Association of the SHBG gene promoter polymorphism with early markers of atherosclerosis in apparently healthy women

Atherosclerosis

Volumn 219, Issue 1, 2011, Pages 205-210

  Saltiki, Katerina ^a   Stamatelopoulos, Kimon ^a   Voidonikola, Paraskevi ^a   Lazaros, Leandros ^b   Mantzou, Emily ^a   Georgiou, Ioannis ^b   Anastasiou, Eleni ^a   Papamichael, Christos ^a   Alevizaki, Maria ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b UNIVERSITY OF IOANNINA   (Greece)

Author keywords

Atherosclerosis; Carotid intima media thickness; Endothelium dependent vasodilatation; SHBG gene polymorphism; Women

Indexed keywords

ANDROGEN; SEX HORMONE BINDING GLOBULIN;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; COMMON CAROTID ARTERY; CORRELATION ANALYSIS; FEMALE; GENETIC POLYMORPHISM; HORMONE ACTION; HUMAN; IMMUNORADIOMETRIC ASSAY; INTIMA; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; MULTIVARIATE ANALYSIS; PHENOTYPE; POSTMENOPAUSE; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; PROSPECTIVE STUDY; THICKNESS; TUNICA MEDIA; VASCULAR ENDOTHELIUM; VASODILATATION; WOMEN'S HEALTH;

ADULT; AGED; ALU ELEMENTS; ATHEROSCLEROSIS; CAROTID ARTERIES; CAROTID INTIMA-MEDIA THICKNESS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES; RISK FACTORS; SEX HORMONE-BINDING GLOBULIN;

EID: 80054999139     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.06.053     Document Type: Article

References (38)

1. Phillips G.B. Is atherosclerotic cardiovascular disease an endocrinological disorder? The estrogen-androgen paradox. J Clin Endocrinol Metab 2005, 90:2708-2711.
2. Saltiki K., Alevizaki M. Coronary heart disease in postmenopausal women: the role of endogenous estrogens and their receptors. Hormones (Athens) 2007, 6:9-24.
3. Phillips G.B., Pinkernell B.H., Jing T.Y. Relationship between serum sex hormones and coronary artery disease in postmenopausal women. Arterioscler Thromb Vasc Biol 1997, 17:695-701.
4. Sam S., Dunaif A. Polycystic ovary syndrome: syndrome XX?. Trends Endocrinol Metab 2003, 14:365-370.
5. Rexrode K.M., Manson J.E., Lee I.M., Ridker P.M., Sluss P.M., Cook N.R., et al. Sex hormone levels and risk of cardiovascular events in postmenopausal women. Circulation 2003, 108:1688-1693.
6. Golden S.H., Maguire A., Ding J., Crouse J.R., Cauley J.A., Zacur H., et al. Endogenous postmenopausal hormones and carotid atherosclerosis: a case-control study of the atherosclerosis risk in communities cohort. Am J Epidemiol 2002, 155:437-445.
7. Bernini G.P., Sgro M., Moretti A., Argenio G.F., Barlascini C.O., Cristofani R., et al. Endogenous androgens and carotid intimal-medial thickness in women. J Clin Endocrinol Metab 1999, 84:2008-2012.
8. Sievers C., Klotsche J., Pieper L., Schneider H.J., Marz W., Wittchen H.U., et al. Low testosterone levels predict all-cause mortality and cardiovascular events in women: a prospective cohort study in German primary care patients. Eur J Endocrinol 2010, 163:699-708.
9. Ling S., Dai A., Williams M.R., Myles K., Dilley R.J., Komesaroff P.A., et al. Testosterone (T) enhances apoptosis-related damage in human vascular endothelial cells. Endocrinology 2002, 143:1119-1125.
10. Haffner S.M., Valdez R.A., Morales P.A., Hazuda H.P., Stern M.P. Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men. J Clin Endocrinol Metab 1993, 77:56-60.
11. Ding E.L., Song Y., Manson J.E., Hunter D.J., Lee C.C., Rifai N., et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009, 361:1152-1163.
12. Sutton-Tyrrell K., Wildman R.P., Matthews K.A., Chae C., Lasley B.L., Brockwell S., et al. Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN). Circulation 2005, 111:1242-1249.
13. Calderon-Margalit R., Schwartz S.M., Wellons M.F., Lewis C.E., Daviglus M.L., Schreiner P.J., et al. Prospective association of serum androgens and sex hormone-binding globulin with subclinical cardiovascular disease in young adult women: the " Coronary Artery Risk Development in Young Adults" women's study. J Clin Endocrinol Metab 2010, 95:4424-4431.
14. Kalme T., Seppala M., Qiao Q., Koistinen R., Nissinen A., Harrela M., et al. Sex hormone-binding globulin and insulin-like growth factor-binding protein-1 as indicators of metabolic syndrome, cardiovascular risk, and mortality in elderly men. J Clin Endocrinol Metab 2005, 90:1550-1556.
15. Hogeveen K.N, Talikka M., Hammond G.L. Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element within an Alu sequence. J Biol Chem 2001, 276:36383-36390.
16. Xita N., Tsatsoulis A., Chatzikyriakidou A., Georgiou I. Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. J Clin Endocrinol Metab 2003, 88:5976-5980.
17. Cousin P., Calemard-Michel L., Lejeune H., Raverot G., Yessaad N., Emptoz-Bonneton A., et al. Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women. J Clin Endocrinol Metab 2004, 89:917-924.
18. Ferk P., Teran N., Gersak K. The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome. Hum Reprod 2007, 22:1031-1036.
19. Xita N., Tsatsoulis A., Stavrou I., Georgiou I. Association of SHBG gene polymorphism with menarche. Mol Hum Reprod 2005, 11:459-462.
20. Xita N., Georgiou I., Lazaros L., Psofaki V., Kolios G., Tsatsoulis A. The role of sex hormone-binding globulin and androgen receptor gene variants in the development of polycystic ovary syndrome. Hum Reprod 2008, 23:693-698.
21. Alevizaki M., Saltiki K., Xita N., Cimponeriu A., Stamatelopoulos K., Mantzou E., et al. The importance of the (TAAAA)n alleles at the SHBG gene promoter for the severity of coronary artery disease in postmenopausal women. Menopause 2008, 15:461-468.
22. Chobanian A.V., Bakris G.L., Black H.R., Cushman W.C., Green L.A., Izzo J.L., et al. Seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Hypertension 2003, 42:1206-1252.
23. Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 85:2486-97.
24. Vermeulen A., Verdonck L., Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999, 84:3666-3672.
25. Saltiki K., Papageorgiou G., Voidonikola P., Mantzou E., Xiromeritis K., Papamichael C., et al. Endogenous estrogen levels are associated with endothelial function in males independently of lipid levels. Endocrine 2010, 37:329-335.
26. Joannides R., Haefeli W.E., Linder L., Richard V., Bakkali E.H., Thuillez C., et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 1995, 91:1314-1319.
27. Simon A., Gariepy J., Chironi G., Megnien J.L., Levenson J. Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 2002, 20:159-169.
28. Haiman C.A., Riley S.E., Freedman M.L., Setiawan V.W., Conti D.V., Le Marchand L. Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating SHBG levels among postmenopausal women: the multiethnic cohort. J Clin Endocrinol Metab 2005, 90:2198-2204.
29. O'Leary D.H., Polak J.F., Kronmal R.A., Manolio T.A., Burke G.L., Wolfson S.K. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999, 340:14-22.
30. Xita N., Tsatsoulis A. Genetic variants of sex hormone-binding globulin and their biological consequences. Mol Cell Endocrinol 2010, 316:60-65.
31. Xita N., Tsatsoulis A. Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental clinical, and genetic association studies. J Clin Endocrinol Metab 2006, 91:1660-1666.
32. Abbott D.H., Dumesic D.A., Franks S. Developmental origin of polycystic ovary syndrome-a hypothesis. J Endocrinol 2002, 174:1-5.
33. Xita N., Milionis H.J., Galidi A., Lazaros L., Katsoulis K., Elisaf M.S., et al. The (TAAAA)n polymorphism of the SHBG gene in men with the metabolic syndrome. Exp Clin Endocrinol Diabetes 2011, 119:126-128.
34. Wu F., Ames R., Evans M.C., France J.T., Reid I.R. Determinants of sex hormone-binding globulin in normal postmenopausal women. Clin Endocrinol (Oxf) 2001, 54:81-87.
35. Lee C.C., Kasa-Vubu J.Z., Supiano M.A. Androgenicity and obesity are independently associated with insulin sensitivity in postmenopausal women. Metabolism 2004, 53:507-512.
36. Ouyang P., Vaidya D., Dobs A., Golden S.H., Szklo M., Heckbert S.R., et al. Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the multi-ethnic study of atherosclerosis. Atherosclerosis 2009, 204:255-261.
37. Wildman R.P., Colvin A.B., Powell L.H., Matthews K.A., Everson-Rose S.A., Hollenberg S., et al. Associations of endogenous sex hormones with the vasculature in menopausal women: the Study of Women's Health Across the Nation (SWAN). Menopause 2008, 15:414-421.
38. Karim R., Hodis H.N., Stanczyk F.Z., Lobo R.A., Mack W.J. Relationship between serum levels of sex hormones and progression of subclinical atherosclerosis in postmenopausal women. J Clin Endocrinol Metab 2008, 93:131-138.