Biomarkers to predict clinical progression in small vessel disease strokes: Prognostic role of albuminuria and oxidized LDL cholesterol

Atherosclerosis

Volumn 219, Issue 1, 2011, Pages 368-372

  Cuadrado Godia, Elisa ^a   Ois, Angel ^a   Garcia Ramallo, Eva ^a   Giralt, Eva ^a   Jimena, Sara ^a   Rubio, Miguel Angel ^a   Rodríguez Campello, Ana ^a   Jiménez Conde, Jordi ^a   Roquer, Jaume ^a  

^a INST MUNIC D INVESTIGACIO MEDICA   (Spain)

Author keywords

Albuminuria; Lacunar infarction; Oxidized low density lipoprotein; Von Willebrand factor

Indexed keywords

ACETYLSALICYLIC ACID; ALBUMIN; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; BIOLOGICAL MARKER; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; OXIDIZED LOW DENSITY LIPOPROTEIN; TRIFLUSAL; VON WILLEBRAND FACTOR;

AGED; ALBUMINURIA; ARTICLE; BRAIN INFARCTION; CEREBROVASCULAR ACCIDENT; COMORBIDITY; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE COURSE; ENDOTHELIAL DYSFUNCTION; FEMALE; HEART FAILURE; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LACUNAR INFARCTION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RANKIN SCALE; RECEIVER OPERATING CHARACTERISTIC; STROKE; UNIVARIATE ANALYSIS; URINALYSIS;

AGED; ALBUMINURIA; BIOLOGICAL MARKERS; DISEASE PROGRESSION; FEMALE; HUMANS; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; PROGNOSIS; STROKE, LACUNAR; VON WILLEBRAND FACTOR;

EID: 80055006990     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.07.114     Document Type: Article

References (26)

1. Arboix A., Marti-Vilalta J.L. Lacunar stroke. Expert Rev Neurother 2009, 9:179-196.
2. Steinke W., Ley S.C. Lacunar stroke is the major cause of progressive motor deficits. Stroke 2002, 33:1510-1516.
3. Serena J., Leira R., Castillo J., et al. Neurological deterioration in acute lacunar infarctions: the role of excitatory and inhibitory neurotransmitters. Stroke 2001, 32:1154-1161.
4. Castellanos M., Castillo J., Garcia M.M., et al. Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target. Stroke 2002, 33:982-987.
5. Audebert H.J., Pellkofer T.S., Wimmer M.L., Haberl R.L. Progression in lacunar stroke is related to elevated acute phase parameters. Eur Neurol 2004, 51:125-131.
6. Roquer J., Segura T., Serena J., Castillo J. Endothelial dysfunction, vascular disease and stroke: the ARTICO study. Cerebrovasc Dis 2009, 27(Suppl. 1):25-37.
7. Wardlaw J.M, Sandercock P.A., Dennis M.S., Starr J. Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?. Stroke 2003, 34:806-812.
8. Knottnerus I.L., Ten Cate H., Lodder J., Kessels F., van Oostenbrugge R.J. Endothelial dysfunction in lacunar stroke: a systematic review. Cerebrovasc Dis 2009, 27:519-526.
9. Ochodnicky P., Henning R.H., van Dokkum R.P., de Zeeuw D. Microalbuminuria and endothelial dysfunction: emerging targets for primary prevention of end-organ damage. J Cardiovasc Pharmacol 2006, 47(Suppl. 2):S151-S162. [discussion S172-6].
10. Vischer U.M. von Willebrand factor, endothelial dysfunction, and cardiovascular disease. J Thromb Haemost 2006, 4:1186-1193.
11. Pennathur S., Heinecke J.W. Oxidative stress and endothelial dysfunction in vascular disease. Curr Diab Rep 2007, 7:257-264.
12. Ay H., Furie K.L., Singhal A., et al. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol 2005, 58:688-697.
13. Ois A., Cuadrado-Godia E., Rodriguez-Campello A., Jimenez-Conde J., Roquer J. High risk of early neurological recurrence in symptomatic carotid stenosis. Stroke 2009, 40:2727-2731.
14. Roquer J., Rodriguez-Campello A., Gomis M., et al. Acute stroke unit care and early neurological deterioration in ischemic stroke. J Neurol 2008, 255:1012-1017.
15. Nakamura K., Saku Y., Ibayashi S., Fujishima M. Progressive motor deficits in lacunar infarction. Neurology 1999, 52:29-33.
16. Wong W.T., Ng C.H., Tsang S.Y., Huang Y., Chen Z.Y. Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. Nutr Metab Cardiovasc Dis 2011, 21(3):157-164.
17. Hwang Y.H., Seo J.G., Lee H.W., Park S.P., Suh C.K. Early neurological deterioration following intravenous recombinant tissue plasminogen activator therapy in patients with acute lacunar stroke. Cerebrovasc Dis 2008, 26:355-359.
18. Kitanaka C., Teraoka A. Clinical features of progressive lacunar infarction-retrospective analysis of patients with motor syndromes. Neurol Med Chir (Tokyo) 1995, 35:663-666.
19. Castillo J., Leira R., Garcia M.M., et al. Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome. Stroke 2004, 35:520-526.
20. Kim Y.S., Lee K.Y., Koh S.H., et al. The role of matrix metalloproteinase 9 in early neurological worsening of acute lacunar infarction. Eur Neurol 2006, 55:11-15.
21. Knottnerus I.L., Govers-Riemslag J.W., Hamulyak K., et al. Endothelial activation in lacunar stroke subtypes. Stroke 2010, 41:1617-1622.
22. Giner V., Tormos C., Chaves F.J., Saez G., Redon J. Microalbuminuria and oxidative stress in essential hypertension. J Intern Med 2004, 255:588-594.
23. Ishikawa T., Hashimoto J., Morito R.H., et al. Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama study. Am J Hypertens 2008, 21:413-418.
24. Levitan I., Volkov S., Subbaiah P.V. Oxidized LDL: diversity, patterns of recognition, and pathophysiology. Antioxid Redox Signal 2010, 13(1):39-75.
25. Rodriguez-Yanez M., Castellanos M., Blanco M., et al. Micro- and macroalbuminuria predict hemorrhagic transformation in acute ischemic stroke. Neurology 2006, 67:1172-1177.
26. Yamamoto H., Bogousslavsky J., van Melle G. Different predictors of neurological worsening in different causes of stroke. Arch Neurol 1998, 55:481-486.