Syntheses of phenylpyrazolodiazepin-7-ones as conformationally rigid analogs of aminopyrazole amide scaffold and their antiproliferative effects on cancer cells

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 22, 2011, Pages 6760-6767

  Kim, Hyangmi ^a   Kim, Minjung ^a   Lee, Junghun ^a   Yu, Hana ^a   Hah, Jung Mi ^a  

^a Hanyang University   (South Korea)

Author keywords

Antiproliferative activity; Cancer cell line; Dihydropyrazolodiazepinone; Kinase inhibitor; Kinase selectivity

Indexed keywords

1 (3 CHLOROPHENYL) 3 [3 [1 (4 METHOXYBENZYL) 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL]PHENYL]UREA; 1 (3,4 DICHLOROPHENYL) 3 [3 (7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL]UREA; 1 (3,4 DICHLOROPHENYL) 3 [3 [1 (4 METHOXYBENZYL) 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL]PHENYL]UREA; 1 (3,5 DICHLOROPHENYL) 3 [3 [1 (4 METHOXYBENZYL) 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL]PHENYL]UREA; 1 (4 CHLOROPHENYL) 3 [3 (7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL]UREA; 1 (4 CHLOROPHENYL) 3 [3 [1 (4 METHOXYBENZYL) 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL]PHENYL]UREA; 1 [3 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL] 3 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [3 [1 (4 METHOXYBENZYL) 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL]PHENYL] 3 [3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [3 [1 (4 METHOXYBENZYL) 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL]PHENYL] 3 [3 MORPHOLINO 5 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [3 [1 (4 METHOXYBENZYL) 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL]PHENYL] 3 [4 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [4 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL] 3 (3 CHLOROPHENYL)UREA; 1 [4 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL] 3 [3 (4 METHYL 1H IMIDAZOL 1 YL) 5 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [4 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL] 3 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 3 [4 (7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL]UREA; 1 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 3 [4 [1 (4 METHOXYBENZYL) 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL]PHENYL]UREA; AMINOPYRAZOLE AMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; N [3 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL] 3 MORPHOLINO 5 (TRIFLUOROMETHYL)BENZAMIDE; N [3 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL] 4 CHLORO 3 (TRIFLUOROMETHYL)BENZAMIDE; N [3 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL] 4 MORPHOLINO 3 (TRIFLUOROMETHYL)BENZAMIDE; N [3 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[4,3 B][1,4]DIAZEPIN 5 YL)PHENYL] 3 (4 METHYL 1H IMIDAZOL 1 YL) 5 (TRIFLUOROMETHYL)BENZAMIDE; N [4 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL] 3 CHLORO 4 (TRIFLUOROMETHYL)BENZAMIDE; N [4 (1 BENZYL 7 OXO 1,6,7,8 TETRAHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 5 YL)PHENYL] 4 MORPHOLINO 3 (TRIFLUOROMETHYL)BENZAMIDE; PHENYL 6,8 DIHYDROPYRAZOLO[3,4 B][1,4]DIAZEPIN 7(1H) ONE DERIVATIVE; PHENYLPYRAZOLODIAZEPIN 7 ONE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; RAF KINASE INHIBITOR; SORAFENIB; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER CELL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MELANOMA CELL;

AMIDES; AZEPINES; CELL GROWTH PROCESSES; CELL LINE, TUMOR; HUMANS; MELANOMA; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS;

PUFFINUS AURICULARIS; TRIFLUORO;

EID: 80054974235     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.042     Document Type: Conference Paper

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