Cyclic tensile stretch load and oxidized low density lipoprotein synergistically induce lectin-like oxidized LDL receptor-1 in cultured bovine chondrocytes, resulting in decreased cell viability and proteoglycan synthesis

Journal of Orthopaedic Research

Volumn 24, Issue 8, 2006, Pages 1782-1790

  Akagi, Masao ^a   Nishimura, Shunji ^a   Yoshida, Kohji ^a   Kakinuma, Takumi ^b   Sawamura, Tatsuya ^c   Munakata, Hiroshi ^a   Hamanishi, Chiaki ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Cell viability; Chondrocytes; Cyclic load; Lectin like oxidized LDL receptor 1 (LOX 1); Oxidized low density lipoprotein (ox LDL)

Indexed keywords

OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROTEOGLYCAN;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; COW; DISEASE COURSE; HYPOTHESIS; MECHANICAL STIMULATION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOGLYCAN SYNTHESIS; RECEPTOR UPREGULATION; STRESS; TENSILE STRENGTH; WEIGHT BEARING;

ANIMALS; CATTLE; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; GENE EXPRESSION REGULATION; LIPOPROTEINS, LDL; OSTEOARTHRITIS; PROTEOGLYCANS; RECEPTORS, OXIDIZED LDL; TENSILE STRENGTH;

EID: 33746998400     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20211     Document Type: Article

References (27)

1. Henrotin YE, Bruckner P, Pujol JP. 2003. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage 11:747-755.
2. Tiku ML, Shah R, Allison GT. 2000. Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis. J Biol Chem 275:20069-20076.
3. Sawamura T, Kume N, Aoyama T, et al. 1997. An endothelial receptor for oxidized low-density lipoprotein. Nature 386:73-77.
4. Nakagawa T, Akagi M, Hoshikawa H, et al. 2002. Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis. Arthritis Rheum 46:2486-2494.
5. Delneste Y, Magistrelli G, Gauchat J, et al. 2002. Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity 17:353-362.
6. Kataoka H, Kume N, Miyamoto S, et al. 2001. Oxidized LDL modulates Bax/ Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 21:955-960.
7. Yoshida H, Kondratenko N, Green S, et al. 1998. Identification of the lectin-like receptor for oxidized low density lipoprotein in human macrophages and its potential role as a scavenger receptor. Biochem J 334:9-13.
8. Nagase M, Ando K, Nagase T, et al. 2001. Redox-sensitive regulation of lox-1 gene expression in vascular endothelium. Biochem Biophys Res Commun 281:720-725.
9. Nakagawa T, Yasuda T, Hoshikawa H, et al. 2002. LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt. Biochem Biophys Res Commun 299:91-97.
10. Nishimura S, Akagi M, Yoshida K, et al. 2004. Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB. Osteoarthritis Cartilage 12:568-576.
11. Kume N, Murase T, Moriwaki H, et al. 1998. Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res 83:322-327.
12. Aoyama T, Fujiwara H, Masaki T, et al. 1999. Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells. J Mol Cell Cardiol 31:2101-2114.
13. Murase T, Kume N, Korenaga R, et al. 1998. Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res 83:328-333.
14. Kakinuma T, Yasuda T, Nakagawa T, et al. 2004. Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage. Arthritis Rheum 50:3495-3503.
15. Chen M, Masaki T, Sawamura T. 2002. LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis [review]. Pharmacol Ther 95:89-100.
16. Li D, Mehta JL. 2000. Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler Thromb Vasc Biol 20: 1116-1122.
17. 2+ channel. J Dent Res 84: 64-68.
18. 2+ mobilization in articular chondrocytes. J Cell Physiol 180:402-408.
19. Maingrette F, Renier G. 2005. Linoleic acid increases lectin-like oxidized LDL receptor-1 (LOX-1) expression in human aortic endothelial cells. Diabetes 54:1506-1513.
20. Yamazaki K, Fukuda K, Matsukawa M, et al. 2003. Cyclic tensile stretch loaded on bovine chondrocytes causes depolymerization of hyaluronan: involvement of reactive oxygen species. Arthritis Rheum 48:3151-3158.
21. Cominacini L, Pasini AF, Garbin U, et al. 2000. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem 275:12633-12638.
22. Chen CH, Jiang T, Yang JH, et al. 2003. Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation 107:2102-2108.
23. Connelly JT, Vanderploeg EJ, Levenston ME. 2004. The influence of cyclic tension amplitude on chondrocyte matrix synthesis: experimental and finite element analyses. Biorheology 41:377-387.
24. Guilak F, Meyer BC, Ratcliffe A, et al. 1994. The effects of matrix compression on proteoglycan metabolism in articular cartilage explants. Osteoarthritis Cartilage 2:91-101.
25. Honda K, Ohno S, Tanimoto K, et al. 2000. The effects of high magnitude cyclic tensile load on cartilage matrix metabolism in cultured chondrocytes. Eur J Cell Biol 79: 601-609.
26. Vanderploeg EJ, Imler SM, Brodkin KR, et al. 2004. Oscillatory tension differentially modulates matrix metabolism and cytoskeletal organization in chondrocytes and fibrochondrocytes. J Biomech 37:1941-1952.
27. Lee RB, Wilkins RJ, Razaq S, et al. 2002. The effect of mechanical stress on cartilage energy metabolism. Biorheology 39:133-143.