메뉴 건너뛰기




Volumn 109, Issue 9, 2011, Pages 1015-1023

HCN3 contributes to the ventricular action potential waveform in the murine heart

Author keywords

cardiac electrophysiology; HCN3 knockout; hyperpolarization activated cyclic nucleotide gated channels; ventricular action potential; ventricular repolarization

Indexed keywords

CYCLIC NUCLEOTIDE GATED CHANNEL;

EID: 80055010250     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.246173     Document Type: Article
Times cited : (64)

References (48)
  • 1
    • 0018387132 scopus 로고
    • How does adrenaline accelerate the heart?
    • DOI 10.1038/280235a0
    • Brown HF, DiFrancesco D, Noble SJ. How does adrenaline accelerate the heart? Nature. 1979;280:235-236. (Pubitemid 9227914)
    • (1979) Nature , vol.280 , Issue.5719 , pp. 235-236
    • Brown, H.F.1    DiFrancesco, D.2    Noble, S.J.3
  • 2
    • 0024598929 scopus 로고
    • Muscarinic modulation of cardiac rate at low acetylcholine concentrations
    • DiFrancesco D, Ducouret P, Robinson RB. Muscarinic modulation of cardiac rate at low acetylcholine concentrations. Science. 1989;243: 669-671. (Pubitemid 19064044)
    • (1989) Science , vol.243 , Issue.4891 , pp. 669-671
    • DiFrancesco, D.1    Ducouret, P.2    Robinson, R.B.3
  • 3
    • 67651030760 scopus 로고    scopus 로고
    • Hyperpolarization-activated cation channels: From genes to function
    • Biel M, Wahl-Schott C, Michalakis S, Zong X. Hyperpolarization-activated cation channels: From genes to function. Physiol Rev. 2009;89: 847-885.
    • (2009) Physiol Rev , vol.89 , pp. 847-885
    • Biel, M.1    Wahl-Schott, C.2    Michalakis, S.3    Zong, X.4
  • 4
    • 0032970234 scopus 로고    scopus 로고
    • The HCN gene family: Molecular basis of the hyperpolarization-activated pacemaker channels
    • DOI 10.1111/j.1749-6632.1999.tb11353.x
    • Santoro B, Tibbs GR. The HCN gene family: Molecular basis of the hyperpolarization-activated pacemaker channels. Ann N Y Acad Sci. 1999;868:741-764. (Pubitemid 29281192)
    • (1999) Annals of the New York Academy of Sciences , vol.868 , pp. 741-764
    • Santoro, B.1    Tibbs, G.R.2
  • 5
    • 0035047603 scopus 로고    scopus 로고
    • Molecular diversity of pacemaker ion channels
    • DOI 10.1146/annurev.physiol.63.1.235
    • Kaupp UB, Seifert R. Molecular diversity of pacemaker ion channels. Annu Rev Physiol. 2001;63:235-257. (Pubitemid 32304318)
    • (2001) Annual Review of Physiology , vol.63 , pp. 235-257
    • Kaupp, U.B.1    Seifert, R.2
  • 6
    • 35648939866 scopus 로고    scopus 로고
    • HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice
    • DOI 10.1038/sj.emboj.7601868, PII 7601868
    • Herrmann S, Stieber J, Stockl G, Hofmann F, Ludwig A. HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice. Embo J. 2007;26:4423-4432. (Pubitemid 350036626)
    • (2007) EMBO Journal , vol.26 , Issue.21 , pp. 4423-4432
    • Herrmann, S.1    Stieber, J.2    Stockl, G.3    Hofmann, F.4    Ludwig, A.5
  • 9
    • 39449098523 scopus 로고    scopus 로고
    • Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP
    • DOI 10.1038/emboj.2008.3, PII EMBOJ20083
    • Harzheim D, Pfeiffer KH, Fabritz L, Kremmer E, Buch T, Waisman A, Kirchhof P, Kaupp UB, Seifert R. Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. Embo J. 2008;27:692-703. (Pubitemid 351273125)
    • (2008) EMBO Journal , vol.27 , Issue.4 , pp. 692-703
    • Harzheim, D.1    Pfeiffer, K.H.2    Fabritz, L.3    Kremmer, E.4    Buch, T.5    Waisman, A.6    Kirchhof, P.7    Kaupp, U.B.8    Seifert, R.9
  • 10
    • 30444452695 scopus 로고    scopus 로고
    • Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel
    • DOI 10.1056/NEJMoa052475
    • Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. N Engl J Med. 2006;354:151-157. (Pubitemid 43076712)
    • (2006) New England Journal of Medicine , vol.354 , Issue.2 , pp. 151-157
    • Milanesi, R.1    Baruscotti, M.2    Gnecchi-Ruscone, T.3    DiFrancesco, D.4
  • 11
    • 34548453724 scopus 로고    scopus 로고
    • Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia
    • DOI 10.1161/CIRCULATIONAHA.107.706887, PII 0000301720070731000005
    • Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H, Pras E, Dascal N, Eldar M, Glikson M. Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. Circulation. 2007;116:463-470. (Pubitemid 47450254)
    • (2007) Circulation , vol.116 , Issue.5 , pp. 463-470
    • Nof, E.1    Luria, D.2    Brass, D.3    Marek, D.4    Lahat, H.5    Reznik-Wolf, H.6    Pras, E.7    Dascal, N.8    Eldar, M.9    Glikson, M.10
  • 16
    • 33646598103 scopus 로고    scopus 로고
    • f in non-pacemaker cells: Role and pharmacological implications
    • DOI 10.1016/j.phrs.2006.03.015, PII S1043661806000545, The Role of the Pacemaker Current If in Cardiovascular Pharmacology
    • Cerbai E, Mugelli A. I(f) in non-pacemaker cells: Role and pharmacological implications. Pharmacol Res. 2006;53:416-423. (Pubitemid 43729046)
    • (2006) Pharmacological Research , vol.53 , Issue.5 , pp. 416-423
    • Cerbai, E.1    Mugelli, A.2
  • 17
    • 0036110328 scopus 로고    scopus 로고
    • Ion channel remodeling in cardiac hypertrophy is prevented by blood pressure reduction without affecting heart weight increase in rats with abdominal aortic banding
    • DOI 10.1097/00005344-200206000-00012
    • Hiramatsu M, Furukawa T, Sawanobori T, Hiraoka M. Ion channel remodeling in cardiac hypertrophy is prevented by blood pressure reduction without affecting heart weight increase in rats with abdominal aortic banding. J Cardiovasc Pharmacol. 2002;39:866-874. (Pubitemid 34538817)
    • (2002) Journal of Cardiovascular Pharmacology , vol.39 , Issue.6 , pp. 866-874
    • Hiramatsu, M.1    Furukawa, T.2    Sawanobori, T.3    Hiraoka, M.4
  • 18
    • 0031963215 scopus 로고    scopus 로고
    • Hyperpolarization-activated inward current in ventricular myocytes from normal and failing human hearts
    • Hoppe UC, Jansen E, Sudkamp M, Beuckelmann DJ. Hyperpolarizationactivated inward current in ventricular myocytes from normal and failing human hearts. Circulation. 1998;97:55-65. (Pubitemid 28036155)
    • (1998) Circulation , vol.97 , Issue.1 , pp. 55-65
    • Hoppe, U.C.1    Jansen, E.2    Sudkamp, M.3    Beuckelmann, D.J.4
  • 22
    • 22844433789 scopus 로고    scopus 로고
    • The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides
    • DOI 10.1074/jbc.M502696200
    • Mistrik P, Mader R, Michalakis S, Weidinger M, Pfeifer A, Biel M. The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides. J Biol Chem. 2005;280:27056-27061. (Pubitemid 41040742)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.29 , pp. 27056-27061
    • Mistrik, P.1    Mader, R.2    Michalakis, S.3    Weidinger, M.4    Pfeifer, A.5    Biel, M.6
  • 24
    • 0032480801 scopus 로고    scopus 로고
    • Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome
    • Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation. 1998;98:1928-1936. (Pubitemid 28509291)
    • (1998) Circulation , vol.98 , Issue.18 , pp. 1928-1936
    • Yan, G.-X.1    Antzelevitch, C.2
  • 25
    • 70349325703 scopus 로고    scopus 로고
    • Is there a significant transmural gradient in repolarization time in the intact heart? Cellular basis of the T wave: A century of controversy
    • Patel C, Burke JF, Patel H, Gupta P, Kowey PR, Antzelevitch C, Yan GX. Is there a significant transmural gradient in repolarization time in the intact heart? Cellular basis of the T wave: A century of controversy. Circ Arrhythm Electrophysiol. 2009;2:80-88.
    • (2009) Circ Arrhythm Electrophysiol , vol.2 , pp. 80-88
    • Patel, C.1    Burke, J.F.2    Patel, H.3    Gupta, P.4    Kowey, P.R.5    Antzelevitch, C.6    Yan, G.X.7
  • 26
    • 0037336635 scopus 로고    scopus 로고
    • Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels
    • DOI 10.1113/jphysiol.2003.039768
    • Azene EM, Xue T, Li RA. Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels. J Physiol. 2003; 547:349-356. (Pubitemid 36304969)
    • (2003) Journal of Physiology , vol.547 , Issue.2 , pp. 349-356
    • Azene, E.M.1    Xue, T.2    Li, R.A.3
  • 27
    • 24144476557 scopus 로고    scopus 로고
    • Effect of input resistance voltage-dependency on DC estimate of membrane capacitance in cardiac myocytes
    • DOI 10.1529/biophysj.105.062828
    • Zaniboni M, Cacciani F, Groppi M. Effect of input resistance voltagedependency on DC estimate of membrane capacitance in cardiac myocytes. Biophys J. 2005;89:2170-2181. (Pubitemid 41233570)
    • (2005) Biophysical Journal , vol.89 , Issue.3 , pp. 2170-2181
    • Zaniboni, M.1    Cacciani, F.2    Groppi, M.3
  • 28
    • 0000492713 scopus 로고
    • Propagated repolarization in heart muscle
    • Cranefield PF, Hoffman BF. Propagated repolarization in heart muscle. J Gen Physiol. 1958;41:633-649.
    • (1958) J Gen Physiol , vol.41 , pp. 633-649
    • Cranefield, P.F.1    Hoffman, B.F.2
  • 29
    • 70449162341 scopus 로고
    • Resting and action potentials of cardiac muscle
    • Weidmann S. Resting and action potentials of cardiac muscle. Ann N Y Acad Sci. 1957;65:663-678.
    • (1957) Ann N y Acad Sci , vol.65 , pp. 663-678
    • Weidmann, S.1
  • 30
    • 73049141695 scopus 로고
    • Membrane excitation in cardiac muscle
    • Weidmann S. Membrane excitation in cardiac muscle. Circulation. 1961; 24:499-505.
    • (1961) Circulation , vol.24 , pp. 499-505
    • Weidmann, S.1
  • 31
  • 33
    • 0033567165 scopus 로고    scopus 로고
    • Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 α subunit
    • DOI 10.1111/j.1469-7793.1999.0011o.x
    • Xu H, Li H, Nerbonne JM. Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative kv4 alpha subunit. J Physiol. 1999;519(Pt 1):11-21. (Pubitemid 29417799)
    • (1999) Journal of Physiology , vol.519 , Issue.1 , pp. 11-21
    • Xu, H.1    Li, H.2    Nerbonne, J.M.3
  • 35
    • 49249098962 scopus 로고    scopus 로고
    • Mathematical model of the neonatal mouse ventricular action potential
    • Wang LJ, Sobie EA. Mathematical model of the neonatal mouse ventricular action potential. Am J Physiol Heart Circ Physiol. 2008;294: H2565-H2575.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Wang, L.J.1    Sobie, E.A.2
  • 36
    • 0030823390 scopus 로고    scopus 로고
    • Genetically induced reduction in small currents has major impact
    • Kass RS. Genetically induced reduction in small currents has major impact. Circulation. 1997;96:1720-1721. (Pubitemid 27400723)
    • (1997) Circulation , vol.96 , Issue.6 , pp. 1720-1721
    • Kass, R.S.1
  • 37
    • 12344316979 scopus 로고    scopus 로고
    • 2+ ions
    • DOI 10.1016/j.ejphar.2004.11.051, PII S0014299904013639
    • van Welie I, Wadman WJ, van Hooft JA. Low affinity block of native and cloned hyperpolarization-activated Ih channels by Ba2f ions. Eur J Pharmacol. 2005;507:15-20. (Pubitemid 40126835)
    • (2005) European Journal of Pharmacology , vol.507 , Issue.1-3 , pp. 15-20
    • Van Welie, I.1    Wadman, W.J.2    Van Hooft, J.A.3
  • 38
    • 0032514164 scopus 로고    scopus 로고
    • + channel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndrome
    • Drici MD, Arrighi I, Chouabe C, Mann JR, Lazdunski M, Romey G, Barhanin J. Involvement of IsK-associated Kchannel in heart rate control of repolarization in a murine engineered model of Jervell and Lange-Nielsen syndrome. Circ Res. 1998;83:95-102. (Pubitemid 28322103)
    • (1998) Circulation Research , vol.83 , Issue.1 , pp. 95-102
    • Drici, M.-D.1    Arrighi, I.2    Chouabe, C.3    Mann, J.R.4    Lazdunski, M.5    Romey, G.6    Barhanin, J.7
  • 39
    • 0023619314 scopus 로고
    • Experimental and theoretical work on excitation and excitation- contraction coupling in the heart
    • DOI 10.1007/BF01945513
    • Noble D. Experimental and theoretical work on excitation and excitationcontraction coupling in the heart. Experientia. 1987;43:1146-1150. (Pubitemid 17167242)
    • (1987) Experientia , vol.43 , Issue.11-12 , pp. 1146-1150
    • Noble, D.1
  • 40
    • 0017681611 scopus 로고
    • Ionic membrane conductance during the time course of the cardiac action potential
    • Goldman Y, Morad M. Ionic membrane conductance during the time course of the cardiac action potential. J Physiol. 1977;268:655-695. (Pubitemid 8154319)
    • (1977) Journal of Physiology , vol.268 , Issue.3 , pp. 655-695
    • Goldman, Y.1    Morad, M.2
  • 41
    • 0026068683 scopus 로고
    • Modulation of collision-induced changes in canine heart repolarization by cycle length
    • Spitzer KW, Steinhaus BM, Hirai M, Haws CW, Burgess MJ. Modulation of collision-induced changes in canine heart repolarization by cycle length. J Electrocardiol. 1991;24:43-52.
    • (1991) J Electrocardiol , vol.24 , pp. 43-52
    • Spitzer, K.W.1    Steinhaus, B.M.2    Hirai, M.3    Haws, C.W.4    Burgess, M.J.5
  • 42
    • 77957689682 scopus 로고    scopus 로고
    • How different two almost identical action potentials can be: A model study on cardiac repolarization
    • Zaniboni M, Riva I, Cacciani F, Groppi M. How different two almost identical action potentials can be: A model study on cardiac repolarization. Math Biosci. 228:56-70.
    • Math Biosci , vol.228 , pp. 56-70
    • Zaniboni, M.1    Riva, I.2    Cacciani, F.3    Groppi, M.4
  • 43
    • 0035867054 scopus 로고    scopus 로고
    • + current
    • DOI 10.1111/j.1469-7793.2001.0145b.x
    • Thorneloe KS, Liu XF, Walsh MP, Shimoni Y. Transmural differences in rat ventricular protein kinase C epsilon correlate with its functional regulation of a transient cardiac Kcurrent. J Physiol. 2001;533: 145-154. (Pubitemid 32499367)
    • (2001) Journal of Physiology , vol.533 , Issue.1 , pp. 145-154
    • Thorneloe, K.S.1    Liu, X.F.2    Walsh, M.P.3    Shimoni, Y.4
  • 45
    • 0030049208 scopus 로고    scopus 로고
    • Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle
    • Nabauer M, Beuckelmann DJ, Uberfuhr P, Steinbeck G. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation. 1996;93:168-177. (Pubitemid 26006581)
    • (1996) Circulation , vol.93 , Issue.1 , pp. 168-177
    • Nabauer, M.1    Beuckelmann, D.J.2    Uberfuhr, P.3    Steinbeck, G.4
  • 46
    • 0031875847 scopus 로고    scopus 로고
    • Transmural heterogeneity of action potentials and Ito1 in myocytes isolated from the human right ventricle
    • Li GR, Feng J, Yue L, Carrier M. Transmural heterogeneity of action potentials and Ito1 in myocytes isolated from the human right ventricle. Am J Physiol. 1998;275:H369-H377.
    • (1998) Am J Physiol , vol.275
    • Li, G.R.1    Feng, J.2    Yue, L.3    Carrier, M.4
  • 47
    • 0037407631 scopus 로고    scopus 로고
    • Treatment with irbesartan counteracts the functional remodeling of ventricular myocytes from hypertensive rats
    • DOI 10.1097/00005344-200305000-00019
    • Cerbai E, De Paoli P, Sartiani L, Lonardo G, Mugelli A. Treatment with irbesartan counteracts the functional remodeling of ventricular myocytes from hypertensive rats. J Cardiovasc Pharmacol. 2003;41:804-812. (Pubitemid 36523185)
    • (2003) Journal of Cardiovascular Pharmacology , vol.41 , Issue.5 , pp. 804-812
    • Cerbai, E.1    De Paoli, P.2    Sartiani, L.3    Lonardo, G.4    Mugelli, A.5
  • 48
    • 0033969241 scopus 로고    scopus 로고
    • Long-term treatment of spontaneously hypertensive rats with losartan and electrophysiological remodeling of cardiac myocytes
    • DOI 10.1016/S0008-6363(99)00344-2, PII S0008636399003442
    • Cerbai E, Crucitti A, Sartiani L, De Paoli P, Pino R, Rodriguez ML, Gensini G, Mugelli A. Long-term treatment of spontaneously hypertensive rats with losartan and electrophysiological remodeling of cardiac myocytes. Cardiovasc Res. 2000;45:388-396. (Pubitemid 30069504)
    • (2000) Cardiovascular Research , vol.45 , Issue.2 , pp. 388-396
    • Cerbai, E.1    Crucitti, A.2    Sartiani, L.3    De Paoli, P.4    Pino, R.5    Rodriguez, M.L.6    Gensini, G.7    Mugelli, A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.