Application of the SeDeM Diagram and a new mathematical equation in the design of direct compression tablet formulation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 69, Issue 3, 2008, Pages 1029-1039

  Suñé Negre, Josep M ^a   Pérez Lozano, Pilar ^a   Miñarro, Montserrat ^a   Roig, Manel ^a   Fuster, Roser ^a   Hernández, Carmen ^b   Ruhí, Ramon ^b   García Montoya, Encarna ^a   Ticó, Josep R ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b BIOIBERICA SA   (Spain)

Author keywords

Angle of Repose ( ); Bulk Density (Da); Direct compression (DC); Expert system; Flowability (t ); Formulation; Inter particle Porosity (Ie); Particle Size ( Pf); SeDeM; Tapped Density (Dc)

Indexed keywords

DILUENT; EXCIPIENT;

ARTICLE; BULK DENSITY; MATHEMATICAL ANALYSIS; PARTICLE SIZE; TABLET COMPRESSION; TABLET FORMULATION; TABLET POROSITY;

ALGORITHMS; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; LUBRICATION; PARTICLE SIZE; POWDERS; TABLETS;

EID: 48149108066     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.01.020     Document Type: Article

References (10)

1. Suñé Negre J.M.a., Roig Carreras M., Fuster García R., Hernández Pérez C., Ruhí Roura R., García Montoya E., Miñarro Carmona M., Pérez Lozano P., and Ticó Grau J.R. Nueva metodología de preformulación galénica para la caracterización de sustancias en relación a su viabilidad para la compresión: Diagrama SeDeM. Cienc. Technol. Pharm. 3 (2005) 125-136
2. Pérez P., Suñé-Negre J.M., Miñarro M., Roig M., Fuster R., Hernández C., Ruhí R., García-Montoya E., and Ticó J.R. A new expert system (SeDeM Diagram) for control batch powder formulation and preformulation drug products. Eur. J. Pharm. Biopharm. 64 (2006) 351-359
3. Herrero-Beaumomt G., Ivorra J.A.R., de Carmen Trabado M., Blanco F.J., Benito P., Martín-Mola E., Paulino J., Marenco J.L., Porto A., Laffon A., Araújo D., Figueroa M., and Blanco J. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms. Arthritis Rheum. 56 2 (2007) 555-567 American College of Rheumatology
4. Anderson J.W., Nicolisi R.J., and Borzellerca J.F. Glucosamine effects in humans: a review of effects on glucose metabolism, side effects and efficacy. Food Chem. Toxicol. 43 (2005) 187-201
5. Pavelkà K., Gatterová J., Olejarová M., Machacek S., Giacovelli G., and Rovati L.C. Glucosamine sulfate use and delay of progression of knee osteoarthritis. Arch. Intern. Med. 162 (2002) 2113-2123
6. Reginster J.-Y., Bruyere O., and Neuprez A. Current role of glucosamine in the treatment of osteoarthritis. Rheumatology 46 (2007) 731-735
7. European Pharmacopeia, fifth ed., vol. 5.08, Council of Europe, Strasbourg (France), 2007, p. 2.9.5.
8. European Pharmacopeia, fifth ed., vol. 5.08, Council of Europe, Strasbourg (France), 2007, p. 2.9.8.
9. European Pharmacopeia, fifth ed., vol. 5.08, Council of Europe, Strasbourg (France), 2007, p. 2.9.7.
10. European Pharmacopeia, fifth ed., vol. 5.08, Council of Europe, Strasbourg (France), 2007, p. 2.9.1.