Comparative immunohistochemical expression of RANK, RANKL and OPG in radicular and dentigerous cysts

Archives of Oral Biology

Volumn 56, Issue 11, 2011, Pages 1256-1263

  De Moraes, Maiara ^a   De Lucena, Hévio Freitas ^a   De Azevedo, Paulo Roberto Medeiros ^a   Queiroz, Lélia Maria Guedes ^a   Costa, Antonio De Lisboa Lopes ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

Author keywords

Dentigerous cyst; Radicular cyst; RANK ligand and osteoprotegerin; Receptor activator of nuclear factor B

Indexed keywords

OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B;

ADOLESCENT; ADULT; ARTICLE; BIOSYNTHESIS; CHILD; COMPARATIVE STUDY; EPITHELIUM; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; JAW DISEASE; MALE; METABOLISM; MIDDLE AGED; ODONTOGENIC CYST; OSTEOCLAST; TERATOMA;

ADOLESCENT; ADULT; CHILD; DENTIGEROUS CYST; EPITHELIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MANDIBULAR DISEASES; MAXILLARY DISEASES; MIDDLE AGED; OSTEOCLASTS; OSTEOPROTEGERIN; RADICULAR CYST; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; YOUNG ADULT;

EID: 80054976277     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.archoralbio.2011.05.009     Document Type: Article

References (37)

1. R.M. Browne The pathogenesis of odontogenic cysts: a review J Oral Pathol 4 1975 31 46
2. C.R.L.V. Figueiredo, J.N. Santos, and R.L.C. Albuquerque Júnior Mecanismos imunopatológicos de formaão e expansão do cisto radicular: uma abordagem atual RPG Rev Pós Grad 6 2 1999 180 187
3. L.M. Lin, G.T. Huang, and P.A. Rosenberg proliferation of epithelial cell rests formation of apical cysts, and regression of apical cysts after periapical wound healing J Endod 33 8 2007 908 916
4. M. Shear Developmental odontogenic cysts. An update J Oral Pathol Med 23 1994 1 11
5. P. Stashenko, R. Teles, and R. D'Souza Periapical inflammatory responses and their modulation Crit Rev Oral Biol Med 9 4 1998 498 521 (Pubitemid 29402013)
6. S.Y. Fukada, T.A. Silva, G.P. Garlet, A.L. Rosa, J.S. Silva, and F.Q. Cunha Factors involved in the T helper type 1 and type 2 cell commitment and osteoclast regulation in inflammatory apical diseases Oral Microbiol Immunol 24 1 2009 25 31
7. L.B. Souza, M.A. Gordón-Núñez, C.F.W. Nonaka, M.C. Medeiros, T.F. Torres, and G.B. Guedes-Emiliano Odontogenic cysts: demographic profile in a Brazilian population over a 38-year period Med Oral Patol Oral Cir Bucal 15 4 2010 e583 e590
8. R.L. Avelar, A.A. Antunes, R.W. Carvalho, P.G. Bezerra, P.J. Oliveira Neto, and E.S. Andrade Odontogenic cysts: a clinicopathological study of 507 cases J Oral Sci 51 4 2009 581 586
9. F.R. Andrade, D.P. Sousa, E.F. Mendona, T.A. Silva, V.S. Lara, and A.C. Batista Expression of bone resorption regulators (RANK RANKL, and OPG) in odontogenic tumors Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106 4 2008 548 555
10. N. Bostanci, T. Ilgenli, G. Emingil, B. Afacan, B. Han, and H. Töz Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio J Clin Periodontol 34 5 2007 370 376
11. T. Crotti, D. Smith, R. Hirsch, S. Soukoulis, H. Weedon, and M. Capone Receptor activator NFκB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis J Periodontal Res 38 4 2003 380 387 (Pubitemid 37465544)
12. F.-H. Chuang, S.-S. Hsue, C.-W. Wu, and Y.-K. Chen Immunohistochemical expression of RANKL RANK and OPG in human oral squamous cell carcinoma J Oral Pathol Med 38 10 2009 753 758
13. H. Kumamoto, and K. Ooya Expression of parathyroid hormone-relates protein (PTHrP), osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-kappaB (RANKL) and osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin (OPG) in ameloblastomas J Oral Pathol Med 33 1 2004 46 52 (Pubitemid 38159976)
14. R. Menezes, C.M. Bramante, K.B.S. Paiva, A. Letra, E. Carneiro, and W.F. Zambuzzi Receptor activator NF-B-ligand and osteoprotegerin protein expression in human radicular cysts and granulomas Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102 3 2006 404 409 (Pubitemid 44251188)
15. R. Menezes, T.P. Garlet, A. Letra, C.M. Bramante, A.P. Campanelli, and R.C. Figueira Differential patterns of receptor activator of nuclear factor kappa b ligand/osteoprotegerin expression in human radicular granulomas: possible association with progressive or stable nature of the lesions J Endod 34 8 2008 932 938
16. T.A. Silva, A.C. Batista, E.F. Mendona, C.R. Leles, S. Fukada, and F.Q. Cunha Comparative expression of RANK RANKL, and OPG in keratocystic odontogenic tumors, ameloblastomas, and dentigerous cysts Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106 3 2008 333 341
17. R. Vernal, A. Dezerega, N. Dutzan, A. Chaparro, R. León, and S. Chandía RANKL in human radicular granuloma: possible involvement in radicular bone destruction Oral Dis 12 2006 283 289 (Pubitemid 43736416)
18. L.C. Hofbauer, and A.E. Heufelder Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology J Mol Med 79 2001 243 253 (Pubitemid 32646379)
19. D. Aeschlimann, and B.A.J. Evans The vital osteoclast: how is it regulated? Cell Death Differ 11 2004 S5 S7
20. J.Y.Y. Tay, B.H. Bay, J.F. Yeo, M. Harris, S. Meghji, and S.T. Dheen Identification of RANKL in osteolytic lesions of the facial skeleton J Dent Res 83 2004 349 353 (Pubitemid 41713774)
21. W.J. Boyle, W.S. Simonet, and D.L. Lacey Osteoclast differentiation and activation Nature 423 2003 337 342 (Pubitemid 40852708)
22. L.C. Hofbauer Pathophysiology of RANK ligand (RANKL) and osteoprotegerin (OPG) Ann Endocrinol 67 2 2006 139 141
23. C.F. Nonaka, A.P. Maia, G.J. Nascimento, R. de Almeida Freitas, L. Batista de Souza, and H.C. Galvão Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106 6 2008 896 902
24. ImageJ: Image processing and analysis in Java [computer program] 2004 National Institutes of Health Bethesda, MD (USA) Computerized Image Systems
25. S. Khosla, and Minireview: The OPG/RANKL/RANK system Endocrinology 142 12 2001 550 555
26. M. Alnaeeli, J. Park, D. Mahamed, J.M. Penninger, and Y-T.A. Teng Dendritic cells at the osteo-immune interface: implications for inflammation induced bone loss J Bone Miner Res 22 2007 775 780 (Pubitemid 351339736)
27. A. Rivollier, M. Mazzorana, J. Tebib, M. Piperno, T. Aitsiselmi, and C. Rabourdin-Combe Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by rheumatoid arthritis microenvironment Blood 104 2004 4029 4037 (Pubitemid 39620153)
28. K. Loser, A. Mehling, S. Loeser, J. Apelt, A. Kuhn, and S. Grabbe Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells Nat Med 12 12 2006 1372 1379 (Pubitemid 44924495)
29. T. Katagiri, and N. Takahashi Regulatory mechanisms of osteoblast and osteoclast differentiation Oral Dis 8 2002 147 159 (Pubitemid 34535063)
30. P.N.R. Nair, G. Sundqvist, and U. Sjögren Experimental evidence supports the abscess theory of development of radicular cysts Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106 2 2008 294 303
31. M. Baud'huin, F. Lamoureux, L. Duplomb, F. Rédini, and D. Heymann RANKL RANK, osteoprotegerin: key partners of osteoimunology and vascular diseases Cell Mol Life Sci 64 2007 2334 2350 (Pubitemid 47402577)
32. R. Leonardi, M. Caltabiano, M. Pagano, V. Pezzuto, C. Loreto, and G. Palestro Detection of vascular endothelial growth factor/vascular permeability factor in periapical lesions J Endod 29 3 2003 180 183 (Pubitemid 43210846)
33. G.K. Mitrou, K.I. Tosios, A. Kyroudi, and A. Skalavounu Odontogenic keratocyst expresses vascular endothelial growth factor: an immunohistochemical study J Oral Pathol Med 38 5 2009 470 475
34. J.-K. Min, Y.-M. Kim, Kim Y-Mi, E.-C. Kim, Y.S. Gho, and I.-J. Kang Vascular endothelial growth factor up-regulates expression of receptor activator of NF-B (RANK) in endothelial cells J Biol Chem 278 41 2003 39548 39557
35. S. Niida, M. Kaku, H. Amano, H. Yoshida, H. Kataoka, and S. Nishikawa Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption J Exp Med 190 2 1999 293 298 (Pubitemid 29354921)
36. M. Nakagawa, T. Kaneda, T. Arakawa, S. Morita, T. Sato, and T. Yomada Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts FEBS Lett 473 2 2000 161 164 (Pubitemid 30254282)
37. N. Kawashima, N. Suzuki, G. Yang, C. Ohi, S. Okuhara, and Nakano-Kawanishi Kinetics of RANKL RANK and OPG expressions in experimentally induced rat radicular lesions Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 5 2007 707 711