DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus

International Archives of Allergy and Immunology

Volumn 157, Issue 3, 2012, Pages 259-268

  Stebbins, Karin J ^a   Broadhead, Alexander R ^a   Musiyenko, Alla ^b   Barik, Sailen ^b   Scott, Jill M ^a   Truong, Yen P ^a   Stearns, Brian A ^a   Hutchinson, John H ^a   Prasit, Peppi ^a   Evans, Jilly F ^a   Lorrain, Daniel S ^a  

^a Amira Pharmaceuticals   (United States)

^b UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

Allergic conjunctivitis; Allergy; CRTh2; DP2; Eye; Prostaglandin D 2; Respiratory syncytial virus

Indexed keywords

AM 156; ANTIALLERGIC AGENT; ANTIHISTAMINIC AGENT; CHEMOATTRACTANT; DECONGESTIVE AGENT; EOSINOPHIL PEROXIDASE; EVANS BLUE; INTERLEUKIN 4; MEPYRAMINE; NAPHAZOLINE PLUS PHENIRAMINE MALEATE; OPCON A; OVALBUMIN; PREDNISOLONE ACETATE; PROSTAGLANDIN D2; PROTEIN CRTH2; RAGWEED ANTIGEN; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC CONJUNCTIVITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOPHIL; CONJUNCTIVAL HYPEREMIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; EOSINOPHIL; EXPERIMENTAL GUINEA PIG; EYE DISCHARGE; EYE INFLAMMATION; FEMALE; MALE; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL VIRUS INFECTION; TH2 CELL;

ADMINISTRATION, TOPICAL; ALLERGENS; AMBROSIA; ANIMALS; ANTI-ALLERGIC AGENTS; BENZYLAMINES; CONJUNCTIVITIS, ALLERGIC; CONJUNCTIVITIS, VIRAL; DISEASE MODELS, ANIMAL; FEMALE; GUINEA PIGS; INTERLEUKIN-4; MALE; MICE; MICE, INBRED BALB C; OVALBUMIN; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS;

EID: 80055024285     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000328769     Document Type: Article

References (49)

1. Gershwin LJ, Dungworth DL, Himes SR, Friebertshauser KE: Immunoglobulin E responses and lung pathology resulting from aerosol exposure of calves to respiratory syncytial virus and Micropolyspora faeni Int Arch Allergy Appl Immunol 1990; 92: 293-300.
2. Boelen A, Andeweg A, Kwakkel J, Lokhorst W, Bestebroer T, Dormans J, Kimman T: Both immunisation with a formalin-inactivated respiratory syncytial virus (RSV) vaccine and a mock antigen vaccine induce severe lung pathology and a Th2 cytokine profile in RSV-challenged mice. Vaccine 2000; 19: 982-991.
3. Varga SM, Wang X, Welsh RM, Braciale TJ: Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen-specific CD4(+) T cells. Immunity 2001; 15: 637-646. (Pubitemid 33016448)
4. Fujishima H: Respiratory syncytial virus may be a pathogen in allergic conjunctivitis. Cornea 2002; 21:S39-S45. (Pubitemid 34188776)
5. Fujishima H, Okamoto Y, Saito I, Tsubota K: Respiratory syncytial virus and allergic conjunctivitis. J Allergy Clin Immunol 1995; 95: 663-667.
6. Tanaka K, Ogawa K, Sugamura K, Nakamura M, Takano S, Nagata K: Cutting edge: Differential production of prostaglandin D2 by human helper T cell subsets. J Immunol 2000; 164: 2277-2280. (Pubitemid 30115452)
7. Urade Y, Ujihara M, Horiguchi Y, Igarashi M, Nagata A, Ikai K, Hayaishi O: Mast cells contain spleen-type prostaglandin D synthetase. J Biol Chem 1990; 265: 371-375.
8. Urade Y, Ujihara M, Horiguchi Y, Ikai K, Hayaishi O: The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues. J Immunol 1989; 143: 2982-2989. (Pubitemid 19281848)
9. Gosset P, Bureau F, Angeli V, Pichavant M, Faveeuw C, Tonnel AB, Trottein F: Prostaglandin D2 affects the maturation of human monocyte-derived dendritic cells: Consequence on the polarization of naive Th cells. J Immunol 2003; 170: 4943-4952. (Pubitemid 36554723)
10. Shirasaki H, Kikuchi M, Kanaizumi E, Himi T: Accumulation of CRTh2-positive leukocytes in human allergic nasal mucosa. Ann Allergy Asthma Immunol 2009; 102: 110-115.
11. Uller L, Ribbene A, Sammut D, Howarth P, Holgate S, Davies D: Up-regulation of epithelial and fibroblast prostaglanding D2 CRTh2-receptors in asthma. World Allergy Organ J 2007:S8. DOI: 10.1097/1001.WOX.0 000301068.0000324143.0000301093.
12. Nakajima T, Asano Y, Shiraishi Y, Niimi K, Wakaki M, Suzuki Y, Shiomi T, Oguma T, Ishizaka A: Expression of pgd2 receptor CRTh2 (DP2) on human lung fibroblasts. J Allergy Clin Immunol 2005; 115:S141.
13. Chiba T, Kanda A, Ueki S, Ito W, Kamada Y, Oyamada H, Saito N, Kayaba H, Chihara J: Prostaglandin D2 induces IL-8 and GM-CSF by bronchial epithelial cells in a CRTh2-independent pathway. Int Arch Allergy Immunol 2006; 141: 300-307. (Pubitemid 44597750)
14. Sargent C, Stinson S, Schmidt J, Dougall I, Bonnert R, Paine S, Saunders M, Foster M: The effect of a selective CRTh2 antagonist on tobacco smoke (TS) induced airway inflammation and remodelling in the mouse. Proceedings of the British Pharmacological Society. 7th James Black Conference, London, 2009, vol 7, pA2 online.
15. Friedlaender MH: Conjunctival provocative tests: A model of human ocular allergy. Trans Am Ophthalmol Soc 1989; 87: 577-597. (Pubitemid 20128129)
16. Satake Y, Akagawa E, Igarashi A, Okada N, Takano Y, Fukagawa K, Tsubota K, Fujishima H: Prostaglandin J2 in tears of patients with severe allergic conjunctival diseases. Invest Ophthalmol Vis Sci 2004; 45: 4848.
17. Fujishima H, Igarashi A, Okada N, Takano Y, Tanaka M, Asano-Kato N, Miyake-Kashima M, Fukagawa K: Pgd2 concentration in tears of patients with severe allergic conjunctival diseases. Invest Ophthalmol Vis Sci 2003; 44: 3749.
18. Woodward DF, Nieves AL, Hawley SB, Joseph R, Merlino GF, Spada CS: The pruritogenic and inflammatory effects of prostanoids in the conjunctiva. J Ocul Pharmacol Ther 1995; 11: 339-347.
19. Stebbins K, Broadhead AR, Correa LD, Scott JM, Truong YP, Stearns BA, Hutchinson JH, Prasit P, Evans JF, Lorrain DS: Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation. Eur J Pharmacol 2010; 638: 142-149.
20. Stebbins KJ, Broadhead AR, Baccei CS, Scott JM, Truong YP, Coate H, Stock NS, Santini AM, Fagan P, Prodanovich P, Bain G, Stearns BA, King CD, Hutchinson JH, Prasit P, Evans JF, Lorrain DS: Pharmacological blockade of the DP2 receptor inhibits cigarette smokeinduced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung. J Pharmacol Exp Ther 2010; 332: 764-775.
21. Musiyenko A, Correa L, Stock N, Hutchinson JH, Lorrain DS, Bain G, Evans JF, Barik S: A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye. Clin Vaccine Immunol 2009; 16: 1654-1659.
22. Sanchis-Merino ME, Montero JA, Ruiz-Moreno JM, Rodriguez AE, Pastor S: Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis. Exp Eye Res 2008; 86: 791-797.
23. Izushi K, Nakahara H, Tai N, Mio M, Watanabe T, Kamei C: The role of histamine H(1) receptors in late-phase reaction of allergic conjunctivitis. Eur J Pharmacol 2002; 440: 79-82. (Pubitemid 34312041)
24. Strath M, Warren DJ, Sanderson CJ: Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors. J Immunol Methods 1985; 83: 209-215. (Pubitemid 16225442)
25. Duguet A, Iijima H, Eum SY, Hamid Q, Eidelman DH: Eosinophil peroxidase mediates protein nitration in allergic airway inflammation in mice. Am J Respir Crit Care Med 2001; 164: 1119-1126. (Pubitemid 33052237)
26. Miyazaki D, Liu G, Clark L, Ono SJ: Prevention of acute allergic conjunctivitis and latephase inflammation with immunostimulatory DNA sequences. Invest Ophthalmol Vis Sci 2000; 41: 3850-3855.
27. Magone MT, Chan CC, Beck L, Whitcup SM, Raz E: Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis. Eur J Immunol 2000; 30: 1841-1850. (Pubitemid 30456180)
28. Shiraishi Y, Asano K, Niimi K, Fukunaga K, Wakaki M, Kagyo J, Takihara T, Ueda S, Nakajima T, Oguma T, Suzuki Y, Shiomi T, Sayama K, Kagawa S, Ikeda E, Hirai H, Nagata K, Nakamura M, Miyasho T, Ishizaka A: Cyclooxygenase-2/ prostaglandin D2/ CRTh2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation. J Immunol 2008; 180: 541-549.
29. Nomiya R, Okano M, Fujiwara T, Maeda M, Kimura Y, Kino K, Yokoyama M, Hirai H, Nagata K, Hara T, Nishizaki K, Nakamura M: CRTh2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice. J Immunol 2008; 180: 5680-5688.
30. Uller L, Mathiesen JM, Alenmyr L, Korsgren M, Ulven T, Hogberg T, Andersson G, Persson CG, Kostenis E: Antagonism of the prostaglandin D2 receptor CRTh2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir Res 2007; 8: 16.
31. Ulven T, Receveur JM, Grimstrup M, Rist O, Frimurer TM, Gerlach LO, Mathiesen JM, Kostenis E, Uller L, Hogberg T: Novel selective orally active CRTh2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem 2006; 49: 6638-6641. (Pubitemid 44749728)
32. Lukacs NW, Berlin AA, Franz-Bacon K, Sasik R, Sprague LJ, Ly TW, Hardiman G, Boehme SA, Bacon KB: CRTh2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation. Am J Physiol Lung Cell Mol Physiol 2008; 295:L767-L779.
33. Minami K, Fujii Y, Kamei C: Participation of chemical mediators in the development of experimental allergic conjunctivitis in rats. Int Immunopharmacol 2004; 4: 1531-1535. (Pubitemid 39200601)
34. Minami K, Kamei C: A chronic model for evaluating the itching associated with allergic conjunctivitis in rats. Int Immunopharmacol 2004; 4: 101-108. (Pubitemid 38223819)
35. del Cuvillo A, Sastre J, Montoro J, Jauregui I, Davila I, Ferrer M, Bartra J, Mullol J, Valero A: Allergic conjunctivitis and H1 antihistamines. J Investig Allergol Clin Immunol 2009; 19(suppl 1):11-18.
36. Owen CG, Shah A, Henshaw K, Smeeth L, Sheikh A: Topical treatments for seasonal allergic conjunctivitis: Systematic review and meta-analysis of efficacy and effectiveness. Br J Gen Pract 2004; 54: 451-456. (Pubitemid 38771894)
37. Soparkar CN, Wilhelmus KR, Koch DD, Wallace GW, Jones DB: Acute and chronic conjunctivitis due to over-the-counter ophthalmic decongestants. Arch Ophthalmol 1997; 115: 34-38.
38. Fukushima Y, Nabe T, Mizutani N, Nakata K, Kohno S: Multiple cedar pollen challenge diminishes involvement of histamine in allergic conjunctivitis of guinea pigs. Biol Pharm Bull 2003; 26: 1696-1700. (Pubitemid 39663528)
39. Xue L, Gyles SL, Wettey FR, Gazi L, Townsend E, Hunter MG, Pettipher R: Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. J Immunol 2005; 175: 6531-6536. (Pubitemid 41598895)
40. Royer JF, Schratl P, Lorenz S, Kostenis E, Ulven T, Schuligoi R, Peskar BA, Heinemann A: A novel antagonist of CRTh2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst. Allergy 2007; 62: 1401-1409. (Pubitemid 350045581)
41. Juntti H, Kokkonen J, Dunder T, Renko M, Niinimaki A, Uhari M: Association of an early respiratory syncytial virus infection and atopic allergy. Allergy 2003; 58: 878-884. (Pubitemid 37046686)
42. Mohapatra SS, Boyapalle S: Epidemiologic, experimental, and clinical links between respiratory syncytial virus infection and asthma. Clin Microbiol Rev 2008; 21: 495-504.
43. Sigurs N, Aljassim F, Kjellman B, Robinson PD, Sigurbergsson F, Bjarnason R, Gustafsson PM: Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax 2010; 65: 1045-1052.
44. Becker Y: Respiratory syncytial virus (RSV)-induced allergy may be controlled by IL-4 and CX3C fractalkine antagonists and CpG ODN as adjuvant: Hypothesis and implications for treatment. Virus Genes 2006; 33: 253-264. (Pubitemid 44401432)
45. Becker Y: Respiratory syncytial virus (RSV) evades the human adaptive immune system by skewing the Th1/Th2 cytokine balance toward increased levels of Th2 cytokines and IgE, markers of allergy -a review. Virus Genes 2006; 33: 235-252. (Pubitemid 44401431)
46. Siegle JS, Hansbro N, Herbert C, Rosenberg HF, Domachowske JB, Asquith KL, Foster PS, Kumar RK: Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice. Respir Res 2010; 11: 14.
47. Bardin PG, Johnston SL, Pattemore PK: Viruses as precipitants of asthma symptoms. II. Physiology and mechanisms. Clin Exp Allergy 1992; 22: 809-822.
48. Pattemore PK, Johnston SL, Bardin PG: Viruses as precipitants of asthma symptoms. I. Epidemiology. Clin Exp Allergy 1992; 22: 325-336.
49. Collins PL, Graham BS: Viral and host factors in human respiratory syncytial virus pathogenesis. J Virol 2008; 82: 2040-2055. (Pubitemid 351293507)