A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye

Clinical and Vaccine Immunology

Volumn 16, Issue 11, 2009, Pages 1654-1659

  Musiyenko, Alla ^a   Correa, Lucia ^b   Stock, Nicholas ^b   Hutchinson, John H ^b   Lorrain, Daniel S ^b   Bain, Gretchen ^b   Evans, Jilly F ^b   Barik, Sailen ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

^b Amira Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [5 (1 ACETYL 2,3 DIHYDRO 1H INDOL 2 YLMETHOXY) 3 TERT BUTYLSULFANYL 1 [4 (5 METHOXY PYRIMIDIN 2 YL) BENZYL] 1H INDOL 2 YL] 2,2 DIMETHYL PROPIONIC ACID; AM 679; ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; INTERLEUKIN 4; PEPTIDOLEUKOTRIENE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BAGG ALBINO MOUSE; CONJUNCTIVITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE MODEL; DRUG STRUCTURE; EXPERIMENTAL INFECTION; EYE INFLAMMATION; FEMALE; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; TH2 CELL; VIRUS INFECTION; VIRUS LOAD;

ANIMALS; CARRIER PROTEINS; ENZYME INHIBITORS; EYE; EYE DISEASES; FEMALE; IMMUNOLOGIC FACTORS; INFLAMMATION; INTERLEUKIN-4; LUNG; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; VIRAL LOAD;

EID: 70350736244     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00220-09     Document Type: Article

References (33)

1. Berger, W., M. T. De Chandt, and C. B. Cairns. 2007. Zileuton: clinical implications of 5-lipoxygenase inhibition in severe airway disease. Int. J. Clin. Pract. 61:663-676.
2. 4-like immunoreactivity in tear fluid from subjects challenged with specific allergen. Prostaglandins 27:369-374.
3. Bitko, V., A. Musiyenko, and S. Barik. 2007. Viral infection of the lungs through the eye. J. Virol. 81:783-790. (Pubitemid 46067904)
4. Bitko, V., A. Musiyenko, O. Shulyayeva, and S. Barik. 2005. Inhibition of respiratory viruses by nasally administered siRNA. Nat. Med. 11:50-55.
5. Bitko, V., N. E. Garmon, T. Cao, B. Estrada, J. E. Oakes, R. N. Lausch, and S. Barik. 2004. Activation of cytokines and NF-kappa B in corneal epithelial cells infected by respiratory syncytial virus: potential relevance in ocular inflammation and respiratory infection. BMC Microbiol. 4:28-38. (Pubitemid 39319736)
6. Cardenas, S. A., A. Auais, and G. Piedimonte. 2005. Palivizumab in the prophylaxis of respiratory syncytial virus infection. Expert Rev. Anti Infect. Ther. 3:719-726.
7. Ciana, P., M. Fumagalli, M. L. Trincavelli, C. Verderio, P. Rosa, D. Lecca, S. Ferrario, C. Parravicini, V. Capra, P. Gelosa, U. Guerrini, S. Belcredito, M. Cimino, L. Sironi, E. Tremoli, G. E. Rovati, C. Martini, and M. P. Abbracchio. 2006. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J. 25:4615-4627. (Pubitemid 44498134)
8. Collins, P. L., and B. S. Graham. 2008. Viral and host factors in human respiratory syncytial virus pathogenesis. J. Virol. 82:2040-2055. (Pubitemid 351293507)
9. Evans, J. F. 2003. The cysteinyl leukotriene receptors. Prostaglandins Leukot. Essent. Fatty Acids 69:117-122.
10. Evans, J. F., A. D. Ferguson, R. T. Moseley, and J. H. Hutchinson. 2008. What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. Trends Pharmacol. Sci. 29:72-78.
11. Everard, M. L. 2006. The relationship between respiratory syncytial virus infections and the development of wheezing and asthma in children. Curr. Opin. Allergy Clin. Immunol. 6:56-61.
12. Falsey, A. R., P. A. Hennessey, M. A. Formica, C. Cox, and E. E. Walsh. 2005. Respiratory syncytial virus infection in elderly and high-risk adults. N. Engl. J. Med. 352:1749-1759.
13. Forton, J. T., K. Rowlands, K. Rockett, N. Hanchard, M. Herbert, D. P. Kwiatkowski, and J. Hull. 2009. Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. Thorax 64:345-352.
14. Fujishima, H., I. Saito, Y. Okamnato, T. Takeuchi, and K. Tsubota. 1998. Respiratory syncytial virus-induced interleukin-4 production by human conjunctival epithelial cells contributes to allergy: preliminary study. Curr. Eye Res. 17:656-662.
15. Fullmer, J. J., A. M. Khan, O. Elidemir, C. Chiapetta, J. M. Stark, and G. N. Colasurdo. 2005. Role of cysteinyl leukotrienes in airway inflammation and responsiveness following RSV infection in BALB/c mice. Pediatr. Allergy Immunol. 16:593-601.
16. Gala, C. L., C. B. Hall, K. C. Schnabel, P. H. Pincus, P. Blossom, S. W. Hildreth, R. F. Betts, and R. G. Douglas, Jr. 1986. The use of eye-nose goggles to control nosocomial respiratory syncytial virus infection. JAMA 256:2706-2708.
17. Gary, R. K., D. F. Woodward, A. L. Nieves, L. S. Williams, J. G. Gleason, and M. A. Wasserman. 1988. Characterization of the conjunctival vasopermeability response to leukotrienes and their involvement in immediate hypersensitivity. Investig. Ophthalmol. Vis. Sci. 29:119-126.
18. Germain, R. N. 1993. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11:403-405.
19. Girgis, D. O., G. D. Sloop, J. M. Reed, and R. J. O'Callaghan. 2003. A new topical model of Staphylococcus corneal infection in the mouse. Investig. Ophthalmol. Vis. Sci. 44:1591-1597.
20. Gyllfors, P., S. E. Dahlen, M. Kumlin, K. Larsson, and B. Dahlen. 2006. Bronchial responsiveness to leukotriene D4 is resistant to inhaled fluticazone propionate. J. Allergy Clin. Immunol. 118:78-83.
21. Hutchinson, J. H., Y. Li, J. M. Arruda, C. Baccei, G. Bain, C. Chapman, L. Correa, J. Darlington, C. D. King, C. Lee, D. Lorrain, P. Prodanovich, H. Rong, A. Santini, N. Stock, P. Prasit, and J. F. Evans. 5-Lipoxygenase- activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6- methoxy-pyridin-3-yl)-benzyl]-5-(pyrindin-2-ylmethoxy)-1H-indol-2-yl]-2, 2-dimethylpropionic acid (AM103). J. Med. Chem., in press.
22. Irkec, M. T., M. Orhan, and U. Erdener. 1999. Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. Ocul. Immunol. Inflamm. 7:35-38.
23. Jones, T. R., and I. W. Rodger. 1999. Role of leukotrienes and leukotriene receptor antagonists in asthma. Pulm. Pharmacol. Ther. 12:107-110.
24. Krauss, H.-P., and D. F. Woodward. 1993. Polymorphonuclear leukocyte infiltration into the subretinal choroid and optic nerve in response to leukotrienes. Investig. Ophthalmol. Vis. Sci. 34:3679-3686.
25. Maekawa, A., Y. Kanaoka, X. Xing, and K. F. Austen. 2008. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl 1 and 2 receptors. Proc. Natl. Acad. Sci. USA 105:16695-16700.
26. Matsuse, H., H. Hirose, T. Tsuchida, S. Fukahori, C. Fukushima, Y. Mizuta, and S. Kohno. 2007. Effects of respiratory syncytial virus infection on dendritic cells and cysteinyl leukotrienes in lung tissues of a murine model of asthma. Allergol. Int. 56:165-169.
27. Murawski, M. R., G. N. Bowen, A. M. Cerny, L. J. Anderson, L. M. Haynes, R. A. Tripp, E. A. Kurt-Jones, and R. W. Finberg. 2009. Respiratory syncytial virus activates innate immunity through Toll-like receptor 2. J. Virol. 83:1492-1500.
28. Nonaka, Y., T. Hiramoto, and N. Fujita. 2005. Identification of endogenous surrogate ligands for human P2Y12 receptors by in silico and in vitro methods. Biochem. Biophys. Res. Commun. 337:281-288.
29. Patel, H., R. Platt, J. M. Lozano, and E. E. Wang. 2004. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst. Rev. 3:CD004878.
30. Penrose, J. F., J. Spector, M. Baldasaro, K. Xu, J. Boyce, J. P. Arm, K. F. Austen, and B. K. Lam. 1996. Cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence and chromosomal localization to 5q35. J. Biol. Chem. 271:11356-11361.
31. Piedimonte, G., G. Renzetti, A. Auais, A. Di Marco, S. Tripodi, F. Colistro, A. Villani, V. Di Ciommo, and R. Cutrera. 2005. Leukotriene synthesis during respiratory syncytial virus bronchiolitis: influence of age and atopy. Pediatr. Pulmonol. 40:285-291.
32. Urnowey, S., T. Ansai, V. Bitko, K. Nakayama, T. Takehara, and S. Barik. 2006. Temporal activation of anti- and pro-apoptotic factors in human gingival fibroblasts infected with the periodontal pathogen, Porphyromonas gingivalis: a potential role of bacterial proteases in host signaling. BMC Microbiol. 6:26.
33. Young, R. N. 1999. Inhibitors of 5-lipoxygenase: a therapeutic potential yet to be fully realized? Eur. J. Chem. 34:671-685.