Use of ADME studies to confirm the safety of ε-polylysine as a preservative in food

Regulatory Toxicology and Pharmacology

Volumn 37, Issue 2, 2003, Pages 328-340

  Hiraki, Jun ^a   Ichikawa, Takafumi ^b   Ninomiya, Shin Ichi ^c   Seki, Hideaki ^c   Uohama, Katsumi ^c   Seki, Hiroshi ^d   Kimura, Shigemi ^d   Yanagimoto, Yukio ^e   Barnett Jr , James W ^f,g  

^a CHISSO CORPORATION   (Japan)

^b Asahikasei Aime Co Ltd   (Japan)

^c ADME/TOX Research Institute   (Japan)

^d BML   (Japan)

^e Life Science Laboratory   (Japan)

^f AAC Consulting Group Inc   (United States)

^g AAC Consulting Group   (United States)

Author keywords

Absorption; Distribution; Excretion; Metabolism; Mutagenicity; Polylysine

Indexed keywords

AMINO ACID; LYSINE; POLYLYSINE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; CHRONIC TOXICITY; CONTROLLED STUDY; DIET RESTRICTION; DISTRIBUTION VOLUME; EXPIRED AIR; FECES; FEEDING; FOOD PRESERVATION; FOOD SAFETY; GASTROINTESTINAL ABSORPTION; HALF LIFE TIME; ISOTOPE LABELING; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY EXCRETION; WHOLE BODY AUTORADIOGRAPHY;

BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES ALBULUS;

EID: 0037392594     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0273-2300(03)00029-1     Document Type: Article

References (15)

1. 14C -polylysine [II]. ADME/TOX Research Institute; Study Number AE-2999-2G.
2. BML, 1995. Mutagenicity testing of ε-polylysine in bacterial reverse mutation assays. BML Report No. 2008.
3. Fukutome A., Kashima M., Aiuchi M. A combined chronic toxicity and carcinogenicity study of polylysine powder in rats by peroral dietary administration. Clin. Rep. 29:1995;1416-1434. (Japan).
4. Grove J.A., Linn T.G., Willett C.J., Henderson L.M. Retention of the α-nitrogen in the metabolic conversion of L-lysine to α-aminoadipate by the rat. Biochem. Biophys. Acta. 215:1970;191-194.
5. Higashino K., Fujioka M., Aoki T., Yamamura Y. Metabolism of lysine in the rat liver. Biochem. Biophys. Res. Commun. 29:1967;95-100.
6. Hiraki J., Hatakeyama M., Morita H., Izumi Y. Improved ε-poly-L-lysine production of an S-(2-aminoethyl)-L-cysteine resistant mutant of Streptomyces albulus. Seibutsu-Kogaku. 76:1998;487-493.
7. Hiraki, J., Suzuki, E., 1999. Process for producing ε-poly-L-lysine with immobilized Streptomyces albulus. US Patent No. 5,900,363.
8. Ishii M., Shirai M., Aiuti M., Hiraide Y. Three month treated orally in dietary toxicity study of polylysine powder in rat. Clin. Rep. 27:1993;2013-2033. (Japan).
9. Kito M., Onji Y., Yoshida T., Nagasawa T. Occurrence of ε-poly-L-lysine-degrading enzyme in ε-poly-L-lysine-tolerant Sphingobacterium multivorum OJ10: purification and characterization. FEMS Microbiol. Lett. 207:2002;147-151.
10. Life Science, 1989. Acute oral toxicity test of ε-polylysine preparation in rats. Life Science Laboratory, Report No. 89-IA2-0202.
11. Rodwell V.M. Carbon catabolism of amino acids. Greenburg D.M. Metabolic Pathways. third ed:1969;Academic Press, New York.
12. Shima S., Sakai H. Polylysine produced by Streptomyces. Agric. Biol. Chem. 41:1977;1807-1809.
13. Tokai Research Laboratories, 1995. Pharmacokinetic studies of polylysine (II). Metabolism in rats. Tokai Research Laboratories, Study Number AE-2229.
14. Tokai Research Laboratories, 1996. Pharmacokinetic studies of polylysine (III). Metabolism in rats. Tokai Research Laboratories, Study Number AE-2317.
15. USDA, 1991. Continuing Survey of Food Intake by Individuals. US Department of Agriculture, Washington, DC.