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Volumn 31, Issue 11, 2011, Pages 1092-1110

Management of menorrhagia associated with chemotherapy-induced thrombocytopenia in women with hematologic malignancy

Author keywords

Chemotherapy; Leuprolide; Menorrhagia; Menses; Pharmacotherapy; Thrombocytopenia; Tranexamic acid

Indexed keywords

AMINOCAPROIC ACID; CONJUGATED ESTROGEN; DANAZOL; DESMOPRESSIN; DROSPIRENONE PLUS ETHINYLESTRADIOL; ESTROGEN; ETHINYLESTRADIOL PLUS GESTODENE; GESTAGEN; GONADORELIN AGONIST; GONADORELIN DERIVATIVE; HYDROXYCHLOROQUINE; IBUPROFEN; INDOMETACIN; LEUPRORELIN; LEVONORGESTREL; MEDROXYPROGESTERONE; MEDROXYPROGESTERONE ACETATE; MEFENAMIC ACID; NAPROXEN; NOMEGESTROL ACETATE; NONSTEROID ANTIINFLAMMATORY AGENT; ORAL CONTRACEPTIVE AGENT; PLACEBO; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TRANEXAMIC ACID; TRIPTORELIN;

EID: 80054925981     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.31.11.1092     Document Type: Review
Times cited : (28)

References (74)
  • 1
    • 43449084928 scopus 로고    scopus 로고
    • Management of Dysfunctional Uterine Bleeding
    • DOI 10.1016/j.ogc.2008.03.001, PII S0889854508000181
    • Casablanca Y. Management of dysfunctional uterine bleeding. Obstet Gynecol Clin North Am 2008;35:219-34. (Pubitemid 351671995)
    • (2008) Obstetrics and Gynecology Clinics of North America , vol.35 , Issue.2 , pp. 219-234
    • Casablanca, Y.1
  • 2
    • 77956114742 scopus 로고    scopus 로고
    • Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding: Systematic review and meta-analysis of data from individual patients
    • [online exclusive article]. Available from
    • Middleton LJ, Champaneria R, Daniels JP, et al. Hysterectomy, endometrial destruction, and levonorgestrel releasing intrauterine system (Mirena) for heavy menstrual bleeding: systematic review and meta-analysis of data from individual patients [online exclusive article]. BMJ 2010;341:c3929. Available from http://dx.doi.org/10.1136/ bmj.c3929.
    • (2010) BMJ , vol.341
    • Middleton, L.J.1    Champaneria, R.2    Daniels, J.P.3
  • 3
    • 37749048550 scopus 로고    scopus 로고
    • Review of quality of life: Menorrhagia in women with or without inherited bleeding disorders
    • Shankar M, Chi C, Kadir RA. Review of quality of life: menorrhagia in women with or without inherited bleeding disorders. Haemophilia 2008;14:15-20.
    • (2008) Haemophilia , vol.14 , pp. 15-20
    • Shankar, M.1    Chi, C.2    Kadir, R.A.3
  • 4
    • 34548170799 scopus 로고    scopus 로고
    • Endometrial bleeding
    • The ESHRE Capri Workshop Group
    • The ESHRE Capri Workshop Group. Endometrial bleeding. Hum Reprod Update 2007;13:421-31.
    • (2007) Hum Reprod Update , vol.13 , pp. 421-431
  • 6
    • 0001758130 scopus 로고    scopus 로고
    • Guidelines for the management of abnormal uterine bleeding
    • Vilos GA, Lefebvre G, Graves GR. Guidelines for the management of abnormal uterine bleeding. J Obstet Gynaecol Can 2001;23:704-9.
    • (2001) J Obstet Gynaecol Can , vol.23 , pp. 704-709
    • Vilos, G.A.1    Lefebvre, G.2    Graves, G.R.3
  • 7
    • 33846496120 scopus 로고    scopus 로고
    • Approach to diagnosis and management of abnormal uterine bleeding
    • Telner DE, Jakubovicz D. Approach to diagnosis and management of abnormal uterine bleeding. Can Fam Physician 2007;53:58-64. (Pubitemid 46166587)
    • (2007) Canadian Family Physician , vol.53 , Issue.1 , pp. 58-64
    • Telner, D.E.1    Jakubovicz, D.2
  • 11
    • 0036169009 scopus 로고    scopus 로고
    • Mechanisms of abnormal uterine bleeding
    • DOI 10.1093/humupd/8.1.60
    • Livingstone MK, Fraser IS. Mechanisms of abnormal uterine bleeding. Hum Reprod Update 2002;8:60-7. (Pubitemid 34144986)
    • (2002) Human Reproduction Update , vol.8 , Issue.1 , pp. 60-67
    • Livingstone, M.1    Fraser, I.S.2
  • 12
    • 51449121454 scopus 로고    scopus 로고
    • Use of the levonorgestrel intrauterine system in women with hemostatic disorders
    • Lukes AS, Reardon B, Arepally G. Use of the levonorgestrel intrauterine system in women with hemostatic disorders. Fertil Steril 2008;90:673-7.
    • (2008) Fertil Steril , vol.90 , pp. 673-677
    • Lukes, A.S.1    Reardon, B.2    Arepally, G.3
  • 13
    • 55949136489 scopus 로고    scopus 로고
    • Review of the confusion in current and historical terminology and definitions for disturbances of menstrual bleeding
    • Woolcock JG, Critchley HOD, Munro MG, Broder MS, Fraser IS. Review of the confusion in current and historical terminology and definitions for disturbances of menstrual bleeding. Fertil Steril 2008;90:2269-80.
    • (2008) Fertil Steril , vol.90 , pp. 2269-2280
    • Woolcock, J.G.1    Critchley, H.O.D.2    Munro, M.G.3    Broder, M.S.4    Fraser, I.S.5
  • 14
    • 61549103459 scopus 로고    scopus 로고
    • Physiological changes associated with the menstrual cycle
    • Farage MA, Neill S, MacLean AB. Physiological changes associated with the menstrual cycle. Obstet Gynecol Surv 2009:64:58-72.
    • (2009) Obstet Gynecol Surv , vol.64 , pp. 58-72
    • Farage, M.A.1    Neill, S.2    MacLean, A.B.3
  • 16
    • 77955373756 scopus 로고    scopus 로고
    • The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges
    • Christian CA, Moenter SM. The neurobiology of preovulatory and estradiol-induced gonadotropin-releasing hormone surges. Endocr Rev 2010;31:544-77.
    • (2010) Endocr Rev , vol.31 , pp. 544-577
    • Christian, C.A.1    Moenter, S.M.2
  • 17
    • 70349938054 scopus 로고    scopus 로고
    • GnRH pulsatility, the pituitary response and reproductive dysfunction
    • Tsutsumi R, Webster NJG. GnRH pulsatility, the pituitary response and reproductive dysfunction. Endocr J 2009;56:729-37.
    • (2009) Endocr J , vol.56 , pp. 729-737
    • Tsutsumi, R.1    Webster, N.J.G.2
  • 18
    • 0442276043 scopus 로고    scopus 로고
    • Benefits and Risks of Pharmacological Agents Used for the Treatment of Menorrhagia
    • DOI 10.2165/00002018-200427020-00001
    • Roy SN, Bhattacharya S. Benefits and risks of pharmacological agents used for the treatment of menorrhagia. Drug Saf 2004;27:75-90. (Pubitemid 38186951)
    • (2004) Drug Safety , vol.27 , Issue.2 , pp. 75-90
    • Roy, S.N.1    Bhattacharya, S.2
  • 19
    • 77957749957 scopus 로고    scopus 로고
    • Clinical practice guidelines on menorrhagia: Management of abnormal uterine bleeding before menopause
    • Marret H, Fauconnier A, Chabbert-Buffet N, et al. Clinical practice guidelines on menorrhagia: management of abnormal uterine bleeding before menopause. Eur J Obstet Gynecol Reprod Biol 2010;152:133-7.
    • (2010) Eur J Obstet Gynecol Reprod Biol , vol.152 , pp. 133-137
    • Marret, H.1    Fauconnier, A.2    Chabbert-Buffet, N.3
  • 20
    • 78349280268 scopus 로고    scopus 로고
    • Menorrhagia impact questionnaire: Assessing the influence of heavy menstrual bleeding on quality of life
    • Bushnell DM, Martin ML, Moore KA, Richter HE, Rubin A, Patrick DL. Menorrhagia impact questionnaire: assessing the influence of heavy menstrual bleeding on quality of life. Curr Med Res Opin 2010;26:2745-55.
    • (2010) Curr Med Res Opin , vol.26 , pp. 2745-2755
    • Bushnell, D.M.1    Martin, M.L.2    Moore, K.A.3    Richter, H.E.4    Rubin, A.5    Patrick, D.L.6
  • 21
    • 77958126215 scopus 로고    scopus 로고
    • Estimating a meaningful reduction in menstrual blood loss for women with heavy menstrual bleeding
    • Lukes AS, Muse K, Richter HE, Moore KA, Patrick DL. Estimating a meaningful reduction in menstrual blood loss for women with heavy menstrual bleeding. Curr Med Res Opin 2010;26:2673-8.
    • (2010) Curr Med Res Opin , vol.26 , pp. 2673-2678
    • Lukes, A.S.1    Muse, K.2    Richter, H.E.3    Moore, K.A.4    Patrick, D.L.5
  • 22
    • 0023913081 scopus 로고
    • Ovarian function following marrow transplantation for aplastic anemia or leukemia
    • Sanders JE, Buckner D, Amos D, et al. Ovarian function following marrow transplantation for aplastic anemia or leukemia. J Clin Oncol 1988;6:813-18.
    • (1988) J Clin Oncol , vol.6 , pp. 813-818
    • Sanders, J.E.1    Buckner, D.2    Amos, D.3
  • 23
    • 0023868608 scopus 로고
    • The relationship of gonadal activity and chemotherapy-induced gonadal damage
    • DOI 10.1001/jama.259.14.2123
    • Rivkees SA, Crawford JD. The relationship of gonadal activity and chemotherapy-induced gonadal damage. JAMA 1988;259:2123-5. (Pubitemid 18088500)
    • (1988) Journal of the American Medical Association , vol.259 , Issue.14 , pp. 2123-2125
    • Rivkees, S.A.1    Crawford, J.D.2
  • 24
    • 0029864362 scopus 로고    scopus 로고
    • Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer
    • Bines J, Oleske DM, Cobleigh MA. Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol 1996;14:1718-29. (Pubitemid 26134232)
    • (1996) Journal of Clinical Oncology , vol.14 , Issue.5 , pp. 1718-1729
    • Bines, J.1    Oleske, D.M.2    Cobleigh, M.A.3
  • 25
    • 0033016816 scopus 로고    scopus 로고
    • Ovarian injury and modern options to preserve fertility in female cancer patients treated with high dose radio-chemotherapy for hemato-oncological neoplasias and other cancers
    • Meirow D. Ovarian injury and modern options to preserve fertility in female cancer patients treated with high dose radiochemotherapy for hemato-oncological neoplasias and other cancers. Leuk Lymphoma 1999;33:65-76. (Pubitemid 29116395)
    • (1999) Leukemia and Lymphoma , vol.33 , Issue.1-2 , pp. 65-76
    • Meirow, D.1
  • 30
    • 34848889621 scopus 로고    scopus 로고
    • Severe menorrhagia associated with thrombocytopenia
    • DOI 10.1097/01.AOG.0000279138.64895.2b, PII 0000625020071000000028
    • Levens ED, Scheinberg P, DeCherney AH. Severe menorrhagia associated with thrombocytopenia. Obstet Gynecol 2007;110:913-17. (Pubitemid 47508759)
    • (2007) Obstetrics and Gynecology , vol.110 , Issue.4 , pp. 913-917
    • Levens, E.D.1    Scheinberg, P.2    DeCherney, A.H.3
  • 31
    • 0029935482 scopus 로고    scopus 로고
    • Treatment and prophylaxis of hypermenorrhea with leuprorelin in premenopausal women affected by acute leukemia at diagnosis [6]
    • DOI 10.1002/(SICI)1096-8652(199603)51:3<248::AID-AJH17>3.0.CO;2-C
    • Sica S, Salutari P, DiMario A, et al. Treatment and prophylaxis of hypermenorrhea with leuprorelin in premenopausal women affected by acute leukemia at diagnosis. Am J Hematol 1996;51:248-9. (Pubitemid 26089779)
    • (1996) American Journal of Hematology , vol.51 , Issue.3 , pp. 248-249
    • Sica, S.1    Salutari, P.2    Di, M.A.3    Chiusolo, P.4    Ruella, S.5    Ortu, L.B.E.6    Leone, G.7    Scirpa, P.8
  • 33
    • 0031897519 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone analogue: Leuprorelin acetate for the prevention of menstrual bleeding in premenopausal women undergoing stem cell transplantation
    • Chiusolo P, Salutari P, Sica S, et al. Luteinizing hormone-releasing hormone analogue: leuprorelin acetate for the prevention of menstrual bleeding in premenopausal women undergoing stem cell transplantation. Bone Marrow Transplant 1998;21:821-3. (Pubitemid 28190627)
    • (1998) Bone Marrow Transplantation , vol.21 , Issue.8 , pp. 821-823
    • Chiusolo, P.1    Salutari, P.2    Sica, S.3    Scirpa, P.4    Laurenti, L.5    Piccirillo, N.6    Leone, G.7
  • 35
    • 33749621106 scopus 로고    scopus 로고
    • Prevention of severe menorrhagia in oncology patients with treatment-induced thrombocytopenia by luteinizing hormone-releasing hormone agonist and depo-medroxyprogesterone acetate
    • DOI 10.1002/cncr.22199
    • Meirow D, Rabinovici J, Katz D, Or R, Ben-Yehuda D. Prevention of severe menorrhagia in oncology patients with treatment-induced thrombocytopenia by luteinizing hormone-releasing hormone agonist and depo-medroxyprogesterone acetate. Cancer 2006;107:1634-41. (Pubitemid 44546925)
    • (2006) Cancer , vol.107 , Issue.7 , pp. 1634-1641
    • Meirow, D.1    Rabinovici, J.2    Katz, D.3    Or, R.4    Ben-Yehuda, D.5
  • 37
    • 0036073843 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of depot leuprorelin
    • Periti P, Mazzei T, Mini E. Clinical pharmacokinetics of depot leuprorelin. Clin Pharmacokinet 2002;41:485-504. (Pubitemid 34804161)
    • (2002) Clinical Pharmacokinetics , vol.41 , Issue.7 , pp. 485-504
    • Periti, P.1    Mazzei, T.2    Mini, E.3
  • 38
    • 0004074875 scopus 로고    scopus 로고
    • Available from Accessed February 21, 2011
    • Sweetman S, ed. Martindale: the complete drug reference. Thomson Reuters. Available from http://www.thomsonhc.com/home/dispatch. Accessed February 21, 2011.
    • Martindale: The Complete Drug Reference
    • Sweetman, S.1
  • 42
    • 0026710248 scopus 로고
    • Treatment of endometriosis with leuprorelin acetate depot: A German multicentre study
    • Gerhard I, Schindler AE, Buhler K, et al. Treatment of endometriosis with leuprorelin acetate depot: a German multicentre study. Clin Ther 1992;14(suppl A):3-16.
    • (1992) Clin Ther , vol.14 , Issue.SUPPL. A , pp. 3-16
    • Gerhard, I.1    Schindler, A.E.2    Buhler, K.3
  • 43
    • 34948906706 scopus 로고    scopus 로고
    • Long-term personalized GnRH agonist therapy without estrogen supplementation for recurrent endometriotic catamenial pneumothorax - Case report
    • Tanaka T. Long-term personalized GnRH agonist therapy without estrogen supplementation for recurrent endometriotic catamenial pneumothorax: case report. Clin Exp Obstet Gynecol 2007;34:179-81. (Pubitemid 47529249)
    • (2007) Clinical and Experimental Obstetrics and Gynecology , vol.34 , Issue.3 , pp. 179-181
    • Tanaka, T.1
  • 44
    • 33745913012 scopus 로고    scopus 로고
    • Ultrasonographic evaluation of the change in uterine fibroids induced by treatment with a GnRH analog
    • Chia CC, Huang SC, Chen SS, et al. Ultrasonographic evaluation of the change in uterine fibroids induced by treatment with a GnRH analog. Taiwanese J Obstet Gynecol 2006;45:124-8.
    • (2006) Taiwanese J Obstet Gynecol , vol.45 , pp. 124-128
    • Chia, C.C.1    Huang, S.C.2    Chen, S.S.3
  • 45
    • 41549096021 scopus 로고    scopus 로고
    • Goserelin versus leuprolide before hysterectomy for uterine fibroids
    • Lim SS, Sockaglingam JK, Tan PC. Goserelin versus leuprolide before hysterectomy for uterine fibroids. Int J Gynecol Obstet 2008;101:178-83.
    • (2008) Int J Gynecol Obstet , vol.101 , pp. 178-183
    • Lim, S.S.1    Sockaglingam, J.K.2    Tan, P.C.3
  • 46
    • 0029034181 scopus 로고
    • Treatment of central precocious puberty with depot leuprorelin
    • for the French Leuprorelin Trial Group
    • Carel JC, Lahlou N, Jaramillo O, et al., for the French Leuprorelin Trial Group. Treatment of central precocious puberty with depot leuprorelin. Eur J Endocrinol 1995;132:699-704.
    • (1995) Eur J Endocrinol , vol.132 , pp. 699-704
    • Carel, J.C.1    Lahlou, N.2    Jaramillo, O.3
  • 47
    • 0036438585 scopus 로고    scopus 로고
    • Long-term suppression of pituitary-gonadal function with three-month depot of leuprorelin acetate in a girl with central precocious puberty
    • DOI 10.1159/000066445
    • Schroeter M, Baus I, Sippell WG, Partsch CJ. Long-term suppression of pituitary-gonadal function with three month depot of leuprorelin acetate in a girl with central precocious puberty. Horm Res 2002;58:292-6. (Pubitemid 35404242)
    • (2002) Hormone Research , vol.58 , Issue.6 , pp. 292-296
    • Schroeter, M.1    Baus, I.2    Sippell, W.G.3    Partsch, C.-J.4
  • 48
    • 34147174002 scopus 로고    scopus 로고
    • Noninfective cutaneous granuloma with leuprorelin acetate - Reality of myth
    • Dangle P, Palit V, Sundaram SK, Weston P. Noninfective cutaneous granuloma with leuprorelin acetate - reality of myth. Urology 2007;69:779.e6.
    • (2007) Urology , vol.69
    • Dangle, P.1    Palit, V.2    Sundaram, S.K.3    Weston, P.4
  • 49
    • 70350489128 scopus 로고    scopus 로고
    • A morphological study of granulomas induced by subcutaneous injection of leuprorelin acetate
    • Watanabe T, Yamada N, Yoshida Y, Yamamoto O. A morphological study of granulomas induced by subcutaneous injection of leuprorelin acetate. J Cutan Pathol 2009;36:1299-302.
    • (2009) J Cutan Pathol , vol.36 , pp. 1299-1302
    • Watanabe, T.1    Yamada, N.2    Yoshida, Y.3    Yamamoto, O.4
  • 51
    • 26444473212 scopus 로고    scopus 로고
    • Noncontraceptive health benefits of combined oral contraception
    • The ESHRE Capri Workshop Group
    • The ESHRE Capri Workshop Group. Noncontraceptive health benefits of combined oral contraception. Hum Reprod Update 2005;11:513-25.
    • (2005) Hum Reprod Update , vol.11 , pp. 513-525
  • 52
    • 2342435372 scopus 로고    scopus 로고
    • Safety concerns and health benefits associated with oral contraception
    • Burkman R, Schlesselman JJ, Zieman M. Safety concerns and health benefits associated with oral contraception. Am J Ob Gyn 2004;190:S5-22.
    • (2004) Am J Ob Gyn , vol.190
    • Burkman, R.1    Schlesselman, J.J.2    Zieman, M.3
  • 54
    • 0014030741 scopus 로고
    • The effect of oral contraceptives on the liver
    • Schaffner F. The effect of oral contraceptives on the liver. JAMA 1966;198:155-7.
    • (1966) JAMA , vol.198 , pp. 155-157
    • Schaffner, F.1
  • 55
    • 0032535021 scopus 로고    scopus 로고
    • Norethisterone treatment, a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation
    • Hagglund H, Remberger M, Klaesson S, Lonnqvist B, Ljungman P, Ringden O. Norethisterone treatment, a major risk factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation. Blood 1998;92:4568-72. (Pubitemid 29005858)
    • (1998) Blood , vol.92 , Issue.12 , pp. 4568-4572
    • Hagglund, H.1    Remberger, M.2    Klaesson, S.3    Lonnqvist, B.4    Ljungman, P.5    Ringden, O.6
  • 57
    • 0028922825 scopus 로고
    • Effects of nonsteroidal anti-inflammatory drugs on platelet function and systemic hemostasis
    • Schafer A. Effects of nonsteroidal anti-inflammatory drugs on platelet function and systemic hemostasis. J Clin Pharmacol 1995;35:209-19.
    • (1995) J Clin Pharmacol , vol.35 , pp. 209-219
    • Schafer, A.1
  • 58
    • 3242662722 scopus 로고    scopus 로고
    • Relationship between platelet count and bleeding risk in thrombocytopenic patients
    • DOI 10.1016/j.tmrv.2004.03.003, PII S0887796304000197
    • Slichter SJ. Relationship between platelet count and bleeding risk in thrombocytopenic patients. Transfus Med Rev 2004;18:153-67. (Pubitemid 38962484)
    • (2004) Transfusion Medicine Reviews , vol.18 , Issue.3 , pp. 153-167
    • Slichter, S.J.1
  • 59
    • 77957220276 scopus 로고    scopus 로고
    • Tranexamic acid treatment for heavy menstrual bleeding
    • Lukes AS, Moore KA, Muse KN, et al. Tranexamic acid treatment for heavy menstrual bleeding. Obstet Gynecol 2010;116:865-75.
    • (2010) Obstet Gynecol , vol.116 , pp. 865-875
    • Lukes, A.S.1    Moore, K.A.2    Muse, K.N.3
  • 60
    • 57349119262 scopus 로고    scopus 로고
    • The risk of venous thromboembolism associated with the use of tranexamic acid and other drugs used to treat menorrhagia: A case-control study using the general practice research database
    • Sundstöm A, Seaman H, Kieler H, Alfredsson L. The risk of venous thromboembolism associated with the use of tranexamic acid and other drugs used to treat menorrhagia: a case-control study using the general practice research database. BJOG 2009;116:91-7.
    • (2009) BJOG , vol.116 , pp. 91-97
    • Sundstöm, A.1    Seaman, H.2    Kieler, H.3    Alfredsson, L.4
  • 61
    • 84861192160 scopus 로고    scopus 로고
    • Pharmacokinetic studies in women of 2 novel oral formulations of tranexamic acid therapy for heavy menstrual bleeding
    • [published online ahead of print January 18, 2011]. Available from
    • Moore KA, Morin I, Marenco T, Lavigne JR, Morelli G. Pharmacokinetic studies in women of 2 novel oral formulations of tranexamic acid therapy for heavy menstrual bleeding [published online ahead of print January 18, 2011]. Am J Ther 2011. Available from http://dx.doi.org/10.1097/MJT.0b013e318205427a.
    • (2011) Am J Ther
    • Moore, K.A.1    Morin, I.2    Marenco, T.3    Lavigne, J.R.4    Morelli, G.5
  • 62
    • 77956583225 scopus 로고    scopus 로고
    • Thorough cardiac QTc interval conductance assessment of a novel oral tranexamic acid treatment for heavy menstrual bleeding
    • Moore KA, Callahan TS, Maison-blanche P, et al. Thorough cardiac QTc interval conductance assessment of a novel oral tranexamic acid treatment for heavy menstrual bleeding. Expert Opin Pharmacother 2010;11:2281-90.
    • (2010) Expert Opin Pharmacother , vol.11 , pp. 2281-2290
    • Moore, K.A.1    Callahan, T.S.2    Maison-blanche, P.3
  • 64
    • 69949103268 scopus 로고    scopus 로고
    • The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: Results of the MEGA case-control study
    • Vlieg AH, Helmerhorst FM, Vandenbrouke JP, et al. The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study. BMJ 2009;339:h2921.
    • (2009) BMJ , vol.339
    • Vlieg, A.H.1    Helmerhorst, F.M.2    Vandenbrouke, J.P.3
  • 65
    • 0019132413 scopus 로고
    • Reduction of menstrual blood loss by danazol in unexplained menorrhagia: Lack of effect of placebo
    • Chimbira TH, Anderson AB, Naish C, Cope E, Turnbull AC. Reduction of menstrual blood loss by danazol in unexplained menorrhagia: lak of effect of placebo. Br J Obstet Gynaecol 1980;87:1152-8. (Pubitemid 11199041)
    • (1980) British Journal of Obstetrics and Gynaecology , vol.87 , Issue.12 , pp. 1152-1158
    • Chimbira, T.H.1    Anderson, A.B.M.2    Naish, C.3
  • 67
    • 0027134824 scopus 로고
    • A comparative study of danazol, a regimen of decreasing doses of danazol, and norethindrone in the treatment of objectively proven unexplained menorrhagia
    • Higham JM, Shaw RW. A comparative study of danazol, a regimen of decreasing doses of danazol, and norethindrone in the treatment of objectively proven unexplained menorrhagia. Am J Obstet Gynecol 1993;169:1134-9. (Pubitemid 24001627)
    • (1993) American Journal of Obstetrics and Gynecology , vol.169 , Issue.5 , pp. 1134-1139
    • Higham, J.M.1    Shaw, R.W.2
  • 70
    • 0030750504 scopus 로고    scopus 로고
    • Efficacy of danazol in a patient with congenital Protein S deficiency: Paradoxical evidence for decreased platelet activation with increased thrombin generation
    • DOI 10.1016/S0049-3848(97)00163-1, PII S0049384897001631
    • Ledford MR, Horton A, Wang G, Brito G, Delgado L. Efficacy of danazol in a patient with congenital protein-S deficiency: paradoxical evidence for decreased platelet activation and increased thrombin generation. Thromb Res 1997;87:473-82. (Pubitemid 27431630)
    • (1997) Thrombosis Research , vol.87 , Issue.5 , pp. 473-482
    • Ledford, M.R.1    Horton, A.2    Wang, G.3    Brito, M.4    Delgado, L.5
  • 71
    • 70349448606 scopus 로고    scopus 로고
    • Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age
    • Luisi S, Razzi S, Lazzeri L, Bocchi C, Severi F, Petraglia F. Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age. Fertil Steril 2009;92:1351-4.
    • (2009) Fertil Steril , vol.92 , pp. 1351-1354
    • Luisi, S.1    Razzi, S.2    Lazzeri, L.3    Bocchi, C.4    Severi, F.5    Petraglia, F.6
  • 73
    • 84857194687 scopus 로고    scopus 로고
    • Intensive menstrual bleeding successfully treated with recombinant factor VIIa in Glanzmann thrombasthenia
    • [published online ahead of print May 11, 2010]. Available from
    • Balci YI, Karabulut A, Kabukcu S, Sari I, Keski A. Intensive menstrual bleeding successfully treated with recombinant factor VIIa in Glanzmann thrombasthenia [published online ahead of print May 11, 2010]. Clin Appl Throb Hemost 2010 Available from http://cat.sagepub.com/content/early/2010/03/22/ 1076029610364518.long.
    • (2010) Clin Appl Throb Hemost
    • Balci, Y.I.1    Karabulut, A.2    Kabukcu, S.3    Sari, I.4    Keski, A.5


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