A double-blind, placebo-controlled assessment of the safety of potential interactions between intravenous cocaine, ethanol, and oral disulfiram

Drug and Alcohol Dependence

Volumn 119, Issue 1-2, 2011, Pages 37-45

  Roache, John D ^a   Kahn, Roberta ^c   Newton, Thomas F ^b,d   Wallace, Christopher L ^a   Murff, William L ^a   De La Garza, Richard ^b,d   Rivera, Oscar ^a   Anderson, Ann ^c   Mojsiak, Jurij ^c   Elkashef, Ahmed ^c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Alcohol; Cardiac risk; Cocaine; Disulfiram; Safety; Treatment

Indexed keywords

ALCOHOL; COCAINE; DISULFIRAM; PHENYLEPHRINE;

ADULT; ARTICLE; CARDIOVASCULAR RESPONSE; CHEMICAL INTERACTION; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COCAINE DEPENDENCE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG ALCOHOL INTERACTION; DRUG COCAINE INTERACTION; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; FLUSHING; HEART RATE; HUMAN; HYPOTENSION; NAUSEA; PRIORITY JOURNAL; QT PROLONGATION; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA;

ADULT; ALCOHOL DETERRENTS; BLOOD PRESSURE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COCAINE; COCAINE-RELATED DISORDERS; DISULFIRAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; ELECTROCARDIOGRAPHY; ETHANOL; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; PLACEBOS; PSYCHIATRIC STATUS RATING SCALES; SUBSTANCE-RELATED DISORDERS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 80055002775     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2011.05.015     Document Type: Article

References (32)

1. Baker J.R., Jatlow P., McCance-Katz E.F. Disulfiram effects on responses to intravenous cocaine administration. Drug Alcohol Depend. 2007, 87:202-209.
2. Beyeler C., Fisch H.U., Preisig R. The disulfiram-alcohol reaction: factors determining and potential tests predicting severity. Alcohol. Clin. Exp. Res. 1985, 9:118-124.
3. Brewer C. How effective is the standard dose of disulfiram? A review of the alcohol-disulfiram reaction in practice. Br. J. Psychol. 1984, 144:200-202.
4. Carroll K.M., Fenton L.R., Ball S.A., Nich C., Frankforter T.L., Shi J., Rounsaville B.J. Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial. Arch. Gen. Psychiatry 2004, 61:264-272.
5. Carroll K.M., Nich C., Ball S.A., McCance E., Rounsaville B.J. Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction 1998, 93:713-727.
6. Chick J. Safety issues concerning the use of disulfiram in treating alcohol dependence. Drug Saf. 1999, 20:427-435.
7. Christensen J.K., Moller I.W., Ronsted P., Angelo H.R., Johansson B. Dose-effect relationship of disulfiram in human volunteers. I: clinical studies. Pharmacol. Toxicol. 1991, 68:163-165.
8. Filip M., Frankowska M., Zaniewska M., Golda A., Przegalinski E. The serotonergic system and its role in cocaine addiction. Pharmacol. Rep. 2005, 57:685-700.
9. Faiman M.D. Biochemical pharmacology of disulfiram. Biochemistry and Pharmacology of Ethanol 1979, vol. 2:325-348. Plenum Press, New York.
10. Foltin R.W., Fischman M.W. Smoked and intravenous cocaine in humans: acute tolerance, cardiovascular and subjective effects. J. Pharmacol. Exp. Ther. 1991, 257:247-261.
11. George T.P., Chawarski M.C., Pakes J., Carroll K.M., Kosten T.R., Schottenfeld R.S. Disulfiram versus placebo for cocaine dependence in buprenorphine-maintained subjects: a preliminary trial. Biol. Psychiatry 2000, 47:1080-1086.
12. Goldstein M., Anagnoste B., Lauber E., McKeregham M.R. Inhibition of dopamine-beta-hydroxylase by disulfiram. Life Sci. 1964, 3:763-767.
13. Haile C.N., Kosten T.R., Kosten T.A. Pharmacogenetic treatments of drug addiction: cocaine, amphetamine, and methamphetamine. Am. J. Drug Alcohol Abuse 2009, 35:161-177.
14. Hameedi F.A., Rosen M.I., McCance-Katz E.F., McMahon T.J., Price L.H., Jatlow P.I., Woods S.W., Kosten T.R. Behavioral, physiological, and pharmacological interaction of cocaine and disulfiram in humans. Biol. Psychiatry 1995, 37:560-563.
15. Higgins S.T., Budney A.J., Bickel W.K., Hughes J.R., Foerg F. Disulfiram therapy in patients abusing cocaine and alcohol. Am. J. Psychiatry 1993, 150:675-676.
16. Johnsen J., Stowell A., Morland J. Clinical responses in relation to blood acetaldehyde levels. Pharmacol. Toxicol. 1992, 70:41-45.
17. Kristenson H. How to get the best out of antabuse. Alcohol Alcohol. 1995, 30:775-783.
18. Lange R.A., Hillis L.D. Cardiovascular complications of cocaine use. N. Engl. J. Med. 2001, 345:351-358.
19. Malcolm R., Olive M.F., Lechner W. The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practice. Expert Opin. Drug Saf. 2008, 7:459-472.
20. McCance-Katz E.F., Kosten T.R., Jatlow P. Disulfiram effects on acute cocaine administration. Drug Alcohol Depend. 1998, 52:27-39.
21. McCance-Katz E.F., Kosten T.R., Jatlow P. Chronic disulfiram treatment effects on intranasal cocaine administration: initial results. Biol. Psychiatry 1998, 43:540-543.
22. Musacchio J., Kopin I.J., Snyder S. Effects of disulfiram on tissue norepinephrine content and subcellular distribution of dopamine, tyramine and their beta-hydroxylated metabolites. Life Sci. 1964, 3:769-775.
23. Mutschler J., Diehl A., Kiefer F. Pronounced paranoia as a result of cocaine-disulfiram interaction: case report and mode of action. J. Clin. Psychopharmacol. 2009, 29:99-101.
24. Pettinati H.M., Kampman K.M., Lynch K.G., Xie H., Dackis C., Rabinowitz A.R., O'Brien C.P. A double-blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence. Addict. Behav. 2008, 33:651-667.
25. Petrakis I.L., Carroll K.M., Nich C., Gordon L.T., McCance-Katz E.F., Frankforter T., Rounsaville B.J. Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts. Addiction 2000, 95:219-228.
26. Ritz M.C., Lamb R.J., Goldberg S.R., Kuhar M.J. Cocaine self-administration appears to be mediated by dopamine uptake inhibition. Prog. Neuropsychopharmacol. Biol. Psychiatry 1988, 12:233-239.
27. SAMHSA National Survey on Drug Use and Health 2007, (Rockville, MD).
28. Sofuoglu M., Kosten T.R. Emerging pharmacological strategies in the fight against cocaine addiction. Expert Opin. Emerg. Drugs 2006, 11:91-98.
29. Sofuoglu M., Sewell R.A. Norepinephrine and stimulant addiction. Addict. Biol. 2009, 14:119-129.
30. Suh J.J., Pettinati H.M., Kampman K.M., O'Brien C.P. The status of disulfiram: a half of a century later. J. Clin. Psychopharmacol. 2006, 26:290-302.
31. Withers N.W., Pulvirenti L., Koob G.F., Gillin J.C. Cocaine abuse and dependence. J. Clin. Psychopharmacol. 1995, 15:63-78.
32. Wright C., Moore R.D. Disulfiram treatment of alcoholism. Am. J. Med. 1990, 88:647-655.