Antimicrobial and immunomodulatory effects of Aloe vera peel extract

Journal of Medicinal Plant Research

Volumn 5, Issue 22, 2011, Pages 5384-5392

  Kwon, Ka Hee ^a   Hong, Min Ki ^a   Hwang, Sun Young ^a   Moon, Bo Youn ^a   Shin, Sook ^a   Baek, Jin Hong ^b   Park, Yong Ho ^a  

^a Seoul National University   (South Korea)

^b KJM Aloe R and D Center   (South Korea)

Author keywords

Aloe vera; Antimicrobial effect; Immunomodulatory effect

Indexed keywords

ALOE EMODIN; ALOE VERA EXTRACT; CONCANAVALIN A; GAMMA INTERFERON; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS; BACTERIAL STRAIN; BACTERIUM COLONY; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISTILLATION; DRUG MEGADOSE; ENTEROCOCCUS; ESCHERICHIA COLI; FEMALE; HUMORAL IMMUNITY; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; KLEBSIELLA PNEUMONIAE; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; SPLEEN CELL; STAPHYLOCOCCUS AUREUS; TH1 CELL; TH2 CELL; VIBRIO;

EID: 80055057245     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Altekruse SF, Cohen ML, Swerdlow DL (1997). Emerging foodborne diseases. Emerg. Infect. Dis., 3: 285-293.
2. Barreiros AP, Schirmacher P, Laufenberg FP, KH Meyer ZB, Schlaak JF (2000). The early immune response in the liver of BALB/c mice infected with S. typhimurium. Scand. J. Immunol., 51: 472-478.
3. Bayston KF, Cohen J (1990). Bacterial endotoxin and current concepts in the diagnosis and treatment of endotoxaemia. J. Med. Microbiol., 31: 73-83.
4. Chen SH, Lin KY, Chang CC, Fang CL, Lin CP (2007). Aloe-emodininduced apoptosis in human gastric carcinoma cells. Food Chem. Toxicol., 45: 2296-2303.
5. Florquin S, Amraoui Z, Abramowicz D, Goldman M (1994). Systemic release and protective role of IL-10 in staphylococcal enterotoxin Binduced shock in mice. J. Immunol., 153: 2618-2623.
6. Gauntt CJ, Wood HJ, McDaniel HR, McAnalley BH (2000). Aloe polymannose enhances anti-coxsackievirus antibody titres in mice. Phytother. Res., 14: 261-266.
7. Grindlay D, Reynolds T (1986). The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. J. Ethnopharmacol., 16: 117-151.
8. Grover JK, Yadav S, Vats V (2002). Medicinal plants of India with antidiabetic potential. J. Ethnopharmacol., 81: 81-100.
9. Im SA, Oh ST, Song S, Kim MR, Kim DS, Woo SS, Jo TH, Park YI, Lee CK (2005). Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity. Int. Immunopharmacol., 5: 271-279.
10. Kim SH, Kwon NH, Kim JY, Lim JY, Bae WK, Kim JM, Noh KM, Hur J, Jung WK, Park KT, Lee JE, Ra JC, Park YH (2002). Antimicrobial activity of natural product made by Opunita ficus-indica var. saboten against Salmonella spp. and Escherichia coli O157:H7.
11. Liu YX, NY Shen, Liu C, Lv Y (2009). Immunosuppressive effects of emodin: an in vivo and in vitro study. Transplant Proc., 41: 1837-1839.
12. Ndhlala AR, Amoo SO, Stafford GI, Finnie JF, Van SJ (2009). Antimicrobial, anti-inflammatory and mutagenic investigation of the South African tree aloe (Aloe barberae). J. Ethnopharmacol., 124: 404-408.
13. Nicola NA (1994). Guidebook to Cytokines and Their Receptors. Oxford U.K.
14. OECD (2000). Guidelines for the testing of chemicals revised draft guideline 423. In.
15. Ozsoy NE, Candoken NA (2009). Implications for degenerative disorders: antioxidative activity, total phenols, flavonoids, ascorbic acid, beta-carotene and beta-tocopherol in Aloe vera. Oxid. Med. Cell Longev. 2: 99-106.
16. Pandey RAM (2010). Antibacterial activities of crude extract of Aloe barbadensis to clinically isolated bacterial pathogens. Appl. Biochem. Biotechnol., 160: 1356-1361.
17. Ribbons KA, Thompson JH, Liu X, Pennline K, Clark DA, Miller MJ (1997). Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis. Eur. J. Pharmacol., 323: 245-254.
18. Rice LB (2006). Antimicrobial resistance in gram-positive bacteria. Am. J. Infect. Control. 34:S11-9; Discussion S64-73.
19. Rodriguez RE, Darias MJ, Diaz RC (2010). Aloe vera as a functional ingredient in foods. Crit. Rev. Food Sci. Nutr., 50: 305-326.
20. Rongione AJ, Kusske AM, Ashley SW, Reber HA, McFadden DW (1997). Interleukin-10 prevents early cytokine release in severe intraabdominal infection and sepsis. J. Surg. Res., 70: 107-112.
21. Saleem R, Faizi S, Siddiqui BS, Ahmed M, Hussain SA, Qazi A, Dar A, Ahmad SI, Qazi MH, Akhtar S, Hasnain SN (2001). Hypotensive effect of chemical constituents from Aloe barbadensis. Planta Med., 67: 757-760.
22. Sherman PM, Ossa JC, Wine E (2010). Bacterial infections: new and emerging enteric pathogens. Curr. Opin. Gastroenterol., 26: 1-4.
23. Takzare N, Hosseini MJ, Hasanzadeh G, Mortazavi H, Takzare A, Habibi P (2009). Influence of Aloe vera gel on dermal wound healing process in rat. Toxicol. Mech. Methods, 19(1): 73-77.
24. USEPA (1998). Health effects test guidlines OPPTS 870.1110. In, acute oral toxicity, Government printing office, Washington DC, U.S.
25. Waihenya RK, Mtambo MM, Nkwengulila G, Minga UM (2002). Efficacy of crude extract of Aloe secundiflora against Salmonella gallinarum in experimentally infected free-range chickens in Tanzania. J. Ethnopharmacol., 79: 317-323.
26. Witte W (2004). International dissemination of antibiotic resistant strains of bacterial pathogens. Infect. Genet. Evol., 4: 187-191.
27. Zinner SH, McCabe WR (1976). Effects of IgM and IgG antibody in patients with bacteremia due to gram-negative bacilli. J. Infect. Dis., 133: 37-45.