The puzzle of multiple sclerosis: Gray matter finds its place

Expert Review of Neurotherapeutics

Volumn 11, Issue 11, 2011, Pages 1565-1568

  Calabrese, Massimiliano ^a   Rinaldi, Francesca ^a   Poretto, Valentina ^a   Gallo, Paolo ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

gray matter pathology; MRI; multiple sclerosis; physical and cognitive disability

Indexed keywords

ARTICLE; BRAIN ATROPHY; COGNITIVE DEFECT; DISEASE COURSE; GRAY MATTER; HUMAN; MULTIPLE SCLEROSIS; PATHOPHYSIOLOGY; PHENOTYPE; WHITE MATTER;

EID: 80054924670     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.11.143     Document Type: Article

References (31)

1. Peterson JW, Bö L, Mörk S, Chang A, Trapp BD. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurology 50(3), 389-400 (2001)
2. Vercellino M, Masera S, Lorenzatti M et al. Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter. J Neuropathol. Exp. Neurol. 68(5), 489-502 (2009)
3. Kutzelnigg A, Lucchinetti CF, Stadelmann C et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain 128(11), 2705-2712 (2005)
4. Kidd D, Barkhof F, McConnell R, Algra PR, Allen IV, Revesz T. Cortical lesions in multiple sclerosis. Brain 122(1), 17-26 (2001)
5. Geurts JJ, Barkhof F. Grey matter pathology in multiple sclerosis. Lancet Neurol. 7(9), 841-851 (2008)
6. Geurts JJ, Pouwels PJ, Uitdehaag BM, Polman CH, Barkhof F, Castelijns JA. Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging. Radiology 236(1), 254-260 (2005)
7. Sailer M, Fischi B, Salat D et al. Focal thinning of the cerebral cortex in multiple sclerosis. Brain 126 (8), 1734-1744 (2003)
8. Dalton CM, Chard DT, Davies GR et al. Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes. Brain 127(5), 1101-1107 (2004)
9. Sastre-Garriga J, Ingle GT, Chard DT, Ramió-Torrentà L, Miller DH, Thompson AJ. Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosis. Neuroimage 22(1), 353-359 (2004)
10. Ramasamy DP, Benedict R, Cox J et al. Extent of cerebellum, subcortical and cortical atrophy in patients with MS. A case-control study. J Neurol. Sci. 282, 47-54 (2009)
11. Calabrese M, Gallo P. Magnetic resonance evidence of cortical onset of multiple sclerosis. Mult. Scler.15 (8), 933-941 (2009)
12. Popescu BF, Bunyan RF, Parisi JE, Ransohoff RM, Lucchinetti CF. A case of multiple sclerosis presenting with inflammatory cortical demyelination. Neurology 76(20), 1705-1710 (2011)
13. Barkhof F. The clinico-radiological paradox in multiple sclerosis revisited. Curr Opin. Neurol. 15(3), 239-245 (2002)
14. Brex PA, Ciccarelli O, O'Riordan JI, Sailer M, ThompsonAJ, Miller DH. A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N. Eng. J Med. 346(3), 158-164 (2002)
15. Fisniku LK, Chard DT, Jackson JS et al. Gray matter atrophy is related to long-term disability in multiple sclerosis. Ann Neurol. 64(3), 247-254 (2008)
16. Roosendaal SD, Bendfeldt K, Vrenken H et al. Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability. Mult. Scler. 17(9), 1098-1106 (2011)
17. Jasperse B, Valsasina P, Neacsu V et al. Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually edited SIENA and SIENAX. J Magn. Reson. Imaging 26(4), 881-885 (2007)
18. De Stefano N, Matthews PM, Filippi M et al. Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology 60(7), 1157-1162 (2003)
19. Calabrese M, Rocca MA, Atzori M et al. A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis. Ann Neurol. 67(3) 376-383 (2010)
20. Roosendaal SD, Moraal B, Pouwels PJ et al. Accumulation of cortical lesions in MS: relation with cognitive impairment. Mult. Scler. 15(6), 708-714 (2009)
21. Calabrese M, Agosta F, Rinaldi F et al. Cortical lesions and atrophy associated with cognitive impairment in relapsingremitting multiple sclerosis. Arch. Neurol. 66(9), 1144-1150 (2009)
22. Rovaris M, Judica E, Gallo A et al. Grey matter damage predicts the evolution of primary progressive multiple sclerosis at 5 years. Brain 129(10), 2628-2634 (2006)
23. Amato MP, Portaccio E, Goretti B et al. Cognitive impairment in early stages of multiple sclerosis. Neurol. Sci. 31, S211-S214 (2010)
24. Calabrese M, Rinaldi F, Mattisi I et al. Widespread cortical thinning characterizes patients with MS with mild cognitive impairment. Neurology 74(4), 321-328 (2010)
25. Filippi M, Rocca MA, Calabrese M et al. Intracortical lesions: relevance for new MRI diagnostic criteria for multiple sclerosis. Neurology 75(22), 1988-1994 (2010)
26. Calabrese M, Rinaldi F, Mattisi I et al. The predictive value of gray matter atrophy in clinically isolated syndromes. Neurology 77(3), 257-263 (2011)
27. Polman CH, Reingold SC, Banwell B et al. Diagnostic criteria for multiple sclerosis: 2010 revision to the McDonald criteria. Ann Neurol. 69(2), 292-302 (2011)
28. Filippi M, Rovaris M, Inglese M et al Interferon b-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet 364(9444), 1489-1496 (2004)
29. Calabrese M, Bernardi V, Atzori M et al. Effect of disease-modifying drugs on cortical lesions and atrophy in relapsing-remitting multiple. Mult. Scler. DOI: 10.1177/1352458510394702 (2011) (Epub ahead of print)
30. Bendfeldt K, Egger H, Nichols TE et al. Effect of immunomodulatory medication on regional gray matter loss in relapsing-remitting multiple sclerosis -a longitudinal MRI study. Brain Res. 14(1325), 174-182 (2010)
31. Derfuss T, Parikh K, Velhin S et al. Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. Proc Natl Acad. Sci. USA 19(106), 8302-8307 (2009)