Tumor accumulation of ε-poly-lysines-based polyamines conjugated with boron clusters

Applied Radiation and Isotopes

Volumn 69, Issue 12, 2011, Pages 1765-1767

  Umano, Masayuki ^a   Uechi, Kazuhiro ^a   Uriuda, Takatoshi ^a   Murayama, Sayuri ^a   Azuma, Hideki ^a   Shinohara, Atsuko ^b   Liu, Young ^c   Ono, Koji ^c   Kirihata, Mitsunori ^a   Yanagie, Hironobu ^d   Nagasaki, Takeshi ^a  

^a Osaka Prefecture University   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Controlled delivery; EPR effect; Poly ion complex; Polymeric carrier; Tumor accumulation

Indexed keywords

CONTROLLED DELIVERY; EPR EFFECT; POLYIONCOMPLEX; POLYMERIC CARRIERS; TUMOR ACCUMULATION;

AMINO ACIDS; BIODEGRADABLE POLYMERS; BORON; BORON COMPOUNDS;

TUMORS;

BOROCAPTATE; BORON 10; DRUG CARRIER; EPSILON POLYLYSINE; NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CROSS LINKING; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; DRUG RETENTION; DRUG SAFETY; DRUG TISSUE LEVEL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR WEIGHT; MOUSE; NEUTRON CAPTURE THERAPY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; ZETA POTENTIAL;

BORON; CELL LINE, TUMOR; HUMANS; POLYAMINES; POLYLYSINE; TISSUE DISTRIBUTION;

EID: 80055075607     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2011.02.048     Document Type: Article

References (9)

1. Azab A.-K., Srebnik M., Doviner V., Rubinstein A. Targeting normal and neoplastic tissues in the rat jejunum and colon with boronated, cationic acrylamide copolymers. J. Controlled Release 2005, 106:14-25.
2. Barth R.F., Adams D.M., Soloway A.H., Alam F., Darby M.V. Boronated starburst dendrimer-monoclonal antibody immunoconjugates: evaluation as a potential delivery system for neutron capture therapy. Bioconjugate Chem. 1994, 5:58-66.
3. Di Meo C., Panza L., Campo F., Capitani D., Mannina L., Banzato A., Rondina M., Rosato A., Crescenzi V. Novel types of carborane-carrier hyaluronan derivatives via "click chemistry". Macromol. Biosci. 2008, 8:670-681.
4. Hamano Y., Nicchu I., Hoshino Y., Kawai T., Nakamori S., Takagi H. Development of gene delivery systems for the ε-poly-L-lysine producer, Streptomyces albulus. J. Biosci. Bioeng. 2005, 99:636-641.
5. Hiraki J., Hatakeyama M., Morita H., Izumi Y. Improved ε-poly-L-lysine production of an S-(2-aminoethyl)-L-cystein resistant mutant of Streptomyces albulus. Seibutsu Kogaku 1982, 76:487-493.
6. Hiraki J., Ichikawa T., Ninomiya S., Seki H., Uohama K., Seki H., Kimura S., Yanagimoto Y., Barnett Jr.J.W. Use of ADME studies to confirm the safety of ε-poly-L-lysine as a preservative in food. Regul. Toxicol. Pharmacol. 2003, 37:328-340.
7. Krijger G.C., Fretz M.M., Woroniecka U.D., Steinbach O.M., Jiskoot W., Storm G., Koning G.A. Tumor cell and tumor vasculature targeted liposomes for neutron capture therapy. Radiochim. Acta 2005, 93:589-593.
8. Maeda H., Wu J., Sawa T., Matsumura Y., Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Controlled Release 2000, 65:271-284.
9. Wu G., Barth R.F., Yang W., Lee R.J., Tiarks W., Backer M.V., Bacler J.M. Boron containing macromolecules and nanovehicles as delivery agents for neutron capture therapy. Anti-Cancer Agents Med. Chem. 2006, 6:167-184.