Modulation of the canonical Wnt pathway by Benzalkonium Chloride in corneal epithelium

Experimental Eye Research

Volumn 93, Issue 4, 2011, Pages 355-362

  Zhou, Yueping ^a   Liu, Qiuping ^a   Zhou, Tong ^a   Lin, Zhirong ^a   Zong, Rongrong ^a   Liu, Zhen ^a   Sun, Feng ^a   Shao, Yi ^a   Liu, Xiaochen ^a   Ma, Jian xing ^b   Liu, Zuguo ^a  

^a XIAMEN UNIVERSITY   (China)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Benzalkonium Chloride (BAC); Cornea; Wnt

Indexed keywords

BENZALKONIUM CHLORIDE; BETA CATENIN; SECRETED FRIZZLED RELATED PROTEIN 1; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CORNEA EPITHELIUM; CYTOTOXICITY; DOWN REGULATION; DRUG EXPOSURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; APOPTOSIS; BENZALKONIUM COMPOUNDS; BETA CATENIN; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; EPITHELIUM, CORNEAL; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; MALE; MICE; PHOSPHORYLATION; PRESERVATIVES, PHARMACEUTICAL; RATS; RATS, WISTAR; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 80055054430     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.04.003     Document Type: Article

References (26)

1. Ayaki M., Yaguchi S., Iwasawa A., Koide R. Cytotoxicity of ophthalmic solutions with and without preservatives to human corneal endothelial cells, epithelial cells and conjunctival epithelial cells. Clin. Exp. Ophthalmol. 2008, 36:553-559.
2. Baudouin C. Detrimental effect of preservatives in eyedrops: implications for the treatment of glaucoma. Acta Ophthalmol. 2008, 86:716-726.
3. Cadigan K.M. Wnt-beta-catenin signaling. Curr. Biol. 2008, 18:943-947.
4. Cha S.H., Lee J.S., Oum B.S., Kim C.D. Corneal epithelial cellular dysfunction from benzalkonium chloride (BAC) in vitro. Clin. Exp. Ophthalmol. 2004, 32:180-184.
5. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006, 127:469-480.
6. Deutschle T., Porkert U., Reiter R., Keck T., Riechelmann H. In vitro genotoxicity and cytotoxicity of benzalkonium chloride. Toxicol. In Vitro. 2006, 20:1472-1477.
7. Figueira E.C., Di Girolamo N., Coroneo M.T., Wakefield D. The phenotype of limbal epithelial stem cells. Invest. Ophthalmol. Vis. Sci. 2007, 48:44-56.
8. Gordon M.D., Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J. Biol. Chem. 2006, 281:22429-22433.
9. Han X., Amar S. Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis. J. Biol. Chem. 2004, 279:2832-2840.
10. Huang H., He X. Wnt/β-catenin signaling: new (and old) players and new insights. Curr. Opin. Cell Biol. 2008, 20:119-125.
11. Jin T., George Fantus I., Sun J. Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin. Cell Signal. 2008, 20:1697-1704.
12. Katoh M., Katoh M. WNT signaling pathway and stem cell signaling network. Clin. Cancer Res. 2007, 13:4042-4045.
13. Kawakita T., Shimmura S., Hornia A., Higa K., Tseng S.C. Stratified epithelial sheets engineered from a single adult murine corneal/limbal progenitor cell. J. Cell Mol. Med. 2008, 12:1303-1316.
14. Lin Z., Liu X., Zhou T., Wang Y., Bai L., He H., Liu Z. A mouse dry eye model induced by topical administration of benzalkonium chloride. Mol. Vis. 2011, 17:257-264.
15. Luo J., Chen J., Deng Z.L., Luo X., Song W.X., Sharff K.A., Tang N., Haydon R.C., Luu H.H., He T.C. Wnt signaling and human diseases: what are the therapeutic implications?. Lab. Invest. 2007, 87:97-103.
16. Lyu J., Joo C.K. Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. J. Biol. Chem. 2005, 280:21653-21660.
17. Lyu J., Joo C.K. Expression of Wnt and MMP in epithelial cells during corneal wound healing. Cornea 2006, 25:S24-S28.
18. McGowan S.L., Edelhauser H.F., Pfister R.R., Whikehart D.R. Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas. Mol. Vis. 2007, 13:1984-2000.
19. Pauloin T., Dutot M., Warnet J.M., Rat P. In vitro modulation of preservative toxicity: high molecular weight hyaluronan decreases apoptosis and oxidative stress induced by benzalkonium chloride. Eur. J. Pharm. Sci. 2008, 34:263-273.
20. Pauly A., Brignole-Baudouin F., Labbé A., Liang H., Warnet J.M., Baudouin C. New tools for the evaluation of toxic ocular surface changes in the rat. Invest. Ophthalmol. Vis. Sci. 2007, 48:5473-5483.
21. Sosne G., Albeiruti A.R., Hollis B., Siddiqi A., Ellenberg D., Kurpakus-Wheater M. Thymosin beta4 inhibits benzalkonium chloride-mediated apoptosis in corneal and conjunctival epithelial cells in vitro. Exp. Eye Res. 2006, 83:502-507.
22. Sutton G., Madigan M., Roufas A., McAvoy J. Secreted frizzled-related protein 1 (SFRP1) is highly upregulated in keratoconus epithelium: a novel finding highlighting a new potential focus for keratoconus research and treatment. Clin. Exp. Ophthalmol. 2010, 38:43-48.
23. Takahashi-Yanaga F., Sasaguri T. The Wnt/β-catenin signaling pathway as a target in drug discovery. J. Pharmacol. Sci. 2007, 104:293-302.
24. Uematsu M., Kumagami T., Kusano M., Yamada K., Mishima K., Fujimura K., Sasaki H., Kitaoka T. Acute corneal epithelial change after instillation of benzalkonium chloride evaluated using a newly developed in vivo corneal transepithelial electric resistance measurement method. Ophthalmic Res. 2007, 39:308-314.
25. Wang H., Tao T., Tang J., Mao Y.H., Li W., Peng J., Tan G., Zhou Y.P., Zhong J.X., Tseng S.C., et al. Importin 13 serves as a potential marker for corneal epithelial progenitor cells. Stem Cells 2009, 27:2516-2526.
26. Xiong C., Chen D., Liu J., Liu B., Li N., Zhou Y., Liang X., Ma P., Ye C., Ge J., et al. A rabbit dry eye model induced by topical medication of a preservative benzalkonium chloride. Invest. Ophthalmol. Vis. Sci. 2008, 49:1850-1856.