Discovery of the improved antagonistic prolactin variants by library screening

Protein Engineering, Design and Selection

Volumn 24, Issue 11, 2011, Pages 855-860

  Liu, Yun ^a   Gong, Wei ^a   Breinholt, Jens ^b   Nørskov Lauritsen, Leif ^b   Zhang, Jinchao ^a,c   Ma, Qinhong ^a,c   Chen, Jianhe ^a   Panina, Svetlana ^b   Guo, Wei ^a   Li, Tengkun ^a   Zhang, Jingyuan ^a   Kong, Meng ^a,d   Liu, Zibing ^a   Mao, Jingjing ^a   Christensen, Leif ^b   Hu, Sean ^a,e   Wang, Lingyun ^a  

^a SIBS Novo Nordisk Translational Research Centre for PreDiabetes   (China)

^b NOVO NORDISK A S   (Denmark)

^c Beijing Kohnoor Science and Technology Co Ltd A210   (China)

^d GE HEALTHCARE   (China)

^e Novozymes Biotech Inc   (United States)

Author keywords

Ba F3 assay; library screening; prolactin receptor antagonist; scintillation proximity assay; surface plasmon resonance

Indexed keywords

CLINICAL TREATMENTS; GROWTH STIMULATORS; IN-VITRO; IN-VIVO; LIBRARY SCREENING; PROLACTIN RECEPTORS; PROSTATE CANCERS; PROTEIN LIBRARY; SURFACE PLASMONS;

DISEASES;

SURFACE PLASMON RESONANCE;

HORMONE RECEPTOR BLOCKING AGENT; MUTANT PROTEIN; PEPTIDE LIBRARY; PROLACTIN; PROLACTIN DERIVATIVE; PROLACTIN RECEPTOR; PROLACTIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MUTATION; PRIORITY JOURNAL; PROTEIN VARIANT; RECEPTOR BINDING; SCREENING;

BREAST NEOPLASMS; FEMALE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMAN GROWTH HORMONE; HUMANS; MALE; MUTATION; PROLACTIN; PROSTATIC NEOPLASMS; PROTEIN BINDING; RECEPTORS, PROLACTIN; SURFACE PLASMON RESONANCE;

EID: 80054925865     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr047     Document Type: Article

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