Haematopoietic development and immunological function in the absence of cathepsin D

BMC Immunology

Volumn 8, Issue , 2007, Pages

  Tulone, Calogero ^a   Uchiyama, Yasuo ^b   Novelli, Marco ^c   Grosvenor, Nicholas ^a   Saftig, Paul ^d   Chain, Benjamin M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BOVINE IMMUNOGLOBULIN; CATHEPSIN D; LIPOFUSCIN; LYSOSOME ENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE; BAGG ALBINO MOUSE; BONE MARROW EXAMINATION; CELL COMPARTMENTALIZATION; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME RECONSTITUTION; ENZYME REGULATION; HEMATOPOIETIC CELL; IMMUNE RESPONSE; IMMUNITY; INNATE IMMUNITY; LYSOSOME STORAGE DISEASE; MOUSE; NONHUMAN; SHEEP ERYTHROCYTE; SPLEEN CELL; ANIMAL; BONE MARROW TRANSPLANTATION; CELL INCLUSION; CONFOCAL MICROSCOPY; CYTOLOGY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HEMATOPOIESIS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYSOSOME; METABOLISM; RADIATION CHIMERA; SPLEEN; T LYMPHOCYTE; THYMUS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BONE MARROW TRANSPLANTATION; CATHEPSIN D; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HEMATOPOIESIS; IMMUNITY, NATURAL; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; LYSOSOMES; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; RADIATION CHIMERA; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND;

EID: 35748958081     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-8-22     Document Type: Article

References (40)

1. Garcia M Platet N Liaudet E Laurent V Derocq D Brouillet JP Rochefort H Biological and clinical significance of cathepsin D in breast cancer metastasis Stem Cells 1996, 14:642-650. 8948022
2. Beaujouin M Baghdiguian S Glondu-Lassis M Berchem G Liaudet-Coopman E Overexpression of both catalytically active and - inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity Oncogene 2006, 25:1967-1973. 10.1038/sj.onc.1209221 16331270
3. Saftig P Hetman M Weber K Heine L Mossmann H Koster A Hess B Evers M von Figura K Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells EMBO J 1995, 14:3599-3608. 394433 7641679
4. Koike M Nakanishi H Saftig P Ezaki J Isahara K Ohsawa Y Schulz-Schaeffer W Watanabe T Waguri S Kametaka S Shibata M Yamamoto K Kominami E Peters C von Figura K Uchiyama Y Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons J Neurosci 2000, 20:6898-6906. 10995834
5. Nakanishi H Zhang J Koike M Nishioku T Okamoto Y Kominami E von Figura K Peters C Yamamoto K Saftig P Uchiyama Y Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice J Neurosci 2001, 21:7526-7533. 11567042
6. Myllykangas L Tyynela J Page-McCaw A Rubin GM Haltia MJ Feany MB Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses Neurobiol Dis 2005, 19:194-199. 10.1016/ j.nbd.2004.12.019 15837574
7. Tyynela J Sohar I Sleat DE Gin RM Donnelly RJ Baumann M Haltia M Lobel P A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration EMBO J 2000, 19:2786-2792. 203370 10856224 10.1093/emboj/19.12.2786
8. Awano T Katz ML O'Brien DP Taylor JF Evans J Khan S Sohar I Lobel P Johnson GS A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis Mol Genet Metab 2006, 87:341-348. 10.1016/j.ymgme.2005.11.005 16386934
9. Steinfeld R Reinhardt K Schreiber K Hillebrand M Kraetzner R Bruck W Saftig P Gartner J Cathepsin D deficiency is associated with a human neurodegenerative disorder Am J Hum Genet 2006, 78:988-998. 1474096 16685649 10.1086/504159
10. Siintola E Partanen S Stromme P Haapanen A Haltia M Maehlen J Lehesjoki AE Tyynela J Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis Brain 2006, 129:1438-1445. 10.1093/brain/awl107 16670177
11. Braulke T Claussen M Saftig P Wendland M Neifer K Schmidt B Zapf J von Figura K Peters C Proteolysis of IGFBPs by cathepsin D in vitro and in cathepsin D-deficient mice Prog Growth Factor Res 1995, 6:265-271. 10.1016/0955-2235(95)00005-4 8817669
12. Rodriguez GM Diment S Role of cathepsin D in antigen presentation of ovalbumin J Immunol 1992, 149:2894-2898. 1328388
13. Deussing J Roth W Saftig P Peters C Ploegh HL Villadangos JA Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation Proc Natl Acad Sci USA 1998, 95:4516-4521. 22521 9539769 10.1073/pnas.95.8.4516
14. Chain BM Free P Medd P Swetman C Tabor AB Terrazzini N The expression and function of cathepsin e in dendritic cells J Immunol 2005, 174:1791-1800. 15699105
15. Moss CX Villadangos JA Watts C Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing Eur J Immunol 2005, 35:3442-3451. 10.1002/eji.200535320 16259009
16. Koike M Nakanishi H Saftig P Ezaki J Isahara K Ohsawa Y Schulz-Schaeffer W Watanabe T Waguri S Kametaka S Shibata M Yamamoto K Kominami E Peters C von Figura K Uchiyama Y Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons J Neurosci 2000, 20:6898-6906. 10995834
17. Koike M Nakanishi H Saftig P Ezaki J Isahara K Ohsawa Y Schulz-Schaeffer W Watanabe T Waguri S Kametaka S Shibata M Yamamoto K Kominami E Peters C von Figura K Uchiyama Y Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons J Neurosci 2000, 20:6898-6906. 10995834
18. Kabeya Y Mizushima N Ueno T Yamamoto A Kirisako T Noda T Kominami E Ohsumi Y Yoshimori T LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J 2000, 19:5720-5728. 305793 11060023 10.1093/emboj/19.21.5720
19. Koike M Nakanishi H Saftig P Ezaki J Isahara K Ohsawa Y Schulz-Schaeffer W Watanabe T Waguri S Kametaka S Shibata M Yamamoto K Kominami E Peters C von Figura K Uchiyama Y Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons J Neurosci 2000, 20:6898-6906. 10995834
20. Schestkowa O Geisel D Jacob R Hasilik A The catalytically inactive precursor of cathepsin D induces apoptosis in human fibroblasts and HeLa cells J Cell Biochem 2007. 17340625
21. Albee L Shi B Perlman H Aspartic protease and caspase 3/7 activation are central for macrophage apoptosis following infection with Escherichia coli J Leukoc Biol 2007, 81:229-237. 10.1189/jlb.0506358 17023557
22. Laurent-Matha V Maruani-Herrmann S Prebois C Beaujouin M Glondu M Noel A Alvarez-Gonzalez ML Blacher S Coopman P Baghdiguian S Gilles C Loncarek J Freiss G Vignon F Liaudet-Coopman E Catalytically inactive human cathepsin D triggers fibroblast invasive growth J Cell Biol 2005, 168:489-499. 10.1083/jcb.200403078 15668295
23. Koike M Nakanishi H Saftig P Ezaki J Isahara K Ohsawa Y Schulz-Schaeffer W Watanabe T Waguri S Kametaka S Shibata M Yamamoto K Kominami E Peters C von Figura K Uchiyama Y Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons J Neurosci 2000, 20:6898-6906. 10995834
24. Deussing J Roth W Saftig P Peters C Ploegh HL Villadangos JA Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation Proc Natl Acad Sci USA 1998, 95:4516-4521. 22521 9539769 10.1073/pnas.95.8.4516
25. Nishioku T Hashimoto K Yamashita K Liou SY Kagamiishi Y Maegawa H Katsube N Peters C von Figura K Saftig P Katunuma N Yamamoto K Nakanishi H Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia J Biol Chem 2002, 277:4816-4822. 10.1074/ jbc.M108382200 11719510
26. Albee L Shi B Perlman H Aspartic protease and caspase 3/7 activation are central for macrophage apoptosis following infection with Escherichia coli J Leukoc Biol 2007, 81:229-237. 10.1189/jlb.0506358 17023557
27. Deussing J Roth W Saftig P Peters C Ploegh HL Villadangos JA Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation Proc Natl Acad Sci USA 1998, 95:4516-4521. 22521 9539769 10.1073/pnas.95.8.4516
28. Moss CX Villadangos JA Watts C Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing Eur J Immunol 2005, 35:3442-3451. 10.1002/eji.200535320 16259009
29. Singh CR Moulton RA Armitige LY Bidani A Snuggs M Dhandayuthapani S Hunter RL Jagannath C Processing and presentation of a mycobacterial antigen 85B epitope by murine macrophages is dependent on the phagosomal acquisition of vacuolar proton ATPase and in situ activation of cathepsin D J Immunol 2006, 177:3250-3259. 16920965
30. Cerro-Vadillo E Madrazo-Toca F Carrasco-Marin E Fernandez-Prieto L Beck C Leyva-Cobian F Saftig P Alvarez-Dominguez C Cutting edge: A novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth J Immunol 2006, 176:1321-1325. 16424157
31. Shacka JJ Roth KA Cathepsin D Deficiency and NCL/Batten Disease: There's More to Death than Apoptosis Autophagy 2007, 3.
32. Koike M Shibata M Waguri S Yoshimura K Tanida I Kominami E Gotow T Peters C von Figura K Mizushima N Saftig P Uchiyama Y Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease) Am J Pathol 2005, 167:1713-1728. 1613187 16314482
33. Shacka JJ Klocke BJ Young C Shibata M Olney JW Uchiyama Y Saftig P Roth KA Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis J Neurosci 2007, 27:2081-2090. 10.1523/JNEUROSCI.5577-06.2007 17314303
34. Menendez-Benito V Neefjes J Autophagy in MHC class II presentation: sampling from within Immunity 2007, 26:1-3. 10.1016/j.immuni.2007.01.005 17241953
35. Moss CX Villadangos JA Watts C Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing Eur J Immunol 2005, 35:3442-3451. 10.1002/eji.200535320 16259009
36. Deussing J Roth W Saftig P Peters C Ploegh HL Villadangos JA Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation Proc Natl Acad Sci USA 1998, 95:4516-4521. 22521 9539769 10.1073/pnas.95.8.4516
37. Koike M Nakanishi H Saftig P Ezaki J Isahara K Ohsawa Y Schulz-Schaeffer W Watanabe T Waguri S Kametaka S Shibata M Yamamoto K Kominami E Peters C von Figura K Uchiyama Y Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons J Neurosci 2000, 20:6898-6906. 10995834
38. Image J http://rsb.info.nih.gov/ij
39. Mitchison NA The carrier effect in the secondary response to hapten-protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis Eur J Immunol 1971, 1:10-17. 10.1002/eji.1830010103 14978856
40. Chiang CL Ledermann JA Rad AN Katz DR Chain BM Hypochlorous acid enhances immunogenicity and uptake of allogeneic ovarian tumor cells by dendritic cells to cross-prime tumor-specific T cells Cancer Immunol Immunother 2006, 55:1384-1395. 10.1007/s00262-006-0127-9 16463039