 351274001)
    • (2008) Neuron , vol.57 , Issue.4 , pp. 475-477
    • Singer, J.H.1
  • 33
    • 55249085812 scopus 로고    scopus 로고
    • Early postnatal development of reciprocal Ia inhibition in the murine spinal cord
    • Wang Z, Li L, Goulding M, Frank E. Early postnatal development of reciprocal Ia inhibition in the murine spinal cord. J Neurophysiol 2008;100:185-196.
    • (2008) J Neurophysiol , vol.100 , pp. 185-196
    • Wang, Z.1    Li, L.2    Goulding, M.3    Frank, E.4
  • 34
    • 0026733697 scopus 로고
    • Involvement of GABA and glycine in recurrent inhibition of spinal motoneurons
    • Schneider SP, Fyffe RE. Involvement of GABA and glycine in recurrent inhibition of spinal motoneurons. J Neurophysiol 1992;68:397-406.
    • (1992) J Neurophysiol , vol.68 , pp. 397-406
    • Schneider, S.P.1    Fyffe, R.E.2
  • 35
    • 85043520712 scopus 로고    scopus 로고
    • Confirmation of the consensus that glycinergic postsynaptic inhibition is responsible for the atonia of REM sleep
    • Chase MH. Confirmation of the consensus that glycinergic postsynaptic inhibition is responsible for the atonia of REM sleep. Sleep 2008;31:1487-1491.
    • (2008) Sleep , vol.31 , pp. 1487-1491
    • Chase, M.H.1
  • 36
    • 85046913698 scopus 로고    scopus 로고
    • Glycine-mediated postsynaptic inhibition is responsible for REM sleep atonia
    • Soja PJ. Glycine-mediated postsynaptic inhibition is responsible for REM sleep atonia. Sleep 2008;31:1483-1486.
    • (2008) Sleep , vol.31 , pp. 1483-1486
    • Soja, P.J.1
  • 37
    • 43649099533 scopus 로고    scopus 로고
    • Glycinergic and GABA(A)- mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia
    • Brooks PL, Peever JH. Glycinergic and GABA(A)- mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia. J Neurosci 2008;28:3535-3545.
    • (2008) J Neurosci , vol.28 , pp. 3535-3545
    • Brooks, P.L.1    Peever, J.H.2
  • 38
    • 0033198294 scopus 로고    scopus 로고
    • Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord
    • Chery N, de Koninck Y. Junctional versus extrajunctional glycine and GABA(A) receptor-mediated IPSCs in identified lamina I neurons of the adult rat spinal cord. J Neurosci 1999;19:7342-7355. (Pubitemid 29404591)
    • (1999) Journal of Neuroscience , vol.19 , Issue.17 , pp. 7342-7355
    • Chery, N.1    De Koninck, Y.2
  • 39
    • 24744450794 scopus 로고    scopus 로고
    • The glycinergic control of spinal pain processing
    • DOI 10.1007/s00018-005-5107-2
    • Zeilhofer HU. The glycinergic control of spinal pain processing. Cell Mol Life Sci 2005;62:2027-2035. (Pubitemid 41291660)
    • (2005) Cellular and Molecular Life Sciences , vol.62 , Issue.18 , pp. 2027-2035
    • Zeilhofer, H.U.1
  • 40
    • 77954615594 scopus 로고    scopus 로고
    • Synaptic pathways and inhibitory gates in the spinal cord dorsal horn
    • Takazawa T, MacDermott AB. Synaptic pathways and inhibitory gates in the spinal cord dorsal horn. Ann NY Acad Sci 2010;1198:153-158.
    • (2010) Ann NY Acad Sci , vol.1198 , pp. 153-158
    • Takazawa, T.1    MacDermott, A.B.2
  • 41
    • 0023091647 scopus 로고
    • Glycine potentiates the NMDA response in cultured mouse brain neurons
    • DOI 10.1038/325529a0
    • Johnson JW, Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 1987; 325:529-531. (Pubitemid 17056733)
    • (1987) Nature , vol.325 , Issue.6104 , pp. 529-531
    • Johnson, J.W.1    Ascher, P.2
  • 42
    • 3042542923 scopus 로고    scopus 로고
    • Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels
    • DOI 10.1113/jphysiol.2004.063321
    • Martina M, Gorfinkel Y, Halman S, et al. Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels. J Physiol 2004;557: 489-500. (Pubitemid 38807389)
    • (2004) Journal of Physiology , vol.557 , Issue.2 , pp. 489-500
    • Martina, M.1    Gorfinkel, Y.2    Halman, S.3    Lowe, J.A.4    Periyalwar, P.5    Schmidt, C.J.6    Bergeron, R.7
  • 44
    • 50549099422 scopus 로고    scopus 로고
    • D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration
    • Wolosker H, Dumin E, Balan L, Foltyn VN. D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration. Febs J 2008;275:3514-3526.
    • (2008) Febs J , vol.275 , pp. 3514-3526
    • Wolosker, H.1    Dumin, E.2    Balan, L.3    Foltyn, V.N.4
  • 45
    • 77956122814 scopus 로고    scopus 로고
    • Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits
    • Pina-Crespo JC, Talantova M, Micu I, et al. Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. J Neurosci 2010;30:11501-11505.
    • (2010) J Neurosci , vol.30 , pp. 11501-11505
    • Pina-Crespo, J.C.1    Talantova, M.2    Micu, I.3
  • 46
    • 77957279267 scopus 로고    scopus 로고
    • Allosteric potentiation of glycine receptor chloride currents by glutamate
    • Liu J, Wu DC, Wang YT. Allosteric potentiation of glycine receptor chloride currents by glutamate. Nat Neurosci 2010;13:1225-1232.
    • (2010) Nat Neurosci , vol.13 , pp. 1225-1232
    • Liu, J.1    Wu, D.C.2    Wang, Y.T.3
  • 47
    • 77955536672 scopus 로고    scopus 로고
    • Nonketotic hyperglycinemia: Proposal of a diagnostic and treatment strategy
    • Suzuki Y, Kure S, Oota M, Hino H, Fukuda M. Nonketotic hyperglycinemia: proposal of a diagnostic and treatment strategy. Pediatr Neurol 2010;43:221-224.
    • (2010) Pediatr Neurol , vol.43 , pp. 221-224
    • Suzuki, Y.1    Kure, S.2    Oota, M.3    Hino, H.4    Fukuda, M.5
  • 48
    • 79956268774 scopus 로고    scopus 로고
    • Late-onset nonketotic hyperglycinemia caused by a novel homozygous missense mutation in the GLDC gene
    • Brunel-Guitton C, Casey B, Coulter-Mackie M, et al. Late-onset nonketotic hyperglycinemia caused by a novel homozygous missense mutation in the GLDC gene. Mol Genet Metab 2011;103:193-196.
    • (2011) Mol Genet Metab , vol.103 , pp. 193-196
    • Brunel-Guitton, C.1    Casey, B.2    Coulter-Mackie, M.3
  • 50
    • 33847323923 scopus 로고    scopus 로고
    • Startle and its disorders
    • Meinck HM. Startle and its disorders. Neurophysiol Clin 2006;36:357-364.
    • (2006) Neurophysiol Clin , vol.36 , pp. 357-364
    • Meinck, H.M.1
  • 51
    • 0033681271 scopus 로고    scopus 로고
    • Autoimmunity to gephyrin in stiff-man syndrome
    • Butler MH, Hayashi A, Ohkoshi N, et al. Autoimmunity to gephyrin in stiff-man syndrome. Neuron 2000;26:307-312.
    • (2000) Neuron , vol.26 , pp. 307-312
    • Butler, M.H.1    Hayashi, A.2    Ohkoshi, N.3
  • 52
    • 52149121731 scopus 로고    scopus 로고
    • Progressive encephalomyelitis, rigidity, and myoclonus: A novel glycine receptor antibody
    • Hutchinson M, Waters P, McHugh J, et al. Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody. Neurology 2008;71:1291-1292.
    • (2008) Neurology , vol.71 , pp. 1291-1292
    • Hutchinson, M.1    Waters, P.2    McHugh, J.3
  • 54
    • 79956150521 scopus 로고    scopus 로고
    • Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived d-serine
    • Miraucourt LS, Peirs C, Dallel R, Voisin DL. Glycine inhibitory dysfunction turns touch into pain through astrocyte-derived d-serine. Pain 2011;152:1340-1348.
    • (2011) Pain , vol.152 , pp. 1340-1348
    • Miraucourt, L.S.1    Peirs, C.2    Dallel, R.3    Voisin, D.L.4
  • 55
    • 34249107728 scopus 로고    scopus 로고
    • Glycine transporter 1 inhibitors and modulation of NMDA receptor-mediated excitatory neurotransmission
    • DOI 10.2174/138945007780618535
    • Sur C, Kinney GG. Glycine transporter 1 inhibitors and modulation of NMDA receptor-mediated excitatory neurotransmission. Curr Drug Targets 2007;8:643-649. (Pubitemid 46785062)
    • (2007) Current Drug Targets , vol.8 , Issue.5 , pp. 643-649
    • Sur, C.1    Kinney, G.G.2
  • 56
    • 36849005064 scopus 로고    scopus 로고
    • Glycine Transport Inhibitors and the Treatment of Schizophrenia
    • DOI 10.1016/j.biopsych.2007.09.017, PII S0006322307008918, Schizophrenia: From Genetics to Treatment
    • Javitt DC. Glycine transport inhibitors and the treatment of schizophrenia. Biol Psychiatry 2008;63:6-8. (Pubitemid 350234898)
    • (2008) Biological Psychiatry , vol.63 , Issue.1 , pp. 6-8
    • Javitt, D.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.