Discovery of new orally active prostaglandin D2 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 22, 2011, Pages 6935-6948

  Iwahashi, Maki ^a   Naganawa, Atsushi ^a   Kinoshita, Atsushi ^a   Shimabukuro, Atsushi ^a   Nishiyama, Toshihiko ^a   Ogawa, Seiji ^a   Matsunaga, Yoko ^a   Tsukamoto, Kohki ^a   Okada, Yutaka ^a   Matsumoto, Ryoji ^a   Nambu, Fumio ^a   Oumi, Rie ^a   Odagaki, Yoshihiko ^a   Katagi, Jun ^a   Yano, Koji ^a   Tani, Kousuke ^a   Nakai, Hisao ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Antagonist; DP receptor; Phenylacetic acid; Prostaglandin

Indexed keywords

(4 CHLORO 3 NITROPHENYL)(HYDROXY)ACETIC ACID; (4 CHLORO 3 NITROPHENYL)[(TRIMETHYLSILYL)OXYL]ACETONITRILE; 1 (4 CHLORO 3 NITROPHENYL)CYCLOPROPANECARBONITRILE; 1 (4 CHLORO 3 NITROPHENYL)CYCLOPROPANECARBOXYLIC ACID; 2 (4 CHLORO 3 NITROPHENYL) 2 METHYLPROPANENITRILE; 2 (4 CHLORO 3 NITROPHENYL) 2 METHYLPROPANOIC ACID; 2 [4 CHLORO 3 [[2,6 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL]AMINO]PHENYL] 2 METHYLPROPANOIC ACID; 2,6 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOIC ACID; 2,6 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL CHLORIDE; 3 BENZOYLAMINOPHENYLACETIC ACID DERIVATIVE; CYCLIC AMP; ETHYL (4 CHLORO 3 NITROPHENYL)(DIFLUORO)ACETATE; ETHYL (4 CHLORO 3 NITROPHENYL)(HYDROXY)ACETATE; ETHYL (4 CHLORO 3 NITROPHENYL)(OXO)ACETATE; MEPYRAMINE; METHYL (3 AMINO 4 CHLOROPHENYL)(DIFLUORO)ACETATE; METHYL 1 (3 AMINO 4 CHLOROPHENYL)CYCLOPROPANECARBOXYLATE; METHYL 1 (4 CHLORO 3 NITROPHENYL)CYCLOPROPANECARBOXYLATE; METHYL 2 (3 AMINO 4 CHLOROPHENYL) 2 METHYLPROPANOATE; METHYL 2 (4 CHLORO 3 NITROPHENYL) 2 METHYLPROPANOATE; PROSTAGLANDIN D2 RECEPTOR ANTAGONIST; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; [3 [[2,3 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL]AMINO] 4 METHYLPHENYL]ACETIC ACID; [3 [[2,3 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL]AMINO]PHENYL]ACETIC ACID; [3 [[2,5 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL]AMINO] 4 METHYLPHENYL]ACETIC ACID; [3 [[2,5 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL]AMINO]PHENYL]ACETIC ACID; [3 [[2,6 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL]AMINO] 4 METHYLPHENYL]ACETIC ACID; [3 [[2,6 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL]AMINO]PHENYL]ACETIC ACID; [4 CHLORO 3 [[2,6 DIMETHYL 4 [(4 METHYL 3,4 DIHYDRO 2H 1,4 BENZOXAZIN 2 YL)METHOXY]BENZOYL]AMINO]PHENYL]ACETIC ACID;

ANIMAL CELL; ANIMAL TISSUE; AREA UNDER THE CURVE; BLOOD VESSEL PERMEABILITY; CHEMICAL MODIFICATION; CONFERENCE PAPER; CONFORMATION; CONJUNCTIVA; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL MODEL; GUINEA PIG; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; THROMBOCYTE RICH PLASMA;

CAVIA;

EID: 80054982175     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.065     Document Type: Article

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