Diffusion Tensor Imaging Detects Retinal Ganglion Cell Axon Damage in the Mouse Model of Optic Nerve Crush

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 9, 2011, Pages 7001-7006

  Zhang, Xu ^a   Sun, Peng ^a   Wang, Jian ^a   Wang, Qing ^b   Song, Sheng Kwei ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROGOLD; MYELIN; NEUROFILAMENT PROTEIN; PHOSPHOPROTEIN; SMI 31; UNCLASSIFIED DRUG; 2 HYDROXY 4,4' DIAMIDINOSTILBENE, METHANESULFONATE SALT; 2-HYDROXY-4,4'-DIAMIDINOSTILBENE, METHANESULFONATE SALT; BIOLOGICAL MARKER; MBP PROTEIN, MOUSE; MYELIN BASIC PROTEIN; STILBAMIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANISOTROPY; ARTICLE; AXIAL DIFFUSIVITY; AXONAL INJURY; CELL COUNT; CELL LOSS; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; FEMALE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE FIBER DEGENERATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NERVE INJURY; PHYSICAL PARAMETERS; PRIORITY JOURNAL; RADIAL DIFFUSIVITY; RETINA GANGLION CELL; ANIMAL; C57BL MOUSE; DISEASE MODEL; METABOLISM; NERVE CRUSH; NERVE DEGENERATION; NERVE FIBER; OPTIC NERVE DISEASE; PATHOLOGY;

ANIMALS; AXONS; BIOLOGICAL MARKERS; CELL COUNT; DIFFUSION TENSOR IMAGING; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, INBRED C57BL; MYELIN BASIC PROTEINS; NERVE CRUSH; NERVE DEGENERATION; NEUROFILAMENT PROTEINS; OPTIC NERVE DISEASES; RETINAL GANGLION CELLS; STILBAMIDINES;

EID: 80054852524     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7619     Document Type: Article

References (32)

1. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. March 2006. 2006;90(3):262-267.
2. Quigley HA, Dunkelberger GR, Green WR. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol. 1989;107(5):453-464.
3. Buckingham BP, Inman DM, Lambert W, et al. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J Neurosci. 2008;28(11):2735-2744.
4. Crish SD, Sappington RM, Inman DM, Horner PJ, Calkins DJ. Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Proc Natl Acad Sci U S A. 2010;107(11):5196-5201.
5. Schlamp CL, Li Y, Dietz JA, Janssen KT, Nickells RW. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci. 2006;7:66.
6. Raff MC, Whitmore AV, Finn JT. Axonal self-destruction and neurodegeneration. Science. 2002;296(5569):868-871.
7. Song SK, Sun SW, Ju WK, Lin SJ, Cross AH, Neufeld AH. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage. 2003;20(3):1714-1722.
8. Kim JH, Loy DN, Liang H-F, Trinkaus K, Schmidt RE, Song S-K. Noninvasive diffusion tensor imaging of evolving white matter pathology in a mouse model of acute spinal cord injury. Magn Reson Med. 2007;58(2):253-260.
9. Song SK, Kim JH, Lin SJ, Brendza RP, Holtzman DM. Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition. Neurobiol Dis. 2004;5(3):640-64704.
10. Song SK, Yoshino J, Le TQ, et al. Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage. 2005; 26(1):132-140.
11. Ashtari M, Cervellione KL, Hasan KM, et al. White matter development during late adolescence in healthy males: a cross-sectional diffusion tensor imaging study. Neuroimage. 2007;35(2):501-510.
12. Hui ES, Fu QL, So KF, Wu EX. Diffusion tensor MR study of optic nerve degeneration in glaucoma. Conf Proc IEEE Eng Med Biol Soc. 2007:4312-4315.
13. Chan KC, Fu Q-I, Hui ES, So K-F, Wu EX. Evaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imaging. NeuroImage. 2008;40(3):1166-1174.
14. Garaci FG, Bolacchi F, Cerulli A, et al. Optic nerve and optic radiation neurodegeneration in patients with glaucoma: in vivo analysis with 3-T diffusion-tensor MR imaging. Radiology. 2009; 252(2):496-501.
15. Mabuchi F, Aihara M, Mackey MR, Lindsey JD, Weinreb RN. Regional optic nerve damage in experimental mouse glaucoma. Invest Ophthalmol Vis Sci. 2004;45(12):4352-4358.
16. Mackenzie P, Cioffi G. How does lowering of intraocular pressure protect the optic nerve? Surv Ophthalmol. 2008;53(suppl. 1): S39-S43.
17. Schwartz M. Optic nerve crush: protection and regeneration. Brain Res Bull. 2004;62(6):467-471.
18. Goldblum D, Mittag T. Prospects for relevant glaucoma models with retinal ganglion cell damage in the rodent eye. Vis Res. 2002;42(4):471-478.
19. Zhang X, Cheng M, Chintala SK. Kainic acid-mediated upregulation of matrix metalloproteinase-9 promotes retinal degeneration. Invest Ophthalmol Vis Sci. 2004;45(7):2374-2383.
20. Barnett EM, Zhang X, Maxwell D, Chang Q, Piwnica-Worms D. Single-cell imaging of retinal ganglion cell apoptosis with a cellpenetrating, activatable peptide probe in an in vivo glaucoma model. Proc Natl Acad Sci U S A. 2009;106(23):9391-9396.
21. Budde MD, Xie M, Cross AH, Song S-K. Axial diffusivity is the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci. 2009;29(9):2805-2813.
22. Naismith RT, Xu J, Tutlam NT, et al. Disability in optic neuritis correlates with diffusion tensor-derived directional diffusivities. Neurology. 2009;72(7):589-594.
23. Kim JH, Loy DN, Wang Q, et al. Diffusion tensor imaging at 3 hours after traumatic spinal cord injury predicts long-term locomotor recovery. J Neurotrauma. 2010;27(3):587-598.
24. Medana IM, Esiri MM. Axonal damage: a key predictor of outcome in human CNS diseases. Brain. 2003;126(3):515-530.
25. Coleman M. Axon degeneration mechanisms: commonality amid diversity. Nat Rev Neurosci. 2005;6:889-898.
26. Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage. 2002;17(3): 1429-1436.
27. Sun S-W, Liang H-F, Schmidt RE, Cross AH, Song S-K. Selective vulnerability of cerebral white matter in a murine model of multiple sclerosis detected using diffusion tensor imaging. Neurobiol Dis. 2007;28(1):30-38.
28. MacDonald CL, Dikranian K, Song SK, Bayly PV, Holtzman DM, Brody DL. Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury. Exp Neurol. 2007;205(1):116-131.
29. Zhang J, Jones M, DeBoy CA, et al. Diffusion tensor magnetic resonance imaging of Wallerian degeneration in rat spinal cord after dorsal root axotomy. J Neurosci. 2009;29(10):3160-3171.
30. Selles-Navarro I, Villegas-Perez MP, Salvador-Silva M, Ruiz-Gomez JM, Vidal-Sanz M. Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals: a quantitative in vivo study. Invest Ophthalmol Vis Sci. 1996;37(10): 2002-2014.
31. Knoferle J, Koch JC, Ostendorf T, et al. Mechanisms of acute axonal degeneration in the optic nerve in vivo. Proc Natl Acad Sci U S A. 2010;107(13):6064-6069.
32. Dahlmann-Noor AH, Vijay S, Limb GA, Khaw PT. Strategies for optic nerve rescue and regeneration in glaucoma and other optic neuropathies. Drug Discov Today. 2010;15(7-8):287-299.