Human nasal olfactory epithelium as a dynamic marker for CNS therapy development

Experimental Neurology

Volumn 232, Issue 2, 2011, Pages 203-211

  Sattler, Rita ^a   Ayukawa, Yoko ^a   Coddington, Luke ^a   Sawa, Akira ^a   Block, David ^c   Chipkin, Richard ^c   Rothstein, Jeffrey D ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c Ruxton Pharmaceuticals   (United States)

Author keywords

ALS; Astrocyte; Astroglia; Glutamate transporter; Nasal biopsy; Olfactory epithelial tissue; Surrogate marker

Indexed keywords

BIOLOGICAL MARKER; EXCITATORY AMINO ACID TRANSPORTER 2; MARKER; PHARMACODYNAMIC MARKER; PLACEBO; THIAMPHENICOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIOLOGICAL THERAPY; CELL TYPE; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; DEGENERATIVE DISEASE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DEVELOPMENT; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG MECHANISM; DRUG PENETRATION; DRUG TARGETING; EMBRYO; HUMAN; HUMAN CELL; MENTAL DISEASE; MOUSE; NASAL BIOPSY; NERVOUS SYSTEM INJURY; NERVOUS TISSUE; NONHUMAN; OLFACTORY EPITHELIUM; PHARMACODYNAMICS; PRIORITY JOURNAL; RODENT; UNSPECIFIED SIDE EFFECT;

ANIMALS; ANIMALS, NEWBORN; ANTI-BACTERIAL AGENTS; ASTROCYTES; BIOLOGICAL ASSAY; BIOLOGICAL MARKERS; BIOPSY; CELL LINE, TRANSFORMED; CENTRAL NERVOUS SYSTEM; DRUG DESIGN; DRUG MONITORING; GENE EXPRESSION; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; LUCIFERASES; MICE; OLFACTORY MUCOSA; OLFACTORY RECEPTOR NEURONS; PRIMARY CELL CULTURE; THIAMPHENICOL;

EID: 80055009336     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.09.002     Document Type: Article

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