α-Tocopherol attenuates NF-κB activation and pro-inflammatory cytokine IL-6 secretion in cancer-bearing mice

Bioscience Reports

Volumn 31, Issue 5, 2011, Pages 421-428

  Sharma, Renu ^a   Vinayak, Manjula ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

tocopherol; Cancer; Interleukin 6 (IL 6); Nuclear factor B (NF B); Pro inflammatory cytokine

Indexed keywords

ALPHA TOCOPHEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; ANTINEOPLASTIC AGENT; PROTEIN BINDING;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CANCER PREVENTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; DRUG EFFECT; DRUG TARGETING; LIPID PEROXIDATION; LIVER PARENCHYMA; LYMPHOMA; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TREATMENT DURATION; AKR MOUSE; ANIMAL; BLOOD; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIVER; LIVER CELL; LYMPHOMA, T-CELL; METABOLISM; PATHOLOGY; PROMOTER REGION; SECRETION (PROCESS); TRANSCRIPTION INITIATION;

MUS;

ALPHA-TOCOPHEROL; ANIMALS; ANTINEOPLASTIC AGENTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTES; HUMANS; INTERLEUKIN-6; LIPID PEROXIDATION; LIVER; LYMPHOMA, T-CELL; MALE; MICE, INBRED AKR; NF-KAPPA B; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; TRANSCRIPTIONAL ACTIVATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80055014489     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSR20100137     Document Type: Article

References (28)

1. Danese, S. and Mantovani, A. (2010) Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. Oncogene 29, 3313-3323
2. Coussens, M. and Werb, Z. (2002) Inflammation and cancer. Nature 420, 860-867
3. Hussain, S. P. and Harris, C. C. (2007) Inflammation and cancer: an ancient link with novel potentials. Int. J. Cancer 121, 2373-2380 (Pubitemid 350022405)
4. McLoughlin, R. M., Jenkins, B. J., Grail, D., Williams, A. S., Fielding, C. A., Parker, C. A., Ernst, M., Topley, N. and Jone, S. A. (2005) IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proc. Natl. Acad. Sci. U.S.A. 102, 9589-9594 (Pubitemid 40981725)
5. Greten, F. R. and Karin, M. (2004) The IKK/NF-κB activation pathway - a target for prevention and treatment of cancer. Cancer Lett. 206, 193-199 (Pubitemid 38317289)
6. Kumar, A., Takada, Y., Boriek, A. M. and Aggarwal, B. B. (2004) Nuclear factor-κB: its role in health and disease. J. Mol. Med. 82, 434-448 (Pubitemid 39044283)
7. Pathak, C., Jaiswal, Y. K. and Vinayak, M. (2008) Queuine mediated inhibition in phosphorylation of tyrosine phosphoproteins in cancer. Mol. Biol. Rep. 35, 369-374
8. Soo, C. C. Y., Haqqani, A. S., Hidiroglou, N., Swanson, J. E., Parker, R. S. and Birnboim, H. C. (2004) Dose-dependent effects of dietary α- and γ-tocopherols on genetic instability in mouse mutatect tumors. J. Natl. Cancer Inst. 96, 796-800 (Pubitemid 38771825)
9. Ohkawa, H., Ohishi, N. and Yagi, K. (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358 (Pubitemid 9194347)
10. Dignam, J. D., Lebovitz, R. M. and Roeder, R. D. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489
11. Bradford, M. M. (1977) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254
12. Liu, S. F., Ye, X. and Malik, A. B. (1999) Inhibition of NF-κB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes. Circulation 12, 1330-1337 (Pubitemid 29440127)
13. Buettner, G. R. (1993) The packing order of free radicals and antioxidants: lipid peroxidation, α-tocopherol, and ascorbate. Arch. Biochem. Biophy. 300, 535-543
14. Azzi, A. and Stocker, A. (2000) Vitamin E: non-antioxidant roles. Prog. Lipid Res. 39, 231-255 (Pubitemid 30224705)
15. Dokter, W. H., Koopmans, S. B. and Vellenga, E. (1996) Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1, NF-IL6 and NF-κB) which are involved in IL-6 regulation. Leukemia 10, 1308-1316 (Pubitemid 26261427)
16. Heinrich, P. C., Behrmann, I., Haan, S., Hermann, H. M., Müller-Newen, G. and Schaper, F. (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 15, 1-20 (Pubitemid 37046923)
17. Verma, N. and Vinayak, M. (2008) Antioxidant action of andrographis paniculata on lymphoma. Mol. Biol. Rep. 35, 535-540
18. Verma, N. and Vinayak, M. (2009) Effect of Terminalia arjuna on antioxidant defense system in cancer. Mol. Biol. Rep. 36, 159-164
19. Pathak, C., Jaiswal, Y. K. and Vinayak, M. (2008) Queuine promotes antioxidant defence system by activating cellular antioxidant enzyme activities in cancer. Biosci. Rep. 28, 73-78
20. Verma, N. and Vinayak, M. (2009) Semicarpus anacardium promotes antioxidant defense system and inhibits anaerobic metabolism during development of lymphoma. Biosci. Rep. 29, 151-164
21. Vasavi, H., Thangaraju, M. and Sachdanandam, R. (1994) Effect of α-tocopherol on lipid peroxidation and antioxidant system in fibrosarcoma bearing Rats. Mol. Cell. Biochem. 131, 125-129
22. Gitanjali, G., Ghalaut, V., Rakshak, M. and Hooda, H. S. (1999) Correlation of lipid peroxidation and α-tocopherol supplementation in patients with cervical carcinoma receiving radical radiotherapy. Gynecol. Obstet. Invest. 48, 197-199 (Pubitemid 29488325)
23. Godbout, J. P., Berg, B. M., Kelley, K. W. and Johnson, R. W. (2004) α-Tocopherol reduces lipopolysaccharide-induced peroxide radical formation and interleukin-6 secretion in primary murine microglia and in brain. J. Neuroimmunol. 149, 101-109 (Pubitemid 38352863)
24. Schumacker, P. T. (2006) Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer cell 3, 175-176
25. Pelicano, H., Carney, D. and Huanga, P. (2004) ROS stress in cancer cells and therapeutic implications. Drug Resistance Updates 7, 97-110 (Pubitemid 38736063)
26. Libermann, T. A. and Baltimore, D. (1990) Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell. Biol. 10, 2327-2334
27. Delhase, M., Li, N. and Karin, M. (2000) Signalling pathways: kinase regulation in inflammatory response. Nature 406, 367-368 (Pubitemid 30625546)
28. Egger, T., Schuligoi, R., Wintersperger, A., Amann, R., Malle, E. and Sattler, W. (2003) Vitamin E (α-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia. Biochem. J. 370, 459-467 (Pubitemid 36315134)