Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation

European Neurology

Volumn 62, Issue 6, 2009, Pages 362-368

  Lee, Eun Mi ^a   Kang, Joong Koo ^a   Yun, Sung Cheol ^b   Kim, Ki Hun ^c   Kim, Sang Joon ^d   Hwang, Kyu Sam ^a   Lee, Sung Gyu ^c  

^a University of Ulsan College of Medicine   (South Korea)

^b Departments of Preventive Medicine   (Taiwan)

^c Department of Surgery

^d Radiology and Research Institute of Radiology

Author keywords

Central pontine myelinolysis; Hypocholesterolemia; Hyponatremia; Liver transplantation; Model for End Stage Liver Disease Na score

Indexed keywords

CYCLOSPORIN; SODIUM ION; TACROLIMUS;

ADULT; ARTICLE; CENTRAL PONTINE MYELINOLYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; ELECTROLYTE DISTURBANCE; FEMALE; HUMAN; HYPOCHOLESTEROLEMIA; HYPONATREMIA; LIVER DYSFUNCTION; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; NEUROIMAGING; NEUROLOGICAL COMPLICATION; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SCORING SYSTEM;

ADOLESCENT; ADULT; FEMALE; HUMANS; HYPONATREMIA; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MONITORING, INTRAOPERATIVE; MYELINOLYSIS, CENTRAL PONTINE; PREDICTIVE VALUE OF TESTS; RISK FACTORS; STATISTICS, NONPARAMETRIC;

EID: 70349588363     PISSN: 00143022     EISSN: None     Source Type: Journal    
DOI: 10.1159/000242426     Document Type: Article

References (37)

1. Boon AP, Carey MP, Adams DH, Buckels J, McMaster P: Central pontine myelinolysis in liver transplantation. J Clin Pathol 1991; 44: 909-914.
2. Estol CJ, Faris AA, Martinez AJ, Ahdab-Barmada M: Central pontine myelinolysis after liver transplantation. Neurology 1989; 39: 493-498.
3. Ghidoni P, Di Bella C, Masini T, Paone G, Matturri L: Central pontine and extrapontine myelinolysis after orthotopic liver transplantation. Transplant Proc 1994; 26: 3602-3603.
4. Bronster DJ, Emre S, Boccagni P, Sheiner PA, Schwartz ME, Miller CM: Central nervous system complications in liver transplant recipients - incidence, timing, and long-term follow-up. Clin Transplant 2000; 14: 1-7.
5. Yu J, Zheng SS, Liang TB, Shen Y, Wang WL, Ke QH: Possible causes of central pontine myelinolysis after liver transplantation. World J Gastroenterol 2004; 10: 2540-2543.
6. Kim BS, Lee SG, Hwang S, Park KM, Kim KH, Ahn CS, Moon DB, Ha TY, Song GW, Kim DS, Moon KM, Jung DH: Neurologic complications in adult living donor liver transplant recipients. Clin Transplant 2007; 21: 544-547.
7. Wszolek ZK, McComb RD, Pfeiffer RF, Steg RE, Wood RP, Shaw BW Jr, Markin RS: Pontine and extrapontine myelinolysis following liver transplantation. Relationship to serum sodium. Transplantation 1989; 48: 1006-1012.
8. Shintani M, Yamashita M, Nakano A, Aotani D, Maeda K, Yamamoto T, Nishimura H: Central pontine and extrapontine myelinolysis associated with type 2 diabetic patient with hypokalemia. Diabetes Res Clin Pract 2005; 68: 75-80.
9. Sugimoto T, Murata T, Omori M, Wada Y: Central pontine myelinolysis associated with hypokalaemia in anorexia nervosa. J Neurol Neurosurg Psychiatry 2003; 74: 353-355.
10. Riggs JE, Schochet SS Jr: Osmotic stress, osmotic myelinolysis, and oligodendrocyte topography. Arch Pathol Lab Med 1989; 113: 1386-1388.
11. Falcone N, Compagnoni A, Meschini C, Perrone C, Nappo A: Central pontine myelinolysis induced by hypophosphatemia following Wernicke's encephalopathy. Neurol Sci 2004; 24: 407-410.
12. Michell AW, Burn DJ, Reading PJ: Central pontine myelinolysis temporally related to hypophosphataemia. J Neurol Neurosurg Psychiatry 2003; 74: 820.
13. Riggs JE, Hogg JP: Central pontine myelinolysis: Association with parenteral magnesium administration. Mil Med 2000; 165: 494-495.
14. Singh N, Yu VL, Gayowski T: Central nervous system lesions in adult liver transplant recipients: Clinical review with implications for management. Medicine (Baltimore) 1994; 73: 110-118.
15. Kabeer MH, Filo RS, Milgrom ML, Pescovitz MD, Leapman SB, Lumeng L, Jindal RM: Central pontine myelinolysis following orthotopic liver transplant: Association with cyclosporine toxicity. Postgrad Med J 1995; 71: 239-241.
16. Fryer JP, Fortier MV, Metrakos P, Verran DJ, Asfar SK, Pelz DM, Wall WJ, Grant DR, Ghent CN: Central pontine myelinolysis and cyclosporine neurotoxicity following liver transplantation. Transplantation 1996; 61: 658-661.
17. Beltran J, Taura P, Garcia-Valdecasas JC, Navasa M, Zavala E, Anglada T, Soley R, Alvarez L, Visa J: Neurological disorders and intraoperative factors in liver transplantation. Transplant Proc 1993; 25: 1749-1750.
18. Abbasoglu O, Goldstein RM, Vodapally MS, Jennings LW, Levy MF, Husberg BS, Klintmalm GB: Liver transplantation in hyponatremic patients with emphasis on central pontine myelinolysis. Clin Transplant 1998; 12: 263-269.
19. Wiesner R, Edwards E, Freeman R, Harper A, Kim R, Kamath P, Kremers W, Lake J, Howard T, Merion RM, Wolfe RA, Krom R: Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology 2003; 124: 91-96.
20. Biggins SW, Kim WR, Terrault NA, Saab S, Balan V, Schiano T, Benson J, Therneau T, Kremers W, Wiesner R, Kamath P, Klintmalm G: Evidence-based incorporation of serum sodium concentration into meld. Gastroenterology 2006; 130: 1652-1660.
21. Wong VW, Chim AM, Wong GL, Sung JJ, Chan HL: Performance of the new MELDNa score in predicting 3-month and 1-year mortality in Chinese patients with chronic hepatitis B. Liver Transpl 2007; 13: 1228-1235.
22. Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, D'Amico G, Dickson ER, Kim WR: A model to predict survival in patients with end-stage liver disease. Hepatology 2001; 33: 464-470.
23. Huo TI, Lin HC, Hsia CY, Huang YH, Wu JC, Chiang JH, Chiou YY, Lui WY, Lee PC, Lee SD: The MELD-Na is an independent shortand long-term prognostic predictor for hepatocellular carcinoma: A prospective survey. Dig Liver Dis 2008; 40: 882-889.
24. Kim WR, Biggins SW, Kremers WK, Wiesner RH, Kamath PS, Benson JT, Edwards E, Therneau TM: Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 2008; 359: 1018-1026.
25. Kumar S, Fowler M, Gonzalez-Toledo E, Jaffe SL: Central pontine myelinolysis, an update. Neurol Res 2006; 28: 360-366.
26. Cramer SC, Stegbauer KC, Schneider A, Mukai J, Maravilla KR: Decreased diffusion in central pontine myelinolysis. AJNR Am J Neuroradiol 2001; 22: 1476-1479.
27. Chu K, Kang DW, Ko SB, Kim M: Diffusionweighted MR findings of central pontine and extrapontine myelinolysis. Acta Neurol Scand 2001; 104: 385-388.
28. Cicognani C, Malavolti M, Morselli-Labate AM, Zamboni L, Sama C, Barbara L: Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis. Arch Intern Med 1997; 157: 792-796.
29. D'Arienzo A, Manguso F, Scaglione G, Vicinanza G, Bennato R, Mazzacca G: Prognostic value of progressive decrease in serum cholesterol in predicting survival in Child- Pugh C viral cirrhosis. Scand J Gastroenterol 1998; 33: 1213-1218.
30. Bramhall SR, Minford E, Gunson B, Buckels JA: Liver transplantation in the UK. World J Gastroenterol 2001; 7: 602-611.
31. Lui CC, Chen CL, Chang YF, Lee TY, Chuang YC, Hsu SP: Subclinical central pontine myelinolysis after liver transplantation. Transplant Proc 2000; 32: 2215-2216.
32. Kato T, Hattori H, Nagato M, Kiuchi T, Uemoto S, Nakahata T, Tanaka K: Subclinical central pontine myelinolysis following liver transplantation. Brain Dev 2002; 24: 179-182.
33. Laureno R, Karp BI: Myelinolysis after correction of hyponatremia. Ann Intern Med 1997; 126: 57-62.
34. Lampl C, Yazdi K: Central pontine myelinolysis. Eur Neurol 2002; 47: 3-10.
35. Rodriguez J, Benito-Leon J, Molina JA, Ramos A, Bermejo F: Central pontine myelinolysis associated with cyclosporin in liver transplantation. Neurologia 1998; 13: 437-440.
36. Bird GL, Meadows J, Goka J, Polson R, Williams R: Cyclosporin-associated akinetic mutism and extrapyramidal syndrome after liver transplantation. J Neurol Neurosurg Psychiatry 1990; 53: 1068-1071.
37. Burkhalter EL, Starzl TE, Van Thiel DH: Severe neurological complications following orthotopic liver transplantation in patients receiving FK 506 and prednisone. J Hepatol 1994; 21: 572-577.