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Volumn 3, Issue , 2010, Pages 157-165

Epigenetic approaches in the treatment of myelodysplastic syndromes: Clinical utility of azacitidine

Author keywords

Azacitidine; Epigenetics; Hypomethylation; Myelodysplastic syndromes

Indexed keywords

4 PHENYLBUTYRIC ACID; 5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; BORTEZOMIB; CLOFARABINE; CYCLOSPORIN; CYTARABINE; DNA METHYLTRANSFERASE; ENTINOSTAT; ERYTHROPOIETIN; ETANERCEPT; GEMTUZUMAB OZOGAMICIN; GRANULOCYTE COLONY STIMULATING FACTOR; HLA DR15 ANTIGEN; HYDROXYUREA; LENALIDOMIDE; PANOBINOSTAT; RETINOIC ACID; THALIDOMIDE; THYMOCYTE ANTIBODY; VALPROIC ACID; VORINOSTAT;

EID: 78649445235     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (8)

References (61)
  • 1
    • 34548453718 scopus 로고    scopus 로고
    • Myelodysplastic syndromes: Review of pathophysiology and current novel treatment approaches
    • Warlick ED, Smith BD. Myelodysplastic syndromes: review of pathophysiology and current novel treatment approaches. Curr Cancer Drug Targets. 2007;7(6):541-558.
    • (2007) Curr Cancer Drug Targets , vol.7 , Issue.6 , pp. 541-558
    • Warlick, E.D.1    Smith, B.D.2
  • 2
    • 0031025368 scopus 로고    scopus 로고
    • Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
    • Herman JG, Civin CI, Issa JP, et al. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res. 1997;57(5):837-841.
    • (1997) Cancer Res , vol.57 , Issue.5 , pp. 837-841
    • Herman, J.G.1    Civin, C.I.2    Issa, J.P.3
  • 3
    • 0036902962 scopus 로고    scopus 로고
    • DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias
    • Leone G, Teofili L, Voso MT, Lubbert M. DNA methylation and demethylating drugs in myelodysplastic syndromes and secondary leukemias. Haematologica. 2002;87(12):1324-1341.
    • (2002) Haematologica , vol.87 , Issue.12 , pp. 1324-1341
    • Leone, G.1    Teofili, L.2    Voso, M.T.3    Lubbert, M.4
  • 4
    • 0032523011 scopus 로고    scopus 로고
    • Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression
    • Quesnel B, Guillerm G, Vereecque R, et al. Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood. 1998;91(8):2985-2990.
    • (1998) Blood , vol.91 , Issue.8 , pp. 2985-2990
    • Quesnel, B.1    Guillerm, G.2    Vereecque, R.3
  • 5
    • 33644878393 scopus 로고    scopus 로고
    • Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients
    • Aggerholm A, Holm MS, Guldberg P, Olesen LH, Hokland P. Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. Eur J Haematol. 2006;76(1):23-32.
    • (2006) Eur J Haematol , vol.76 , Issue.1 , pp. 23-32
    • Aggerholm, A.1    Holm, M.S.2    Guldberg, P.3    Olesen, L.H.4    Hokland, P.5
  • 6
    • 0141502199 scopus 로고    scopus 로고
    • Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy- related myelodysplasia and acute myeloid leukemia
    • Christiansen DH, Andersen MK, Pedersen-Bjergaard J. Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy- related myelodysplasia and acute myeloid leukemia. Leukemia. 2003;17(9): 1813-1819.
    • (2003) Leukemia , vol.17 , Issue.9 , pp. 1813-1819
    • Christiansen, D.H.1    Andersen, M.K.2    Pedersen-Bjergaard, J.3
  • 7
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
    • Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer. 2006;106(8):1794-1803.
    • (2006) Cancer , vol.106 , Issue.8 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3
  • 8
    • 33846011361 scopus 로고    scopus 로고
    • Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
    • Kantarjian H, Oki Y, Garcia-Manero G, et al. Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood. 2007;109(1):52-57.
    • (2007) Blood , vol.109 , Issue.1 , pp. 52-57
    • Kantarjian, H.1    Oki, Y.2    Garcia-Manero, G.3
  • 9
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the Cancer and Leukemia Group B
    • Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the Cancer and Leukemia Group B. J Clin Oncol. 2002;20(10):2429-2440.
    • (2002) J Clin Oncol , vol.20 , Issue.10 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3
  • 10
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman LR, McKenzie DR, Peterson BL, et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol. 2006;24(24):3895-3903.
    • (2006) J Clin Oncol , vol.24 , Issue.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3
  • 11
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol. 2009;10(3):223-232.
    • (2009) Lancet Oncol , vol.10 , Issue.3 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3
  • 12
    • 21044439177 scopus 로고    scopus 로고
    • Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes
    • Kaminskas E, Farrell A, Abraham S, et al. Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes. Clin Cancer Res. 2005;11(10):3604-3608.
    • (2005) Clin Cancer Res , vol.11 , Issue.10 , pp. 3604-3608
    • Kaminskas, E.1    Farrell, A.2    Abraham, S.3
  • 13
    • 43949136445 scopus 로고    scopus 로고
    • Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
    • Stresemann C, Lyko F. Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int J Cancer. 2008; 123(1):8-13.
    • (2008) Int J Cancer , vol.123 , Issue.1 , pp. 8-13
    • Stresemann, C.1    Lyko, F.2
  • 14
    • 67449147110 scopus 로고    scopus 로고
    • Targeting DNA methylation
    • Issa JP, Kantarjian HM. Targeting DNA methylation. Clin Cancer Res. 2009;15(12):3938-3946.
    • (2009) Clin Cancer Res , vol.15 , Issue.12 , pp. 3938-3946
    • Issa, J.P.1    Kantarjian, H.M.2
  • 15
    • 37549022694 scopus 로고    scopus 로고
    • DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes
    • Griffiths EA, Gore SD. DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes. Semin Hematol. 2008;45(1):23-30.
    • (2008) Semin Hematol , vol.45 , Issue.1 , pp. 23-30
    • Griffiths, E.A.1    Gore, S.D.2
  • 16
    • 34250661469 scopus 로고    scopus 로고
    • DNA demethylating agents and histone deacetylase inhibitors in hematologic malignancies
    • Fandy TE, Carraway H, Gore SD. DNA demethylating agents and histone deacetylase inhibitors in hematologic malignancies. Cancer J. 2007;13(1):40-48.
    • (2007) Cancer J , vol.13 , Issue.1 , pp. 40-48
    • Fandy, T.E.1    Carraway, H.2    Gore, S.D.3
  • 17
    • 27144535374 scopus 로고    scopus 로고
    • Trapped in action: Direct visualization of DNA methyltransferase activity in living cells
    • Schermelleh L, Spada F, Easwaran HP, et al. Trapped in action: direct visualization of DNA methyltransferase activity in living cells. Nat Methods. 2005;2(10):751-756.
    • (2005) Nat Methods , vol.2 , Issue.10 , pp. 751-756
    • Schermelleh, L.1    Spada, F.2    Easwaran, H.P.3
  • 18
    • 70350506791 scopus 로고    scopus 로고
    • Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
    • Fandy TE, Herman JG, Kerns P, et al. Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. Blood. 2009;114(13):2764-2773.
    • (2009) Blood , vol.114 , Issue.13 , pp. 2764-2773
    • Fandy, T.E.1    Herman, J.G.2    Kerns, P.3
  • 19
    • 71149106051 scopus 로고    scopus 로고
    • In vitro basis for treatment with hypomethylating agents and histone deacetylase inhibitors: Can epigenetic changes be used to monitor treatment?
    • Gore SD. In vitro basis for treatment with hypomethylating agents and histone deacetylase inhibitors: can epigenetic changes be used to monitor treatment? Leuk Res. 2009;33 Suppl 2:S2-S6.
    • (2009) Leuk Res , vol.33 , Issue.SUPPL. 2
    • Gore, S.D.1
  • 20
    • 77449149371 scopus 로고    scopus 로고
    • DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
    • Shen L, Kantarjian H, Guo Y, et al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol. 2010;28(4):605-613.
    • (2010) J Clin Oncol , vol.28 , Issue.4 , pp. 605-613
    • Shen, L.1    Kantarjian, H.2    Guo, Y.3
  • 21
    • 0015839018 scopus 로고
    • 5-Azacytidine: A new active agent for the treatment of acute leukemia
    • Karon M, Sieger L, Leimbrock S, et al. 5-Azacytidine: a new active agent for the treatment of acute leukemia. Blood. 1973;42(3):359-365.
    • (1973) Blood , vol.42 , Issue.3 , pp. 359-365
    • Karon, M.1    Sieger, L.2    Leimbrock, S.3
  • 22
    • 0015844307 scopus 로고
    • Treatment of acute leukemia with 5-azacytidine (NSC-102816)
    • McCredie KB, Bodey GP, Burgess MA, et al. Treatment of acute leukemia with 5-azacytidine (NSC-102816). Cancer Chemother Rep. 1973;57(3):319-323.
    • (1973) Cancer Chemother Rep , vol.57 , Issue.3 , pp. 319-323
    • McCredie, K.B.1    Bodey, G.P.2    Burgess, M.A.3
  • 23
    • 0017249671 scopus 로고
    • A phase I study of 5-azacytidine (NSC- 102816)
    • Shnider BI, Baig M, Colsky J. A phase I study of 5-azacytidine (NSC- 102816). J Clin Pharmacol. 1976;16(4):205-212.
    • (1976) J Clin Pharmacol , vol.16 , Issue.4 , pp. 205-212
    • Shnider, B.I.1    Baig, M.2    Colsky, J.3
  • 24
    • 0017083209 scopus 로고
    • 5-Azacytidine (NSC 102816): A new drug for the treatment of myeloblastic leukemia
    • Vogler WR, Miller DS, Keller JW. 5-Azacytidine (NSC 102816): a new drug for the treatment of myeloblastic leukemia. Blood. 1976; 48(3):331-337.
    • (1976) Blood , vol.48 , Issue.3 , pp. 331-337
    • Vogler, W.R.1    Miller, D.S.2    Keller, J.W.3
  • 25
    • 84863802233 scopus 로고    scopus 로고
    • US Food and Drug Administration, Accessed Feb 1, 2010
    • US Food and Drug Administration. http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050794s011lbl.pdf. Accessed Feb 1, 2010.
  • 26
    • 64649097534 scopus 로고    scopus 로고
    • Hematologic response to three alternative dosing schedules of azacitidine in patients with myelodysplastic syndromes
    • Lyons RM, Cosgriff TM, Modi SS, et al. Hematologic response to three alternative dosing schedules of azacitidine in patients with myelodysplastic syndromes. J Clin Oncol. 2009;27(11):1850-1856.
    • (2009) J Clin Oncol , vol.27 , Issue.11 , pp. 1850-1856
    • Lyons, R.M.1    Cosgriff, T.M.2    Modi, S.S.3
  • 27
    • 79959797344 scopus 로고    scopus 로고
    • A comparative pharmacokinetic/ pharmacodynamic (PK/PD) evaluation of azacitidine following subcutaneous (SC) and oral administration in subjects with myelodysplastic syndromes (MDS) or acute myelogenous leukemia (AML), results from a phase 1 study
    • MacBeth KJ, Laille E, Ning Y, et al. A comparative pharmacokinetic/ pharmacodynamic (PK/PD) evaluation of azacitidine following subcutaneous (SC) and oral administration in subjects with myelodysplastic syndromes (MDS) or acute myelogenous leukemia (AML), results from a phase 1 study. ASH Annu Meet Abstr. 2009;114(22):1772.
    • (2009) ASH Annu Meet Abstr , vol.114 , Issue.22 , pp. 1772
    • Macbeth, K.J.1    Laille, E.2    Ning, Y.3
  • 28
    • 77954527827 scopus 로고    scopus 로고
    • A phase 1, open-label, dose-escalation study to evaluate the safety, pharmacokinetics, and pharmacodynamics of oral azacitidine in patients with myelodysplastic syndromes (MDS) or acute myelogenous leukemia (AML)
    • Garcia-Manero G, Gore SD, Skikne B, et al. A phase 1, open-label, dose-escalation study to evaluate the safety, pharmacokinetics, and pharmacodynamics of oral azacitidine in patients with myelodysplastic syndromes (MDS) or acute myelogenous leukemia (AML). ASH Annu Meet Abstr. 2009;114(22):117.
    • (2009) ASH Annu Meet Abstr , vol.114 , Issue.22 , pp. 117
    • Garcia-Manero, G.1    Gore, S.D.2    Skikne, B.3
  • 30
    • 16244400457 scopus 로고    scopus 로고
    • FDA drug approval summary: Azacitidine (5-azacytidine, Vidaza) for injectable suspension
    • Kaminskas E, Farrell AT, Wang YC, Sridhara R, Pazdur R. FDA drug approval summary: azacitidine (5-azacytidine, Vidaza) for injectable suspension. Oncologist. 2005;10(3):176-182.
    • (2005) Oncologist , vol.10 , Issue.3 , pp. 176-182
    • Kaminskas, E.1    Farrell, A.T.2    Wang, Y.C.3    Sridhara, R.4    Pazdur, R.5
  • 31
    • 0020679784 scopus 로고
    • Plasma and cerebrospinal fluid pharmacokinetics of 5-Aza-2'-deoxycytidine in rabbits and dogs
    • Chabot GG, Rivard GE, Momparler RL. Plasma and cerebrospinal fluid pharmacokinetics of 5-Aza-2'-deoxycytidine in rabbits and dogs. Cancer Res. 1983;43(2):592-597.
    • (1983) Cancer Res , vol.43 , Issue.2 , pp. 592-597
    • Chabot, G.G.1    Rivard, G.E.2    Momparler, R.L.3
  • 32
    • 0027154222 scopus 로고
    • Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes
    • Silverman LR, Holland JF, Weinberg RS, et al. Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes. Leukemia. 1993;7 Suppl 1: S21-S29.
    • (1993) Leukemia , vol.7 , Issue.SUPPL. 1
    • Silverman, L.R.1    Holland, J.F.2    Weinberg, R.S.3
  • 33
    • 0034554786 scopus 로고    scopus 로고
    • Report of an international working group to standardize response criteria for myelodysplastic syndromes
    • Cheson BD, Bennett JM, Kantarjian H, et al. Report of an international working group to standardize response criteria for myelodysplastic syndromes. Blood. 2000;96(12):3671-3674.
    • (2000) Blood , vol.96 , Issue.12 , pp. 3671-3674
    • Cheson, B.D.1    Bennett, J.M.2    Kantarjian, H.3
  • 34
    • 0037092962 scopus 로고    scopus 로고
    • Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: A Cancer and Leukemia Group B study
    • Kornblith AB, Herndon JE II, Silverman LR, et al. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study. J Clin Oncol. 2002;20(10):2441-2452.
    • (2002) J Clin Oncol , vol.20 , Issue.10 , pp. 2441-2452
    • Kornblith, A.B.1    Herndon, J.E.I.I.2    Silverman, L.R.3
  • 35
    • 76549092572 scopus 로고    scopus 로고
    • 5-azacitidine prolongs overall survival in patients with myelodysplastic syndrome - a systematic review and meta-analysis
    • Gurion R, Vidal L, Gafter-Gvili A, et al. 5-azacitidine prolongs overall survival in patients with myelodysplastic syndrome - a systematic review and meta-analysis. Haematologica. 2010;95(2):303-310.
    • (2010) Haematologica , vol.95 , Issue.2 , pp. 303-310
    • Gurion, R.1    Vidal, L.2    Gafter-Gvili, A.3
  • 36
    • 31444438952 scopus 로고    scopus 로고
    • Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome
    • Maslak P, Chanel S, Camacho LH, et al. Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome. Leukemia. 2006;20(2):212-217.
    • (2006) Leukemia , vol.20 , Issue.2 , pp. 212-217
    • Maslak, P.1    Chanel, S.2    Camacho, L.H.3
  • 37
    • 58149174109 scopus 로고    scopus 로고
    • Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers
    • Braiteh F, Soriano AO, Garcia-Manero G, et al. Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers. Clin Cancer Res. 2008;14(19):6296-6301.
    • (2008) Clin Cancer Res , vol.14 , Issue.19 , pp. 6296-6301
    • Braiteh, F.1    Soriano, A.O.2    Garcia-Manero, G.3
  • 38
    • 34948845116 scopus 로고    scopus 로고
    • Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome
    • Soriano AO, Yang H, Faderl S, et al. Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood. 2007;110(7):2302-2308.
    • (2007) Blood , vol.110 , Issue.7 , pp. 2302-2308
    • Soriano, A.O.1    Yang, H.2    Faderl, S.3
  • 39
    • 57049171822 scopus 로고    scopus 로고
    • Hydroxyurea, azacitidine and gemtuzumab ozogamicin therapy in patients with previously untreated non-M3 acute myeloid leukemia and high-risk myelodysplastic syndromes in the elderly: Results from a pilot trial
    • Nand S, Godwin J, Smith S, et al. Hydroxyurea, azacitidine and gemtuzumab ozogamicin therapy in patients with previously untreated non-M3 acute myeloid leukemia and high-risk myelodysplastic syndromes in the elderly: results from a pilot trial. Leuk Lymphoma. 2008;49(11):2141-2147.
    • (2008) Leuk Lymphoma , vol.49 , Issue.11 , pp. 2141-2147
    • Nand, S.1    Godwin, J.2    Smith, S.3
  • 40
    • 84863787828 scopus 로고    scopus 로고
    • The tolerability of combination therapy with thalidomide and 5-azacitidine in patients with advanced myelodysplastic syndromes (MDS)
    • Kenealy MK, Seymour JF, Linda C, et al. The tolerability of combination therapy with thalidomide and 5-azacitidine in patients with advanced myelodysplastic syndromes (MDS). ASH Annu Meet Abstr. 2009;114(22):1749.
    • (2009) ASH Annu Meet Abstr , vol.114 , Issue.22 , pp. 1749
    • Kenealy, M.K.1    Seymour, J.F.2    Linda, C.3
  • 41
    • 77952316378 scopus 로고    scopus 로고
    • Phase I combination trial of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromes
    • Sekeres MA, List AF, Cuthbertson D, et al. Phase I combination trial of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromes. J Clin Oncol. 2010;28(13):2253-2258.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2253-2258
    • Sekeres, M.A.1    List, A.F.2    Cuthbertson, D.3
  • 42
    • 67549109557 scopus 로고    scopus 로고
    • Feasibility of allo- SCT after hypomethylating therapy with decitabine for myelodysplastic syndrome
    • De Padua Silva L, de Lima M, Kantarjian H, et al. Feasibility of allo- SCT after hypomethylating therapy with decitabine for myelodysplastic syndrome. Bone Marrow Transplant. 2009;43(11):839-843.
    • (2009) Bone Marrow Transplant , vol.43 , Issue.11 , pp. 839-843
    • De Padua, S.L.1    de Lima, M.2    Kantarjian, H.3
  • 43
    • 76749156659 scopus 로고    scopus 로고
    • 5-Azacitidine for myelodysplasia before allogeneic hematopoietic cell transplantation
    • Field T, Perkins J, Huang Y, et al. 5-Azacitidine for myelodysplasia before allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2010;45(2):255-260.
    • (2010) Bone Marrow Transplant , vol.45 , Issue.2 , pp. 255-260
    • Field, T.1    Perkins, J.2    Huang, Y.3
  • 44
    • 74949115148 scopus 로고    scopus 로고
    • Immunomodulatory effect of 5-azacytidine (5-azaC): Potential role in the transplantation setting
    • Sanchez-Abarca LI, Gutierrez-Cosio S, Santamaria C, et al. Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting. Blood. 2010;115(1):107-121.
    • (2010) Blood , vol.115 , Issue.1 , pp. 107-121
    • Sanchez-Abarca, L.I.1    Gutierrez-Cosio, S.2    Santamaria, C.3
  • 45
    • 77649296804 scopus 로고    scopus 로고
    • Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil
    • Platzbecker U, Aul C, Ehninger G, Giagounidis A. Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil. Ann Hematol. 2010;89(4):427-428.
    • (2010) Ann Hematol , vol.89 , Issue.4 , pp. 427-428
    • Platzbecker, U.1    Aul, C.2    Ehninger, G.3    Giagounidis, A.4
  • 46
    • 70349502130 scopus 로고    scopus 로고
    • Quality of life and use of red cell transfusion in patients with myelodysplastic syndromes. A systematic review
    • Pinchon DJ, Stanworth SJ, Doree C, Brunskill S, Norfolk DR. Quality of life and use of red cell transfusion in patients with myelodysplastic syndromes. A systematic review. Am J Hematol. 2009;84(10):671-677.
    • (2009) Am J Hematol , vol.84 , Issue.10 , pp. 671-677
    • Pinchon, D.J.1    Stanworth, S.J.2    Doree, C.3    Brunskill, S.4    Norfolk, D.R.5
  • 47
    • 33845292619 scopus 로고    scopus 로고
    • A mathematical model for the evaluation of amplitude of hemoglobin fluctuations in elderly anemic patients affected by myelodysplastic syndromes: Correlation with quality of life and fatigue
    • Caocci G, Baccoli R, Ledda A, Littera R, La Nasa G. A mathematical model for the evaluation of amplitude of hemoglobin fluctuations in elderly anemic patients affected by myelodysplastic syndromes: correlation with quality of life and fatigue. Leuk Res. 2007;31(2):249-252.
    • (2007) Leuk Res , vol.31 , Issue.2 , pp. 249-252
    • Caocci, G.1    Baccoli, R.2    Ledda, A.3    Littera, R.4    la Nasa, G.5
  • 48
    • 23844489776 scopus 로고    scopus 로고
    • Hemoglobin level threshold for cardiac remodeling and quality of life in myelodysplastic syndrome
    • Oliva EN, Dimitrov BD, Benedetto F, D'Angelo A, Nobile F. Hemoglobin level threshold for cardiac remodeling and quality of life in myelodysplastic syndrome. Leuk Res. 2005;29(10):1217-1219.
    • (2005) Leuk Res , vol.29 , Issue.10 , pp. 1217-1219
    • Oliva, E.N.1    Dimitrov, B.D.2    Benedetto, F.3    D'angelo, A.4    Nobile, F.5
  • 49
    • 28444489284 scopus 로고    scopus 로고
    • Darbepoetin alfa for the treatment of anemic patients with low- and intermediate-1-risk myelodysplastic syndromes
    • Stasi R, Abruzzese E, Lanzetta G, Terzoli E, Amadori S. Darbepoetin alfa for the treatment of anemic patients with low- and intermediate-1-risk myelodysplastic syndromes. Ann Oncol. 2005;16(12):1921-1927.
    • (2005) Ann Oncol , vol.16 , Issue.12 , pp. 1921-1927
    • Stasi, R.1    Abruzzese, E.2    Lanzetta, G.3    Terzoli, E.4    Amadori, S.5
  • 50
    • 31744444200 scopus 로고    scopus 로고
    • Erythropoietin plus granulocyte colony-stimulating factor is better than erythropoietin alone to treat anemia in low-risk myelodysplastic syndromes: Results from a randomized single-centre study
    • Balleari E, Rossi E, Clavio M, et al. Erythropoietin plus granulocyte colony-stimulating factor is better than erythropoietin alone to treat anemia in low-risk myelodysplastic syndromes: results from a randomized single-centre study. Ann Hematol. 2006;85(3):174-180.
    • (2006) Ann Hematol , vol.85 , Issue.3 , pp. 174-180
    • Balleari, E.1    Rossi, E.2    Clavio, M.3
  • 51
    • 3142619150 scopus 로고    scopus 로고
    • Health, economic, and qualityof- life effects of erythropoietin and granulocyte colony-stimulating factor for the treatment of myelodysplastic syndromes: A randomized, controlled trial
    • Casadevall N, Durieux P, Dubois S, et al. Health, economic, and qualityof- life effects of erythropoietin and granulocyte colony-stimulating factor for the treatment of myelodysplastic syndromes: a randomized, controlled trial. Blood. 2004;104(2):321-327.
    • (2004) Blood , vol.104 , Issue.2 , pp. 321-327
    • Casadevall, N.1    Durieux, P.2    Dubois, S.3
  • 52
    • 46949086842 scopus 로고    scopus 로고
    • Phase 2, single-arm trial to evaluate the effectiveness of darbepoetin alfa for correcting anaemia in patients with myelodysplastic syndromes
    • Gabrilove J, Paquette R, Lyons RM, et al. Phase 2, single-arm trial to evaluate the effectiveness of darbepoetin alfa for correcting anaemia in patients with myelodysplastic syndromes. Br J Haematol. 2008; 142(3):379-393.
    • (2008) Br J Haematol , vol.142 , Issue.3 , pp. 379-393
    • Gabrilove, J.1    Paquette, R.2    Lyons, R.M.3
  • 53
    • 40049097939 scopus 로고    scopus 로고
    • Common troublesome symptoms and their impact on quality of life in patients with myelodysplastic syndromes (MDS): Results of a large internet-based survey
    • Steensma DP, Heptinstall KV, Johnson VM, et al. Common troublesome symptoms and their impact on quality of life in patients with myelodysplastic syndromes (MDS): results of a large internet-based survey. Leuk Res. 2008;32(5):691-698.
    • (2008) Leuk Res , vol.32 , Issue.5 , pp. 691-698
    • Steensma, D.P.1    Heptinstall, K.V.2    Johnson, V.M.3
  • 54
    • 42049097308 scopus 로고    scopus 로고
    • Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine
    • Borthakur G, Ahdab SE, Ravandi F, et al. Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine. Leuk Lymphoma. 2008;49(4):690-695.
    • (2008) Leuk Lymphoma , vol.49 , Issue.4 , pp. 690-695
    • Borthakur, G.1    Ahdab, S.E.2    Ravandi, F.3
  • 55
    • 84863796859 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available from, Accessed May 9, 2010
    • ClinicalTrials.gov. Available from: http://www.clinicaltrials.gov. Accessed May 9, 2010.
  • 56
    • 33745586575 scopus 로고    scopus 로고
    • Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older
    • Faderl S, Verstovsek S, Cortes J, et al. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older. Blood. 2006;108(1):45-51.
    • (2006) Blood , vol.108 , Issue.1 , pp. 45-51
    • Faderl, S.1    Verstovsek, S.2    Cortes, J.3
  • 57
    • 19944433802 scopus 로고    scopus 로고
    • Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
    • Faderl S, Gandhi V, O'Brien S, et al. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Blood. 2005;105(3):940-947.
    • (2005) Blood , vol.105 , Issue.3 , pp. 940-947
    • Faderl, S.1    Gandhi, V.2    O'Brien, S.3
  • 58
    • 77954911871 scopus 로고    scopus 로고
    • Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome
    • Faderl S, Garcia-Manero G, Estrov Z, et al. Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome. J Clin Oncol. 2010;28(16):2755-2760.
    • (2010) J Clin Oncol , vol.28 , Issue.16 , pp. 2755-2760
    • Faderl, S.1    Garcia-Manero, G.2    Estrov, Z.3
  • 59
    • 77952602288 scopus 로고    scopus 로고
    • Anti-thymocyte globulin plus etanercept as therapy for myelodysplastic syndromes (MDS): A phase II study
    • Scott BL, Ramakrishnan A, Fosdal M, et al. Anti-thymocyte globulin plus etanercept as therapy for myelodysplastic syndromes (MDS): a phase II study. Br J Haematol. 2010;149(5):706-710.
    • (2010) Br J Haematol , vol.149 , Issue.5 , pp. 706-710
    • Scott, B.L.1    Ramakrishnan, A.2    Fosdal, M.3
  • 60
    • 77952650645 scopus 로고    scopus 로고
    • Epigenetic therapy in myelodysplastic syndromes
    • Musolino C, Sant'antonio E, Penna G, et al. Epigenetic therapy in myelodysplastic syndromes. Eur J Haematol. 2010;84(6):463-467.
    • (2010) Eur J Haematol , vol.84 , Issue.6 , pp. 463-467
    • Musolino, C.1    Sant'antonio, E.2    Penna, G.3
  • 61
    • 71149101593 scopus 로고    scopus 로고
    • Review of azacitidine trials in intermediate-2-and high-risk myelodysplastic syndromes
    • Fenaux P, Ades L. Review of azacitidine trials in intermediate-2-and high-risk myelodysplastic syndromes. Leuk Res. 2009;33 Suppl 2: S7-S11.
    • (2009) Leuk Res , vol.33 , Issue.SUPPL. 2
    • Fenaux, P.1    Ades, L.2


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