Oxidative damage in neurodegenerative diseases

Neuroscientist

Volumn 3, Issue 1, 1997, Pages 21-27

  Beal, M Flint ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's; Amyotrophic lateral sclerosis; Free radicals; Huntington's; Parkinson's; Peroxynitrite

Indexed keywords

EID: 0003163908     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385849700300112     Document Type: Review

References (65)

1. Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr 1993;57:715S-725S.
2. •: In vitro and in vivo. Free Radic Biol Med 1994;16:29-33.
3. Beckman JS, Carson M, Smith CD, Koppenol WH. ALS, SOD and peroxynitrite. Nature 1993;364:584.
4. Pou S, Pou WS, Bredt DS, et al. Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem 1992;267:24173-24176.
5. Kooy NW, Royall JA, Ischiropoulos H, et al. Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic Biol Med 1994;16:149-156.
6. Ischiropoulos H, Zhu L, Beckman J. Peroxynitrite formation from macrophage derived nitric oxide. Arch Biochem Biophys 1992; 298:446-451.
7. Ischiropoulos H, Zhu L, Chen J, et al. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 1992;298:431-437.
8. Cross AR, Jones OTG. Enzymic mechanisms of superoxide production. Biochim Biophys Acta 1991;1057:281-298.
9. Bovis A, Chance B. The mitochondrial generation of hydrogen peroxide. Biochem J 1973;134:707-716.
10. Imlay JA, Linn S. DNA damage and oxygen radical toxicity. Science 1988;240:1302-1309.
11. o State) restores growth of a manganese-superoxide dismutase-deficient Saccharomyces cerevisiae in hypoeroxia. J Biol Chem 1993;268:26699-26703.
12. De Jong AMP, Albracht SPJ. Ubisemiquinones as obligatory intermediates in the electron transfer from NADH to ubiquinone. Eur J Biochem 1994;222:975-982.
13. Cadenas E, Boveris A, Ragen CI, et al. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch Biochem Biophys 1977;180:248-257.
14. Loschen G, Azzi A, Richter C, et al. Superoxide radicals as precursors of mitochondrial hydrogen peroxide. FEBS Lett 1974;42: 68-72.
15. 2 in brain mitochondria. J Neurochem 1986;47:1-8.
16. Nohl H, Jordan W. The mitochondrial site of superoxide formation. Biochem Biophys Res Commun 1986;138:533-539.
17. Turrens JF, Boveris A. Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria. Biochem J 1980;191:421-427.
18. Zoccarato F, Cavallini L, Deana R, et al. Pathways of hydrogen peroxide generation in guinea pig cerebral cortex mitochondria. Biochem Biophys Res Commun 1988;154:727-734.
19. Takeshige K, Minakami S. NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation. Biochem J 1979;180:129-135.
20. Beal MF. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 1992;31:119-130.
21. +: implications for neurodegeneration. J Neurochem 1994;63:584-591.
22. Dugan LL, Sensi SL, Canzoniero LMT, et al. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J Neurosci 1995;15:6377-6388.
23. Bindokas VP, Jordan J, Lee CC, Miller RJ. Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci 1996;16:1324-1336.
24. Reynolds IJ, Hastings TG. Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J Neurosci 1995;15:3318-3327.
25. Patel M, Day BJ, Crapo JD, Fridovich I, McNamara JO. Requirement for superoxide in excitotoxic cell death. Neuron 1996;16: 345-355.
26. Hensley K, Hall N, Subramaniam R, et al. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J Neurochem 1995;65:2146-2156.
27. Mecocci P, MacGarvey U, Beal MF. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 1994;36:747-751.
28. Brown RH Jr. Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell 1995;80:687-692.
29. Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 1994;264:1772-1775.
30. Ripps ME, Huntley GW, Hof PR, Morrison JH, Gordon JW. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 1995;92:689-693.
31. Wong PC, Pardo CA, Borchelt DR, et al. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 1995;14:1105-1116.
32. Wiedau-Pazos M, Goto JJ, Rabizadeh S, et al. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science 1996;271:515-518.
33. Bowling AC, Schulz JB, Brown RH Jr, Beal MF. Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 1993;61:2322-2325.
34. Shaw PJ, Ince PG, Falkous G, Mantle D. Oxidative damage to protein in sporadic motor neuron disease spinal cord. Ann Neurol 1995;38:691-695.
35. Beal MF, Ferrante RJ, Matthews RT, Kowall NW, Brown RH. 3-Nitrotyrosine in ALS. Soc Neurosci Abstr 1996;22:1943.
36. Shinobu L, Ferrante RJ, Schulz JB, et al. Increased 3-nitrotyrosine and oxidative damage in mice with a human Cu,Zn superoxide dismutase mutation. Unpublished data.
37. 2 peptide. Proc Natl Acad Sci U S A 1996;93:3377-3382.
38. Collard J-F, Cote F, Julien J-P. Defective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 1995;375:61-64.
39. Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 1994;77:817-827.
40. Thomas T, Thomas G, McLendon C, Sutton T, Mullan M. β-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 1996;380:168-171.
41. Meda L, Cassatella MA, Szendrel GI, et al. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 1995;374: 647-650.
42. Multhaup G, Schlicksupp A, Hesse L, et al. The amyloid precursor protein of Alzheimer's disease in the reduction of copper (H) to copper (I). Science 1996;271:1406-1409.
43. Busciglio J, Yankner BA. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 1995;378:776-779.
44. Lakis J, Glasco S, Miller SW, ThaL LJ, Davis RE. Production of reactive oxygen species correlates with decreased cytochrome oxidase activity in Alzheimer's disease cybrids. Soc Neurosci Abstr 1995;21:979.
45. Furuta A, Price DL, Pardo CA, et al. Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. Am J Pathol 1995;146:357-367.
46. Pappolla MA, Omar RA, Kim KS, Robakis NK. Immunohistochemical evidence of antioxidant stress in Alzheimer's disease. Am J Pathol 1992;140:621-628.
47. Smith MA, Kutty RK, Richey PL, et al. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am J Pathol 1994;145:42-47.
48. Yan S-D, Chen X, Schmidt A-M, et al. Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc Natl Acad Sci U S A 1994;91:7787-7791.
49. Schipper HM, Cisse S, Stopa EG. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain. Ann Neurol 1995;37:758-768.
50. Premkumar DRD, Smith MA, Richey PL, et al. Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease. J Neurochem 1995;65:1399-1402.
51. Smith MA, Rudnicka-Nawrot M, Richey PL, et al. Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease. J Neurochem 1995;64:2660-2666.
52. Smith MA, Sayre LM, Anderson V, et al. In situ detection of oxidative modifications in Alzheimer's disease. Nature 1996;382: 120-121.
53. Penn AMVV, Roberts T, Hodder J, Allen PS, Zhu G, Martin WRW. Generalized mitochondrial dysfunction in Parkinson's disease detected by magnetic resonance spectroscopy of muscle. Neurology 1995;45:2097-2099.
54. Sanchez-Ramos JR, Overvik E, Ames BN. A marker of oxyradical-mediated DNA damage (8-hydroxy-2′deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain. Neurodegeneration 1994;3:197-204.
55. Dexter DT, Sian J, Rose S, et al. Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Ann Neurol 1994;35:38-44.
56. Yoritaka A, Hattori N, Uchida K, Tanaka M, Stadtman ER, Mizuno Y. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson's disease. Proc Natl Acad Sci U S A 1996;93:2696-2701.
57. Przedborski S, Kostic V, Jackson-Lewis V, et al. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. J Neurosci 1992;12:1658-1667.
58. Schulz JB, Matthews RT, Muqit MMK, Browne SE, Beal MF. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J Neurochem 1995;64:936-939.
59. Przedborski S, Jackon-Lewis V, Yokoyama R, Shibata T, Dawson VL, Dawson TM. Role of nitric oxide in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci U S A 1996;93:4565-4571.
60. Hantraye P, Brouillet E, Ferrante R, et al. Inhibition of neuronal nitric oxide synthase prevents MPTP induced Parkinsonism in baboons. Nature Medicine 1996;2:1017-1021.
61. Burke JR, Enghild JJ, Martin ME, et al. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nat Med 1996;2:347-350.
62. Browne SE, Bowling AC, MacGarvey U, Beal MF. Oxidative DNA damage and impaired mitochondrial metabolism in Huntington's disease. Soc Neurosci Abstr 1995;21:489.
63. Brouillet E, Hantraye P, Ferrante RJ, et al. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates. Proc Natl Acad Sci USA 1995;92:7105-7109.
64. Beal MF, Ferrante RJ, Henshaw R, et al. 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice. J Neurochem 1995;65:919-922.
65. Gurney ME, Cutting FB, Zhai P, et al. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol 1996;39:147-157.