Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Tulone, Calogero ^a   Sponaas, Anne Marit ^b   Raiber, Eun Ang ^a   Tabor, Alethea B ^a   Langhorne, Jean ^b   Chain, Benny M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN D; CATHEPSIN E; EPITOPE; GLYCOPROTEIN P 15095; MEROZOITE SURFACE PROTEIN 1; RECOMBINANT MEROZOITE SURFACE PROTEIN 1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN G; PARASITE ANTIGEN; PROTEINASE INHIBITOR;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; ERYTHROCYTE; IN VIVO STUDY; MALARIA; MEROZOITE; MOUSE; NONHUMAN; ANIMAL; ANTIBODY PRODUCTION; BONE MARROW CELL; CHEMISTRY; CHIMERA; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PARASITEMIA; PARASITOLOGY; PHENOTYPE; PLASMODIUM CHABAUDI; SPLEEN;

ANIMALS; ANTIBODY FORMATION; ANTIGEN PRESENTATION; ANTIGENS, PROTOZOAN; BONE MARROW CELLS; CATHEPSIN D; CHIMERA; DENDRITIC CELLS; ERYTHROCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOGLOBULIN G; MALARIA; MEROZOITE SURFACE PROTEIN 1; MEROZOITES; MICE; PARASITEMIA; PHENOTYPE; PLASMODIUM CHABAUDI; PROTEASE INHIBITORS; SPLEEN;

EID: 80055050302     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024886     Document Type: Article

References (24)

1. Langhorne J, Ndungu FM, Sponaas AM, Marsh K, (2008) Immunity to malaria: more questions than answers. Nat Immunol 9: 725-732.
2. Banchereau J, Steinman RM, (1998) Dendritic cells and the control of immunity. Nature 392: 245-252.
3. Holder AA, Freeman RR, (1982) Biosynthesis and processing of a Plasmodium falciparum schizont antigen recognized by immune serum and a monoclonal antibody. J Exp Med 156: 1528-1538.
4. Blackman MJ, Heidrich HG, Donachie S, McBride JS, Holder AA, (1990) A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies. J Exp Med 172: 379-382.
5. Kinyanjui SM, Conway DJ, Lanar DE, Marsh K, (2007) IgG antibody responses to Plasmodium falciparum merozoite antigens in Kenyan children have a short half-life. Malar J 6: 82.
6. Hensmann M, Li C, Moss C, Lindo V, Greer F, et al. (2004) Disulfide bonds in merozoite surface protein 1 of the malaria parasite impede efficient antigen processing and affect the in vivo antibody response. Eur J Immunol 34: 639-648.
7. Quin SJ, Seixas EM, Cross CA, Berg M, Lindo V, et al. (2001) Low CD4(+) T cell responses to the C-terminal region of the malaria merozoite surface protein-1 may be attributed to processing within distinct MHC class II pathways. Eur J Immunol 31: 72-81.
8. Chain BM, Free P, Medd P, Swetman C, Tabor AB, et al. (2005) The expression and function of cathepsin E in dendritic cells. J Immunol 174: 1791-1800.
9. Saftig P, Hetman M, Weber K, Heine L, Mossmann H, et al. (1995) Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J 14: 3599-3608.
10. Tulone C, Uchiyama Y, Novelli M, Grosvenor N, Saftig P, Chain BM, (2007) Haematopoietic development and immunological function in the absence of cathepsin D. BMC Immunol 8: 22.
11. Free P, Hurley CA, Kageyama T, Chain BM, Tabor AB, (2006) Mannose-pepstatin conjugates as targeted inhibitors of antigen processing. Org Biomol Chem 4: 1817-1830.
12. Zaidi N, Maurer A, Nieke S, Kalbacher H, (2008) Cathepsin D: a cellular roadmap. Biochem Biophys Res Commun 376: 5-9.
13. Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, et al. (2000) Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci 20: 6898-6906.
14. Deussing J, Roth W, Saftig P, Peters C, Ploegh HL, et al. (1998) Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proc Natl Acad Sci U S A 95: 4516-4521.
15. Singh CR, Moulton RA, Armitige LY, Bidani A, Snuggs M, et al. (2006) Processing and presentation of a mycobacterial antigen 85B epitope by murine macrophages is dependent on the phagosomal acquisition of vacuolar proton ATPase and in situ activation of cathepsin D. J Immunol 177: 3250-3259.
16. Phan UT, Arunachalam B, Cresswell P, (2000) Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action. J Biol Chem 275: 25907-25914.
17. Bennett K, Levine T, Ellis JS, Peanasky RJ, Kay J, et al. (1992) Antigen processing for presentation by class II MHC requires cleavage by cathepsin E. Eur J Immunol 22: 1519-1524.
18. Raiber EA, Tulone C, Zhang Y, Martinez-Pomares L, Steed E, et al. (2010) Targeted delivery of antigen processing inhibitors to antigen presenting cells via mannose receptors. ACS Chem Biol 5: 461-476.
19. Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi Y, et al. (2002) Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia. J Biol Chem 277: 4816-4822.
20. Yanagawa M, Tsukuba T, Nishioku T, Okamoto Y, Okamoto K, et al. (2007) Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages. J Biol Chem 282: 1851-1862.
21. Meding SJ, Langhorne J, (1991) CD4+ T cells and B cells are necessary for the transfer of protective immunity to Plasmodium chabaudi chabaudi. Eur J Immunol 21: 1433-1438.
22. Preiser PR, Jarra W, Capiod T, Snounou G, (1999) A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malaria. Nature 398: 618-622.
23. Moore MJ, Hay FC, Wood J, Brown KN, (1991) In vivo effects of anti-idiotype on Plasmodium chabaudi infection in mice. Immunology 74: 31-36.
24. Rasband W, (2007) Image J.