메뉴 건너뛰기




Volumn 52, Issue 11, 2011, Pages 2045-2049

Myelodysplastic syndromes: The role of the immune system in pathogenesis

Author keywords

Immunotherapeutic approaches; Myeloid leukemias, dysplasias; NK cell biology; T cell mediated immunity

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; LENALIDOMIDE; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL RECEPTOR NKG2D;

EID: 80054967360     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.584002     Document Type: Review
Times cited : (29)

References (37)
  • 1
    • 33749388952 scopus 로고    scopus 로고
    • Immunologic abnormalities in myelodysplastic syndromes: Clinical features and characteristics of the lymphoid population
    • Marisavljevic D, Kraguljac N, Rolovic Z. Immunologic abnormalities in myelodysplastic syndromes: clinical features and characteristics of the lymphoid population. Med Oncol 2006;23:385-392.
    • (2006) Med Oncol , vol.23 , pp. 385-392
    • Marisavljevic, D.1    Kraguljac, N.2    Rolovic, Z.3
  • 2
    • 0029071829 scopus 로고
    • Immunemediated complications in patients with myelodysplastic syndromes-clinical and cytogenetic features
    • Billstrom R, Johansson H, Johansson B, Mitelman F. Immunemediated complications in patients with myelodysplastic syndromes-clinical and cytogenetic features. Eur J Haematol 1995;55:42-48.
    • (1995) Eur J Haematol , vol.55 , pp. 42-48
    • Billstrom, R.1    Johansson, H.2    Johansson, B.3    Mitelman, F.4
  • 3
    • 0034782479 scopus 로고    scopus 로고
    • Oligoclonal T cell expansion in myelodysplastic syndrome: Evidence for an autoimmune process
    • Epperson DE, Nakamura R, Saunthararajah Y, Melenhorst J, Barrett AJ. Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process. Leuk Res 2001;25:1075-1083.
    • (2001) Leuk Res , vol.25 , pp. 1075-1083
    • Epperson, D.E.1    Nakamura, R.2    Saunthararajah, Y.3    Melenhorst, J.4    Barrett, A.J.5
  • 4
    • 7344223859 scopus 로고    scopus 로고
    • Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles
    • Molldrem JJ, Jiang YZ, Stetler-Stevenson M, Mavroudis D, Hensel N, Barrett AJ. Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles. Br J Haematol 1998;102:1314-1322.
    • (1998) Br J Haematol , vol.102 , pp. 1314-1322
    • Molldrem, J.J.1    Jiang, Y.Z.2    Stetler-Stevenson, M.3    Mavroudis, D.4    Hensel, N.5    Barrett, A.J.6
  • 5
    • 0036400123 scopus 로고    scopus 로고
    • Molecular and flow cytometric characterization of the CD4 and CD8 T-cell repertoire in patients with myelodysplastic syndrome
    • Melenhorst JJ, Eniafe R, Follmann D, Nakamura R, Kirby M, Barrett AJ. Molecular and flow cytometric characterization of the CD4 and CD8 T-cell repertoire in patients with myelodysplastic syndrome. Br J Haematol 2002;119:97-105.
    • (2002) Br J Haematol , vol.119 , pp. 97-105
    • Melenhorst, J.J.1    Eniafe, R.2    Follmann, D.3    Nakamura, R.4    Kirby, M.5    Barrett, A.J.6
  • 6
    • 0036252621 scopus 로고    scopus 로고
    • Biology of natural killer cells in cancer and infection
    • Miller JS. Biology of natural killer cells in cancer and infection. Cancer Invest 2002;20:405-419.
    • (2002) Cancer Invest , vol.20 , pp. 405-419
    • Miller, J.S.1
  • 7
    • 0346749331 scopus 로고    scopus 로고
    • Natural killer cells and cancer
    • Wu J, Lanier LL. Natural killer cells and cancer. Adv Cancer Res 2003;90:127-156.
    • (2003) Adv Cancer Res , vol.90 , pp. 127-156
    • Wu, J.1    Lanier, L.L.2
  • 8
    • 33644538600 scopus 로고    scopus 로고
    • Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndromes
    • Kiladjian JJ, Bourgeois E, Lobe I, et al. Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndromes. Leukemia 2006;20:463-470.
    • (2006) Leukemia , vol.20 , pp. 463-470
    • Kiladjian, J.J.1    Bourgeois, E.2    Lobe, I.3
  • 9
    • 34249740754 scopus 로고    scopus 로고
    • Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors
    • Epling-Burnette PK, Bai F, Painter JS, et al. Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood 2007;109:4816-4824.
    • (2007) Blood , vol.109 , pp. 4816-4824
    • Epling-Burnette, P.K.1    Bai, F.2    Painter, J.S.3
  • 10
    • 77956437512 scopus 로고    scopus 로고
    • Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34(+) blasts in myelodysplastic syndrome
    • Carlsten M, Baumann BC, Simonsson M, et al. Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34(+) blasts in myelodysplastic syndrome. Leukemia 2010;24: 1607-1616.
    • (2010) Leukemia , vol.24 , pp. 1607-1616
    • Carlsten, M.1    Baumann, B.C.2    Simonsson, M.3
  • 11
    • 0025868236 scopus 로고
    • The occurrence subtype and significance of haemopoietic inhibitory T cells (HIT cells) in myelodysplasia: An in vitro study
    • Smith MA, Smith JG. The occurrence subtype and significance of haemopoietic inhibitory T cells (HIT cells) in myelodysplasia: an in vitro study. Leuk Res 1991;15: 597-601.
    • (1991) Leuk Res , vol.15 , pp. 597-601
    • Smith, M.A.1    Smith, J.G.2
  • 13
    • 0031888417 scopus 로고    scopus 로고
    • Cyclosporin A therapy in hypoplastic MDS patients and certain refractory anaemias without hypoplastic bone marrow
    • Jonasova A, Neuwirtova R, Cermak J, et al. Cyclosporin A therapy in hypoplastic MDS patients and certain refractory anaemias without hypoplastic bone marrow. Br J Haematol 1998;100:304-309.
    • (1998) Br J Haematol , vol.100 , pp. 304-309
    • Jonasova, A.1    Neuwirtova, R.2    Cermak, J.3
  • 14
    • 33947388858 scopus 로고    scopus 로고
    • Prevalence and clinical association of clonal T-cell expansions in myelodysplastic syndrome
    • Epling-Burnette PK, Painter JS, Rollison DE, et al. Prevalence and clinical association of clonal T-cell expansions in myelodysplastic syndrome. Leukemia 2007;21:659-667.
    • (2007) Leukemia , vol.21 , pp. 659-667
    • Epling-Burnette, P.K.1    Painter, J.S.2    Rollison, D.E.3
  • 15
    • 34547957665 scopus 로고    scopus 로고
    • CD4+CD25high Foxp3+regulatory T cells in myelodysplastic syndrome (MDS)
    • Kordasti SY, Ingram W, Hayden J, et al. CD4+CD25high Foxp3+regulatory T cells in myelodysplastic syndrome (MDS). Blood 2007;110:847-850.
    • (2007) Blood , vol.110 , pp. 847-850
    • Kordasti, S.Y.1    Ingram, W.2    Hayden, J.3
  • 16
    • 58849142953 scopus 로고    scopus 로고
    • Clinical significance of regulatory T cells in patients with myelodysplastic syndrome
    • Hamdi W, Ogawara H, Handa H, Tsukamoto N, Nojima Y, Murakami H. Clinical significance of regulatory T cells in patients with myelodysplastic syndrome. Eur J Haematol 2009;82:201-207.
    • (2009) Eur J Haematol , vol.82 , pp. 201-207
    • Hamdi, W.1    Ogawara, H.2    Handa, H.3    Tsukamoto, N.4    Nojima, Y.5    Murakami, H.6
  • 17
    • 62549141807 scopus 로고    scopus 로고
    • Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+regulatory T cells in myelodysplastic syndromes (MDS)
    • Kotsianidis I, Bouchliou I, Nakou E, et al. Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+regulatory T cells in myelodysplastic syndromes (MDS). Leukemia 2009;23:510-518.
    • (2009) Leukemia , vol.23 , pp. 510-518
    • Kotsianidis, I.1    Bouchliou, I.2    Nakou, E.3
  • 18
    • 72249104044 scopus 로고    scopus 로고
    • Immune dysregulation and dyserythropoiesis in the myelodysplastic syndromes
    • Alfinito F, Sica M, Luciano L, et al. Immune dysregulation and dyserythropoiesis in the myelodysplastic syndromes. Br J Haematol 2010;148:90-98.
    • (2010) Br J Haematol , vol.148 , pp. 90-98
    • Alfinito, F.1    Sica, M.2    Luciano, L.3
  • 19
    • 77956920766 scopus 로고    scopus 로고
    • Characterization of cytokineinduced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells
    • Lechner MG, Liebertz DJ, Epstein AL. Characterization of cytokineinduced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. J Immunol 2010;185:2273-2284.
    • (2010) J Immunol , vol.185 , pp. 2273-2284
    • Lechner, M.G.1    Liebertz, D.J.2    Epstein, A.L.3
  • 20
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009;9:162-174.
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 21
    • 31344474166 scopus 로고    scopus 로고
    • Myeloid suppressor cells in cancer: Recruitment, phenotype, properties, and mechanisms of immune suppression
    • Serafini P, Borrello I, Bronte V. Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin Cancer Biol 2006;16:53-65.
    • (2006) Semin Cancer Biol , vol.16 , pp. 53-65
    • Serafini, P.1    Borrello, I.2    Bronte, V.3
  • 22
    • 68849128500 scopus 로고    scopus 로고
    • Th erapeutic targeting of myeloid-derived suppressor cells
    • Ugel S, Delpozzo F, Desantis G, et al. Th erapeutic targeting of myeloid-derived suppressor cells. Curr Opin Pharmacol 2009; 9:470-481.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 470-481
    • Ugel, S.1    Delpozzo, F.2    Desantis, G.3
  • 23
    • 48549085973 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells
    • Serafini P, MgebroffS, Noonan K, Borrello I. Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells. Cancer Res 2008;68:5439-5449.
    • (2008) Cancer Res , vol.68 , pp. 5439-5449
    • Serafini, P.1    Mgebroffs Noonan, K.2    Borrello, I.3
  • 24
    • 78649445235 scopus 로고    scopus 로고
    • Epigenetic approaches in the treatment of myelodysplastic syndromes: Clinical utility of azacitidine
    • McCormack SE, Warlick ED. Epigenetic approaches in the treatment of myelodysplastic syndromes: clinical utility of azacitidine. Onco Targets Th er 2010;3:157-165.
    • (2010) Onco Targets Ther , vol.3 , pp. 157-165
    • McCormack, S.E.1    Warlick, E.D.2
  • 25
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
    • Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 2002;20:2429-2440.
    • (2002) J Clin Oncol , vol.20 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3
  • 26
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman LR, McKenzie DR, Peterson BL, et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 2006;24:3895-3903.
    • (2006) J Clin Oncol , vol.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3
  • 27
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009;10:223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 28
    • 33749438404 scopus 로고    scopus 로고
    • Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
    • List A, Dewald G, Bennett J, et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006;355:1456-1465.
    • (2006) N Engl J Med , vol.355 , pp. 1456-1465
    • List, A.1    Dewald, G.2    Bennett, J.3
  • 29
    • 43049154824 scopus 로고    scopus 로고
    • Induction of MHC class I-related chain B (MICB) by 5-aza-2 '-deoxycytidine
    • Tang KF, He CX, Zeng GL, et al. Induction of MHC class I-related chain B (MICB) by 5-aza-2 '-deoxycytidine. Biochem Biophys Res Commun 2008;370:578-583.
    • (2008) Biochem Biophys Res Commun , vol.370 , pp. 578-583
    • Tang, K.F.1    He, C.X.2    Zeng, G.L.3
  • 30
    • 58049132791 scopus 로고    scopus 로고
    • DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors
    • Liu Y, Kuick R, Hanash S, Richardson B. DNA methylation inhibition increases T cell KIR expression through effects on both promoter methylation and transcription factors. Clin Immunol 2009;130:213-224.
    • (2009) Clin Immunol , vol.130 , pp. 213-224
    • Liu, Y.1    Kuick, R.2    Hanash, S.3    Richardson, B.4
  • 31
    • 0037108489 scopus 로고    scopus 로고
    • Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells
    • Santourlidis S, Trompeter HI, Weinhold S, et al. Crucial role of DNA methylation in determination of clonally distributed killer cell Ig-like receptor expression patterns in NK cells. J Immunol 2002;169: 4253-4261.
    • (2002) J Immunol , vol.169 , pp. 4253-4261
    • Santourlidis, S.1    Trompeter, H.I.2    Weinhold, S.3
  • 32
    • 67349255288 scopus 로고    scopus 로고
    • Demethylating treatment suppresses natural killer cell cytolytic activity
    • Gao XN, Lin J, Wang LL, Yu L. Demethylating treatment suppresses natural killer cell cytolytic activity. Mol Immunol 2009; 46:2064-2070.
    • (2009) Mol Immunol , vol.46 , pp. 2064-2070
    • Gao, X.N.1    Lin, J.2    Wang, L.L.3    Yu, L.4
  • 33
    • 19944430437 scopus 로고    scopus 로고
    • Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: Clinical application
    • Hayashi T, Hideshima T, Akiyama M, et al. Molecular mechanisms whereby immunomodulatory drugs activate natural killer cells: clinical application. Br J Haematol 2005;128:192-203.
    • (2005) Br J Haematol , vol.128 , pp. 192-203
    • Hayashi, T.1    Hideshima, T.2    Akiyama, M.3
  • 34
    • 77949423620 scopus 로고    scopus 로고
    • Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients
    • Chan AC, Neeson P, Leeansyah E, et al. Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients. Leukemia 2010;24:592-600.
    • (2010) Leukemia , vol.24 , pp. 592-600
    • Chan, A.C.1    Neeson, P.2    Leeansyah, E.3
  • 35
    • 79951996237 scopus 로고    scopus 로고
    • Immunosuppressive therapy for patients with myelodysplastic syndrome: A prospective randomized multicenter phase III trial comparing antithymocyte globulin plus cyclosporine with best supportive care-SAKK 33/99
    • Passweg JR, Giagounidis AAN, Simcock M, et al. Immunosuppressive therapy for patients with myelodysplastic syndrome: a prospective randomized multicenter phase III trial comparing antithymocyte globulin plus cyclosporine with best supportive care-SAKK 33/99. J Clin Oncol 2011;29:303-309.
    • (2011) J Clin Oncol , vol.29 , pp. 303-309
    • Passweg, J.R.1    Giagounidis, A.A.N.2    Simcock, M.3
  • 36
    • 45149093744 scopus 로고    scopus 로고
    • Factors affecting response and survival in patients with myelodysplasia with immunosuppressive therapy
    • Sloand EM, Wu CO, Greenberg P, et al. Factors affecting response and survival in patients with myelodysplasia with immunosuppressive therapy. J Clin Oncol 2008;26:2505-2511.
    • (2008) J Clin Oncol , vol.26 , pp. 2505-2511
    • Sloand, E.M.1    Wu, C.O.2    Greenberg, P.3
  • 37
    • 79951980136 scopus 로고    scopus 로고
    • Targeting immune dysregulation in myelodysplastic syndromes
    • Olnes MJ, Sloand EM. Targeting immune dysregulation in myelodysplastic syndromes. JAMA 2011;305:814-819.
    • (2011) JAMA , vol.305 , pp. 814-819
    • Olnes, M.J.1    Sloand, E.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.