Reversing age-related decline in working memory

Rejuvenation Research

Volumn 14, Issue 5, 2011, Pages 557-559

  Mendelsohn, Andrew R ^a   Larrick, James W ^a  

^a Panorama Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; GUANFACINE; POTASSIUM CHANNEL;

AGING; AMNESIA; BRAIN NERVE CELL; CHEMICAL ANALYSIS; CONFERENCE PAPER; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC POTENTIAL; WORKING MEMORY;

AGING; ANIMALS; BRAIN; HUMANS; MEMORY DISORDERS; MEMORY, SHORT-TERM; NEURONS;

MACACA MULATTA;

EID: 80055015499     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2011.1247     Document Type: Conference Paper

References (12)

1. Moore TL, Killiany RJ, Herndon JG, Rosene DL, Moss MB. Executive system dysfunction occurs as early as middleage in the rhesus monkey. Neurobiol Aging 2006;27: 1484-1493. (Pubitemid 44279888)
2. Moore TL, Schettler SP, Killiany RJ, Herndon JG, Luebke JI, Moss MB, Rosene DL. Cognitive impairment in aged rhesus monkeys associated with monoamine receptors in the prefrontal cortex. Behav Brain Res 2005;160:208-221. (Pubitemid 40603518)
3. Hara Y, Rapp PR, Morrison JH. Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age (Dordr) 2011; Jun 28. [Epub ahead of print, PMID:21710198]
4. Wang M, Gamo NJ, Yang Y, Jin LE, Wang X-J, Laubach M, Mazer JA, Lee D, Arnsten AFT. Neuronal basis of agerelated working memory decline. Nature 2011;476:210-213.
5. Downs JL, Dunn MR, Borok E, Shanabrough M, Horvath TL, Kohama SG, Urbanski HF. Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque. Neurobiol Aging 2007;28:1286-1295. (Pubitemid 46810055)
6. Ramos BP, Stark D, Verduzco L, van Dyck CH, Arnsten AFT. Alpha2a-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of camp signaling in aging animals. Learn Mem 2006;13:770-776. (Pubitemid 44871678)
7. Ramos BP, Birnbaum SG, Lindenmayer I, Newton SS, Duman RS, Arnsten AFT. Dysregulation of protein kinase a signaling in the aged prefrontal cortex: New strategy for treating agerelated cognitive decline. Neuron 2003;40:835-845. (Pubitemid 37431042)
8. Baxter MG. Age-related memory impairment. Is the cure worse than the disease? Neuron 2003;40:669-670. (Pubitemid 37431028)
9. Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory. Proc Natl Acad Sci USA 1998;95:15020-15025. (Pubitemid 29003749)
10. Bach ME, Barad M, Son H, Zhuo M, Lu Y-F, Shih R, Mansuy I, Hawkins RD, Kandel ER. Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc Natl Acad Sci USA 1999;96:5280-5285. (Pubitemid 29214574)
11. Jakala P, Riekkinen M, SirviÜ J, Koivisto E, Kejonen K, Vanhanen M, Riekkinen P Jr. Guanfacine, but not clonidine, improves planning and working memory performance in humans. Neuropsychopharmacology 1999;20:460-470. (Pubitemid 29123873)
12. Muller U, Clark L, Lam ML, Moore RM, Murphy CL, Richmond NK, Sandhu RS, Wilkins IA, Menon DK, Sahakian BJ, Robbins TW. Lack of effects of guanfacine on executive and memory functions in healthy male volunteers. Psychopharmacology (Berl) 2005;182:205-213. (Pubitemid 41464613)