Signal 3 requirement for memory CD8 + T-cell activation is determined by the infectious pathogen

European Journal of Immunology

Volumn 41, Issue 11, 2011, Pages 3176-3186

  Keppler, Selina J ^a   Aichele, Peter ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

IL 12; Infection; Memory T cells; Signal 3; Type I IFN

Indexed keywords

INTERFERON; INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL ACTIVITY; CELL EXPANSION; CELLULAR IMMUNITY; CONTROLLED STUDY; IN VIVO STUDY; LISTERIA MONOCYTOGENES; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VACCINIA VIRUS;

ANIMALS; ARENAVIRIDAE INFECTIONS; CD8-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; CYTOKINES; FLOW CYTOMETRY; IMMUNOLOGIC MEMORY; LISTERIOSIS; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; VACCINIA;

EID: 80054949877     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201141537     Document Type: Article

References (30)

1. Kaech, S. M., Hemby, S., Kersh, E. and Ahmed, R., Molecular and functional profiling of memory CD8 T cell differentiation. Cell 2002. 111: 837-851.
2. Opferman, J. T., Ober, B. T. and Ashton-Rickardt, P. G., Linear differentiation of cytotoxic effectors into memory T lymphocytes. Science 1999. 283: 1745-1748.
3. Sarkar, S., Kalia, V., Haining, W. N., Konieczny, B. T., Subramaniam, S. and Ahmed, R., Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J. Exp. Med. 2008. 205: 625-640.
4. D'Souza, W. N. and Hedrick, S. M., Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J. Immunol. 2006. 177: 777-781.
5. Rao, R. R., Li, Q., Odunsi, K. and Shrikant, P. A., The mTOR kinase determines effector versus memory CD8+T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 32: 67-78.
6. Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P. et al., mTOR regulates memory CD8 T-cell differentiation. Nature 2009. 460: 108-112.
7. Badovinac, V. P. and Harty, J. T., Manipulating the rate of memory CD8+ T cell generation after acute infection. J. Immunol. 2007. 179: 53-63.
8. Chang, J. T., Palanivel, V. R., Kinjyo, I., Schambach, F., Intlekofer, A. M., Banerjee, A., Longworth, S. A. et al., Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 2007. 315: 1687-1691.
9. Curtsinger, J. M., Johnson, C. M. and Mescher, M. F., CD8 T cell clonal expansion and development of effector function require prolonged exposure to antigen, costimulation, and signal 3 cytokine. J. Immunol. 2003. 171: 5165-5171.
10. Curtsinger, J. M., Schmidt, C. S., Mondino, A., Lins, D. C., Kedl, R. M., Jenkins, M. K. and Mescher, M. F., Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J. Immunol. 1999. 162: 3256-3262.
11. Curtsinger, J. M., Valenzuela, J. O., Agarwal, P., Lins, D. and Mescher, M. F., Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J. Immunol. 2005. 174: 4465-4469.
12. Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L. et al., Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 2007. 27: 281-295.
13. Aichele, P., Unsoeld, H., Koschella, M., Schweier, O., Kalinke, U. and Vucikuja, S., CD8 T cells specific for lymphocytic choriomeningitis virus require type I IFN receptor for clonal expansion. J. Immunol. 2006. 176: 4525-4529.
14. Kolumam, G. A., Thomas, S., Thompson, L. J., Sprent, J. and Murali-Krishna, K., Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J. Exp. Med. 2005. 202: 637-650.
15. Keppler, S. J., Theil, K., Vucikuja, S. and Aichele, P., Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8(+) T cells. Eur. J. Immunol. 2009. 39: 1774-1783.
16. Wilson, D. C., Matthews, S. and Yap, G. S., IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+effector subpopulations during Toxoplasma gondii infection. J. Immunol. 2008. 180: 5935-5945.
17. Wiesel, M., Kratky, W. and Oxenius, A., Type I IFN substitutes for T cell help during viral infections. J. Immunol. 186: 754-763.
18. Pearce, E. L. and Shen, H., Generation of CD8 T cell memory is regulated by IL-12. J. Immunol. 2007. 179: 2074-2081.
19. Xiao, Z., Casey, K. A., Jameson, S. C., Curtsinger, J. M. and Mescher, M. F., Programming for CD8 T cell memory development requires IL-12 or type I IFN. J. Immunol. 2009. 182: 2786-2794.
20. Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
21. Schmidt, C. S. and Mescher, M. F., Peptide antigen priming of naive, but not memory, CD8 T cells requires a third signal that can be provided by IL-12. J. Immunol. 2002. 168: 5521-5529.
22. Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M. et al., Control of effector CD8+T cell function by the transcription factor Eomesodermin. Science 2003. 302: 1041-1043.
23. Prlic, M. and Bevan, M. J., Exploring regulatory mechanisms of CD8+ T cell contraction. Proc. Natl. Acad. Sci. USA 2008. 105: 16689-16694.
24. Harty, J. T. and Badovinac, V. P., Shaping and reshaping CD8+ T-cell memory. Nat. Rev. Immunol. 2008. 8: 107-119.
25. Magram, J., Connaughton, S. E., Warrier, R. R., Carvajal, D. M., Wu, C. Y., Ferrante, J., Stewart, C. et al., IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 1996. 4: 471-481.
26. Muller, U., Steinhoff, U., Reis, L. F., Hemmi, S., Pavlovic, J., Zinkernagel, R. M. and Aguet, M., Functional role of type I and type II interferons in antiviral defense. Science 1994. 264: 1918-1921.
27. Pinschewer, D. D., Perez, M., Jeetendra, E., Bachi, T., Horvath, E., Hengartner, H., Whitt, M. A. et al., Kinetics of protective antibodies are determined by the viral surface antigen. J. Clin. Invest. 2004. 114: 988-993.
28. Zenewicz, L. A., Foulds, K. E., Jiang, J., Fan, X. and Shen, H., Nonsecreted bacterial proteins induce recall CD8 T cell responses but do not serve as protective antigens. J. Immunol. 2002. 169: 5805-5812.
29. Battegay, M., Cooper, S., Althage, A., Banziger, J., Hengartner, H. and Zinkernagel, R. M., Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J. Virol. Methods 1991. 33: 191-198.
30. Aichele, P., Brduscha-Riem, K., Oehen, S., Odermatt, B., Zinkernagel, R. M., Hengartner, H. and Pircher, H., Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology. Immunity 1997. 6: 519-529.