Cytokine Gene Expression in the Tissues of Dogs Infected by Leishmania infantum

Journal of Comparative Pathology

Volumn 145, Issue 4, 2011, Pages 336-344

  Barbosa, M A G ^a   Alexandre Pires, G ^b   Soares Clemente, M ^c   Marques, C ^c   Rodrigues, O Roos ^c   De Brito, T Villa ^b   Da Fonseca, I Pereira ^b   Alves, L C ^a   Santos Gomes, G M ^c  

^a UNIVERSIDADE FEDERAL RURAL DE PERNAMBUCO   (Brazil)

^b FACULDADE DE MEDICINA VETERINÁRIA   (Portugal)

^c INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

Canine leishmaniosis; Cytokine; Gene expression; Tissue

Indexed keywords

ADVANTIX; ALLOPURINOL; DELTAMETHRIN; GAMMA INTERFERON; IMIDACLOPRID; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; MEGLUMINE ANTIMONATE; MESSENGER RNA; PERMETHRIN; SCALIBOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; FEMALE; GENE EXPRESSION; GENETIC CODE; IMMUNE RESPONSE; LEISHMANIA INFANTUM; LEISHMANIASIS; LEUKOCYTE; LYMPH NODE; MALE; NONHUMAN; PRIORITY JOURNAL; TH1 TH2 BALANCE;

ANIMALS; BONE MARROW; BRAZIL; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION REGULATION; HOST-PARASITE INTERACTIONS; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-2; INTERLEUKIN-4; INTERLEUKINS; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; LYMPH NODES; MALE; PORTUGAL; RNA, MESSENGER; TH1 CELLS; TH2 CELLS; TROPICAL CLIMATE; URBAN HEALTH;

ANIMALIA; CANIS FAMILIARIS; LEISHMANIA INFANTUM; PROTOZOA;

EID: 80054972515     PISSN: 00219975     EISSN: 15323129     Source Type: Journal    
DOI: 10.1016/j.jcpa.2011.03.001     Document Type: Article

References (38)

1. Abranches P., Santos-Gomes G., Rachamim N., Campino L., Schnur L.F., et al. An experimental model for canine visceral leishmaniasis. Parasite Immunology 1991, 13:537-550.
2. Alves C.F., de Amorim I.F., Moura E.P., Ribeiro R.R., Alves C.F., et al. Expression of IFN-gamma, TNF-alpha, IL-10 and TGF-beta in lymph nodes associates with parasite load and clinical form of disease in dogs naturally infected with Leishmania (Leishmania) chagasi. Veterinary Immunology and Immunopathology 2009, 128:349-358.
3. Almeida M.C., Vilhena V., Barral A., Barral-Netto M. Leishmanial infection: analysis of its first steps. Memórias do Instituto Oswaldo Cruz 2003, 98:861-870.
4. Awasthi A., Mathur R.H., Saha B. Immune response to Leishmania infection. Indian Journal of Medical Research 2004, 119:238-258.
5. Brachelente C., Muller N., Doherr M.G., Sattler U., Welle M. Cutaneous leishmaniasis in naturally infected dogs is associated with a T helper-2-biased immune response. Veterinary Pathology 2005, 42:166-175.
6. Chamizo C., Moreno J., Alvar J. Semi-quantitative analysis of cytokine expression in asymptomatic canine leishmaniasis. Veterinary Immunology and Immunopathology 2005, 103:67-75.
7. Corrêa A.P.F.L., Dossi A.C.S., Vasconcelos R.O., Munari D.P., Lima V.M.F. Evaluation of transforming growth factor beta-1, interleukin-10, and interferon-γ in male symptomatic and asymptomatic dogs naturally infected by Leishmania (Leishmania) chagasi. Veterinary Parasitology 2007, 143:267-274.
8. Gomes-Pereira S., Rodrigues O.R., Santos-Gomes G.M. Dynamics of CD62L/CD45RB CD4+ and CD8+ lymphocyte subsets in hepatic and splenic tissues during murine visceral leishmaniasis. Immunology Letters 2004, 95:63-70.
9. João A., Pereira M.A., Cortes S., Santos-Gomes G.M. Canine leishmaniasis chemotherapy: dog's clinical condition and risk of Leishmania transmission. Journal of Veterinary Medicine Series A 2006, 53:540-545.
10. Lima V.M.F., Gonçalves M.E., Ikeda F.A., Luvizotto M.C.R., Feitosa M.M. Anti-Leishmania antibodies in cerebrospinal fluid from dogs with visceral leishmaniasis. Brazilian Journal of Medical and Biological Research 2003, 36:485-489.
11. Malek T.R., Yu A., Scibelli P., Lichtenheld M.G., Codias E.K. Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells. Journal of Immunology 2001, 166:1675-1683.
12. Manna L., Reale S., Picillo E., Vitale F., Gravino A.E. Interferon-gamma (IFN-γ), IL-4 expression levels and Leishmania DNA load as prognostic markers for monitoring response to treatment of leishmaniotic dogs with miltefosine and allopurinol. Cytokine 2008, 44:288-292.
13. Manna L., Reale S., Viola E., Vitale F., Manzillo V.F., et al. Leishmania DNA load and cytokine expression levels in asymptomatic naturally infected dogs. Veterinary Parasitology 2006, 142:271-280.
14. Miralles G.D., Stoeckle M.Y., McDermott D.F., Finkelman F.D., Murray H.W. Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis. Infection and Immunity 1994, 62:1058-1063.
15. Molina R., Amela C., Nieto J., San-Andrés M., González F., et al. Infectivity of dogs naturally infected with Leishmania infantum to colonized Phlebotomus perniciosus. Transactions of the Royal Society of Tropical Medicine and Hygiene 1994, 88:491-493.
16. Moreno J., Nieto J., Chamizo C., Gonzalez F., Blanco F., et al. The immune response and PMBC subsets in canine visceral leishmaniasis before, and after, chemotherapy. Veterinary Immunology and Immunopathology 1999, 71:181-195.
17. Overbergh L., Valckx D., Waer M., Mathieu C. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 1999, 11:305-312.
18. Park A.Y., Hondowicz B., Kopf M., Scott P. The role of IL-12 in maintaining resistance to Leishmania major. Journal of Immunology 2002, 168:5771-5777.
19. Peters D., Peters I.R., Farnir F., Clercx C., Day M.J. Real-time RT-PCR quantification of mRNA encoding cytokines and chemokines in histologically normal canine nasal, bronchial and pulmonary tissue. Veterinary Immunology and Immunopathology 2005, 104:195-204.
20. Pinelli E., Gonzalo R.M., Boog C.J.P., Rutten V.P.M.G., del Real G., et al. Leishmania infantum-specific T cells lines derived from asymptomatic dogs that lyse infected macrophages in a major histocompatibility complex-restricted manner. European Journal of Immunology 1995, 25:1594-1600.
21. Pinelli E., Killick-Kendrick R., Wagenaar J., Bernadina W., del Real G., et al. Cellular and humoral immune responses in dogs experimentally and naturally infected with Leishmania infantum. Infection and Immunity 1994, 62:229-235.
22. Pinelli E., Van der Kaaij S.Y., Slappendel R., Fragio C., Ruitenberg E.J., et al. Detection of canine cytokine gene expression by reverse transcription-polymerase chain reaction. Veterinary Immunology and Immunopathology 1999, 69:121-126.
23. Quinnell R.J., Courtenay O., Shaw M.A., Day M.J., Garcez L.M., et al. Tissue cytokine responses in canine visceral leishmaniasis. Journal of Infectious Diseases 2001, 183:1421-1424.
24. Rodrigues O.R., Moura R.A., Gomes-Pereira S., Santos-Gomes G.M. H-2 complex influences cytokine gene expression in Leishmania infantum-infected macrophages. Cell Immunology 2006, 243:118-126.
25. Rosa R., Rodrigues O.R., Marques C., Santos-Gomes G.M. Leishmania infantum soluble proteins released by the parasite exert differential effects on host immune response. Experimental Parasitology 2005, 109:106-114.
26. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. Journal of Immunology 1995, 155:1151-1164.
27. Sanchez-Robert E., Altet L., Alberola J., Rodriguez-Cortés A., Ojeda A., et al. Longitudinal analysis of cytokine gene expression and parasite load in PBMC in Leishmania infantum experimentally infected dogs. Veterinary Immunology and Immunopathology 2008, 125:168-175.
28. Santos-Gomes G.M., Rosa R., Leandro C., Cortes S., Romão P., et al. Cytokine expression during the outcome of canine experimental infection by Leishmania infantum. Veterinary Immunology and Immunopathology 2002, 88:21-30.
29. Sauter S.N., Allenspach K., Gaschen F., Grone A.E., Ontsouka, et al. Cytokine expression in an ex vivo culture system of duodenal samples from dogs with chronic enteropathies: modulation by probiotic bacteria. Domestic Animal Endocrinology 2005, 29:605-622.
30. Thornton A.M., Donovan E.E., Piccirillo C.A., Shevach E.M. Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. Journal of Immunology 2004, 172:6519-6523.
31. Thornton A.M., Shevach E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. Journal of Experimental Medicine 1998, 188:287-296.
32. Travi B.L., Ferro C., Cadena H., Montoya-Lerma J., Adler G.H. Canine visceral leishmaniasis: dog infectivity to sand flies from non-endemic areas. Research in Veterinary Science 2002, 72:83-86.
33. Travi B.L., Tabares C.J., Cadena H., Ferro C., Osorio Y. Canine visceral leishmaniasis in Colombia: relationship between clinical and parasitological status and infectivity for sand flies. American Journal of Tropical Medicine and Hygiene 2001, 64:119-124.
34. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nature Reviews Immunology 2003, 3:133-146.
35. Waldmann T.A. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nature Reviews Immunology 2006, 6:595-601.
36. Waldmann T.A., Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annual Review of Immunology 1999, 17:19-49.
37. Wilson M.E., Weinstock J.V. Hepatic granulomas in murine visceral leishmaniasis caused by Leishmania chagasi. Methods 1996, 9:248-254.
38. Zijlstra E.E., el-Hassan A.M. Leishmaniasis in Sudan. Post kala-azar dermal leishmaniasis. Transactions of the Royal Society of Tropical Medicine and Hygiene 2001, 95:S59-S76.