Design and synthesis of 2-(1, 3-dioxoisoindolin-2-yl)-N-(4-oxo-2- substitutedthiazolidin-3-yl) acetamide derivatives as potential anticonvulsant agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 11, 2011, Pages 5448-5455

  Nikalje, Anna Pratima G ^a   Khan, Firoz Kalam ^a   Ghodke, Mangesh ^a  

^a Y B CHAVAN COLLEGE OF PHARMACY   (India)

Author keywords

Anticonvulsants; Behavioral activity; Microwave assisted; Neurotoxicity; Thiazolidinyl acetamide

Indexed keywords

2 (1, 3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N [2 (2 HYDROXY PHENYL) 4 OXO THIAZOLIDIN 3 YL] ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N (2 FURAN 2 YL 4 OXO THIAZOLIDIN 3 YL) ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N (4 OXO 2 PARA TOLYLTHIAZOLIDIN 3 YL) ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N (4 OXO 2 PHENYLTHIAZOLIDIN 3 YL) ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N (4 OXO 2 PYRIDIN 3 YL THIAZOLIDIN 3 YL) ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N (4 OXO 2 STYRYL THIAZOLIDIN 3 YL) ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N (4 OXO 2 THIOPHEN 2 YL THIAZOLIDIN 3 YL) ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N [2 (1H INDOL 3YL) 4 OXO THIAZOLIDIN 3 YL ] ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N [2 (4 HYDROXY 3 METHOXY PHENYL) 4 OXO THIAZOLIDIN 3 YL] ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N [2 (4 HYDROXY PHENYL 4 OXO THIAZOLIDIN 3 YL] ACETAMIDE; 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) N [2 (4 METHOXY METHOXYPHENYL) 4 OXO THIAZOLIDIN 3 YL] ACETAMIDE; 2 (1,3 DIOXOISOINDOLIN 2 YL) N (4 OXO 2 SUBSTITUTEDTHIAZOLIDIN 3 YL) ACETAMIDE DERIVATIVE; ACETAMIDE DERIVATIVE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; DIAZEPAM; LAMOTRIGINE; METHYLENE 2 (1,3 DIOXO ISOINDOLIN 2 YL) ACETOHYDRAZIDE; N [2 (2, CHLORO 6 FLUORO PHENYL) 4 OXO THIAZOLIDIN 3 YL] 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) ACETAMIDE; N [2 (2,4 DICHLORO PHENYL) 4 OXO THIAZOLIDIN 3 YL] 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) ACETAMIDE; N [2 (3,4 DIMETHOXY PHENYL) 4 OXO THIAZOLIDIN 3 YL] 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) ACETAMIDE; N [2 (4 CHLORO PHENYL) 4 OXO THIAZOLIDIN 3 YL] 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) ACETAMIDE; N [2 (4 DIMETHYLAMINO PHENYL) 4 OXO THIAZOLIDIN 3 YL] 2 (1,3 DIOXO 1,3 DIHYDRO ISOINDOL 2 YL) ACETAMIDE; PENTETRAZOLE; PHENYTOIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG SYNTHESIS; ELECTRIC SHOCK; ELECTRON; HYDROGEN BOND; LOCOMOTION; MALE; MENTAL PERFORMANCE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHARMACOLOGY; PHARMACOPHORE; SEIZURE;

ACETAMIDES; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; GREEN CHEMISTRY TECHNOLOGY; MALE; MICE; MICROWAVES; TOXICITY TESTS, ACUTE;

EID: 80054901658     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.09.003     Document Type: Article

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