Effects of the novel amiodarone-like compound SAR114646A on cardiac ion channels and ventricular arrhythmias in rats

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 384, Issue 3, 2011, Pages 231-244

  Goegelein, Heinz ^a   Gautier, Patrick ^b   Roccon, Alain ^b   O'Connor, Stephen ^b   Ruetten, Hartmut ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^b SANOFI   (France)

Author keywords

Antiarrhythmic; Ion channels; SAR114646A

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT; CALCIUM CHANNEL L TYPE; CELL PROTEIN; HCN4 PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; ION CHANNEL; POTASSIUM CHANNEL KV1.5; SAR 114646A; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTERIAL PRESSURE; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG SCREENING; DRUG SOLUBILITY; FEMALE; HEART LEFT ATRIUM; HEART MUSCLE CELL; HEART PAPILLARY MUSCLE; HEART RATE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; IC 50; INHIBITION KINETICS; ISOLATED HEART; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT;

ACTION POTENTIALS; AMIODARONE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART ATRIA; HEART VENTRICLES; ION CHANNELS; MALE; MUSCLE CELLS; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; PAPILLARY MUSCLES; PATCH-CLAMP TECHNIQUES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FIBRILLATION;

EID: 80054937446     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-011-0664-4     Document Type: Article

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