Ameliorative effect of Aegle marmelos leaf extract on early stage alloxan-induced diabetic cardiomyopathy in rats

Pharmaceutical Biology

Volumn 49, Issue 11, 2011, Pages 1137-1143

  Bhatti, Rajbir ^a   Sharma, Shikha ^a   Singh, Jatinder ^b   Ishar, Mohan Paul S ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

^b GOVERNMENT MEDICAL COLLEGE   (India)

Author keywords

Antidiabetic; Antihyperglycemic; Antioxidant; Lipidperoxidation; Oxidative stress; Phytopharmaceuticals

Indexed keywords

AEGLE MARMELOS EXTRACT; CATALASE; CHOLESTEROL; CREATINE KINASE; GLUCOSE; GLUTATHIONE; LACTATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TOLBUTAMIDE;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DOSE RESPONSE; DRUG MECHANISM; FEMALE; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; MALE; NONHUMAN; PLANT LEAF; RAT; WISTAR RAT;

AEGLE; ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; CATALASE; CHOLESTEROL; CREATINE KINASE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; GLUTATHIONE; HYPOGLYCEMIC AGENTS; L-LACTATE DEHYDROGENASE; MALE; MYOCARDIUM; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SOLVENTS; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TIME FACTORS;

AEGLE MARMELOS; RATTUS; RATTUS NORVEGICUS; RUTACEAE;

EID: 80054881991     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2011.572077     Document Type: Article

References (28)

1. Aebi H. (1974). Catalase. Methods of Enzymatic Analysis. 2nd edition, New York: Academic Press, pp. 673-685.
2. Asbun J, Villarreal FJ. (2006). The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. J Am Coll Cardiol, 47, 693-700.
3. Babu PV, Sabitha KE, Shyamaladevi CS. (2006). Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. Chem Biol Interact, 162, 114-120.
4. Bhandari U, Ansari MN. (2009). Ameliorative effect of an ethanol extract of Embelica ribes fruits on isoproterenol induced cardiotoxicity in diabetic rats. Pharm Biol, 47, 669-674.
5. Cai L, Kang YJ. (2003). Cell death and diabetic cardiomyopathy. Cardiovasc Toxicol, 3, 219-228.
6. Cai L, Wang Y, Zhou G, Chen T, Song Y, Li X, Kang YJ. (2006). Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. j Am Coll Cardiol, 48, 1688-1697.
7. CPCSEA. (2003). CPCSEA guidelines for laboratory animal facility. Indian J Pharmacol, 35, 257-274.
8. Dallak M, Bashir N, Abbas M, Elassa R, Haidara M, Khalil M, Al-Khateeb MA. (2009). Concomitant down regulation of glycolytic enzymes, upregulation of gluconeogenic enzymes and potential hepatonephroprotective effects following the chronic administration of hypoglycaemic, insulinotropic Citrullus colocynthis pulp extract. Am J Biochem and Biotech, 5, 153-161.
9. Dallak MM, Mikhailidis DP, Haidara MA, Bin-Jaliah IM, Tork OM, Rateb MA, Yassin HZ, Al-Refaie ZA, Ibrahim IM, Elawa SM, Rashed LA, Afifi NA. (2008). Oxidative stress as a common mediator for apoptosis induced-cardiac damage in diabetic rats. Open Cardiovasc Med j, 2, 70-78.
10. Das AV, Padayatti PS, Paulose CS. (1996). Effect of leaf extract of Aegle marmelose (L.) Correa ex Roxb. on histological and ultrastructural changes in tissues of streptozotocin induced diabetic rats. Indian j Exp Biol, 34, 341-345.
11. Duzguner V, Kaya S. (2007). Effect of zinc on the lipid peroxidation and the antioxidant defense systems of the alloxan-induced diabetic rabbits. Free Radic Biol Med, 42, 1481-1486.
12. Ellman GL. (1959). Tissue sulfhydryl groups. Arch Biochem Biophys, 82, 70-77.
13. Gireesh G, Reas SK, Jobin M, Paulose CS. (2008). Decreased muscarinic M1 receptor gene expression in the cerebral cortex of streptozotocin-induced diabetic rats and Aegle marmelose leaf extracts therapeutic function. j Ethnopharmacol, 116, 296-304.
14. Haidara MA, Yassin HZ, Rateb M, Ammar H, Zorkani MA. (2006). Role of oxidative stress in development of cardiovascular complications in diabetes mellitus. Curr Vasc Pharmacol, 4, 215-227.
15. Huang TH, Teoh AW, Lin BL, Lin DS, Roufogalis B. (2009). The role of herbal PPAR modulators in the treatment of cardiometabolic syndrome. Pharmacol Res, 60, 195-206.
16. Hughes BP. (1962). A method for the estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase activity in normal and pathological sera. Clin Chim Acta, 7, 597-603.
17. Kakiuchi N, Senaratne LR, Huang SL, Yang XW, Hattori M, Pilapitiya U, Namba T. (1991). Effects of constituents of Beli (Aegle marmelos) on spontaneous beating and calcium-paradox of myocardial cells. Planta Med, 57, 43-46.
18. Kapadia R, Yi JH, Vemuganti R. (2008). Mechanisms of antiinflammatory and neuroprotective actions of PPAR-? agonists. Front Biosci, 13, 1813-1826.
19. Kar A, Choudhary BK, Bandyopadhyay NG. (2003). Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. j Ethnopharmacol, 84, 105-108.
20. Kesari AN, Gupta RK, Singh SK, Diwakar S, Watal G. (2006). Hypoglycemic and antihyperglycemic activity of Aegle marmelos seed extract in normal and diabetic rats. j Ethnopharmacol, 107, 374-379.
21. King J. (1959). A routine method for the estimation of lactic dehydrogenase activity. j Med Lab Technol, 16, 265-272.
22. Maity P, Hansda D, Bandyopadhyay U, Mishra DK. (2009). Biological activities of crude extracts and chemical constituents of Bael, Aegle marmelos (L.) Corr. Indian j Exp Biol, 47, 849-861.
23. Mazumder R, Bhattacharya S, Mazumder A, Pattnaik AK, Tiwary PM, Chaudhary S. (2006). Antidiarrhoeal evaluation of Aegle marmelos (Correa) Linn. root extract. Phytother Res, 20, 82-84.
24. Mishra A, Bhatti R, Singh A, Singh Ishar MP. (2010). Ameliorative effect of the cinnamon oil from Cinnamomum zeylanicum upon early stage diabetic nephropathy. Planta Med, 76, 412-417.
25. Misra HP, Fridovich I. (1972). The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem, 247, 3170-3175.
26. Ohkawa H, Ohishi N, Yagi K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95, 351-358.
27. Sefi M, Fetoui H, Makni M, Zeghal N. (2010). Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats. Food Chem Toxicol, 48, 1986-1993.
28. Zhang CH, Zhang WJ, Xu J, Yu XJ, Lv J, Jing AY, Chen LN, Hu H, Sun Q. (2006). A method to produce animal model of diabetic cardiomyopathy. Wei Sheng Yan Jiu, 35, 707-711.