Synthesis and anticonvulsant activity of some new thiazolo[3,2-a][1,3] diazepine, benzo[d]thiazolo[5,2-a][12,6]diazepine and benzo[d]oxazolo[5,2-a][12, 6]diazepine analogues

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5567-5572

  El Subbagh, Hussein I ^a   Hassan, Ghada S ^b,c   El Azab, Adel S ^b,d   Abdel Aziz, Alaa A M ^b,c   Kadi, Adnan A ^b   Al Obaid, Abdulrahman M ^b   Al Shabanah, Othman A ^b   Sayed Ahmed, Mohamed M ^b  

^a FUTURE UNIVERSITY IN EGYPT   (Egypt)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c MANSOURA UNIVERSITY   (Egypt)

^d Al Azhar University   (Egypt)

Author keywords

Anticonvulsant activity; Benzo d oxazolo 5,2 a 12,6 diazepine; Benzo d thiazolo 5,2 a 12,6 diazepine; Synthesis; Thiazolo 3,2 a 1,3 diazepine

Indexed keywords

2 BROMO 6,7 DIHYDRO THIAZOLO[3,2-A][1,3]DIAZEPIN 8 (5H)ONE; 2 BROMO 6,7 DIHYDRO THIAZOLO[3,2-A][1,3]DIAZEPINE 8 (5H)THIONE; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 CHLORO BENZO[D]OXAZOLO[5,2-A][12,6]DIAZEPIN 10 ONE; 4 CHLORO N(6 CHLORO BENZO[D]THIAZOL 2 YL)BUTANAMIDE; 4 CHLORO N(6 METHYL BENZO[D]THIAZOL 2 YL)BUTANAMIDE; 4 CHLORO N(THIAZOL 2 YL)BUTANAMIDE; 6,7 DIHYDRO THIAZOLO[3,2-A][1,3]DIAZEPIN 8 (5H)ONE; 6,7 DIHYDRO THIAZOLO[3,2-A][1,3]DIAZEPINE 8 (5H)THIONE; 6,7 DIHYDRO THIAZOLO[3,2-A][1,3]DIAZEPINE DERIVATIVE; ANTICONVULSIVE AGENT; BENZO[D]OXAZOLO[5,2-A][12,6]DIAZEPINE DERIVATIVE; BENZO[D]THIAZOLO[5,2-A][12,6]DIAZEPINE DERIVATIVE; BICUCULLINE; N(5 BROMO THIAZOL 2 YL) 4 CHLORO BUTANAMIDE; N(BENZO[D]THIAZOL 2 YL) 4 CHLORO BUTANAMIDE; PENTETRAZOLE; PICROTOXIN; UNCLASSIFIED DRUG;

ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG SCREENING; DRUG SYNTHESIS; LD 50; SEIZURE; TONIC SEIZURE;

ANIMALS; ANTICONVULSANTS; AZEPINES; CHEMISTRY TECHNIQUES, SYNTHETIC; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; MICE; PENTYLENETETRAZOLE; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80054943747     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.021     Document Type: Article

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