Optimization of parameters of the SeDeM Diagram Expert System: Hausner index (IH) and relative humidity (%RH)

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 79, Issue 2, 2011, Pages 464-472

  Suñé Negre, Josep M ^a   Pérez Lozano, Pilar ^a   Roig, Manel ^a   Fuster, Roser ^a   Hernández, Carmen ^b   Ruhí, Ramon ^b   García Montoya, Encarna ^a   Miñarro, Montserrat ^a   Ticó, Josep R ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b BIOIBERICA SA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANTOSE; ALPHA LACTOSE; AVICEL 101; AVICEL 112; BETA CYCLODEXTRIN; CALCIUM CARBONATE; CHONDROITIN SULFATE; EXCIPIENT; GLUCOSAMINE SULFATE; ISOMALT; KLEPTOSE; LACTOSE; LUDIPRES; LYCATAB; MANNITOL; MICROCEL 100; MICROCEL 101; MICROCEL 102; MICROCEL 250; MICROCRYSTALLINE CELLULOSE; PEARLITOL 200; PHARMABURST; POVIDONE; PROSOLV; SILICON DIOXIDE; STARCH; UNCLASSIFIED DRUG; VIVAPUR 101; VIVAPUR 102; VIVAPUR 12;

ARTICLE; CALCULATION; COMPRESSION; DRUG FORMULATION; HUMIDITY; MATHEMATICAL ANALYSIS; PROCESS OPTIMIZATION; RELIABILITY;

EID: 80054967235     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.04.002     Document Type: Article

References (7)

1. J.M. Suñé Negre, M. Roig Carreras, R. Fuster García, C. Hernández Pérez, R. Ruhí Roura, E. García Montoya, M. Miñarro Carmona, P. Pérez Lozano, J.R. Ticó Grau, Nueva metodología de preformulación galénica para la caracterización de sustancias en relación a su viabilidad para la compresión: Diagrama SeDeM, Cienc. Technol. Pharm. 3 (2005) 125-136.
2. P. Pérez-Lozano, J.M. Suñé-Negre, M. Miñarro, M. Roig, R. Fuster, E. García-Montoya, C. Hernández, R. Ruhí, J.R. Ticó, A new expert systems (SeDeM Diagram) for control batch powder formulation and preformulation drug products, Eur. J. Pharm. Biopharm. 64 (2006) 351-359. (Pubitemid 44585211)
3. J.M. Suñé-Negre, P. Pérez-Lozano, M. Miñarro, M. Roig, R. Fuster, C. Hernández, R. Ruhí, E. García- Montoya, J.R. Ticó, Application of the SeDeM Diagram and a new mathematical equation in the design of direct compression tablet formulation, Eur. J. Pharm. Biopharm. 69 (2008) 1029-1039.
4. J.E. Aguilar-Díaz, E. García-Montoya, P. Pérez-Lozano, J.M. Suñé-Negre, M. Miñarro, J.R. Ticó, The use of the SeDeM Diagram Expert System to determine the suitability of diluents-disintegrants for direct compression and their use in formulation of ODT, Eur. J. Pharm. Biopharm. 73 (2009) 414-423.
5. European Pharmacopoeia, sixth ed. (6.1), Council of Europe, Strasbourg, France, 2008 (2.9.34).
6. J.C. Guyot, C. Mathis, M. Traisnel, A. Verain, Galenica 6: Poudres & formes unitaires obtenues par division ou agglutination (formes orales solides I). Technique et Documentation (Lavoisier), Paris, 1984, pp. 147-175.
7. L. Braidotti, D. Bulgarelli, Tecnica Farmaceutica, first ed., Ed. Scientifica LG Gualagni, Milan, 1974, p. 192.