CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia

Cellular Immunology

Volumn 260, Issue 2, 2010, Pages 113-118

  Ravindran, C ^a   Cheng, Yung Chih ^a   Liang, Shu Mei ^a  

^a AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

Author keywords

Amyloid beta; CCL9; CCR1; CpG ODNs; Macrophage; Microglia; TLR9

Indexed keywords

CCL9 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR CCR1; CPG OLIGODEOXYNUCLEOTIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GENE EXPRESSION; MACROPHAGE ACTIVATION; MICROGLIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; UPREGULATION;

AMYLOID BETA-PROTEIN; ANIMALS; CELL LINE; CHEMOKINES, CC; CHLOROQUINE; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONOIDS; FLOW CYTOMETRY; IMIDAZOLES; MACROPHAGE INFLAMMATORY PROTEINS; MACROPHAGES; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID DIFFERENTIATION FACTOR 88; OLIGODEOXYRIBONUCLEOTIDES; PEPTIDE FRAGMENTS; PYRIDINES; RECEPTORS, CCR1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 9; TRANSFECTION; UP-REGULATION;

EID: 71349087314     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2009.10.001     Document Type: Article

References (30)

1. Bafica A., Scanga C.A., Equils O., and Sher A. The induction of toll-like receptor tolerance enhances rather than suppresses HIV-1 gene expression in transgenic mice. J. Leukoc Biol. 75 (2004) 460-466
2. Kuo C.C., Kuo C.W., Liang C.M., and Liang S.M. A transcriptomic and proteomic analysis of the effect of CpG-ODN on human THP-1 monocytic leukemia cells. Proteomics 5 (2005) 894-906
3. Rothenfusser S., Tuma E., Endres S., and Hartmann G. Plasmacytoid dendritic cells: the key to CpG. Hum. Immunol. 63 (2002) 1111-1119
4. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3 (2003) 133-146
5. Cardon L.R., Burge C., Clayton D.A., and Karlin S. Pervasive CpG suppression in animal mitochondrial genomes. Proc. Natl. Acad. Sci. USA 91 (1994) 3799-3803
6. Razin A., and Friedman J. DNA methylation and its possible biological roles. Prog. Nucleic Acid Res. Mol. Biol. 25 (1981) 33-52
7. Klinman D.M., Yi A.K., Beaucage S.L., Conover J., and Krieg A.M. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc. Natl. Acad. Sci. USA 93 (1996) 2879-2883
8. Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., Koretzky G.A., and Klinman D.M. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374 (1995) 546-549
9. Akhtar M., Watson J.L., Nazli A., and McKay D.M. Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent, NF-kappaB-independent pathway. FASEB J 17 (2003) 1319-1321
10. Kielian T. Toll-like receptors in central nervous system glial inflammation and homeostasis. J. Neurosci. Res. 83 (2006) 711-730
11. Deng G.M., Liu Z.Q., and Tarkowski A. Intracisternally localized bacterial DNA containing CpG motifs induces meningitis. J. Immunol. 167 (2001) 4616-4626
12. Schluesener H.J., Seid K., Deininger M., and Schwab J. Transient in vivo activation of rat brain macrophages/microglial cells and astrocytes by immunostimulatory multiple CpG oligonucleotides. J. Neuroimmunol. 113 (2001) 89-94
13. Takeshita S., Takeshita F., Haddad D.E., Janabi N., and Klinman D.M. Activation of microglia and astrocytes by CpG oligodeoxynucleotides. Neuroreport 12 (2001) 3029-3032
14. Iribarren P., Chen K., Hu J., Gong W., Cho E.H., Lockett S., Uranchimeg B., and Wang J.M. CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein-coupled receptor mFPR2. FASEB J 19 (2005) 2032-2034
15. Rollins B.J. Chemokines. Blood 90 (1997) 909-928
16. Ono S.J., Nakamura T., Miyazaki D., Ohbayashi M., Dawson M., and Toda M. Chemokines: roles in leukocyte development, trafficking, and effector function. J. Allergy Clin. Immunol. 111 (2003) 1185-1199 (quiz 1200)
17. Takeshita S., Takeshita F., Haddad D.E., Ishii K.J., and Klinman D.M. CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression. Cell. Immunol. 206 (2000) 101-106
18. Poltorak A.N., Bazzoni F., Smirnova I.I., Alejos E., Thompson P., Luheshi G., Rothwell N., and Beutler B. MIP-1 gamma: molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo. J. Inflamm. 45 (1995) 207-219
19. Mohamadzadeh M., Poltorak A.N., Bergstressor P.R., Beutler B., and Takashima A. Dendritic cells produce macrophage inflammatory protein-1 gamma, a new member of the CC chemokine family. J. Immunol. 156 (1996) 3102-3106
20. Youn B.S., Jang I.K., Broxmeyer H.E., Cooper S., Jenkins N.A., Gilbert D.J., Copeland N.G., Elick T.A., Fraser Jr. M.J., and Kwon B.S. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J. Immunol. 155 (1995) 2661-2667
21. Hara T., Bacon K.B., Cho L.C., Yoshimura A., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Schall T.J., and Miyajima A. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J. Immunol. 155 (1995) 5352-5358
22. Lean J.M., Murphy C., Fuller K., and Chambers T.J. CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. J. Cell. Biochem. 87 (2002) 386-393
23. Kuo C.C., Liang S.M., and Liang C.M. CpG-B oligodeoxynucleotide promotes cell survival via up-regulation of Hsp70 to increase Bcl-xL and to decrease apoptosis-inducing factor translocation. J. Biol. Chem. 281 (2006) 38200-38207
24. Rutz M., Metzger J., Gellert T., Luppa P., Lipford G.B., Wagner H., and Bauer S. Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur. J. Immunol. 34 (2004) 2541-2550
25. Hacker H., Mischak H., Miethke T., Liptay S., Schmid R., Sparwasser T., Heeg K., Lipford G.B., and Wagner H. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17 (1998) 6230-6240
26. Culbert A.A., Skaper S.D., Howlett D.R., Evans N.A., Facci L., Soden P.E., Seymour Z.M., Guillot F., Gaestel M., and Richardson J.C. MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. J. Biol. Chem. 281 (2006) 23658-23667
27. Zhang Z., Guo K., and Schluesener H.J. The immunostimulatory activity of CpG oligonucleotides on microglial N9 cells is affected by a polyguanosine motif. J. Neuroimmunol. 161 (2005) 68-77
28. Viola A., and Luster A.D. Chemokines and their receptors: drug targets in immunity and inflammation. Annu. Rev. Pharmacol. Toxicol. 48 (2008) 171-197
29. Stalder M., Deller T., Staufenbiel M., and Jucker M. 3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid. Neurobiol. Aging 22 (2001) 427-434
30. El Khoury J., and Luster A.D. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol. Sci. 29 (2008) 626-632