Calcium imaging in gentamicin ototoxicity: Increased intracellular calcium relates to oxidative stress and late apoptosis

International Journal of Pediatric Otorhinolaryngology

Volumn 75, Issue 12, 2011, Pages 1616-1622

  Chang, Jiwon ^a   Yang, Ji Yun ^a   Choi, June ^a   Jung, Hak Hyun ^a   Im, Gi Jung ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Apoptosis; Calcium; Cochlea; Fura 2; Gentamicins; Meniere's disease; Reactive oxygen species

Indexed keywords

AMINOGLYCOSIDE; CALCIUM; CISPLATIN; GENTAMICIN; IONOMYCIN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL FUNCTION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG CYTOTOXICITY; DRUG INDUCED DISEASE; HUMAN; HUMAN CELL; OTOTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL;

APOPTOSIS; CALCIUM; CELL DEATH; CELL LINE; CELL SURVIVAL; COCHLEA; GENTAMICINS; HUMANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 80055045552     PISSN: 01655876     EISSN: 18728464     Source Type: Journal    
DOI: 10.1016/j.ijporl.2011.09.027     Document Type: Article

References (20)

1. Schuknecht H.F. Ablation therapy for the relief of meniere's disease. Laryngoscope 1956, 66:859-870.
2. Kaplan D.M., Nedzelski J.M., Chen J.M., Shipp D.B. Intratympanic gentamicin for the treatment of unilateral meniere's disease. Laryngoscope 2000, 110:1298-1305.
3. Cohen-Kerem R., Kisilevsky V., Einarson T.R., Kozer E., Koren G., Rutka J.A. Intratympanic gentamicin for meniere's disease: a meta-analysis. Laryngoscope 2004, 114:2085-2091.
4. Kaplan D.M., Nedzelski J.M., Al-Abidi A., Chen J.M., Shipp D.B. Hearing loss following intratympanic instillation of gentamicin for the treatment of unilateral meniere's disease. J. Otolaryngol. 2002, 31:106-111.
5. Carey J. Intratympanic gentamicin for the treatment of meniere's disease and other forms of peripheral vertigo. Otolaryngol. Clin. North Am. 2004, 37:1075-1090.
6. Quiros Y., Vicente-Vicente L., Morales A.I., Lopez-Novoa J.M., Lopez-Hernandez F.J. An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin. Toxicol. Sci. 2011, 119:245-256.
7. 2+ channels in the heart by reactive oxygen species: mechanism for mediating pathology. Clin. Exp. Pharmacol. Physiol. 2008, 35:229-234.
8. 2. Biomed. Environ. Sci. 2010, 23:371-377.
9. Cerella C., Diederich M., Ghibelli L. The dual role of calcium as messenger and stressor in cell damage, death, and survival. Int. J. Cell Biol. 2010, 2010:546163.
10. Schacht J. Mechanism for aminoglycoside ototoxicity: basic science research. Ototoxicity 2004, 93-100. BC Decker Inc, London. 1st ed. P.S. Roland, J.A. Rutka (Eds.).
11. Orrenius S., Nicotera P. The calcium ion and cell death. J. Neural Transm. Suppl. 1994, 43:1-11.
12. Farber J.L. The role of calcium in cell death. Life Sci. 1981, 29:1289-1295.
13. Orrenius S., McConkey D.J., Nicotera P. Role of calcium in toxic and programmed cell death. Adv. Exp. Med. Biol. 1991, 283:419-425.
14. Kalinec G.M., Webster P., Lim D.J., Kalinec F. A cochlear cell line as an in vitro system for drug ototoxicity screening. Audiol. Neurootol. 2003, 8:177-189.
15. Kim H.J., Oh G.S., Lee J.H., Lyu A.R., Ji H.M., Lee S.H., et al. Cisplatin ototoxicity involves cytokines and stat6 signaling network. Cell Res. 2011, 21:944-956.
16. Im G.J., Chang J.W., Choi J., Chae S.W., Ko E.J., Jung H.H. Protective effect of korean red ginseng extract on cisplatin ototoxicity in HEI-OC1 auditory cells. Phytother. Res. 2010, 24:614-621.
17. Banerjee A., Parnes L.S. The biology of intratympanic drug administration and pharmacodynamics of round window drug absorption. Otolaryngol. Clin. North Am. 2004, 37:1035-1051.
18. Hibi T., Suzuki T., Nakashima T. Perilymphatic concentration of gentamicin administered intratympanically in guinea pigs. Acta Otolaryngol. 2001, 121:336-341.
19. Hoffer M.E., Allen K., Kopke R.D., Weisskopf P., Gottshall K., Wester D. Transtympanic versus sustained-release administration of gentamicin: Kinetics, morphology, and function. Laryngoscope 2001, 111:1343-1357.
20. Plontke S.K., Mynatt R., Gill R.M., Borgmann S., Salt A.N. Concentration gradient along the scala tympani after local application of gentamicin to the round window membrane. Laryngoscope 2007, 117:1191-1198.