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Volumn 10, Issue 3, 2011, Pages 469-472

A rationale for mTOR inhibitors as chemoprevention agents in Peutz-Jeghers syndrome

Author keywords

Chemoprevention; Clinical trial; Hamartomatous polyps; mTOR; Peutz Jeghers syndrome

Indexed keywords

EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE LKB1; RAPAMYCIN;

EID: 80055000509     PISSN: 13899600     EISSN: 15737292     Source Type: Journal    
DOI: 10.1007/s10689-011-9471-9     Document Type: Conference Paper
Times cited : (21)

References (15)
  • 1
    • 33847006970 scopus 로고    scopus 로고
    • Small-intestinal Peutz-Jeghers polyps resected by endoscopic polypectomy with double-balloon enteroscopy and removal confirmed by ultrasonography
    • 17089186 10.1007/s10620-006-9381-0 1:STN:280:DC%2BD2s%2FgtFCisA%3D%3D
    • Y Matsumoto N Manabe S Tanaka A Fukumoto T Yamaguchi M Shimamoto M Nakao Y Mitsuoka K Chayama 2006 Small-intestinal Peutz-Jeghers polyps resected by endoscopic polypectomy with double-balloon enteroscopy and removal confirmed by ultrasonography Dig Dis Sci 51 2337 2340 17089186 10.1007/s10620-006-9381-0 1:STN:280:DC%2BD2s%2FgtFCisA%3D%3D
    • (2006) Dig Dis Sci , vol.51 , pp. 2337-2340
    • Matsumoto, Y.1    Manabe, N.2    Tanaka, S.3    Fukumoto, A.4    Yamaguchi, T.5    Shimamoto, M.6    Nakao, M.7    Mitsuoka, Y.8    Chayama, K.9
  • 4
    • 0023640995 scopus 로고
    • Peutz-Jeghers polyposis associated with carcinoma of the digestive organs. Report of three cases and review of the literature
    • DOI 10.1007/BF02554629
    • F Konishi NE Wyse T Muto T Sawada Y Morioka H Sugimura K Yamaguchi 1987 Peutz-Jeghers polyposis associated with carcinoma of the digestive organs. Report of three cases and review of the literature Dis Colon Rectum 30 790 799 3308369 10.1007/BF02554629 1:STN:280:DyaL1c%2Fgtl2gsg%3D%3D (Pubitemid 17168049)
    • (1987) Diseases of the Colon and Rectum , vol.30 , Issue.10 , pp. 790-799
    • Konishi, F.1    Wyse, N.E.2    Muto, T.3    Sawada, T.4    Morioka, Y.5    Sugimura, H.6    Yamaguchi, K.7
  • 7
    • 77953230425 scopus 로고    scopus 로고
    • High cancer risk in Peutz-Jeghers syndrome: A systematic review and surveillance recommendations
    • 20051941 10.1038/ajg.2009.725 author reply 1265
    • MG van Lier A Wagner EM Mathus-Vliegen EJ Kuipers EW Steyerberg ME van Leerdam 2010 High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations Am J Gastroenterol 105 1258 1264 20051941 10.1038/ajg.2009.725 author reply 1265
    • (2010) Am J Gastroenterol , vol.105 , pp. 1258-1264
    • Van Lier, M.G.1    Wagner, A.2    Mathus-Vliegen, E.M.3    Kuipers, E.J.4    Steyerberg, E.W.5    Van Leerdam, M.E.6
  • 9
    • 2342504508 scopus 로고    scopus 로고
    • Frequent Inactivation of PTEN by Promoter Hypermethylation in Microsatellite Instability-High Sporadic Colorectal Cancers
    • DOI 10.1158/0008-5472.CAN-2401-2
    • A Goel CN Arnold D Niedzwiecki JM Carethers JM Dowell L Wasserman C Compton RJ Mayer MM Bertagnolli CR Boland 2004 Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers Cancer Res 64 3014 3021 15126336 10.1158/0008-5472.CAN-2401-2 1:CAS:528:DC%2BD2cXjs1ehsbo%3D (Pubitemid 38581399)
    • (2004) Cancer Research , vol.64 , Issue.9 , pp. 3014-3021
    • Goel, A.1    Arnold, C.N.2    Niedzwiecki, D.3    Carethers, J.M.4    Dowell, J.M.5    Wasserman, L.6    Compton, C.7    Mayer, R.J.8    Bertagnolli, M.M.9    Boland, C.R.10
  • 11
    • 39749102904 scopus 로고    scopus 로고
    • Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling
    • DOI 10.1158/1078-0432.CCR-07-4007
    • C Wei CI Amos N Zhang X Wang A Rashid CL Walker RR Behringer ML Frazier 2008 Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling Clin Cancer Res 14 1167 1171 18281551 10.1158/1078-0432.CCR- 07-4007 1:CAS:528:DC%2BD1cXhvF2nsb4%3D (Pubitemid 351302565)
    • (2008) Clinical Cancer Research , vol.14 , Issue.4 , pp. 1167-1171
    • Wei, C.1    Amos, C.I.2    Zhang, N.3    Wang, X.4    Rashid, A.5    Walker, C.L.6    Behringer, R.R.7    Frazier, M.L.8
  • 12
    • 62749135926 scopus 로고    scopus 로고
    • Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model
    • 19147279 10.1016/j.canlet.2008.11.036 1:CAS:528:DC%2BD1MXjslOktbw%3D
    • C Wei CI Amos N Zhang J Zhu X Wang ML Frazier 2009 Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model Cancer Lett 277 149 154 19147279 10.1016/j.canlet.2008.11.036 1:CAS:528:DC%2BD1MXjslOktbw%3D
    • (2009) Cancer Lett , vol.277 , pp. 149-154
    • Wei, C.1    Amos, C.I.2    Zhang, N.3    Zhu, J.4    Wang, X.5    Frazier, M.L.6
  • 13
    • 67650480092 scopus 로고    scopus 로고
    • MTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
    • 19541609 10.1073/pnas.0900465106 1:CAS:528:DC%2BD1MXptVWgu78%3D
    • DB Shackelford DS Vasquez J Corbeil S Wu M Leblanc CL Wu DR Vera RJ Shaw 2009 mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome Proc Natl Acad Sci USA 106 11137 11142 19541609 10.1073/pnas.0900465106 1:CAS:528:DC%2BD1MXptVWgu78%3D
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 11137-11142
    • Shackelford, D.B.1    Vasquez, D.S.2    Corbeil, J.3    Wu, S.4    Leblanc, M.5    Wu, C.L.6    Vera, D.R.7    Shaw, R.J.8
  • 14
    • 67749110462 scopus 로고    scopus 로고
    • Oral rapamycin reduces tumour burden and vascularization in Lkb1(±) mice
    • 19434632 10.1002/path.2562 1:CAS:528:DC%2BD1MXhtFGgs7%2FK
    • J Robinson C Lai A Martin E Nye I Tomlinson A Silver 2009 Oral rapamycin reduces tumour burden and vascularization in Lkb1(±) mice J Pathol 219 35 40 19434632 10.1002/path.2562 1:CAS:528:DC%2BD1MXhtFGgs7%2FK
    • (2009) J Pathol , vol.219 , pp. 35-40
    • Robinson, J.1    Lai, C.2    Martin, A.3    Nye, E.4    Tomlinson, I.5    Silver, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.