CD11c+ Cells are Significantly Decreased in the Duodenum, Ileum and Colon of Dogs with Inflammatory Bowel Disease

Journal of Comparative Pathology

Volumn 145, Issue 4, 2011, Pages 359-366

  Kathrani, A ^a   Schmitz, S ^a   Priestnall, S L ^a   Smith, K C ^a   Werling, D ^a   Garden, O A ^a   Allenspach, K ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

CD11c; Dendritic cell; Dog; Inflammatory bowel disease

Indexed keywords

GLYCOPROTEIN P 15095;

ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL POPULATION; CHRONIC INFLAMMATION; COLON; CONTROLLED STUDY; DENDRITIC CELL; DUODENUM; ENDOSCOPIC BIOPSY; ENTERITIS; FEMALE; ILEUM; IMMUNOFLUORESCENCE MICROSCOPY; MALE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD11C; BIOPSY; CELL COUNT; CELL DIFFERENTIATION; COLON; DENDRITIC CELLS; DOG DISEASES; DOGS; DUODENUM; ENDOSCOPY, GASTROINTESTINAL; FEMALE; ILEUM; INFLAMMATORY BOWEL DISEASES; MALE; SEVERITY OF ILLNESS INDEX; SINGLE-BLIND METHOD;

ANIMALIA; CANIS FAMILIARIS; MURINAE;

EID: 80055008991     PISSN: 00219975     EISSN: 15323129     Source Type: Journal    
DOI: 10.1016/j.jcpa.2011.03.010     Document Type: Article

References (37)

1. Abreu M.T., Fukata M., Arditi M. TLR signaling in the gut in health and disease. Journal of Immunology 2005, 174:4453-4460.
2. Allenspach K., House A., Smith K., McNeill F.M., Hendricks A., et al. Evaluation of mucosal bacteria and histopathology, clinical disease activity and expression of Toll-like receptors in German shepherd dogs with chronic enteropathies. Veterinary Microbiology 2010, 146:326-335.
3. Allenspach K., Wieland B., Grone A., Gaschen F. Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. Journal of Veterinary Internal Medicine 2007, 21:700-708.
4. Baumgart D.C., Thomas S., Przesdzing I., Metzke D., Bielecki C., et al. Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease. Clinical and Experimental Immunology 2009, 157:423-436.
5. Bernstein C.N., Sargent M., Gallatin W.M. Beta-2 integrin/ICAM expression in Crohn's disease. Clinical Immunology and Immunopathology 1998, 86:147-160.
6. Casamian-Sorrosal D., Willard M.D., Murray J.K., Hall E.J., Taylor S.S., et al. Comparison of histopathologic findings in biopsies from the duodenum and ileum of dogs with enteropathy. Journal of Veterinary Internal Medicine 2010, 24:80-83.
7. Cerquetella M., Spaterna A., Laus F., Tesei B., Rossi G., et al. Inflammatory bowel disease in the dog: differences and similarities with humans. World Journal of Gastroenterology 2010, 16:1050-1056.
8. Craven M., Simpson J.W., Ridyard A.E., Chandler M.L. Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). Journal of Small Animal Practice 2004, 45:336-342.
9. Danilenko D.M., Moore P.F., Rossitto P.V. Canine leukocyte cell adhesion molecules (LeuCAMs): characterization of the CD11/CD18 family. Tissue Antigens 1992, 40:13-21.
10. Day M.J., Bilzer T., Mansell J., Wilcock B., Hall E.J., et al. Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group. Journal of Comparative Pathology 2008, 138:S1-S43.
11. Duchmann R., Kaiser I., Hermann E., Mayet W., Ewe K., et al. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clinical and Experimental Immunology 1995, 102:448-455.
12. German A.J., Hall E.J., Day M.J. Immune cell populations within the duodenal mucosa of dogs with enteropathies. Journal of Veterinary Internal Medicine 2001, 15:14-25.
13. Henri S., Vremec D., Kamath A., Waithman J., Williams S., et al. The dendritic cell populations of mouse lymph nodes. Journal of Immunology 2001, 167:741-748.
14. Ihanus E., Uotila L.M., Toivanen A., Varis M., Gahmberg C.G. Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4. Blood 2007, 109:802-810.
15. Isotani M., Katsuma K., Tamura K., Yamada M., Yagihara H., et al. Efficient generation of canine bone marrow-derived dendritic cells. Journal of Veterinary Medical Science 2006, 68:809-814.
16. Jergens A.E., Moore F.M., Haynes J.S., Miles K.G. Idiopathic inflammatory bowel disease in dogs and cats: 84 cases (1987-1990). Journal of the American Veterinary Medical Association 1992, 201:1603-1608.
17. Krajina T., Leithauser F., Moller P., Trobonjaca Z., Reimann J. Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis. European Journal of Immunology 2003, 33:1073-1083.
18. Landers C.J., Cohavy O., Misra R., Yang H., Lin Y.C., et al. Selected loss of tolerance evidenced by Crohn's disease-associated immune responses to auto- and microbial antigens. Gastroenterology 2002, 123:689-699.
19. Magalhaes J.G., Tattoli I., Girardin S.E. The intestinal epithelial barrier: how to distinguish between the microbial flora and pathogens. Seminars in Immunology 2007, 19:106-115.
20. Malizia G., Calabrese A., Cottone M., Raimondo M., Trejdosiewicz L.K., et al. Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease. Gastroenterology 1991, 100:150-159.
21. Mielcarek M., Kucera K.A., Nash R., Torok-Storb B., McKenna H.J. Identification and characterization of canine dendritic cells generated in vivo. Biology of Blood and Marrow Transplantation 2007, 13:1286-1293.
22. Petty H.R., Todd R.F. Integrins as promiscuous signal transduction devices. Immunology Today 1996, 17:209-212.
23. Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004, 118:229-241.
24. Ricklin Gutzwiller M.E., Moulin H.R., Zurbriggen A., Roosje P., Summerfield A. Comparative analysis of canine monocyte- and bone-marrow-derived dendritic cells. Veterinary Research 2010, 41:40-51.
25. Sands B.E., Abreu M.T., Ferry G.D., Griffiths A.M., Hanauer S.B., et al. Design issues and outcomes in IBD clinical trials. Inflammatory Bowel Diseases 2005, 11(Suppl. 1):S22-S28.
26. Schreiner N.M., Gaschen F., Grone A., Sauter S.N., Allenspach K. Clinical signs, histology, and CD3-positive cells before and after treatment of dogs with chronic enteropathies. Journal of Veterinary Internal Medicine 2008, 22:1079-1083.
27. Silva M.A., Lopez C.B., Riverin F., Oligny L., Menezes J., et al. Characterization and distribution of colonic dendritic cells in Crohn's disease. Inflammatory Bowel Diseases 2004, 10:504-512.
28. Springer T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994, 76:301-314.
29. Stagg A.J., Hart A.L., Knight S.C., Kamm M.A. The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut 2003, 52:1522-1529.
30. Stewart M., Thiel M., Hogg N. Leukocyte integrins. Current Opinion in Cell Biology 1995, 7:690-696.
31. Strauch U.G., Grunwald N., Obermeier F., Gurster S., Rath H.C. Loss of CD103+ intestinal dendritic cells during colonic inflammation. World Journal of Gastroenterology 2010, 16:21-29.
32. Sydora B.C., Tavernini M.M., Wessler A., Jewell L.D., Fedorak R.N. Lack of interleukin-10 leads to intestinal inflammation, independent of the time at which luminal microbial colonization occurs. Inflammatory Bowel Diseases 2003, 9:87-97.
33. Wang Y.S., Chi K.H., Liao K.W., Liu C.C., Cheng C.L., et al. Characterization of canine monocyte-derived dendritic cells with phenotypic and functional differentiation. Canadian Journal of Veterinary Research 2007, 71:165-174.
34. Washabau R.J., Day M.J., Willard M.D., Hall E.J., Jergens A.E., et al. Endoscopic, biopsy, and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. Journal of Veterinary Internal Medicine 2010, 24:10-26.
35. Willard M.D., Jergens A.E., Duncan R.B., Leib M.S., McCracken M.D., et al. Interobserver variation among histopathologic evaluations of intestinal tissues from dogs and cats. Journal of the American Veterinary Medical Association 2002, 220:1177-1182.
36. Willard M.D., Moore G.E., Denton B.D., Day M.J., Mansell J., et al. Effect of tissue processing on assessment of endoscopic intestinal biopsies in dogs and cats. Journal of Veterinary Internal Medicine 2010, 24:84-89.
37. Xavier R.J., Podolsky D.K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007, 448:427-434.