Exon 11 deletion in the myocyte enhancer factor (MEF)2A and early onset coronary artery disease gene in a Sicilian family

European Journal of Preventive Cardiology

Volumn 18, Issue 4, 2011, Pages 557-560

  Maiolino, Giuseppe ^a   Colonna, Stefania ^a   Zanchetta, Mario ^a   Pedon, Luigi ^a   Seccia, Teresa Maria ^b   Cesari, Maurizio ^b   Vigili de Kreutzenberg, Saula ^b   Avogaro, Angelo ^b   Rossi, Gian Paolo ^b  

^a Cittadella General Hospital   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Coronary artery disease; deletion; genetic susceptibility; risk factors

Indexed keywords

MYOCYTE ENHANCER FACTOR 2;

ACCURACY; ANGIOCARDIOGRAPHY; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; EXON; GENE DELETION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; ITALY; MAJOR CLINICAL STUDY; ONSET AGE; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL;

AGE OF ONSET; CASE-CONTROL STUDIES; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; DNA MUTATIONAL ANALYSIS; EXONS; GENE DELETION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HEREDITY; HUMANS; MADS DOMAIN PROTEINS; MALE; MIDDLE AGED; MYOGENIC REGULATORY FACTORS; PEDIGREE; PHENOTYPE; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SICILY;

EID: 80054870325     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1177/1741826710397112     Document Type: Article

References (16)

1. Assmann G, Cullen P, Schulte H. Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study. Circulation 2002; 105: 310–310.
2. Raiko JR, Magnussen CG, Kivimaki M, Taittonen L, Laitinen T, Kahonen M, et al. Cardiovascular risk scores in the prediction of subclinical atherosclerosis in young adults: evidence from the cardiovascular risk in a young Finns study. Eur J Cardiovasc Prev Rehabil 2010; 17: 549–549.
3. Cesari M, Maiolino G, Colonna S, Zanchetta M, Pedon L, Maiolino P, et al. Under treatment with lipid-lowering drugs of high-risk coronary heart disease patients of the GENICA study. J Cardiovasc Pharmacol 2003; 42: 484–484.
4. Shiffman D, Chasman DI, Zee RY, Iakoubova OA, Louie JZ, Devlin JJ, et al. A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study. J Am Coll Cardiol 2008; 51: 444–444.
5. Wang L, Fan C, Topol SE, Topol EJ, Wang Q. Mutation of MEF2A in an inherited disorder with features of coronary artery disease. Science 2003; 302: 1578–1578.
6. Black BL, Molkentin JD, Olson EN. Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. Mol Cell Biol 1998; 18: 69–69.
7. Edmondson DG, Lyons GE, Martin JF, Olson EN. Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development 1994; 120: 1251–1251.
8. Kajimoto K, Shioji K, Tago N, Tomoike H, Nonogi H, Goto Y, et al. Assessment of MEF2A mutations in myocardial infarction in Japanese patients. Circ J 2005; 69: 1192–1192.
9. Lieb W, Mayer B, Konig IR, Borwitzky I, Gotz A, Kain S, et al. Lack of association between the MEF2A gene and myocardial infarction. Circulation 2008; 117: 185–185.
10. Guella I, Rimoldi V, Asselta R, Ardissino D, Francolini M, Martinelli N, et al. Association and functional analyses of MEF2A as a susceptibility gene for premature myocardial infarction and coronary artery disease. Circ Cardiovasc Genet 2009; 2: 165–165.
11. Weng L, Kavaslar N, Ustaszewska A, Doelle H, Schackwitz W, Hebert S, et al. Lack of MEF2A mutations in coronary artery disease. J Clin Invest 2005; 115: 1016–1016.
12. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens 2007; 25: 1751–1751.
13. Rossi GP, Cesari M, De Toni R, Zanchetta M, Maiolino G, Pedon L, et al. Antibodies to oxidized low-density lipoproteins and angiographically assessed coronary artery disease in white patients. Circulation 2003; 108: 2467–2467.
14. Rossi GP, Cesari M, Zanchetta M, Colonna S, Maiolino G, Pedon L, et al. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol 2003; 41: 930–930.
15. Rossi GP, Maiolino G, Zanchetta M, Sticchi D, Pedon L, Cesari M, et al. The T(-786)C endothelial nitric oxide synthase genotype predicts cardiovascular mortality in high-risk patients. J Am Coll Cardiol 2006; 48: 1166–1166.
16. Horan PG, Allen AR, Hughes AE, Patterson CC, Spence M, McGlinchey PG, et al. Lack of MEF2A Delta7aa mutation in Irish families with early onset ischaemic heart disease, a family based study. BMC Med Genet 2006; 7: 65–65.