Short-term and long-term effects of orthopedic biodegradable implants

Journal of Long-Term Effects of Medical Implants

Volumn 21, Issue 2, 2011, Pages 93-122

  Amini, Ami R ^a   Wallace, James S ^a   Nukavarapu, Syam P ^a,b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Biodegradable; Fibrosis; Foreign body reaction; Inflammation; Orthopedic biomaterials

Indexed keywords

DEGRADATION; SURGERY;

BIODEGRADABLE; FIBROSIS; FOREIGN BODY REACTIONS; INFLAMMATION; ORTHOPEDIC BIOMATERIALS;

PATHOLOGY;

BIOMATERIAL;

ARTICLE; BIODEGRADABLE IMPLANT; BONE REGENERATION; COST; FOREIGN BODY REACTION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MAXILLOFACIAL PROSTHESIS; ORTHOPEDIC EQUIPMENT; REOPERATION;

EID: 80055054447     PISSN: 10506934     EISSN: None     Source Type: Journal    
DOI: 10.1615/JLongTermEffMedImplants.v21.i2.10     Document Type: Article

References (165)

1. Reichert WM, Ratner BD, Anderson J, Coury A, Hoffman AS, Laurencin CT, Tirrell D. 2010 Panel on the Biomaterials Grand Challenges. J Biomed Mater Res A. 2011 Feb;96(2):275-87
2. Mittal R, Morley J, Dinopoulos H, Drakoulakis E, Vermani E, Giannoudis P. Use of bioresorbable implants for stabilisation of distal radius fractures: the United Kingdom patients' perspective. Injury. 2005 Feb;36(2):333-8
3. Kulkarni RK, Pani KC, Neuman C, Leonard F. Polylactic acid for surgical implants. Arch Surg. 1966 Nov;93(5):839-43
4. Rokkanen P, Bostman O, Vainionpaa S, Makela EA, Hirvensalo E, Partio EK, Vihtonen K, Patiala H, Tormala P. Absorbable devices in the fixation of fractures. J Trauma. 1996 Mar;40(3 Suppl):S123-7
5. Rokkanen P, Bostman O, Hirvensalo E, Makela E, Partio E, Patiala H, Vainionpaa SI, Vihtonen K, Tormala P. Bioabsorbable fixation in orthopaedic surgery and traumatology. Biomaterials. 2000 Dec;21(24):2607-13
6. Bostman O. Economic considerations on avoiding implant removals after fracture fixation by using absorbable devices. Scand J Soc Med. 1994 Mar;22(1):41-5
7. Bostman O, Pihlajamaki H. Routine implant removal after fracture surgery: a potentially reducible consumer of hospital resources in trauma units. J Trauma. 1996 Nov;41(5):846-9
8. Huiskes R, Weinans H, van Rietbergen B. The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials. Clin Orthop Relat Res. 1992 Jan;(274):124-34
9. Kim YK, Yeo HH, Lim SC. Tissue response to titanium plates: a transmitted electron microscopic study. J Oral Maxillofac Surg. 1997 Apr;55(4):322-6
10. Matthew IR, Frame JW. Ultrastructural analysis of metal particles released from stainless steel and titanium miniplate components in an animal model. J Oral Maxillofac Surg. 1998 Jan;56(1):45-50
11. Wong L, Dufresne CR, Richtsmeier JT, Manson PN. The effect of rigid fixation on growth of the neurocranium. Plast Reconstr Surg. 1991 Sep;88(3):395-403
12. Alpert B, Seligson D. Removal of asymptomatic bone plates used for orthognathic surgery and facial fractures. J Oral Maxillofac Surg. 1996 May;54(5):618-21
13. Taylor M, Tanner KE. Fatigue failure of cancellous bone: a possible cause of implant migration and loosening. J Bone Joint Surg Br. 1997 Mar;79(2):181-2
14. Juutilainen T, Patiala H, Ruuskanen M, Rokkanen P. Comparison of costs in ankle fractures treated with absorbable or metallic fixation devices. Arch Orthop Trauma Surg. 1997;116(4):204-8
15. Meinel L, Hofmann S, Karageorgiou V, Kirker-Head C, McCool J, Gronowicz G, Zichner L, Langer R, Vunjak-Novakovic G, Kaplan DL. The inflammatory responses to silk films in vitro and in vivo. Biomaterials. 2005 Jan;26(2):147-55
16. Pihlajamaki H, Salminen S, Tynninen O, Bostman O, Laitinen O. Tissue restoration after implantation of polyglycolide, polydioxanone, polylevolactide, and metallic pins in cortical bone: an experimental study in rabbits. Calcif Tissue Int. 2010 Jul;87(1):90-8
17. Witte F, Ulrich H, Rudert M, Willbold E. Biodegradable magnesium scaffolds: Part 1: appropriate inflammatory response. J Biomed Mater Res A. 2007 Jun;81(3):748-56
18. Zhang E, Xu L, Yu G, Pan F, Yang K. In vivo evaluation of biodegradable magnesium alloy bone implant in the first 6 months implantation. J Biomed Mater Res A. 2009 Sep;90(3): 882-93
19. Laschke M, Strohe A, Scheuer C, Eglin D, Verrier S, Alini M, Pohlemann T, Menger MD. In vivo biocompatibility and vascularization of biodegradable porous polyurethane scaffolds for tissue engineering. Acta Biomater. 2009 Jul;5(6):1991-2001
20. Nukavarapu S, Kumbar S, Brown J, Krogman N, Weikel A, Hindenlang M, Nair LS, Allcock HR, Laurencin CT. Polyphosphazene/ nano-hydroxyapatite composite microsphere scaffolds for bone tissue engineering. Biomacromolecules. 2008 Jul;9(7):1818-25
21. Mistry AS, Mikos AG. Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol. 2005;94:1-22
22. Garvin K, Feschuk C. Polylactide-polyglycolide antibiotic implants. Clin Orthop Relat Res. 2005 Aug(437):105-10
23. Puleo D, Nanci A. Understanding and controlling the bone-implant interface. Biomaterials. 1999 Dec;20(23-24):2311-21
24. Bonnema H, Popa E, van Timmeren M, van Wachem P, de Leij L, van Luyn M. Distribution patterns of the membrane glycoprotein CD44 during the foreign-body reaction to a degradable biomaterial in rats and mice. J Biomed Mater Res A. 2003 Mar;64(3):502-8
25. Reed AM, Gilding DK. Biodegradable polymers for use in surgery-poly(glycolic)/ poly(lactic acid) homo-and copolymers: 2. In vitro degradation. Polymer. 1981;22(4):494-8
26. Gilding DK, Reed AM. Biodegradable polymers for use in surgery-polyglycolic/ poly(lactic acid) homo-and copolymers: 1. Polymer. 1979;20(12):1459-64
27. Ambrose CG, Clanton TO. Bioabsorbable implants: review of clinical experience in orthopedic surgery. Ann Biomed Eng. 2004 Jan;32(1):171-7
28. Ciccone WJ, Motz C, Bentley C, Tasto JP. Bioabsorbable implants in orthopaedics: new developments and clinical applications. J Am Acad Orthop Surg. 2001 Sep-Oct;9(5):280-8
29. Pietrzak W, Verstynen M, Sarver D. Bioabsorbable fixation devices: status for the craniomaxillofacial surgeon. J Craniofac Surg. 1997;8(2):92-6
30. Nukavarapu SP, Kumbar SG, Allcock HR, Laurencin CT. Biodegradable polyphosphazene scaffolds for tissue engineering. In: Andrianov AK, editor. Polyphosphazenes for Biomedical Applications. Hoboken (NJ): Wiley; 2009. p. 117-38
31. Middleton JC, Tipton AJ. Synthetic biodegradable polymers as orthopedic devices. Biomaterials. 2000 Dec;21(23):2335-46
32. Vaccaro AR. The role of the osteoconductive scaffold in synthetic bone graft. Orthopedics. 2002 May;25(5 Suppl):S571-8
33. Nukavarapu S, Wallace J, Elgendy H, Lieberman J, Laurencin C. Bone and Biomaterials. An Introduction to Biomaterials and their Applications. Taylor & Francis Group, in press.
34. Bridges AW, Garcia AJ. Anti-inflammatory polymeric coatings for implantable biomaterials and devices. J Diabetes Sci Technol. 2008 Nov;2(6):984-94
35. Brunski J, Puleo D, Nanci A. Biomaterials and biomechanics of oral and maxillofacial implants: current status and future developments. Int J Oral Maxillofac Implants. 2000 Jan-Feb;15(1):15-46
36. Vroman L. Effect of absorbed proteins on the wettability of hydrophilic and hydrophobic solids. Nature. 1962 Nov;196:476-7
37. Wilson C, Clegg R, Leavesley D, Pearcy M. Mediation of biomaterial-cell interactions by adsorbed proteins: a review. Tissue Eng. 2005 Jan-Feb;11(1-2):1-18
38. Roach P, Eglin D, Rohde K, Perry C. Modern biomaterials: a review-bulk properties and implications of surface modifications. J Mater Sci Mater Med. 2007 Jul;18(7): 1263-77
39. Nuss KM, von Rechenberg B. Biocompatibility issues with modern implants in bone-a review for clinical orthopedics. Open Orthop J. 2008;2:66-78
40. Luttikhuizen D, Harmsen M, Van Luyn M. Cellular and molecular dynamics in the foreign body reaction. Tissue Eng. 2006 Jul;12(7):1955-70
41. Zdolsek J, Eaton JW, Tang L. Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans. J Transl Med. 2007;5:31.
42. Kasemo B, Gold J. Implant surfaces and interface processes. Adv Dent Res. 1999 Jun;13:8-20
43. Ward W, Li A, Siddiqui Y, Federiuk I, Wang X. Increased expression of interleukin-13 and connective tissue growth factor, and their potential roles during foreign body encapsulation of subcutaneous implants. J Biomater Sci Polym Ed. 2008;19(8):1065-72
44. Hu W, Eaton J, Ugarova T, Tang L. Molecular basis of biomaterial-mediated foreign body reactions. Blood. 2001 Aug;98(4):1231-8
45. Luttikhuizen D, van Amerongen M, de Feijter P, Petersen A, Harmsen M, van Luyn M. The correlation between difference in foreign body reaction between implant locations and cytokine and MMP expression. Biomaterials. 2006 Dec;27(34):5763-70
46. Muller-Eberhard H. Molecular organization and function of the complement system. Annu Rev Biochem. 1988;57:321-47
47. Nilsson B, Ekdahl K, Mollnes T, Lambris J. The role of complement in biomaterial-induced inflammation. Mol Immunol. 2007 Jan;44(1-3):82-94
48. Kao W, Hubbell J, Anderson J. Protein-mediated macrophage adhesion and activation on biomaterials: a model for modulating cell behavior. J Mater Sci Mater Med. 1999 Oct-Nov;10(10/11):601-5
49. Tang L, Jennings T, Eaton J. Mast cells mediate acute inflammatory responses to implanted biomaterials. Proc Natl Acad Sci U S A. 1998 Jul;95(15):8841-6
50. Rucker M, Laschke M, Junker D, Carvalho C, Schramm A, Mulhaupt R, Gellrich NC, Menger MD. Angiogenic and inflammatory response to biodegradable scaffolds in dorsal skinfold chambers of mice. Biomaterials. 2006 Oct;27(29):5027-38
51. Santavirta S, Konttinen Y, Saito T, Gronblad M, Partio E, Kemppinen P, Rokkanen P. Immune response to polyglycolic acid implants. J Bone Joint Surg Br. 1990 Jul;72(4):597-600
52. Higgins D, Basaraba R, Hohnbaum A, Lee E, Grainger D, Gonzalez-Juarrero M. Localized immunosuppressive environment in the foreign body response to implanted biomaterials. Am J Pathol. 2009 Jul;175(1):161-70
53. Xia Z, Triffitt J. A review on macrophage responses to biomaterials. Biomed Mater. 2006 Mar;1(1):R1-9
54. Shen M, Horbett T. The effects of surface chemistry and adsorbed proteins on monocyte/ macrophage adhesion to chemically modified polystyrene surfaces. J Biomed Mater Res. 2001 Dec;57(3):336-45
55. Xia Z, Zhu T, Du J, Zheng Q, Wang L, Li S, Chang CY, Fang SY. Macrophages in degradation of collagen/hydroxylapatite (CHA), beta-tricalcium phosphate ceramics (TCP) artificial bone graft. An in vivo study. Chin Med J (Engl). 1994 Nov;107(11):845-9
56. Takebe J, Champagne C, Offenbacher S, Ishibashi K, Cooper L. Titanium surface topography alters cell shape and modulates bone morphogenetic protein 2 expression in the J774A.1 macrophage cell line. J Biomed Mater Res A. 2003 Feb;64(2):207-16
57. Lu J, Descamps M, Dejou J, Koubi G, Hardouin P, Lemaitre J, Proust JP. The biodegradation mechanism of calcium phosphate biomaterials in bone. J Biomed Mater Res. 2002;63(4):408-12
58. Labow R, Sa D, Matheson L, Santerre J. Polycarbonate-urethane hard segment type influences esterase substrate specificity for human-macrophage-mediated biodegradation. J Biomater Sci Polym Ed. 2005;16(9):1167-77
59. Solheim E, Sudmann B, Bang G, Sudmann E. Biocompatibility and effect on osteogenesis of poly(ortho ester) compared to poly(DL-lactic acid). J Biomed Mater Res. 2000 Feb;49(2):257-63
60. Khouw I, van Wachem P, de Leij L, van Luyn M. Inhibition of the tissue reaction to a biodegradable biomaterial by monoclonal antibodies to IFN-gamma. J Biomed Mater Res. 1998 Aug;41(2):202-10
61. Jones J, McNally A, Chang D, Qin L, Meyerson H, Colton E, Kwon IL, Matsuda T, An derson JM. Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials. J Biomed Mater Res A. 2008 Jan;84(1):158-66
62. Rodriguez A, Macewan S, Meyerson H, Kirk J, Anderson J. The foreign body reaction in Tcell-deficient mice. J Biomed Mater Res A. 2009 Jul;90(1):106-13
63. Jones KS. Effects of biomaterial-induced inflammation on fibrosis and rejection. Semin Immunol. 2008 Apr;20(2):130-6
64. Muldashev E, Muslimov S, Musina L, Nigmatullin R, Lebedeva A, Shangina O, Khasanov RA. The role of macrophages in the tissues regeneration stimulated by the biomaterials. Cell Tissue Bank. 2005;6(2): 99-107
65. Brodbeck W, Patel J, Voskerician G, Christenson E, Shive M, Nakayama Y, Matsuda T, Ziats NP, Anderson JM. Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo. Proc Natl Acad Sci U S A. 2002 Aug;99(16):10287-92
66. Piattelli A, Franco M, Ferronato G, Santello M, Martinetti R, Scarano A. Resorption of composite polymer-hydroxyapatite membranes: a time-course study in rabbit. Biomaterials. 1997 Apr;18(8):629-33
67. Sack U, Kuhn H, Kampfer I, Genest M, Arnold S, Pfeiffer G, Emmrich F. Orthotopic implantation of inflamed synovial tissue from RA patients induces a characteristic arthritis in immunodeficient (SCID) mice. J Autoimmun. 1996 Feb;9(1):51-8
68. Gallagher W, Lynch I, Allen L, Miller I, Penney S, O'Connor D, Pennington S, Keenan AK, Dawson KA. Molecular basis of cellbiomaterial interaction: insights gained from transcriptomic and proteomic studies. Biomaterials. 2006 Dec;27(35):5871-82
69. Siebers M, ter Brugge P, Walboomers X, Jansen J. Integrins as linker proteins between osteoblasts and bone replacing materials. A critical review. Biomaterials. 2005 Jan;26(2):137-46
70. Pihlajamaki H, Visuri T. Long-term outcome after surgical treatment of unresolved Osgood-Schlatter disease in young men: surgical technique. J Bone Joint Surg Am. 2010 Sep;92 Suppl 1 Pt 2:258-64
71. Sitharaman B, Shi X, Walboomers X, Liao H, Cuijpers V, Wilson L, Mikos AG, Jansen JA. In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for bone tissue engineering. Bone. 2008 Aug;43(2):362-70
72. Staiger M, Pietak A, Huadmai J, Dias G. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials. 2006 Mar;27(9):1728-34
73. Usui Y, Aoki K, Narita N, Murakami N, Nakamura I, Nakamura K, Ishigaki N, Yamazaki H, Horiuchi H, Kato H, Taruta S, Kim YA, Endo M, Saito N. Carbon nanotubes with high bone-tissue compatibility and boneformation acceleration effects. Small. 2008 Feb;4(2):240-6
74. Witte F, Ulrich H, Palm C, Willbold E. Biodegradable magnesium scaffolds: Part II: peri-implant bone remodeling. J Biomed Mater Res A. 2007 Jun;81(3):757-65
75. Ambrose C, Clanton T. Bioabsorbable implants: review of clinical experience in orthopedic surgery. Ann Biomed Eng. 2004 Jan;32(1):171-7
76. Anderson J, Rodriguez A, Chang D. Foreign body reaction to biomaterials. Semin Immunol. 2008 Apr;20(2):86-100
77. Lu L, Peter S, Lyman M, Lai H, Leite S, Tamada J, Uyama S, Vacanti JP, Langer R, Mikos AG. In vitro and in vivo degradation of porous poly(DL-lactic-co-glycolic acid) foams. Biomaterials. 2000 Sep;21(18): 1837-45
78. Nair Pn PR, Schug J. Observations on healing of human tooth extraction sockets implanted with bioabsorbable polylacticpolyglycolic acids (PLGA) copolymer root replicas: a clinical, radiographic, and histologic follow-up report of 8 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 May;97(5):559-69
79. Spector JA, Mehrara BJ, Greenwald JA, Saadeh PB, Steinbrech DS, Bouletreau PJ, Smith LP, Longaker MT. Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment. Am J Physiol Cell Physiol. 2001 Jan;280(1): C72-80
80. Sung H, Meredith C, Johnson C, Galis Z. The effect of scaffold degradation rate on threedimensional cell growth and angiogenesis. Biomaterials. 2004 Nov;25(26):5735-42
81. Bostman O, Pihlajamaki H. Late foreignbody reaction to an intraosseous bioabsorbable polylactic acid screw. A case report. J Bone Joint Surg Am. 1998 Dec;80(12):1791-4
82. Bostman O, Pihlajamaki H. Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation: a review. Biomaterials. 2000 Dec;21(24):2615-21
83. Weiler A, Helling H, Kirch U, Zirbes T, Rehm K. Foreign-body reaction and the course of osteolysis after polyglycolide implants for fracture fixation: experimental study in sheep. J Bone Joint Surg Br. 1996 May;78(3): 369-76
84. Pihlajamaki H, Salminen S, Laitinen O, Tynninen O, Bostman O. Tissue response to polyglycolide, polydioxanone, polylevolactide, and metallic pins in cancellous bone: An experimental study on rabbits. J Orthop Res. 2006 Aug;24(8):1597-606
85. Pihlajamaki H, Bostman O, Tynninen O, Laitinen O. Long-term tissue response to bioabsorbable poly-L-lactide and metallic screws: an experimental study. Bone. 2006 Oct;39(4):932-7
86. Morais J, Papadimitrakopoulos F, Burgess D. Biomaterials/tissue interactions: possible solutions to overcome foreign body response. AAPS J. 2010 Jun;12(2):188-96
87. Pistner H, Stallforth H, Gutwald R, Muhling J, Reuther J, Michel C. Poly(L-lactide): a long-term degradation study in vivo. Part II: Physico-mechanical behaviour of implants. Biomaterials. 1994 May;15(6):439-50
88. Rubin JP, Yaremchuk MJ. Complications and toxicities of implantable biomaterials used in facial reconstructive and aesthetic surgery: a comprehensive review of the literature. Plast Reconstr Surg. 1997 Oct;100(5):1336-53
89. Matlaga B, Yasenchak L, Salthouse T. Tissue response to implanted polymers: the significance of sample shape. J Biomed Mater Res. 1976 May;10(3):391-7
90. Park J, Davies J. Red blood cell and platelet interactions with titanium implant surfaces. Clin Oral Implants Res. 2000 Dec;11(6): 530-9
91. Davies J. Understanding peri-implant endosseous healing. J Dent Educ. 2003 Aug;67(8):932-49
92. Ziats N, Miller K, Anderson J. In vitro and in vivo interactions of cells with biomaterials. Biomaterials. 1988 Jan;9(1):5-13
93. Behling C, Spector M. Quantitative characterization of cells at the interface of longterm implants of selected polymers. J Biomed Mater Res. 1986 May-Jun;20(5):653-66
94. Salthouse T. Some aspects of macrophage behavior at the implant interface. J Biomed Mater Res. 1984 Apr;18(4):395-401
95. Taylor S, Gibbons D. Effect of surface texture on the soft tissue response to polymer implants. J Biomed Mater Res. 1983 Mar;17(2):205-27
96. Buser D, Schenk R, Steinemann S, Fiorellini J, Fox C, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res. 1991 Jul;25(7):889-902
97. Lossdorfer S, Schwartz Z, Wang L, Lohmann C, Turner J, Wieland M, Cochran DL, Boyan BD. Microrough implant surface topographies increase osteogenesis by reducing osteoclast formation and activity. J Biomed Mater Res A. 2004 Sep;70(3):361-9
98. Schwartz Z, Boyan B. Underlying mechanisms at the bone-biomaterial interface. J Cell Biochem. 1994 Nov;56(3):340-7
99. Schroeder A, van der Zypen E, Stich H, Sutter F. The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. J Maxillofac Surg. 1981 Feb;9(1):15-25
100. Rich A, Harris A. Anomalous preferences of cultured macrophages for hydrophobic and roughened substrata. J Cell Sci. 1981 Aug;50:1-7
101. Thomas K, Cook S. An evaluation of variables influencing implant fixation by direct bone apposition. J Biomed Mater Res. 1985 Oct;19(8):875-901
102. Rumpler M, Woesz A, Dunlop J, van Dongen J, Fratzl P. The effect of geometry on threedimensional tissue growth. J R Soc Interface. 2008 Oct;5(27):1173-80
103. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 2005 Sep;26(27):5474-91
104. Tsuruga E, Takita H, Itoh H, Wakisaka Y, Kuboki Y. Pore size of porous hydroxyapatite as the cell-substratum controls BMPinduced osteogenesis. J Biochem. 1997 Feb;121(2):317-24
105. Kuboki Y, Jin Q, Takita H. Geometry of carriers controlling phenotypic expression in BMP-induced osteogenesis and chondrogenesis. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S105-15
106. Vogler EA. Structure and reactivity of water at biomaterial surfaces. Adv Colloid Interface Sci. 1998 Feb;74:69-117
107. Ma Z, Mao Z, Gao C. Surface modification and property analysis of biomedical polymers used for tissue engineering. Colloids Surf B Biointerfaces. 2007 Nov;60(2):137-57
108. Lewandowska K, Balachander N, Sukenik C, Culp L. Modulation of fibronectin adhesive functions for fibroblasts and neural cells by chemically derivatized substrata. J Cell Physiol. 1989 Nov;141(2):334-45
109. Absolom D, Zingg W, Neumann A. Protein adsorption to polymer particles: role of surface properties. J Biomed Mater Res. 1987 Feb;21(2):161-71
110. Grinnell F, Feld M. Fibronectin adsorption on hydrophilic and hydrophobic surfaces detected by antibody binding and analyzed during cell adhesion in serum-containing medium. J Biol Chem. 1982 May;257(9):4888-93
111. Altankov G, Grinnell F, Groth T. Studies on the biocompatibility of materials: fibroblast reorganization of substratum-bound fibronectin on surfaces varying in wettability. J Biomed Mater Res. 1996 Mar;30(3): 385-91
112. Eriksson C, Nygren H, Ohlson K. Implantation of hydrophilic and hydrophobic titanium discs in rat tibia: cellular reactions on the surfaces during the first 3 weeks in bone. Biomaterials. 2004 Aug;25(19):4759-66
113. Oh SH, Kang SG, Lee JH. Degradation behavior of hydrophilized PLGA scaffolds prepared by melt-molding particulate-leaching method: comparison with control hydrophobic one. J Mater Sci Mater Med. 2006 Feb;17(2):131-7
114. Brodbeck W, Nakayama Y, Matsuda T, Colton E, Ziats N, Anderson J. Biomaterial surface chemistry dictates adherent monocyte/ macrophage cytokine expression in vitro. Cytokine. 2002 Jun;18(6):311-9
115. Brodbeck W, Shive M, Colton E, Nakayama Y, Matsuda T, Anderson J. Influence of biomaterial surface chemistry on the apoptosis of adherent cells. J Biomed Mater Res. 2001 Jun;55(4):661-8
116. Collier T, Anderson J, Brodbeck W, Barber T, Healy K. Inhibition of macrophage development and foreign body giant cell formation by hydrophilic interpenetrating polymer network. J Biomed Mater Res A. 2004 Jun;69(4):644-50
117. Jones J, Chang D, Meyerson H, Colton E, Kwon I, Matsuda T, Anderson JM. Proteomic analysis and quantification of cytokines and chemokines from biomaterial surface-adherent macrophages and foreign body giant cells. J Biomed Mater Res A. 2007 Dec;83(3):585-96
118. Anderson J, Jones J. Phenotypic dichotomies in the foreign body reaction. Biomaterials. 2007 Dec;28(34):5114-20
119. Bzowska M, Guzik K, Barczyk K, Ernst M, Flad H, Pryjma J. Increased IL-10 production during spontaneous apoptosis of monocytes. Eur J Immunol. 2002 Jul;32(7): 2011-20
120. Nair A, Zou L, Bhattacharyya D, Timmons R, Tang L. Species and density of implant surface chemistry affect the extent of foreign body reactions. Langmuir. 2008 Mar;24(5):2015-24
121. Tziampazis E, Kohn J, Moghe PV. PEGvariant biomaterials as selectively adhesive protein templates: model surfaces for controlled cell adhesion and migration. Biomaterials. 2000 Mar;21(5):511-20
122. Unsworth LD, Sheardown H, Brash JL. Protein-resistant poly(ethylene oxide)-grafted surfaces: chain density-dependent multi ple mechanisms of action. Langmuir. 2008 Mar;24(5):1924-9
123. Unsworth LD, Sheardown H, Brash JL. Polyethylene oxide surfaces of variable chain density by chemisorption of PEO-thiol on gold: adsorption of proteins from plasma studied by radiolabelling and immunoblotting. Biomaterials. 2005 Oct;26(30):5927-33
124. Michel R, Pasche S, Textor M, Castner DG. Influence of PEG architecture on protein adsorption and conformation. Langmuir. 2005 Dec;21(26):12327-32
125. Vadgama P. Modifying surfaces and interfaces for improved biomaterial performance. Med Device Technol. 2007 Jan-Feb;18(1):22-5
126. Liu X, Smith L, Hu J, Ma P. Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering. Biomaterials. 2009 Apr;30(12):2252-8
127. Nukavarapu S, Kumbar S, Merrell J, Laurencin C. Electrospun polymeric nanofiber scaffolds for tissue regeneration. In: Laurencin CT, Nair LS, editors. Nanotechnology and Tissue Engineering: The Scaffold. New York: CRC Presss; 2008. p. 199-219
128. Nukavarapu S, Kumbar S, Nair L, Laurencin C. Nanostructures for Tissue Engineering/ Regenerative Medicine. In: Gonsalves K, Halberstadt C, Laurencin CT, Nair L, editors. Biomedical Nanostructures. Hoboken (NJ): John Wiley & Sons, Inc.; 2008. p. 371-401
129. Igwe J, Amini A, Mickael P, Laurencin C, Nukavarapu S. Nanostructured Scaffolds for Bone Tissue Engineering. In: Zilberman M, editor. Studies in Mechanobiology, Tissue Engineering and Biomaterials. New York: Springer; 2011.
130. Shin S, Park H, Kim K, Lee M, Choi Y, Park Y, Lee YM, Ku Y, Rhyu IC, Han SB, Lee SJ, Chung CP. Biological evaluation of chitosan nanofiber membrane for guided bone regeneration. J Periodontol. 2005 Oct;76(10):1778-84
131. Appleford MR, Oh S, Oh N, Ong JL. In vivo study on hydroxyapatite scaffolds with trabecular architecture for bone repair. J Biomed Mater Res A. 2009 Jun;89(4):1019-27
132. Hunt JA, Callaghan JT. Polymer-hydroxyapatite composite versus polymer interference screws in anterior cruciate ligament reconstruction in a large animal model. Knee Surg Sports Traumatol Arthrosc. 2008 Jul;16(7):655-60
133. Lickorish D, Chan J, Song J, Davies JE. An in-vivo model to interrogate the transition from acute to chronic inflammation. Eur Cell Mater. 2004;8:12-9; discussion 20.
134. Onuki Y, Bhardwaj U, Papadimitrakopoulos F, Burgess D. A review of the biocompatibility of implantable devices: current challenges to overcome foreign body response. J Diabetes Sci Technol. 2008 Nov;2(6): 1003-15
135. Wang Q, Wang J, Lu Q, Detamore MS, Berkland C. Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects. Biomaterials. 2010 Jun;31(18):4980-6
136. Zolnik BS, Burgess DJ. Evaluation of in vivo-in vitro release of dexamethasone from PLGA microspheres. J Control Release. 2008 Apr;127(2):137-45
137. Hickey T, Kreutzer D, Burgess DJ, Moussy F. In vivo evaluation of a dexamethasone/PLGA microsphere system designed to suppress the inflammatory tissue response to implantable medical devices. J Biomed Mater Res. 2002 Aug;61(2):180-7
138. Patil SD, Papadimitrakopoulos F, Burgess DJ. Dexamethasone-loaded poly(lactic-coglycolic) acid microspheres/poly(vinyl alcohol) hydrogel composite coatings for inflammation control. Diabetes Technol Ther. 2004 Dec;6(6):887-97
139. Bhardwaj U, Sura R, Papadimitrakopoulos F, Burgess DJ. Controlling acute inflammation with fast releasing dexamethasone-PLGA microsphere/pva hydrogel composites for implantable devices. J Diabetes Sci Technol. 2007 Jan;1(1):8-17
140. Kim DH, Martin DC. Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery. Biomaterials. 2006 May;27(15): 3031-7
141. Kim H, Kim HW, Suh H. Sustained release of ascorbate-2-phosphate and dexametha sone from porous PLGA scaffolds for bone tissue engineering using mesenchymal stem cells. Biomaterials. 2003 Nov;24(25):4671-9
142. Khaled KA, Sarhan HA, Ibrahim MA, Ali AH, Naguib YW. Prednisolone-loaded PLGA microspheres. in vitro characterization and in vivo application in adjuvant-induced arthritis in mice. AAPS PharmSci-Tech. 2010 Jun;11(2):859-69
143. Zhong Y, Bellamkonda RV. Controlled release of anti-inflammatory agent alpha-MSH from neural implants. J Control Release. 2005 Sep;106(3):309-18
144. Dugina TN, Kiseleva EV, Lange MA, Vasil'eva TV, Grandfils C, Markvicheva EA, Bespalova ZhD, Pal'keeva ME, Strukova SM. Effect of synthetic peptide thrombin receptor agonist encapsulated in microparticles based on lactic and glycolic acid copolymer on healing of experimental skin wounds in mice. Bull Exp Biol Med. 2004 Nov;138(5):463-6
145. Pataro AL, Oliveira MF, Teixeira KI, Turchetti-Maia RM, Lopes MT, Wykrota FH, Sinisterra RD, Cortes ME. Polymer: bioceramic composites optimization by tetracycline addition. Int J Pharm. 2007 May;336(1):75-81
146. Gerritsen M, Kros A, Sprakel V, Lutterman JA, Nolte RJ, Jansen JA. Biocompatibility evaluation of sol-gel coatings for subcutaneously implantable glucose sensors. Biomaterials. 2000 Jan;21(1):71-8
147. Wang XH, Li DP, Wang WJ, Feng QL, Cui FZ, Xu YX, Song XH. Covalent immobilization of chitosan and heparin on PLGA surface. Int J Biol Macromol. 2003 Nov;33(1-3):95-100
148. van Bilsen PH, Popa ER, Brouwer LA, Vincent J, Taylor CE, de Leij LF, Hendriks M, van Luyn MJ. Ongoing foreign body reaction to subcutaneous implanted (heparin) modified Dacron in rats. J Biomed Mater Res A. 2004 Mar;68(3):423-7
149. Fu J, Ji J, Yuan W, Shen J. Construction of anti-adhesive and antibacterial multilayer films via layer-by-layer assembly of heparin and chitosan. Biomaterials. 2005 Nov;26(33):6684-92
150. Rele SM, Cui W, Wang L, Hou S, Barr-Zarse G, Tatton D, Gnanou Y, Esko JD, Chaikof EL. Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties. J Am Chem Soc. 2005 Jul;127(29):10132-3
151. Tseng PY, Rele SS, Sun XL, Chaikof EL. Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factorinduced thrombin generation in a flow model. Biomaterials. 2006 Apr;27(12):2637-50
152. Du YJ, Brash JL, McClung G, Berry LR, Klement P, Chan AK. Protein adsorption on polyurethane catheters modified with a novel antithrombin-heparin covalent complex. J Biomed Mater Res A. 2007 Jan;80(1): 216-25
153. Rusanova AV, Makarova AM, Strukova SM, Markvicheva EA, Gorbachyova LR, Stashevskaya KS, Vasil'eva TV, Sidorova EI, Bespalova ZhD, Grandfils Ch. Thrombin receptor agonist peptide immobilized in microspheres stimulates reparative processes in rats with gastric ulcer. Bull Exp Biol Med. 2006 Jul;142(1):35-8
154. Udipi K, Ornberg RL, Thurmond KB, Settle SL, Forster D, Riley D. Modification of inflammatory response to implanted biomedical materials in vivo by surface bound superoxide dismutase mimics. J Biomed Mater Res. 2000 Sep;51(4):549-60
155. Kim DH, Smith JT, Chilkoti A, Reichert WM. The effect of covalently immobilized rhIL-1ra-ELP fusion protein on the inflammatory profile of LPS-stimulated human monocytes. Biomaterials. 2007 Aug;28(23):3369-77
156. Nguyen KT, Shaikh N, Shukla KP, Su SH, Eberhart RC, Tang L. Molecular responses of vascular smooth muscle cells and phagocytes to curcumin-eluting bioresorbable stent materials. Biomaterials. 2004 Oct;25(23):5333-46
157. Su SH, Nguyen KT, Satasiya P, Greilich PE, Tang L, Eberhart RC. Curcumin impregnation improves the mechanical properties and reduces the inflammatory response associated with poly(L-lactic acid) fiber. J Biomater Sci Polym Ed. 2005;16(3):353-70
158. Pan CJ, Tang JJ, Weng YJ, Wang J, Huang N. Preparation, characterization and anticoagulation of curcumin-eluting controlled biodegradable coating stents. J Control Release. 2006 Nov;116(1):42-9
159. Hahn SK, Jelacic S, Maier RV, Stayton PS, Hoffman AS. Anti-inflammatory drug delivery from hyaluronic acid hydrogels. J Biomater Sci Polym Ed. 2004;15(9):1111-9
160. Park JS, Yang HN, Woo DG, Jeon SY, Park KH. The promotion of chondrogenesis, osteogenesis, and adipogenesis of human mesenchymal stem cells by multiple growth factors incorporated into nanospherecoated microspheres. Biomaterials. 2011 Jan;32(1):28-38
161. Fioretti F, Mendoza-Palomares C, Helms M, Al Alam D, Richert L, Arntz Y, Rinckenbach S, Garnier F, Haikel Y, Gangloff SC, Benkirane-Jessel N. Nanostructured assemblies for dental application. ACS Nano. 2010 Jun;4(6):3277-87
162. Patil SD, Papadimitrakopoulos F, Burgess DJ. Concurrent delivery of dexamethasone and VEGF for localized inflammation control and angiogenesis. J Control Release. 2007 Jan;117(1):68-79
163. Park JS, Yang HN, Jeon SY, Woo DG, Na K, Park KH. Osteogenic differentiation of human mesenchymal stem cells using RGDmodified BMP-2 coated microspheres. Biomaterials. 2010 Aug;31(24):6239-48
164. Xie XH, Yu XW, Zeng SX, Du RL, Hu YH, Yuan Z, Lu EY, Dai KR, Tang TT. Enhanced osteointegration of orthopaedic implant gradient coating composed of bioactive glass and nanohydroxyapatite. J Mater Sci Mater Med. 2010 Jul;21(7):2165-73
165. Williams D. On the mechanisms of biocompatibility. Biomaterials. 2008 Jul;29(20):2941-53.