Neuroprotection by freezing ischemic penumbra evolution without cerebral blood flow augmentation with a postsynaptic density-95 protein inhibitor

Stroke

Volumn 42, Issue 11, 2011, Pages 3265-3270

  Bråtane, Bernt T ^a   Cui, Hong ^b   Cook, Douglas J ^b   Bouley, James ^a   Tymianski, Michael ^b   Fisher, Marc ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

cerebral ischemia; DWI; mismatch; MR imaging; penumbra; PWI; stroke; Tat NR2B9c

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; NEUROPROTECTIVE AGENT; OXYGEN; PLACEBO; POSTSYNAPTIC DENSITY PROTEIN 95; TAT NR2B9; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN TISSUE; CELL VIABILITY; CONTROLLED STUDY; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; RAT; SPIN LABELING; STAINING;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CELLS, CULTURED; CEREBROVASCULAR CIRCULATION; FREEZING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MICE; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDES; RATS; RATS, WISTAR;

EID: 80055023987     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.618801     Document Type: Article

References (30)

1. O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. 1026 experimental treatments in acute stroke. Ann Neurol. 2006;59:467-477. (Pubitemid 43358067)
2. Molina CA, Saver JL. Extending reperfusion therapy for acute ischemic stroke: emerging pharmacological, mechanical, and imaging strategies. Stroke. 2005;36:2311-2320. (Pubitemid 41429268)
3. Juttler E, Kohrmann M, Schellinger PD. Therapy for early reperfusion after stroke. Nat Clin Pract Cardiovasc Med. 2006;3:656-663. (Pubitemid 44811525)
4. Omae T, Hasegawa Y, Ogata J, Tamaki K, Minematsu K, Yamaguchi T. The competitive NMDA antagonist, CGS-19755, improves postischemic hypoperfusion in selectively vulnerable regions in gerbils. J Neurol Sci. 1996;138:105-113. (Pubitemid 26194282)
5. Takizawa S, Hogan M, Hakim AM. The effects of a competitive NMDA receptor antagonist (CGS-19755) on cerebral blood flow and pH in focal ischemia. J Cereb Blood Flow Metab. 1991;11:786-793.
6. Del Zoppo GJ. Why do all drugs work in animals but none in stroke patients? 1. Drugs promoting cerebral blood flow. J Intern Med. 1995; 237:79-88.
7. Sun HS, Doucette TA, Liu Y, Fang Y, Teves L, Aarts M, et al. Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat. Stroke. 2008;39:2544-2553.
8. Sattler R, Xiong Z, Lu WY, Hafner M, MacDonald JF, Tymianski M. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science. 1999;284:1845-1848.
9. Aarts M, Liu Y, Liu L, Besshoh S, Arundine M, Gurd JW, et al. Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science. 2002;298:846-850. (Pubitemid 35231541)
10. Neumann-Haefelin T, Wittsack HJ, Wenserski F, Siebler M, Seitz RJ, Modder U, et al. Diffusion- and perfusion-weighted MRI. The DWI/PWI mismatch region in acute stroke. Stroke. 1999;30:1591-1597. (Pubitemid 29379608)
11. Henninger N, Fisher M. Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke. 2007;38:2779-2786. (Pubitemid 47494018)
12. Menzies SA, Hoff JT, Betz AL. Middle cerebral artery occlusion in rats: A neurological and pathological evaluation of a reproducible model. Neurosurgery. 1992;31:100 -106, discussion 106-107.
13. Meng X, Fisher M, Shen Q, Sotak CH, Duong TQ. Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia. Ann Neurol. 2004;55:207-212. (Pubitemid 38166997)
14. Li F, Irie K, Anwer MS, Fisher M. Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model. J Cereb Blood Flow Metab. 1997;17:1132-1135. (Pubitemid 27459342)
15. Schmidt KF, Ziu M, Schmidt NO, Vaghasia P, Cargioli TG, Doshi S, et al. Volume reconstruction techniques improve the correlation between histological and in vivo tumor volume measurements in mouse models of human gliomas. J Neurooncol. 2004;68:207-215. (Pubitemid 38878254)
16. Sattler R, Charlton MP, Hafner M, Tymianski M. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity. J Neurochem. 1998;71:2349-2364. (Pubitemid 28531245)
17. Tymianski M, Sattler R, Zabramski JM, Spetzler RF. Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity. J Cereb Blood Flow Metab. 1998; 18:848-867. (Pubitemid 28359903)
18. Sattler R, Charlton MP, Hafner M, Tymianski M. Determination of the time course and extent of neurotoxicity at defined temperatures in cultured neurons using a modified multiwell plate fluorescence scanner. J Cereb Blood Flow Metab. 1997;17:455-463. (Pubitemid 27188542)
19. Goldberg MP, Choi DW. Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J Neurosci. 1993;13:3510-3524. (Pubitemid 23241187)
20. Auer RN, Siesjo BK. Biological differences between ischemia, hypoglycemia, and epilepsy. Ann Neurol. 1988;24:699-707. (Pubitemid 19019022)
21. Arai H, Passonneau JV, Lust WD. Energy metabolism in delayed neuronal death of CA1 neurons of the hippocampus following transient ischemia in the gerbil. Metab Brain Dis. 1986;1:263-278.
22. Busza AL, Allen KL, King MD, van Bruggen N, Williams SR, Gadian DG. Diffusion-weighted imaging studies of cerebral ischemia in gerbils. Potential relevance to energy failure. Stroke. 1992;23:1602-1612.
23. Hossmann KA, Fischer M, Bockhorst K, Hoehn-Berlage M. NMR imaging of the apparent diffusion coefficient (ADC) for the evaluation of metabolic suppression and recovery after prolonged cerebral ischemia. J Cereb Blood Flow Metab. 1994;14:723-731. (Pubitemid 24266524)
24. Li F, Han SS, Tatlisumak T, Liu KF, Garcia JH, Sotak CH, et al. Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats. Ann Neurol. 1999;46:333-342. (Pubitemid 29416271)
25. Liu KF, Li F, Tatlisumak T, Garcia JH, Sotak CH, Fisher M, et al. Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia. Stroke. 2001;32:1897-1905. (Pubitemid 32772227)
26. Moncada S, Erusalimsky JD. Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol. 2002;3: 214-220.
27. Brown GC, Borutaite V. Nitric oxide inhibition of mitochondrial respiration and its role in cell death. Free Radic Biol Med. 2002;33: 1440-1450. (Pubitemid 35351587)
28. Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, et al. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell. 1996;84:757-767. (Pubitemid 26094205)
29. Niessen F, Hilger T, Hoehn M, Hossmann KA. Thrombolytic treatment of clot embolism in rat: comparison of intra-arterial and intravenous application of recombinant tissue plasminogen activator thrombolytic treatment of clot embolism in rat: comparison of intra-arterial. Stroke. 2002;33:2999-3005. (Pubitemid 35462878)
30. Fisher M. New approaches to neuroprotective drug development. Stroke. 2011;42:S24-S27.