In vitro analysis and mechanical properties of twin screw extruded single-layered and coextruded multilayered poly(caprolactone) scaffolds seeded with human fetal osteoblasts for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 99 A, Issue 3, 2011, Pages 354-366

  Ergun, Asli ^a   Yu, Xiaojun ^a   Valdevit, Antonio ^a   Ritter, Arthur ^a   Kalyon, Dilhan M ^a  

^a Stevens Institute of Technology   (United States)

Author keywords

bone; extrusion and coextrusion; poly(caprolactone); scaffold; tissue engineering

Indexed keywords

ALIZARIN RED; ALKALINE PHOSPHATASE; BONE GRAFT SUBSTITUTES; BONE TISSUE ENGINEERING; BONE TISSUE REGENERATION; CANCELLOUS BONE; CELL MIGRATION; CELL VIABILITY; CO-EXTRUSION TECHNIQUES; COMPRESSIVE FATIGUE; CONTINUOUS MIXING; EXTRACELLULAR MATRICES; IN-VITRO; IN-VITRO ANALYSIS; MATRIX SYNTHESIS; MULTI-LAYERED; OSTEOGENIC SUPPLEMENTS; PREOSTEOBLASTIC CELLS; TISSUE CONSTRUCTS; TWIN SCREW; TWIN SCREW EXTRUSION;

BIOMECHANICS; BONE; COEXTRUSION; CONFOCAL MICROSCOPY; CYTOLOGY; MECHANICAL PROPERTIES; MULTILAYERS; PHOSPHATASES; SCANNING ELECTRON MICROSCOPY; SCREWS; TISSUE;

SCAFFOLDS (BIOLOGY);

ALKALINE PHOSPHATASE; POLYCAPROLACTONE; TISSUE SCAFFOLD;

ARTICLE; BIOMECHANICS; BONE DEVELOPMENT; BONE MATRIX; BONE MINERALIZATION; BONE REGENERATION; BONE SCREW; BONE TISSUE; CELL CULTURE; CELL DIFFERENTIATION; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONFOCAL MICROSCOPY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FETUS; FOAM; HUMAN; HUMAN CELL; NANOFABRICATION; OSSIFICATION; OSTEOBLAST; POROSITY; SCANNING ELECTRON MICROSCOPY; TISSUE ENGINEERING; TWIN SCREW;

ALKALINE PHOSPHATASE; BIOMECHANICS; BONE AND BONES; BONE SCREWS; CALCIUM; CELL COMMUNICATION; CELL COUNT; CELLS, CULTURED; COMPRESSIVE STRENGTH; FETUS; HUMANS; MATERIALS TESTING; MECHANICAL PHENOMENA; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; OSTEOBLASTS; POLYESTERS; STRESS, MECHANICAL; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 80054973797     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.33190     Document Type: Article

References (48)

1. Kanczler JM, Oreffo ROC,. Osteogenesis and angiogenesis: The potential for engineering bone. Eur Cell Mater 2008; 15: 100-114. (Pubitemid 351955734)
2. Botchwey EA, Pollack SR, Levine EM, Laurencin CT,. Bone tissue engineering in a rotating bioreactor using a microcarrier matrix system. J Biomed Mater Res 2001; 55: 242-253. (Pubitemid 32198507)
3. Porter JR, Ruckh TT, Popat CK,. Bone tissue engineering: A review in bone biomimetics and drug delivery strategies. Biotechnol Prog 2009; 25: 1539-1560.
4. Van Gaalen SM, Dhert WJA, Van Den Muysenberg A, Oner FC, Van Blitterswijk C, Verbout AJ, De Bruijn JD,. Bone tissue engineering for spine fusion: An experimental study on ectopic and orthotopic implants in rats. Tissue Eng. 2004; 10 (1/2): 231-239. (Pubitemid 38199378)
5. Healy KE, Guldberg RE,. Bone tissue engineering. J Musculoskelet NeuronaI Interact 2007; 7: 328-330.
6. Qian Y, Lin Z, Chen J, Fan Y, Davey T, Cake M, Day R, Dai K, Xu J, Zheng M,. Natural bone collagen scaffold combined with autologous enriched bone marrow cells for induction of osteogenesis in an ovine spinal fusion model. Tissue Eng 2009; 15: 3547-3558.
7. Chau AMT, Mobbs RJ,. Bone graft substitutes in anterior cervical discectomy and fusion. Eur Spine J 2009; 18: 449-464.
8. Frohlich M, Grayson WL, Wan LQ, Marolt D, Drobnic M, Vunjak-Novakovic G,. Tissue engineered bone grafts: Biological requirements, tissue culture and clinical relevance. Cur Stem Cell Res Ther 2008; 3: 254-264.
9. Wang J, Yu X,. Preparation, characterization and in vitro analysis of novel structured nanofibrous scaffolds for bone tissue engineering. Acta Biomater 2010; 6: 3004-3012.
10. Wang J, Valmikinathan CM, Liu W, Laurencin CT, Yu X,. Spiral-structured nanofibrous, 3D scaffolds for bone tissue engineering. J Biomed Mater Res A 2010; 93: 753-762.
11. Langer R, Vacanti JP,. Tissue engineering. Science 1993; 260: 920-926. (Pubitemid 23209960)
12. Navarro M, Michiardi A, Castano O, Planell JA,. Biomaterials in orthopaedics. J R Soc Interface 2008; 5: 1137-1158.
13. Nair LS, Laurencin CT,. Biodegradable polymers as biomaterials. Prog Polym Sci 2007; 32: 762-798. (Pubitemid 47198287)
14. Martina M, Hutmacher DM,. Biodegradable polymers applied in tissue engineering research: A review. Polym Int 2007; 56: 145-157. (Pubitemid 46165222)
15. Gunatillake PA, Adhikari R,. Biodegradable synthetic polymers for tissue engineering. Eur Cell Mater 2003; 5: 1-16. (Pubitemid 38957397)
16. Yang S, Leong K-F, Du Z, Chua C-K,. The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Eng 2001; 7: 679-689. (Pubitemid 34042301)
17. Liu CZ, Czernuszka JT,. Development of biodegradable scaffolds for tissue engineering: A perspective on emerging technology. Mater Sci Technol 2007; 23: 379-391. (Pubitemid 47447699)
18. Hutmacher DW, Sittinger M, Risbud MV,. Scaffold-based tissue engineering: Rationale for computer-aided design and solid-form fabrication systems. Trends Biotechnol 2004; 22: 355-362.
19. Smith LA, Ma PX,. Nano-fibrous scaffolds for tissue engineering. Colloids Surf B Biointerfaces 2004; 39: 124-131.
20. Khademhosseini A, Langer R, Borenstein J, Vacanti JP,. Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci USA 2006; 103: 2480-2487.
21. Erisken C, Kalyon D, Wang H,. A hybrid twin screw extrusion/ electrospinning method to process nanoparticle-incorporated electrospun nanofibers. Nanotechnology 2008; 19: 165302.
22. Erisken C, Kalyon DM, Wang H,. Functionally and continuously graded electrospun polycaprolactone and β-tricalcium phosphate nanocomposites for interface tissue engineering applications. Biomaterials 2008; 29: 4065-4073.
23. Ozkan S, Kalyon D, Yu X,. Functionally graded β-TCP/PCL nanocomposite scaffolds for bone tissue engineering: In vitro evaluation with human fetal osteoblast cells. J Biomed Mater Res A 2009; 92: 1007-1018.
24. Yang X, Chen X, Wang H,. Acceleration of osteogenic differentiation of preosteoblastic cells by chitosan containing nanofibrous scaffolds. Biomacromolecules 2009; 10: 2772-2778.
25. Leong KF, Chua CK, Sudarmadji N, Yeong WY,. Engineering functionally graded tissue engineering scaffolds. J Mech Behav Biomed Mater 2008; 1: 140-152. (Pubitemid 351217067)
26. Kalyon D,. An analytical model for steady co-extrusion of viscoplastic fluids in thin slit dies with wall slip. Polym Eng Sci 2010; 50: 652-664.
27. Hutmacher DW, Schantaz T, Zein I, Ng KW, Teoh SH, Tan KC,. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res A 2001; 55: 203-216. (Pubitemid 32198503)
28. Ciapetti G, Ambrosio L, Savarino L, Granchi D, Cenni E, Baldini N, Pagani S, Guizzardi S, Causa F, Giunti A,. Osteoblast growth and function in porous poly ε-caprolactone matrices for bone repair: A preliminary study. Biomaterials 2003; 24: 3815-3824. (Pubitemid 36773615)
29. Brouwers JEM, Ruchelsman M, Rietbergen B, Bouxsein ML,. Determination of rat vertebral bone compressive fatigue properties in untreated intact rats and zoledronic-acid-treated, ovariectimized rats. Osteoporos Int 2009; 20: 1377-1384.
30. Haddock SM, Yeh OC, Mummaneni PV, Rosenberg WS, Keaveny TM,. Similarity in the fatigue behavior of trabecular bone across site and species. J Biomech 2004; 37: 181-187. (Pubitemid 38050048)
31. Reignier J, Huneault MA,. Preparation, of interconnected poly (ε-caprolactone) porous scaffolds by a combination of polymer and salt particulate leaching. Polymer 2006; 47: 4703-4717. (Pubitemid 44183740)
32. Malik M, Kalyon DM,. Three-dimensional finite element simulation of processing of generalized newtonian fluids in counter-rotating and tangential twin screw extruder and die combination. Int Polym Process 2005; 20: 398-409. (Pubitemid 43041406)
33. Kalyon DM, Malik M,. An integrated approach for numerical analysis of coupled flow and heat transfer in co-rotating twin screw extruders. Int Polym Process 2007; 22: 293-302.
34. Karageorgiou V, Kaplan D,. Porosity of 3D biomaterials and osteogenesis. Biomaterials 2005; 26: 5474-5491.
35. Wang J, Cheung MK, Mi Y,. Miscibility and morphology in crystalline/amorphous blends of poly(caprolactone)/poly(4-vinylphenol) as studied by DSC. FTIR and 13C solid state NMR. Polymer 2002; 43: 1357-1364. (Pubitemid 33140084)
36. Burr DB, Milgrom C, Fyhrie D, Forwood M, Nyska M, Finestone A, Hoshaw S, Saiag E, Simkin A,. In vivo measurement of human tibial strains during vigorous activity. Bone 1996; 18: 405-410. (Pubitemid 26152302)
37. Tsigkou O, Hench LL, Boccaccini AR, Polak JM, Stevens MM,. Enhanced differentiation and mineralization of human fetal osteoblasts on PDLLA containing Bioglass® composite films in the absence of osteogenic supplements. J Biomed Mater Res A 2006; 80: 837-851.
38. Setzer B, Bachle M, Metzger MC, Kohal RJ,. The gene-expression and phenotypic response of hFOB 1.19 osteoblasts to surface-modified titanium and zirconia. Biomaterials 2009; 30: 979-990.
39. Anselme K,. Osteoblast adhesion on biomaterials. Biomaterials 2000; 21: 667-681. (Pubitemid 30109157)
40. Akay G, Birch MA, Bokhari MA,. Microcellular polyHIPE polymer supports osteoblast growth and bone formation in vitro. Biomaterials 2004; 25: 3991-4000. (Pubitemid 38388565)
41. Goldstein AS, Juarez TM, Helmke CD, Gustin MC, Mikos AG,. Effect of convection on osteoblastic cell growth and function in biodegradable polymer foam scaffolds. Biomaterials 2001; 22: 1279-1288. (Pubitemid 32409949)
42. Lian JB, Stein GS,. Concepts of osteoblastic growth and differentiation: Basis for modulation of bone cell development and tissue formation. Crit Rev Oral Biol Med 1992; 3: 269-305.
43. Kalyon DM, Erisken C, Wang H,. Viscoelastic and biomechanical properties of osteochondral tissue constructs generated from polycaprolactone and beta-tricalcium phosphate composites. J Biomech Eng 2010; 132: 091013.
44. Shea LD, Wang D, Franceschi RT, Mooney DJ,. Engineered bone development from a pre-osteoblast cell line on three-dimensional scaffolds. Tissue Eng 2000; 6: 605-617.
45. Yaszemski MJ, Payne RG, Hayes WC, Langer R, Mikos AG,. Evolution of bone transplantation: Molecular, cellular and tissue strategies to engineer human bone. Biomaterials 1996; 17: 175-185. (Pubitemid 26031373)
46. Hutmacher DW,. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000; 21: 2529-2543.
47. Rajadhyaksh A, Kamerlink J, Xavier S, Knee E, Valdevit A, Errico T,. Determination of prosthesis migration and stability in three lumbar total disc arthroplasty designs. In: Annual Meeting of the Orthopaedic Research Society (ORS), New Orleans, LA; March 6-9, 2010. #1451.
48. Chung R, Jakimaviciute V, ElSayed T, Valdevit A, Ritter A, Errico T,. Bone isotropy characterization under fatigue loading within the vertebral body. In: Annual Meeting of the Orthopaedic Research Society (ORS), New Orleans, LA; March 6-9, 2010. #633.